Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin I2 (prostacyclin) receptor (IP) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin D2 receptor (DP) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 1 (subtype EP1), 42kDa | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 3 (subtype EP3) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin F receptor (FP) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Homo sapiens | thromboxane A2 receptor | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 2 (subtype EP2), 53kDa | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | rhodopsin orphan GPCR | prostaglandin D2 receptor (DP) | 359 aa | 312 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 2.1124 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 2.0485 | 0.9697 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 2.1124 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.9911 | 0.4683 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 2.0485 | 0.9697 | 1 |
Echinococcus multilocularis | thymidylate synthase | 2.0485 | 0.9697 | 1 |
Echinococcus granulosus | thymidylate synthase | 2.0485 | 0.9697 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 2.1124 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1416 | 0.0655 | 0.0676 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1416 | 0.0655 | 0.0676 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1416 | 0.0655 | 0.0676 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0154 | 0.0057 | 0.0059 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 2.1124 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.9911 | 0.4683 | 0.4455 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1416 | 0.0655 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 2.1124 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 2.0485 | 0.9697 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0154 | 0.0057 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 2.0485 | 0.9697 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.9911 | 0.4683 | 0.483 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0154 | 0.0057 | 0.0059 |
Brugia malayi | thymidylate synthase | 2.0485 | 0.9697 | 1 |
Onchocerca volvulus | 2.0485 | 0.9697 | 1 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 2.0485 | 0.9697 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 180 nM | Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells | ChEMBL. | 15026044 |
EC50 (functional) | = 180 nM | Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells | ChEMBL. | 15026044 |
Ki (binding) | = 12 nM | Binding affinity was determined against prostanoid EP4 receptor | ChEMBL. | 15026044 |
Ki (binding) | = 12 nM | Binding affinity towards EP4 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | = 12 nM | Binding affinity was determined against prostanoid EP4 receptor | ChEMBL. | 15026044 |
Ki (binding) | = 12 nM | Binding affinity towards EP4 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | = 3340 nM | Binding affinity towards EP3 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | = 3340 nM | Binding affinity towards EP3 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards EP1 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards DP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards FP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards IP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards TP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards EP1 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards DP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards FP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards IP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards TP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | = 20000 nM | Binding affinity was determined against prostanoid EP3 receptor | ChEMBL. | 15026044 |
Ki (binding) | = 20000 nM | Binding affinity was determined against prostanoid EP3 receptor | ChEMBL. | 15026044 |
Ki (binding) | = 28000 nM | Binding affinity was determined against prostanoid EP1 receptor | ChEMBL. | 15026044 |
Ki (binding) | = 28000 nM | Binding affinity was determined against prostanoid EP1 receptor | ChEMBL. | 15026044 |
Ki (binding) | = 164000 nM | Binding affinity was determined against prostanoid EP2 receptor | ChEMBL. | 15026044 |
Ki (binding) | = 164000 nM | Binding affinity was determined against prostanoid EP2 receptor | ChEMBL. | 15026044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.