Detailed information for compound 1370537

Basic information

Technical information
  • TDR Targets ID: 1370537
  • Name: N-[5-[(2,6-dichlorophenyl)methylsulfanyl]-1,3 ,4-thiadiazol-2-yl]-2-(1,3-dioxo-3a,4,7,7a-te trahydroisoindol-2-yl)acetamide
  • MW: 483.391 | Formula: C19H16Cl2N4O3S2
  • H donors: 1 H acceptors: 5 LogP: 3.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1nnc(s1)SCc1c(Cl)cccc1Cl)CN1C(=O)C2C(C1=O)CC=CC2
  • InChi: 1S/C19H16Cl2N4O3S2/c20-13-6-3-7-14(21)12(13)9-29-19-24-23-18(30-19)22-15(26)8-25-16(27)10-4-1-2-5-11(10)17(25)28/h1-3,6-7,10-11H,4-5,8-9H2,(H,22,23,26)
  • InChiKey: KKAYQVYWRUCTPF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[5-[(2,6-dichlorophenyl)methylthio]-1,3,4-thiadiazol-2-yl]-2-(1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)acetamide
  • N-[5-[(2,6-dichlorobenzyl)thio]-1,3,4-thiadiazol-2-yl]-2-(1,3-diketo-3a,4,7,7a-tetrahydroisoindol-2-yl)acetamide
  • N-[5-[(2,6-dichlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]-2-(1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)ethanamide
  • T5270935
  • MLS000569774
  • SMR000155250

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0356 0.0356
Schistosoma mansoni bromodomain containing protein 0.0076 0.2395 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0356 0.0356
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0313 0.0654
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1806 0.1962
Loa Loa (eye worm) ctsf protein 0.002 0.0356 0.0281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0356 0.0356
Echinococcus granulosus cathepsin l1 0.0014 0.0113 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0356 0.0245
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Onchocerca volvulus 0.002 0.0356 0.0245
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1806 0.2066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0356 0.732
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0356 0.0743
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1379
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0313 0.0232
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0356 0.0281
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0356 0.0743
Onchocerca volvulus 0.002 0.0356 0.0245
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2175 0.8997
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0313 0.0654
Onchocerca volvulus 0.0024 0.0486 0.0377
Schistosoma mansoni zinc finger protein 0.0024 0.048 0.1002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Schistosoma mansoni hypothetical protein 0.0019 0.0313 0.0654
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0313 0.0358
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0356 0.0407
Plasmodium vivax vivapain-2 0.002 0.0356 0.3825
Brugia malayi Cathepsin L-like precursor 0.002 0.0356 0.0407
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0882 0.1841
Schistosoma mansoni rab6-interacting 0.0024 0.0486 0.1015
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.061 0.1273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0356 1
Onchocerca volvulus 0.002 0.0356 0.0245
Leishmania major cysteine peptidase A (CPA) 0.002 0.0356 0.0298
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0113 0.3182
Brugia malayi PHD-finger family protein 0.003 0.0713 0.0816
Schistosoma mansoni hypothetical protein 0.0024 0.0486 0.1015
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0486 1
Echinococcus multilocularis cysteine protease 0.002 0.0356 0.0743
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.093 0.1942
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0356 0.0281
Leishmania major cathepsin L-like protease 0.002 0.0356 0.0298
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0356 0.0743
Onchocerca volvulus Cathepsin L homolog 0.002 0.0356 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0356 0.0356
Leishmania major cathepsin L-like protease 0.0077 0.2417 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4853 0.5494
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1806 0.2066
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.1677 0.3502
Onchocerca volvulus 0.002 0.0356 0.0245
Brugia malayi Cathepsin L-like precursor 0.0014 0.0113 0.0129
Loa Loa (eye worm) hypothetical protein 0.0085 0.2721 0.3022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.2238 0.4672
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0486 0.1015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0356 0.0356
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0369 0.0771
Onchocerca volvulus 0.0036 0.093 0.0826
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0486 0.1015
Loa Loa (eye worm) fibroinase 0.002 0.0356 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.874 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0356 1
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0486 0.0432
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0313 0.0358
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0356 0.0743
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.1677 0.3502
Trypanosoma brucei ISWI complex protein 0.0018 0.0292 0.121
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2417 1
Schistosoma mansoni hypothetical protein 0.0019 0.0313 0.0654
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Echinococcus multilocularis GPCR, family 2 0.0019 0.0313 0.0654
Trypanosoma cruzi ISWI complex protein 0.0018 0.0292 0.121
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0356 0.1472
Leishmania major cathepsin L-like protease 0.0077 0.2417 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1115 0.1161
Brugia malayi Pre-SET motif family protein 0.0036 0.093 0.1064
Brugia malayi cathepsin L-like precursor 0.0014 0.0113 0.0129
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0486 0.5225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0486 0.0432
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4853 0.5494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0113 0.0113
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0356 0.0743
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2417 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0113 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0356 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Brugia malayi Bromodomain containing protein 0.0091 0.2908 0.3327
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0113 0.0236
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0486 0.1015
Schistosoma mansoni zinc finger protein 0.0018 0.0292 0.061
Leishmania major cathepsin L-like protease 0.002 0.0356 0.0298
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0018 0.0292 0.061
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.2238 0.4672
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0369 0.0771
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Echinococcus multilocularis zinc finger protein 0.0024 0.048 0.1002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0356 0.0356
Onchocerca volvulus 0.002 0.0356 0.0245
Brugia malayi Doublecortin family protein 0.0024 0.0486 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.061 0.1273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Loa Loa (eye worm) cysteine protease 0.002 0.0356 0.0281
Echinococcus granulosus GPCR family 2 0.0019 0.0313 0.0654
Echinococcus granulosus zinc finger protein 0.0024 0.048 0.1002
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0356 0.0743
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0356 0.732
Leishmania major cathepsin L-like protease 0.002 0.0356 0.0298
Brugia malayi hypothetical protein 0.0024 0.0486 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Brugia malayi Cathepsin L-like precursor 0.002 0.0356 0.0407
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.093 0.1942
Loa Loa (eye worm) hypothetical protein 0.0019 0.0313 0.0232
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0113 0.0129
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1115 0.1276
Echinococcus granulosus RUN 0.0024 0.0486 0.1015
Loa Loa (eye worm) hypothetical protein 0.002 0.0356 0.0281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.1677 0.3502
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0356 0.0356
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1819 0.7525
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0369 0.0771
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0486 0.1015
Schistosoma mansoni lipoxygenase 0.01 0.3234 0.6753
Brugia malayi MH2 domain containing protein 0.0144 0.4853 0.5552
Loa Loa (eye worm) hypothetical protein 0.0052 0.1491 0.1597
Loa Loa (eye worm) hypothetical protein 0.0057 0.1677 0.1813
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0526 0.0479
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0396 0.0328
Brugia malayi hypothetical protein 0.0024 0.0486 0.0556
Onchocerca volvulus 0.0024 0.0486 0.0377
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.1677 0.3502
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.061 0.1273
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0369 0.0771
Schistosoma mansoni hypothetical protein 0.0019 0.0313 0.0654
Brugia malayi Cathepsin L-like precursor 0.002 0.0356 0.0407
Trypanosoma cruzi ISWI complex protein 0.0018 0.0292 0.121
Onchocerca volvulus 0.002 0.0356 0.0245
Echinococcus granulosus cathepsin l1 0.002 0.0356 0.0743
Brugia malayi Cathepsin L-like precursor 0.002 0.0356 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Schistosoma mansoni polycystin 1-related 0.0024 0.0486 0.1015
Schistosoma mansoni lipoxygenase 0.0142 0.4789 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1196 0.2498
Brugia malayi Cathepsin L-like precursor 0.002 0.0356 0.0407
Schistosoma mansoni hypothetical protein 0.0041 0.1115 0.2328
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0356 0.0743
Loa Loa (eye worm) hypothetical protein 0.0049 0.1407 0.15
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0356 0.0356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Schistosoma mansoni loxhd1 0.0024 0.0486 0.1015
Loa Loa (eye worm) hypothetical protein 0.006 0.1806 0.1962
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.093 0.1942
Loa Loa (eye worm) hypothetical protein 0.0024 0.0486 0.0432
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.4789 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0313 0.0654
Onchocerca volvulus 0.002 0.0356 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Echinococcus multilocularis cysteine protease 0.002 0.0356 0.0743
Schistosoma mansoni rab6-interacting 0.0024 0.0486 0.1015
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0356 0.0743
Brugia malayi Cathepsin L-like precursor 0.0014 0.0113 0.0129
Leishmania major cathepsin L-like protease 0.0077 0.2417 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0356 0.0407
Brugia malayi Pre-SET motif family protein 0.0251 0.874 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.093 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0356 0.0356
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1196 0.2498
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0486 0.1015
Leishmania major cathepsin L-like protease 0.002 0.0356 0.0298
Plasmodium vivax SET domain protein, putative 0.0036 0.093 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2417 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.4789 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0356 0.0356
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.2417 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0486 0.1015
Echinococcus multilocularis RUN 0.0024 0.0486 0.1015
Schistosoma mansoni hypothetical protein 0.0019 0.0313 0.0654
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0356 0.732
Brugia malayi Bromodomain containing protein 0.0046 0.13 0.1487
Leishmania major cathepsin L-like protease 0.002 0.0356 0.0298
Schistosoma mansoni hypothetical protein 0.0025 0.0526 0.1098
Plasmodium vivax vivapain-2 0.002 0.0356 0.3825
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0313 0.0654
Onchocerca volvulus Cathepsin F homolog 0.002 0.0356 0.0245
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2417 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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