Detailed information for compound 1370719

Basic information

Technical information
  • TDR Targets ID: 1370719
  • Name: N-[2,2,2-trichloro-1-(6-methylpyrimidin-4-yl) sulfanylethyl]formamide
  • MW: 300.593 | Formula: C8H8Cl3N3OS
  • H donors: 1 H acceptors: 3 LogP: 3.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CNC(C(Cl)(Cl)Cl)Sc1ncnc(c1)C
  • InChi: 1S/C8H8Cl3N3OS/c1-5-2-6(13-3-12-5)16-7(14-4-15)8(9,10)11/h2-4,7H,1H3,(H,14,15)
  • InChiKey: WVBNXKFXDRDCSO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2,2,2-trichloro-1-(6-methylpyrimidin-4-yl)sulfanyl-ethyl]formamide
  • N-[2,2,2-trichloro-1-[(6-methyl-4-pyrimidinyl)thio]ethyl]formamide
  • N-[2,2,2-trichloro-1-[(6-methylpyrimidin-4-yl)thio]ethyl]formamide
  • N-[2,2,2-trichloro-1-(6-methylpyrimidin-4-yl)sulfanyl-ethyl]methanamide
  • MLS001011125
  • SMR000353137
  • T0501-7712

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei monoglyceride lipase, putative 0.0877 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0151 0.0669
Mycobacterium ulcerans hypothetical protein 0.0052 0.0334 0.0302
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0877 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1424 0.1395
Toxoplasma gondii hypothetical protein 0.0052 0.0334 0.5206
Trichomonas vaginalis conserved hypothetical protein 0.0877 1 1
Schistosoma mansoni chromobox protein 0.0084 0.0714 0.3165
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0052 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0052 0.0334 0.1252
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0587 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0162 0.0606
Toxoplasma gondii thioredoxin reductase 0.0057 0.0398 0.6401
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.006 0.0026
Plasmodium falciparum alpha/beta hydrolase, putative 0.0052 0.0334 0.0302
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0052 0.0334 0.0334
Plasmodium falciparum exported lipase 1 0.0052 0.0334 0.0302
Brugia malayi amidase 0.0216 0.2256 0.8446
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.006 0.0026
Plasmodium falciparum esterase, putative 0.0877 1 1
Echinococcus granulosus abhydrolase domain containing protein 13 0.0052 0.0334 0.0668
Brugia malayi Pre-SET motif family protein 0.0251 0.2671 1
Onchocerca volvulus 0.01 0.0904 0.2547
Echinococcus multilocularis chromobox protein 1 0.0084 0.0714 0.1426
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0052 0.0334 0.0334
Plasmodium vivax PST-A protein 0.0052 0.0334 0.0302
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0334 0.0302
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0052 0.0334 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0334 0.0334
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0052 0.0334 0.0302
Schistosoma mansoni amidase 0.0216 0.2256 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0151 0.0565
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0052 0.0334 0.0302
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.006 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.006 0.0857
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0052 0.0334 0.0668
Plasmodium falciparum esterase, putative 0.0052 0.0334 0.0302
Onchocerca volvulus 0.005 0.0312 0.0516
Echinococcus multilocularis expressed protein 0.0451 0.5006 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0587 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.01 0.0904 0.3386
Loa Loa (eye worm) hypothetical protein 0.0036 0.0151 0.0565
Chlamydia trachomatis acyltransferase family protein 0.0052 0.0334 1
Plasmodium falciparum exported lipase 2 0.0052 0.0334 0.0302
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1254 0.1224
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0026 0.0034 0.0068
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0052 0.0334 0.5206
Plasmodium falciparum alpha/beta hydrolase, putative 0.0052 0.0334 0.0302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0151 0.0669
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1254 0.1224
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3861 0.3861
Trypanosoma cruzi serine peptidase, putative 0.0052 0.0334 0.0302
Plasmodium falciparum alpha/beta hydrolase, putative 0.0052 0.0334 0.0302
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0052 0.0334 0.1482
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1254 0.1224
Plasmodium vivax alpha/beta hydrolase, putative 0.0052 0.0334 0.0302
Onchocerca volvulus 0.0286 0.3078 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0334 0.0334
Mycobacterium leprae conserved hypothetical protein 0.0028 0.006 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0334 0.0334
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0904 0.1807
Plasmodium falciparum lysophospholipase, putative 0.0877 1 1
Echinococcus multilocularis Phospholipase carboxylesterase 0.0052 0.0334 0.0668
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0587 0.0555
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0323 0.0553
Brugia malayi MGC79044 protein 0.0052 0.0334 0.1252
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0323 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0877 1 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0052 0.0334 0.0302
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0052 0.0334 0.5206
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0398 0.1488
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3861 0.3861
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0398 0.0794
Mycobacterium ulcerans hydrolase 0.0052 0.0334 0.0302
Echinococcus granulosus expressed protein 0.0451 0.5006 1
Plasmodium falciparum thioredoxin reductase 0.0057 0.0398 0.0365
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0398 0.0365
Echinococcus granulosus chromobox protein 1 0.0084 0.0714 0.1426
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0334 0.0334
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0052 0.0334 0.0668
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.006 0.0026
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0281 0.0409
Plasmodium falciparum lysophospholipase, putative 0.0877 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0334 0.1252
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1424 0.1395
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1748 0.172
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0151 0.1732
Entamoeba histolytica hypothetical protein 0.0028 0.006 0.006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0312 0.1384
Brugia malayi Heterochromatin protein 1 0.0084 0.0714 0.2673
Echinococcus granulosus fatty acid amide hydrolase 1 0.0216 0.2256 0.4507
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0877 1 1
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.3861 1
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0026 0.0034 0.015
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0904 0.4009
Plasmodium falciparum lysophospholipase, putative 0.0052 0.0334 0.0302
Plasmodium vivax PST-A protein 0.0052 0.0334 0.0302
Brugia malayi Thioredoxin reductase 0.0057 0.0398 0.1488
Mycobacterium ulcerans hypothetical protein 0.0052 0.0334 0.0302
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1748 0.172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0151 0.0669
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0052 0.0334 0.0334
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0052 0.0334 0.0334
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3861 0.3861
Plasmodium vivax PST-A protein 0.0052 0.0334 0.0302
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0587 0.0555
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0047 0.0281 0.1052
Plasmodium falciparum lysophospholipase, putative 0.0052 0.0334 0.0302
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1254 0.1224
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0398 0.0794
Brugia malayi Amidase family protein 0.0026 0.0034 0.0127
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0334 0.0302
Schistosoma mansoni fatty-acid amide hydrolase 0.0026 0.0034 0.015
Loa Loa (eye worm) hypothetical protein 0.0052 0.0334 0.1252
Plasmodium vivax glutathione reductase, putative 0.0057 0.0398 0.0365
Mycobacterium ulcerans hypothetical protein 0.0877 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0334 0.0334
Echinococcus granulosus abhydrolase domain containing 3 0.0052 0.0334 0.0668
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0052 0.0334 0.0302
Toxoplasma gondii peptidase S15, putative 0.0052 0.0334 0.5206
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0052 0.0334 0.1252
Mycobacterium tuberculosis Conserved hypothetical protein 0.0052 0.0334 0.0302
Entamoeba histolytica ;Alias 0.0052 0.0334 0.0334
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0398 0.0365
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0026 0.0034 0.0068
Plasmodium falciparum alpha/beta hydrolase, putative 0.0052 0.0334 0.0302
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0026 0.0034 0.0068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0151 0.0302
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0877 1 1
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0052 0.0334 0.0302
Leishmania major hypothetical protein, conserved 0.0052 0.0334 0.0302
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3861 0.3861
Trypanosoma cruzi serine peptidase, putative 0.0052 0.0334 0.0302
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0323 0.0323
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0052 0.0334 0.0302
Plasmodium vivax PST-A protein 0.0052 0.0334 0.0302
Brugia malayi chromobox protein homolog 3 0.0047 0.0281 0.1052
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0587 0.0555
Mycobacterium tuberculosis Probable reductase 0.013 0.1254 0.1224
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0877 1 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0714 0.1426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3861 0.3861
Plasmodium vivax PST-A protein 0.0052 0.0334 0.0302
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.006 0.0026
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0877 1 1
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0052 0.0334 0.0302
Echinococcus granulosus fatty acid amide hydrolase 1 0.0026 0.0034 0.0068
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0216 0.2256 0.4507
Brugia malayi glutathione reductase 0.0057 0.0398 0.1488
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2671 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3861 0.3861
Toxoplasma gondii phospholipase/carboxylesterase 0.0052 0.0334 0.5206
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0904 0.3386
Trypanosoma brucei trypanothione reductase 0.0057 0.0398 0.0365
Echinococcus multilocularis abhydrolase domain containing 3 0.0052 0.0334 0.0668
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0052 0.0334 0.0334
Trypanosoma cruzi monoglyceride lipase, putative 0.0877 1 1
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0052 0.0334 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0334 0.0334
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0052 0.0334 0.0302
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0151 0.0302
Trypanosoma brucei monoglyceride lipase, putative 0.0877 1 1
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0904 0.1807
Mycobacterium tuberculosis Possible lysophospholipase 0.0877 1 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0877 1 1
Brugia malayi Protein C20orf22 0.0052 0.0334 0.1252
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1424 0.1395
Toxoplasma gondii hypothetical protein 0.0052 0.0334 0.5206
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.012 0.012
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0052 0.0334 0.0334
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0877 1 1
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0714 0.0714
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0151 0.0302
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0587 0.1173
Plasmodium falciparum glutathione reductase 0.0057 0.0398 0.0365
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0714 0.2673
Plasmodium falciparum prodrug activation and resistance esterase 0.0052 0.0334 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0334 0.0334
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0216 0.2256 0.8446
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3078 0.3078
Toxoplasma gondii hypothetical protein 0.0052 0.0334 0.5206
Brugia malayi MGC83647 protein 0.0052 0.0334 0.1252
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0052 0.0334 0.0302
Entamoeba histolytica hypothetical protein 0.0052 0.0334 0.0334
Plasmodium falciparum epoxide hydrolase 2 0.0052 0.0334 0.0302
Loa Loa (eye worm) glutathione reductase 0.0057 0.0398 0.1488
Toxoplasma gondii protein c14orf29, putative 0.0052 0.0334 0.5206
Leishmania major hypothetical protein, conserved 0.0052 0.0334 0.0302
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3861 0.3861
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0216 0.2256 0.4507
Plasmodium vivax lysophospholipase, putative 0.0052 0.0334 0.0302
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0587 0.2604
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0587 0.1173
Brugia malayi putative amidase 0.0026 0.0034 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3861 0.3861
Chlamydia trachomatis hydrolase 0.0052 0.0334 1
Entamoeba histolytica hypothetical protein 0.0052 0.0334 0.0334
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1748 0.172
Plasmodium falciparum esterase, putative 0.0052 0.0334 0.0302
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0587 0.0555
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0877 1 1
Schistosoma mansoni chromobox protein 0.0084 0.0714 0.3165
Echinococcus granulosus chromobox protein 1 0.0084 0.0714 0.1426
Loa Loa (eye worm) amidase 0.0026 0.0034 0.0127
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.3861 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1254 0.1224
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0052 0.0334 0.1482
Plasmodium vivax lysophospholipase, putative 0.0052 0.0334 0.0302
Echinococcus granulosus fatty acid amide hydrolase 1 0.0216 0.2256 0.4507
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0334 0.0302
Plasmodium vivax PST-A protein 0.0877 1 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0216 0.2256 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0281 0.0281
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.006 0.0026
Loa Loa (eye worm) amidase 0.0026 0.0034 0.0127
Plasmodium vivax alpha/beta hydrolase, putative 0.0052 0.0334 0.0302
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0398 0.0365
Plasmodium vivax lysophospholipase, putative 0.0052 0.0334 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0334 0.0334
Plasmodium vivax unspecified product 0.0052 0.0334 0.0302
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0052 0.0334 0.0302
Plasmodium vivax SET domain protein, putative 0.0036 0.0151 0.0118
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.006 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3861 0.3861
Mycobacterium ulcerans lysophospholipase 0.0877 1 1
Brugia malayi Amidase family protein 0.0026 0.0034 0.0127
Plasmodium falciparum lysophospholipase, putative 0.0877 1 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.006 0.0067
Schistosoma mansoni peptidase 0.0052 0.0334 0.1482
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0334 0.0334
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0052 0.0334 0.0302
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1254 0.1224
Echinococcus granulosus Phospholipase carboxylesterase 0.0052 0.0334 0.0668
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1424 0.1395
Leishmania major monoglyceride lipase, putative 0.0877 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0334 0.1252
Toxoplasma gondii phospholipase 0.0052 0.0334 0.5206
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0587 0.2604
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0136 0.0271
Plasmodium vivax unspecified product 0.0052 0.0334 0.0302
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0052 0.0334 0.5206
Plasmodium falciparum BEM46-like protein, putative 0.0052 0.0334 0.0302
Leishmania major trypanothione reductase 0.0057 0.0398 0.0365
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3861 0.3861
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0052 0.0334 0.0334
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0052 0.0334 0.0334
Toxoplasma gondii hypothetical protein 0.0052 0.0334 0.5206

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0029 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 1.7741 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 31.3814 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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