TDR Targets

Basic information

Technical information

TDR Targets ID: 1370757
Name: [3-(2-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5 -yl]methyl 4-bromobenzoate
MW: 390.228 | Formula: C18H16BrNO4
H donors: 0 H acceptors: 1 LogP: 4.06 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1C1=NOC(C1)COC(=O)c1ccc(cc1)Br
InChi: 1S/C18H16BrNO4/c1-22-17-5-3-2-4-15(17)16-10-14(24-20-16)11-23-18(21)12-6-8-13(19)9-7-12/h2-9,14H,10-11H2,1H3
InChiKey: JJEZDPCOPZNUOC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[3-(2-methoxyphenyl)-4,5-dihydroisoxazol-5-yl]methyl 4-bromobenzoate
4-bromobenzoic acid [3-(2-methoxyphenyl)-4,5-dihydroisoxazol-5-yl]methyl ester
SMR000260898
T0503-2990
MLS000391865

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TYRA-2 protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0092	0.021	0.1151
Schistosoma mansoni	hypothetical protein	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	g protein coupled receptor	0.0092	0.021	0.021
Echinococcus multilocularis	serotonin receptor	0.0092	0.021	0.021
Schistosoma mansoni	adenoreceptor	0.0092	0.021	0.021
Schistosoma mansoni	histamine h1 receptor	0.0092	0.021	0.021
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0092	0.021	0.021
Echinococcus granulosus	sex peptide receptor	0.0092	0.021	0.021
Echinococcus multilocularis	neuropeptide s receptor	0.0092	0.021	0.021
Echinococcus granulosus	neuropeptide receptor	0.0092	0.021	0.021
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0302	0.2982	0.5
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.021	0.021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Brugia malayi	neuropeptide F receptor	0.0092	0.021	0.1151
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0092	0.021	0.021
Echinococcus multilocularis	g protein coupled receptor	0.0092	0.021	0.021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.021	0.021
Schistosoma mansoni	amine GPCR	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0092	0.021	0.021
Brugia malayi	hypothetical protein	0.0092	0.021	0.1151
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0092	0.021	0.021
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0092	0.021	0.021
Echinococcus granulosus	neuropeptides capa receptor	0.0092	0.021	0.021
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0092	0.021	0.021
Echinococcus multilocularis	fmrfamide receptor	0.0092	0.021	0.021
Echinococcus multilocularis	neuropeptide receptor	0.0092	0.021	0.021
Onchocerca volvulus		0.0215	0.1825	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0092	0.021	0.1151
Schistosoma mansoni	opsin-like receptor	0.0092	0.021	0.021
Schistosoma mansoni	growth hormone secretagogue receptor	0.0092	0.021	0.021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.021	0.021
Schistosoma mansoni	myosin xvIII	0.0092	0.021	0.021
Echinococcus granulosus	fmrfamide receptor	0.0092	0.021	0.021
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.1589	0.1589
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0302	0.2982	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Chlamydia trachomatis	dihydrofolate reductase	0.0088	0.0146	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Schistosoma mansoni	opsin-like receptor	0.0092	0.021	0.021
Echinococcus granulosus	neuropeptides capa receptor	0.0092	0.021	0.021
Brugia malayi	hypothetical protein	0.0092	0.021	0.1151
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0215	0.1825	0.1825
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0092	0.021	0.1151
Echinococcus granulosus	g protein coupled receptor	0.0092	0.021	0.021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.021	0.021
Mycobacterium tuberculosis	Hypothetical protein	0.0102	0.0338	0.1148
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.021	0.021
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0092	0.021	0.021
Schistosoma mansoni	amine GPCR	0.0092	0.021	0.021
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	neuropeptide Y receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Schistosoma mansoni	amine GPCR	0.0092	0.021	0.021
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0092	0.021	0.021
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.021	0.021
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0092	0.021	0.021
Echinococcus granulosus	g protein coupled receptor	0.0092	0.021	0.021
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0338	0.5
Brugia malayi	G-protein coupled receptor	0.0092	0.021	0.1151
Brugia malayi	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	neuropeptide receptor	0.0092	0.021	0.021
Echinococcus granulosus	dihydrofolate reductase	0.0088	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Brugia malayi	hypothetical protein	0.0092	0.021	0.1151
Echinococcus multilocularis	fmrfamide receptor	0.0092	0.021	0.021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.021	0.021
Echinococcus multilocularis	serotonin receptor	0.0092	0.021	0.021
Echinococcus multilocularis	neuropeptide Y receptor	0.0092	0.021	0.021
Echinococcus multilocularis	sex peptide receptor	0.0092	0.021	0.021
Brugia malayi	ORL1-like opioid receptor	0.0092	0.021	0.1151
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.021	0.021
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.1589	0.1589
Schistosoma mansoni	neuropeptide receptor	0.0092	0.021	0.021
Echinococcus multilocularis	microtubule associated protein 2	0.0833	1	1
Brugia malayi	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Schistosoma mansoni	neuropeptide receptor	0.0092	0.021	0.021
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.1589	0.8704
Brugia malayi	GnHR receptor homolog	0.0092	0.021	0.1151
Echinococcus multilocularis	dro:myosuppressin receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.021	0.021
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0092	0.021	0.021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.021	0.021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.021	0.021
Echinococcus multilocularis	G protein coupled receptor 139	0.0092	0.021	0.021
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0092	0.021	0.021
Schistosoma mansoni	biogenic amine receptor	0.0092	0.021	0.021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.021	0.021
Schistosoma mansoni	opsin-like receptor	0.0092	0.021	0.021
Brugia malayi	hypothetical protein	0.0102	0.0338	0.1854
Mycobacterium ulcerans	thymidylate synthase	0.0215	0.1825	1
Schistosoma mansoni	hypothetical protein	0.0092	0.021	0.021
Brugia malayi	Dopamine receptor	0.0092	0.021	0.1151
Loa Loa (eye worm)	melatonin receptor type 1A	0.0092	0.021	0.1151
Schistosoma mansoni	alpha-glucosidase	0.0169	0.1227	0.1227
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.021	0.021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.021	0.021
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0092	0.021	0.1151
Brugia malayi	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	neuropeptide FF receptor 2	0.0092	0.021	0.021
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0302	0.2982	0.5
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0092	0.021	0.021
Brugia malayi	Dopamine receptor protein 1	0.0092	0.021	0.1151
Brugia malayi	follicle stimulating hormone receptor	0.0092	0.021	0.1151
Loa Loa (eye worm)	thymidylate synthase	0.0215	0.1825	1
Brugia malayi	putative neuropeptide receptor	0.0092	0.021	0.1151
Brugia malayi	neuropeptide F receptor	0.0092	0.021	0.1151
Schistosoma mansoni	biogenic amine receptor	0.0092	0.021	0.021
Brugia malayi	G-protein coupled receptor	0.0092	0.021	0.1151
Echinococcus multilocularis	neuropeptide receptor	0.0092	0.021	0.021
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0092	0.021	0.021
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0302	0.2982	0.5
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Brugia malayi	RE15519p	0.0092	0.021	0.1151
Schistosoma mansoni	hypothetical protein	0.0092	0.021	0.021
Echinococcus multilocularis	g protein coupled receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	tm gpcr rhodopsin	0.0092	0.021	0.021
Echinococcus multilocularis	g-protein coupled receptor	0.0092	0.021	0.021
Schistosoma mansoni	neuropeptide receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	G-protein coupled receptor	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus multilocularis	neuropeptides capa receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0092	0.021	0.021
Echinococcus granulosus	neuropeptide receptor A26	0.0092	0.021	0.021
Schistosoma mansoni	dihydrofolate reductase	0.0088	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0092	0.021	0.021
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0092	0.021	0.1151
Brugia malayi	putative neuropeptide receptor NPR1	0.0092	0.021	0.1151
Brugia malayi	Serotonin receptor	0.0092	0.021	0.1151
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.021	0.021
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0302	0.2982	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0092	0.021	0.021
Brugia malayi	G protein-coupled receptor F59B2.13	0.0092	0.021	0.1151
Brugia malayi	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	dro:myosuppressin receptor	0.0092	0.021	0.021
Schistosoma mansoni	amine GPCR	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	somatostatin receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	neuropeptide F receptor	0.0092	0.021	0.1151
Echinococcus multilocularis	neuropeptides capa receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	thymidylate synthase	0.0215	0.1825	0.1825
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Brugia malayi	dihydrofolate reductase family protein	0.0088	0.0146	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.021	0.021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.021	0.021
Brugia malayi	AKH receptor	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0092	0.021	0.021
Echinococcus granulosus	7tm_1 domain containing protein	0.0092	0.021	0.021
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0092	0.021	0.021
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0092	0.021	0.021
Echinococcus multilocularis	neuropeptide Y receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0092	0.021	0.021
Schistosoma mansoni	biogenic amine receptor	0.0092	0.021	0.021
Echinococcus multilocularis	g protein coupled receptor	0.0092	0.021	0.021
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0092	0.021	0.1151
Echinococcus granulosus	tm gpcr rhodopsin	0.0092	0.021	0.021
Brugia malayi	sulfakinin receptor protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Brugia malayi	thymidylate synthase	0.0215	0.1825	1
Schistosoma mansoni	amine GPCR	0.0092	0.021	0.021
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0092	0.021	0.021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.021	0.021
Echinococcus granulosus	serotonin receptor	0.0092	0.021	0.021
Schistosoma mansoni	microtubule-associated protein tau	0.0833	1	1
Echinococcus granulosus	G protein coupled receptor 139	0.0092	0.021	0.021
Brugia malayi	larval opioid receptor	0.0092	0.021	0.1151
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0215	0.1825	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0092	0.021	0.021
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0092	0.021	0.021
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.1589	0.8704
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Schistosoma mansoni	alpha-glucosidase	0.0169	0.1227	0.1227
Echinococcus granulosus	tm gpcr rhodopsin	0.0092	0.021	0.021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.021	0.021
Brugia malayi	Serotonin receptor	0.0092	0.021	0.1151
Brugia malayi	Dihydrofolate reductase	0.0088	0.0146	0.0798
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0092	0.021	0.021
Echinococcus granulosus	biogenic amine 5HT receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	neuropeptide F receptor	0.0092	0.021	0.1151
Schistosoma mansoni	neuropeptide F-like receptor	0.0092	0.021	0.021
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0092	0.021	0.1151
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0092	0.021	0.021
Echinococcus granulosus	neuropeptide Y receptor	0.0092	0.021	0.021
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0092	0.021	0.021
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0092	0.021	0.021
Schistosoma mansoni	hypothetical protein	0.0092	0.021	0.021
Echinococcus multilocularis	somatostatin receptor	0.0092	0.021	0.021
Echinococcus multilocularis	neuropeptide receptor A26	0.0092	0.021	0.021
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0092	0.021	0.021
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	biogenic amine 5HT receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	orexin receptor type 2	0.0092	0.021	0.021
Loa Loa (eye worm)	G-protein coupled receptor	0.0092	0.021	0.1151
Schistosoma mansoni	neuropeptide receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Brugia malayi	hypothetical protein	0.0092	0.021	0.1151
Echinococcus granulosus	allatostatin A receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	dihydrofolate reductase	0.0088	0.0146	0.0798
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.021	0.021
Echinococcus multilocularis	dihydrofolate reductase	0.0088	0.0146	0.0146
Schistosoma mansoni	neuropeptide f receptor 76f	0.0092	0.021	0.021
Echinococcus granulosus	g-protein coupled receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0092	0.021	0.1151
Brugia malayi	G protein-coupled receptor	0.0092	0.021	0.1151
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0092	0.021	0.021
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0092	0.021	0.021
Brugia malayi	hypothetical protein	0.0092	0.021	0.1151
Onchocerca volvulus		0.0114	0.0493	0.175
Echinococcus granulosus	7TM GPCR rhodopsin	0.0092	0.021	0.021
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0092	0.021	0.1151
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0092	0.021	0.021
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0092	0.021	0.021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.021	0.021
Echinococcus multilocularis	thymidylate synthase	0.0215	0.1825	0.1825
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0092	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Brugia malayi	Melatonin receptor type 1A	0.0092	0.021	0.1151
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.021	0.021
Echinococcus multilocularis	orexin receptor type 2	0.0092	0.021	0.021
Echinococcus granulosus	hypothetical protein	0.0092	0.021	0.021
Echinococcus granulosus	neuropeptide s receptor	0.0092	0.021	0.021
Brugia malayi	hypothetical protein	0.0092	0.021	0.1151
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.1589	0.1589
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0302	0.2982	0.5
Loa Loa (eye worm)	hypothetical protein	0.0092	0.021	0.1151
Brugia malayi	Dopamine receptor protein 2	0.0092	0.021	0.1151
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0092	0.021	0.021
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0215	0.1825	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.021	0.021
Echinococcus multilocularis	allatostatin A receptor	0.0092	0.021	0.021
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0092	0.021	0.021
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0092	0.021	0.021

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.5849 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	21.3313 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (binding)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1505400

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1370757