Detailed information for compound 1371487

Basic information

Technical information
  • TDR Targets ID: 1371487
  • Name: 3-[5-[2-(2-methoxyphenyl)ethyl]-1,3,4-oxadiaz ol-2-yl]-N-(3-pyridin-3-yloxypropyl)propanami de
  • MW: 410.466 | Formula: C22H26N4O4
  • H donors: 1 H acceptors: 4 LogP: 2.47 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CCc1nnc(o1)CCC(=O)NCCCOc1cccnc1
  • InChi: 1S/C22H26N4O4/c1-28-19-8-3-2-6-17(19)9-11-21-25-26-22(30-21)12-10-20(27)24-14-5-15-29-18-7-4-13-23-16-18/h2-4,6-8,13,16H,5,9-12,14-15H2,1H3,(H,24,27)
  • InChiKey: BPZGQGLEAYXRNZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[5-[2-(2-methoxyphenyl)ethyl]-1,3,4-oxadiazol-2-yl]-N-[3-(3-pyridyloxy)propyl]propanamide
  • 3-[5-[2-(2-methoxyphenyl)ethyl]-1,3,4-oxadiazol-2-yl]-N-[3-(3-pyridyloxy)propyl]propionamide
  • 3-{5-[2-(2-methoxyphenyl)ethyl]-1,3,4-oxadiazol-2-yl}-N-[3-(pyridin-3-yloxy)propyl]propanamide
  • MLS000733960
  • SMR000317206

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis raf serine:threonine protein kinase 0.0047 0.0268 0.0268
Echinococcus multilocularis serine:threonine protein kinase N2 0.0067 0.0511 0.0511
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0168 0.0168
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0047 0.0268 0.0268
Echinococcus multilocularis Diacylglycerol kinase theta 0.0047 0.0268 0.0268
Entamoeba histolytica hypothetical protein 0.0039 0.0168 0.0333
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0465 0.092
Brugia malayi ShTK domain containing protein 0.009 0.079 0.079
Brugia malayi small heat shock protein 0.0612 0.7238 0.7238
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0186 0.0186
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0186 0.0186
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0702 0.0702
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0168 0.0168
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0067 0.0511 0.0511
Entamoeba histolytica protein kinase, putative 0.0067 0.0511 0.1011
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0702 0.0702
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0101 0.0928 0.1417
Brugia malayi hypothetical protein 0.0039 0.0168 0.0168
Schistosoma mansoni vav2 0.0047 0.0268 0.0268
Brugia malayi PXA domain containing protein 0.0039 0.0168 0.0168
Echinococcus granulosus fatty acid amide hydrolase 1 0.0836 1 1
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0101 0.0928 0.0928
Brugia malayi hypothetical protein 0.0043 0.022 0.022
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0101 0.0928 0.0928
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0168 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0047 0.0268 0.0268
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0435 0.5053 1
Echinococcus granulosus protein kinase C gamma type 0.0236 0.2602 0.2602
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0286 0.0286
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.009 0.079 0.079
Entamoeba histolytica protein kinase, putative 0.0067 0.0511 0.1011
Entamoeba histolytica hypothetical protein 0.0039 0.0168 0.0333
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0047 0.0268 0.0268
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0101 0.0928 0.0928
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Loa Loa (eye worm) hypothetical protein 0.0047 0.0268 0.0268
Schistosoma mansoni amidase 0.0836 1 1
Toxoplasma gondii diacylglycerol kinase, putative 0.0047 0.0268 0.5255
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.2079 0.2079
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0047 0.0268 0.0268
Schistosoma mansoni tyrosinase precursor 0.009 0.079 0.079
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0836 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0047 0.0268 0.0268
Brugia malayi putative amidase 0.0101 0.0928 0.0928
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Schistosoma mansoni serine/threonine protein kinase 0.0284 0.3187 0.3187
Loa Loa (eye worm) hypothetical protein 0.034 0.3879 0.3879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.0168
Trypanosoma brucei rac serine-threonine kinase, putative 0.0067 0.0511 0.1011
Onchocerca volvulus 0.009 0.079 0.1723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.0168
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0168 0.0168
Toxoplasma gondii AGC kinase 0.0067 0.0511 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0067 0.0511 0.0511
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0067 0.0511 0.0511
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0049 0.0286 0.0286
Schistosoma mansoni unc-13 (munc13) 0.0054 0.0349 0.0349
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0067 0.0511 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0168 0.0333
Loa Loa (eye worm) hypothetical protein 0.009 0.079 0.079
Schistosoma mansoni serine/threonine protein kinase 0.0284 0.3187 0.3187
Schistosoma mansoni diacylglycerol kinase theta 0.0047 0.0268 0.0268
Mycobacterium tuberculosis Possible lysophospholipase 0.0435 0.5053 0.7715
Brugia malayi Variant SH3 domain containing protein 0.0047 0.0268 0.0268
Brugia malayi RhoGAP domain containing protein 0.0047 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.021 0.228 0.228
Onchocerca volvulus 0.0054 0.0349 0.0266
Loa Loa (eye worm) tyrosinase 1 0.009 0.079 0.079
Loa Loa (eye worm) AGC/AKT protein kinase 0.0067 0.0511 0.0511
Leishmania major cathepsin L-like protease 0.0063 0.0465 0.092
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0702 0.0702
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0168 0.0168
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0101 0.0928 0.1417
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Plasmodium falciparum lysophospholipase, putative 0.0435 0.5053 1
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0168 0.0168
Echinococcus granulosus N chimaerin 0.0047 0.0268 0.0268
Echinococcus multilocularis RNA directed DNA polymerase 0.0163 0.1695 0.1695
Brugia malayi Amidase family protein 0.0101 0.0928 0.0928
Echinococcus multilocularis protein kinase c eta type 0.0047 0.0268 0.0268
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0047 0.0268 0.0268
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Schistosoma mansoni serine/threonine kinase 0.0067 0.0511 0.0511
Schistosoma mansoni hypothetical protein 0.0043 0.022 0.022
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0168 0.0168
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0047 0.0268 0.0268
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0168 0.0168
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0101 0.0928 0.1417
Echinococcus multilocularis unc 13 (munc13) 0.0054 0.0349 0.0349
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0067 0.0511 0.0511
Mycobacterium ulcerans amidase 0.0101 0.0928 0.1417
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0604 0.1195
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.079 0.079
Mycobacterium ulcerans amidase 0.0101 0.0928 0.1417
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0168 0.0168
Brugia malayi Pleckstrin Homology Domain 0.0047 0.0268 0.0268
Brugia malayi hypothetical protein 0.007 0.0546 0.0546
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0186 0.0186
Brugia malayi protein kinase C II. 0.0194 0.2079 0.2079
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0168 0.0168
Brugia malayi Protein kinase c protein 2 0.0218 0.2378 0.2378
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0292 0.3294 0.3294
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0101 0.0928 0.0928
Loa Loa (eye worm) RasGEF domain-containing protein 0.0047 0.0268 0.0268
Brugia malayi Ras association domain family 1 isoform A 0.0047 0.0268 0.0268
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0168 0.0168
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0168 0.0168
Leishmania major monoglyceride lipase, putative 0.0435 0.5053 1
Schistosoma mansoni diacylglycerol kinase theta 0.0047 0.0268 0.0268
Brugia malayi diacylglycerol kinase 0.0047 0.0268 0.0268
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0435 0.5053 1
Brugia malayi Protein kinase domain containing protein 0.0067 0.0511 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0168 0.0333
Echinococcus granulosus serine:threonine protein kinase N2 0.0075 0.0604 0.0604
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0067 0.0511 0.0511
Echinococcus granulosus Protein kinase C brain isozyme 0.0284 0.3187 0.3187
Onchocerca volvulus 0.007 0.0546 0.0917
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0168 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0286 0.0286
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0782 0.0782
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0163 0.1695 0.1695
Echinococcus multilocularis serine:threonine protein kinase N2 0.014 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0047 0.0268 0.0268
Brugia malayi Protein kinase domain containing protein 0.0067 0.0511 0.0511
Schistosoma mansoni protein kinase C mu 0.0047 0.0268 0.0268
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0168 0.0168
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0435 0.5053 1
Schistosoma mansoni hypothetical protein 0.0072 0.0576 0.0576
Onchocerca volvulus 0.0082 0.0702 0.1432
Mycobacterium ulcerans hypothetical protein 0.0435 0.5053 0.7715
Echinococcus granulosus protein kinase c iota type 0.0114 0.1096 0.1096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0168 0.0333
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0511 0.0511
Entamoeba histolytica hypothetical protein 0.0043 0.022 0.0435
Loa Loa (eye worm) hypothetical protein 0.0047 0.0268 0.0268
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0049 0.0286 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0465 0.092
Onchocerca volvulus 0.009 0.079 0.1723
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0268 0.0268
Brugia malayi RhoGAP domain containing protein 0.0047 0.0268 0.0268
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0465 0.092
Onchocerca volvulus 0.0292 0.3294 1
Leishmania major hypothetical protein, conserved 0.0101 0.0928 0.1836
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0067 0.0511 0.0511
Brugia malayi p70 ribosomal S6 kinase beta 0.0067 0.0511 0.0511
Entamoeba histolytica hypothetical protein 0.0043 0.022 0.0435
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0435 0.5053 1
Echinococcus granulosus expressed protein 0.0765 0.9127 0.9127
Brugia malayi RhoGEF domain containing protein 0.0047 0.0268 0.0268
Entamoeba histolytica hypothetical protein 0.0039 0.0168 0.0333
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0435 0.5053 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0067 0.0511 0.0511
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0054 0.0349 0.0349
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.079 0.079
Echinococcus granulosus protein kinase c epsilon type 0.0194 0.2079 0.2079
Loa Loa (eye worm) hypothetical protein 0.0163 0.1695 0.1695
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0168 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Echinococcus granulosus Diacylglycerol kinase theta 0.0047 0.0268 0.0268
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0101 0.0928 0.1836
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0168 0.0168
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0067 0.0511 0.0511
Entamoeba histolytica hypothetical protein 0.0043 0.022 0.0435
Onchocerca volvulus 0.009 0.079 0.1723
Trypanosoma brucei monoglyceride lipase, putative 0.0435 0.5053 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0168 0.0168
Plasmodium falciparum esterase, putative 0.0435 0.5053 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0284 0.3187 0.3187
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0268 0.0531
Mycobacterium ulcerans amidase 0.0101 0.0928 0.1417
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0435 0.5053 1
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0168 0.0168
Echinococcus multilocularis N chimaerin 0.0047 0.0268 0.0268
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.022 0.022
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0168 0.0168
Echinococcus multilocularis jun protein 0.0089 0.0782 0.0782
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0101 0.0928 1
Brugia malayi bZIP transcription factor family protein 0.0089 0.0782 0.0782
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0194 0.2079 0.2079
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0054 0.0349 0.0349
Schistosoma mansoni atypical protein kinase C 0.0114 0.1096 0.1096
Echinococcus granulosus NDR protein kinase 0.0067 0.0511 0.0511
Echinococcus multilocularis serine threonine protein kinase 0.0236 0.2602 0.2602
Echinococcus granulosus unc 13 munc13 0.0054 0.0349 0.0349
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0168 0.0168
Schistosoma mansoni fatty-acid amide hydrolase 0.0836 1 1
Brugia malayi Protein kinase domain containing protein 0.0067 0.0511 0.0511
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0397 0.0786
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0047 0.0268 0.0268
Echinococcus granulosus myotubularin protein 13 0.0047 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0349
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.009 0.079 0.079
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0435 0.5053 1
Leishmania major cathepsin L-like protease 0.0063 0.0465 0.092
Schistosoma mansoni jun-related protein 0.0072 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.0168
Loa Loa (eye worm) amidase 0.0101 0.0928 0.0928
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0268 0.0531
Onchocerca volvulus 0.009 0.079 0.1723
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0511 0.0511
Echinococcus granulosus fatty acid amide hydrolase 1 0.0101 0.0928 0.0928
Echinococcus multilocularis expressed protein 0.0765 0.9127 0.9127
Echinococcus granulosus Rac GTPase activating protein 1 0.0047 0.0268 0.0268
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0168 0.0168
Mycobacterium ulcerans peptide amidase, GatA 0.0101 0.0928 0.1417
Loa Loa (eye worm) amidase 0.0101 0.0928 0.0928
Echinococcus granulosus fatty acid amide hydrolase 1 0.0836 1 1
Trypanosoma cruzi amidase, putative 0.0101 0.0928 0.1836
Mycobacterium ulcerans amidase 0.0101 0.0928 0.1417
Entamoeba histolytica hypothetical protein 0.0043 0.022 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0168 0.0333
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0168 0.0168
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Echinococcus multilocularis serine:threonine protein kinase 38 0.0067 0.0511 0.0511
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.079 0.079
Schistosoma mansoni protein kinase C mu 0.0049 0.0286 0.0286
Schistosoma mansoni rac gtpase activating protein 0.0047 0.0268 0.0268
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0186 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0435 0.5053 1
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0026 0 0.5
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0511 0.1011
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0049 0.0286 0.0286
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0836 1 1
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0101 0.0928 0.1836
Entamoeba histolytica protein kinase, putative 0.0067 0.0511 0.1011
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0171 0.1793 0.1793
Trypanosoma brucei monoglyceride lipase, putative 0.0435 0.5053 1
Mycobacterium ulcerans short chain dehydrogenase 0.0556 0.6549 1
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0101 0.0928 0.1417
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0168 0.0333
Mycobacterium ulcerans lysophospholipase 0.0435 0.5053 0.7715
Brugia malayi diacylglycerol kinase 0.0047 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.0168
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0047 0.0268 0.0268
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0168 0.0168
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0292 0.3294 0.3294
Brugia malayi hypothetical protein 0.0039 0.0168 0.0168
Brugia malayi Common central domain of tyrosinase family protein 0.009 0.079 0.079
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0047 0.0268 0.0268
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0168 0.0168
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0101 0.0928 0.1417
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0168 0.0333
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0049 0.0286 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0168 0.0168
Echinococcus granulosus jun protein 0.0089 0.0782 0.0782
Mycobacterium tuberculosis Probable oxidoreductase 0.0556 0.6549 1
Schistosoma mansoni unc-13 (munc13) 0.0054 0.0349 0.0349
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0067 0.0511 0.0511
Brugia malayi C1-like domain containing protein 0.0049 0.0286 0.0286
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0465 0.092
Schistosoma mansoni tyrosinase precursor 0.009 0.079 0.079
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0168 0.0168
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.079 0.079
Entamoeba histolytica protein kinase, putative 0.0067 0.0511 0.1011
Loa Loa (eye worm) hypothetical protein 0.0087 0.0752 0.0752
Brugia malayi Amidase family protein 0.0101 0.0928 0.0928
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.079 0.079
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0049 0.0286 0.0286
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0435 0.5053 1
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0298 0.0589
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0168 0.0168
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.022 0.022
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0168 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0435 0.5053 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0168 0.0168
Mycobacterium ulcerans amidase 0.0101 0.0928 0.1417
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0101 0.0928 0.1836
Plasmodium vivax PST-A protein 0.0435 0.5053 1
Brugia malayi PXA domain containing protein 0.0039 0.0168 0.0168
Brugia malayi protein kinase C3,putative 0.0049 0.0286 0.0286
Loa Loa (eye worm) AGC/NDR protein kinase 0.0067 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0047 0.0268 0.0268
Brugia malayi Hr1 repeat family protein 0.0067 0.0511 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0168 0.0333
Trypanosoma cruzi monoglyceride lipase, putative 0.0435 0.5053 1
Entamoeba histolytica hypothetical protein 0.0047 0.0268 0.0531
Brugia malayi Protein kinase domain containing protein 0.0049 0.0286 0.0286
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0168 0.0168
Echinococcus multilocularis protein kinase c iota type 0.0114 0.1096 0.1096
Echinococcus multilocularis myotubularin protein 13 0.0047 0.0268 0.0268
Schistosoma mansoni hypothetical protein 0.0047 0.0268 0.0268
Loa Loa (eye worm) raf kinase 0.0047 0.0268 0.0268
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0168 0.0168
Schistosoma mansoni protein kinase C 0.0054 0.0349 0.0349
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0186 0.0186
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0435 0.5053 1
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0101 0.0928 0.1417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0268 0.0268
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0066 0.0493 0.0976
Echinococcus multilocularis Rac GTPase activating protein 1 0.0047 0.0268 0.0268
Schistosoma mansoni fatty-acid amide hydrolase 0.0101 0.0928 0.0928
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0168 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0511 0.0511
Echinococcus granulosus RNA directed DNA polymerase 0.0163 0.1695 0.1695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Leishmania major cathepsin L-like protease 0.0063 0.0465 0.092
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0067 0.0511 0.0511
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0168 0.0168
Echinococcus granulosus raf serine:threonine protein kinase 0.0047 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0359 0.4121 0.4121
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0836 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0268 0.0268
Plasmodium falciparum lysophospholipase, putative 0.0435 0.5053 1
Echinococcus multilocularis protein kinase c epsilon type 0.0194 0.2079 0.2079
Trypanosoma cruzi amidase, putative 0.0101 0.0928 0.1836
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0186 0.0186
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0101 0.0928 0.5
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0067 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0612 0.7238 0.7238
Echinococcus granulosus protein kinase c eta type 0.0047 0.0268 0.0268
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.022 0.022
Plasmodium falciparum lysophospholipase, putative 0.0435 0.5053 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0702 0.0702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0465 0.092
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0101 0.0928 0.5
Loa Loa (eye worm) hypothetical protein 0.0292 0.3294 0.3294
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0782 0.0782
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.0168

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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