Detailed information for compound 1371676

Basic information

Technical information
  • TDR Targets ID: 1371676
  • Name: N-(cycloheptylideneamino)-2-[(3,5-dimethylphe nyl)methylsulfanyl]acetamide
  • MW: 318.477 | Formula: C18H26N2OS
  • H donors: 1 H acceptors: 1 LogP: 4.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NN=C1CCCCCC1)CSCc1cc(C)cc(c1)C
  • InChi: 1S/C18H26N2OS/c1-14-9-15(2)11-16(10-14)12-22-13-18(21)20-19-17-7-5-3-4-6-8-17/h9-11H,3-8,12-13H2,1-2H3,(H,20,21)
  • InChiKey: VLPRYZHCIBMFOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(cycloheptylideneamino)-2-[(3,5-dimethylphenyl)methylthio]acetamide
  • N-(cycloheptylideneamino)-2-[(3,5-dimethylbenzyl)thio]acetamide
  • N-(cycloheptylideneamino)-2-[(3,5-dimethylphenyl)methylsulfanyl]ethanamide
  • ZINC00067028
  • AG-205/37023122
  • A1709/0072827
  • MLS000700265
  • N'-cycloheptylidene-2-[(3,5-dimethylbenzyl)sulfanyl]acetohydrazide
  • SMR000225780

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.0077 0.0269
Trypanosoma brucei cytochrome P450, putative 0.0081 0.0156 0.0692
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0022 0.0078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0077 0.0077
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0042 0.0137
Loa Loa (eye worm) hypothetical protein 0.0378 0.0982 0.3623
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0053 0.0077 0.0077
Onchocerca volvulus 0.0077 0.0144 0.1291
Treponema pallidum fructose-bisphosphate aldolase 0.1571 0.4293 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0399 0.1463
Schistosoma mansoni acetylcholinesterase 0.0169 0.0399 0.0399
Onchocerca volvulus 0.0077 0.0144 0.1291
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Brugia malayi Pre-SET motif family protein 0.0214 0.0525 0.1929
Loa Loa (eye worm) hypothetical protein 0.0169 0.0399 0.1463
Loa Loa (eye worm) hypothetical protein 0.0086 0.0169 0.061
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0114 0.0114
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0033 0.0022 0.0035
Trypanosoma brucei unspecified product 0.0028 0.001 0.0023
Trichomonas vaginalis inositol monophosphatase, putative 0.0117 0.0255 0.0583
Plasmodium vivax DNA gyrase subunit A, putative 0.0131 0.0294 0.1325
Brugia malayi Pre-SET motif family protein 0.0031 0.0016 0.0043
Chlamydia trachomatis DNA gyrase subunit B 0.0354 0.0915 1
Plasmodium falciparum telomerase reverse transcriptase 0.0545 0.1445 0.6595
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0767 0.2062 1
Mycobacterium ulcerans DNA gyrase subunit A 0.0131 0.0294 0.1346
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.0019 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0144 0.0638
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0042 0.0084
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0767 0.2062 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0032 0.0019 0.0066
Trypanosoma brucei polo-like protein kinase 0.0098 0.0202 0.0904
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0202 0.0459
Leishmania major hypothetical protein, conserved 0.0032 0.0019 0.0066
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0006 0.0008
Onchocerca volvulus 0.0031 0.0016 0.0092
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0034 0.0025 0.003
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0111 0.0111
Brugia malayi Probable DNA topoisomerase II 0.0608 0.1619 0.5987
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0111 0.0111
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0005 0.0003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0053 0.0077 0.0077
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0032 0.0019 0.0032
Loa Loa (eye worm) hypothetical protein 0.0053 0.0077 0.0269
Onchocerca volvulus Bile acid receptor homolog 0.0053 0.0077 0.0664
Loa Loa (eye worm) hypothetical protein 0.0247 0.0617 0.2273
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0042 0.0084
Trypanosoma brucei developmentally regulated phosphoprotein 0.0032 0.0019 0.0066
Trypanosoma cruzi cytochrome P450, putative 0.0081 0.0156 0.0692
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0354 0.0915 0.417
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0062 0.0062
Plasmodium falciparum DNA topoisomerase 3, putative 0.0033 0.0022 0.008
Loa Loa (eye worm) hypothetical protein 0.0071 0.0129 0.0463
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0016 0.0016
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0032 0.0019 0.0032
Toxoplasma gondii ABC1 family protein 0.0077 0.0144 0.0638
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.015
Schistosoma mansoni inositol monophosphatase 0.0117 0.0255 0.0255
Schistosoma mansoni tsg101-related 0.0059 0.0096 0.0096
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0032 0.0019 0.0066
Trichomonas vaginalis receptor histidine kinase, putative 0.0032 0.0019 0.0032
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0068 0.012 0.043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0068 0.0068
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0169 0.0399 0.0399
Schistosoma mansoni cytochrome P450 0.0034 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0053 0.0077 0.0269
Brugia malayi Cell division protein ftsZ 0.0154 0.0357 0.1309
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.0525 0.1929
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0174 0.0627
Echinococcus multilocularis rho GTPase activating protein 20 0.0033 0.0022 0.0022
Brugia malayi hypothetical protein 0.0126 0.0281 0.1024
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0019 0.0066
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0033 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0054 0.008 0.008
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0144 0.0638
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.001 0.0023
Schistosoma mansoni endoplasmin 0.0032 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0047 0.0061 0.0211
Chlamydia trachomatis DNA gyrase subunit A 0.0131 0.0294 0.3045
Loa Loa (eye worm) TOPoisomerase family member 0.0608 0.1619 0.5987
Schistosoma mansoni heat shock protein 0.0032 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1571 0.4293 1
Echinococcus multilocularis dnaJ subfamily C 6 0.0067 0.0118 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0641 0.1483
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0034 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0088 0.0192
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0053 0.0077 0.0664
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0061 0.0209
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0087 0.0174 0.0627
Loa Loa (eye worm) hypothetical protein 0.035 0.0903 0.3333
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0045 0.015
Trypanosoma brucei DNA topoisomerase III, putative 0.0033 0.0022 0.008
Onchocerca volvulus 0.0087 0.0174 0.1569
Schistosoma mansoni DNA topoisomerase type I 0.0813 0.2188 0.2188
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0034 0.0025 0.003
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0088 0.0381
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0077 0.0146 0.1307
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0293 0.1393
Echinococcus multilocularis carboxylesterase 5A 0.0997 0.2701 0.2701
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0053 0.0077 0.0269
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0144 0.0611
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.0129 0.0129
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0333 0.1538
Trypanosoma brucei heat shock protein, putative 0.0032 0.0019 0.0066
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0019 0.0066
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0202 0.0202
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0117 0.0255 0.1149
Brugia malayi Carboxylesterase family protein 0.0169 0.0399 0.1463
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0144 0.0611
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0042 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0016 0.0016
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0033 0.0022 0.008
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0048 0.0048
Leishmania major cytochrome p450-like protein 0.0081 0.0156 0.0692
Loa Loa (eye worm) hypothetical protein 0.0077 0.0144 0.0517
Mycobacterium tuberculosis Probable reductase 0.013 0.0293 0.134
Brugia malayi hypothetical protein 0.0071 0.0129 0.0463
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0006 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0641 0.1483
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0641 0.1483
Trypanosoma brucei trypanothione reductase 0.0057 0.009 0.0389
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0354 0.0915 0.2097
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0019 0.0032
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0293 0.134
Trypanosoma brucei telomerase reverse transcriptase 0.0088 0.0176 0.0783
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0034 0.0025 0.003
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0042 0.0169
Loa Loa (eye worm) hypothetical protein 0.0084 0.0163 0.0587
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.0019 0.0066
Trypanosoma brucei heat shock protein, putative 0.0032 0.0019 0.0066
Onchocerca volvulus 0.0077 0.0144 0.1291
Loa Loa (eye worm) DnaJ domain-containing protein 0.0067 0.0118 0.0421
Loa Loa (eye worm) hypothetical protein 0.0318 0.0814 0.3001
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0748 0.2008 0.743
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0293 0.134
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0293 0.134
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0019 0.0066
Loa Loa (eye worm) ThiF family protein 0.0033 0.0022 0.0063
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0033 0.0022 0.008
Mycobacterium ulcerans glutaminase 0.0287 0.0729 0.3475
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0019 0.0066
Brugia malayi Bromodomain containing protein 0.0042 0.0048 0.0162
Leishmania major DNA topoisomerase III, putative 0.0033 0.0022 0.008
Loa Loa (eye worm) hypothetical protein 0.0042 0.0048 0.0161
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.0156 0.056
Echinococcus granulosus neuroligin 0.0169 0.0399 0.0399
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0045 0.0128
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0034 0.0025 0.003
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0034 0.0025 0.003
Echinococcus granulosus FTZ F1 alpha 0.0053 0.0077 0.0077
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0202 0.0904
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0032 0.0019 0.0019
Brugia malayi Carboxylesterase family protein 0.0169 0.0399 0.1463
Trypanosoma brucei protein kinase, putative 0.0056 0.0088 0.0381
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0202 0.0202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0144 0.0144
Schistosoma mansoni DNA polymerase eta 0.0041 0.0045 0.0045
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Mycobacterium leprae Probable two component sensor kinase MprB 0.0032 0.0019 0.0061
Loa Loa (eye worm) DNA topoisomerase I 0.0813 0.2188 0.8098
Onchocerca volvulus 0.0169 0.0399 0.3687
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0045 0.0093
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0032 0.0019 0.0032
Plasmodium falciparum heat shock protein 90 0.0032 0.0019 0.0066
Loa Loa (eye worm) hypothetical protein 0.0169 0.0399 0.1463
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0006 0.0002
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0354 0.0915 1
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0144 0.0669
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.005 0.0069 0.0069
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0032 0.0019 0.0032
Loa Loa (eye worm) acetylcholinesterase 1 0.0997 0.2701 1
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0397 0.3668
Loa Loa (eye worm) glutathione reductase 0.0057 0.009 0.0315
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0144 0.0323
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.0053 0.0077 0.0077
Schistosoma mansoni cell polarity protein 0.0142 0.0326 0.0326
Schistosoma mansoni tsg101-related 0.0049 0.0066 0.0066
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0034 0.0025 0.003
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0682 0.1825 0.8339
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0422 0.0972
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0041 0.0041
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0045 0.0056 0.0056
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0077 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0202 0.0459
Brugia malayi ThiF family protein 0.005 0.0069 0.0237
Leishmania major DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0202 0.1836
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0062 0.0062
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0025 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0174 0.0627
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0042 0.0084
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0033 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0034 0.0025 0.003
Leishmania major cytochrome p450-like protein 0.0034 0.0025 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0144 0.0638
Leishmania major mitochondrial DNA topoisomerase II 0.0682 0.1825 0.8339
Schistosoma mansoni intermediate filament proteins 0.0087 0.0174 0.0174
Schistosoma mansoni sumo-1-activating enzyme E1a 0.005 0.0069 0.0069
Trypanosoma brucei heat shock protein, putative 0.0032 0.0019 0.0066
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0125 0.0446
Schistosoma mansoni cell polarity protein 0.0142 0.0326 0.0326
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1571 0.4293 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0045 0.0128
Echinococcus granulosus DNA topoisomerase 1 0.0813 0.2188 0.2188
Onchocerca volvulus 0.0169 0.0399 0.3687
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0397 0.0914
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0053 0.0077 0.0269
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0053 0.0077 0.0269
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0009 0.0019
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0019 0.0032
Loa Loa (eye worm) glutaminase 2 0.0287 0.0729 0.2686
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0608 0.1619 0.5987
Onchocerca volvulus 0.0104 0.0219 0.1996
Brugia malayi hypothetical protein 0.0028 0.0008 0.0013
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0025 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0034 0.0025 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0202 0.0459
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0034 0.0025 0.003
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0006 0.0002
Brugia malayi hypothetical protein 0.0748 0.2008 0.743
Loa Loa (eye worm) TAR-binding protein 0.007 0.0125 0.0446
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0033 0.0022 0.0078
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0833 0.2244 0.2244
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0028 0.0009 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0053 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0035 0.0028 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Brugia malayi nuclear hormone receptor 0.0053 0.0077 0.0269
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0045 0.0185
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1571 0.4293 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0077 0.0077
Mycobacterium ulcerans lipase LipD 0.0077 0.0144 0.0611
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0034 0.0025 0.003
Plasmodium falciparum topoisomerase I 0.0813 0.2188 1
Plasmodium vivax topoisomerase I, putative 0.0813 0.2188 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0117 0.0255 0.1149
Onchocerca volvulus 0.0243 0.0607 0.5637
Mycobacterium ulcerans putative regulatory protein 0.0077 0.0146 0.062
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.009 0.009
Echinococcus granulosus heat shock protein 90 0.0032 0.0019 0.0019
Leishmania major DNA topoisomerase III, putative 0.0033 0.0022 0.008
Loa Loa (eye worm) inositol-1 0.0117 0.0255 0.093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0077 0.0269
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0006 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0117 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0144 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0053 0.0077 0.0269
Plasmodium vivax DNA gyrase subunit B, putative 0.0354 0.0915 0.417
Trichomonas vaginalis hypothetical protein 0.0035 0.0028 0.0052
Loa Loa (eye worm) hypothetical protein 0.0193 0.0468 0.1719
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0053 0.0077 0.0269
Brugia malayi cytochrome P450 0.0034 0.0025 0.0076
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0042 0.0084
Loa Loa (eye worm) carboxylesterase 0.0169 0.0399 0.1463
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0088 0.0088
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0034 0.0025 0.0094
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0053 0.0077 0.0077
Trichomonas vaginalis spcc417.12 protein, putative 0.0169 0.0399 0.0918
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0034 0.0034
Echinococcus multilocularis tar DNA binding protein 0.007 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0088
Schistosoma mansoni BC026374 protein (S09 family) 0.0169 0.0399 0.0399
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0077 0.0077
Echinococcus multilocularis inositol monophosphatase 1 0.0117 0.0255 0.0255
Trichomonas vaginalis receptor histidine kinase, putative 0.0032 0.0019 0.0032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0033 0.0022 0.0022
Mycobacterium ulcerans carboxylesterase, LipT 0.0169 0.0399 0.186
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0034 0.0025 0.003
Trypanosoma brucei glucosidase, putative 0.004 0.0042 0.0169
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0019 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0016 0.0016
Brugia malayi nuclear receptor RXR 0.0028 0.0008 0.0013
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.0429 0.0429
Mycobacterium ulcerans beta-lactamase 0.0077 0.0144 0.0611
Onchocerca volvulus Huntingtin homolog 0.0126 0.0281 0.2574
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0019 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0077 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0053 0.0077 0.0269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0062 0.0062
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0006 0.0002
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0005 0.0003
Schistosoma mansoni tar DNA-binding protein 0.007 0.0125 0.0125
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0169 0.0399 0.186
Echinococcus multilocularis acetylcholinesterase 0.0997 0.2701 0.2701
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0053 0.0077 0.0077
Schistosoma mansoni bromodomain containing protein 0.007 0.0125 0.0125
Schistosoma mansoni coup transcription factor 0.0053 0.0077 0.0077
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0682 0.1825 0.8339
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0068 0.0068
Loa Loa (eye worm) steroid hormone receptor 0.0053 0.0077 0.0269
Echinococcus multilocularis ecdysone induced protein 78C 0.0053 0.0077 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0077 0.0269
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0144 0.0611
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0006 0.0002
Echinococcus granulosus sentrin specific protease 8 0.0068 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0053 0.0077 0.0269
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0034 0.0025 0.003
Brugia malayi ThiF family protein 0.0033 0.0022 0.0063
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0117 0.0255 0.2639
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0034 0.0025 0.003
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0009 0.0019
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1571 0.4293 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0608 0.1619 0.3763
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0117 0.0117
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0202 0.0904
Loa Loa (eye worm) hypothetical protein 0.0077 0.0144 0.0517
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0034 0.0025 0.003
Echinococcus granulosus ecdysone induced protein 78C 0.0053 0.0077 0.0077
Schistosoma mansoni steroid hormone receptor ad4bp 0.0053 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0169 0.0399 0.1463
Mycobacterium tuberculosis Conserved protein 0.0077 0.0144 0.0611
Loa Loa (eye worm) hypothetical protein 0.0042 0.0048 0.0162
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0019 0.0066
Trypanosoma brucei unspecified product 0.0028 0.001 0.0023
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0034 0.0025 0.003
Echinococcus multilocularis conserved hypothetical protein 0.0709 0.19 0.19
Toxoplasma gondii cytochrome p450 superfamily protein 0.0034 0.0025 0.0094
Echinococcus granulosus dna polymerase kappa 0.0041 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0077 0.0144 0.0517
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0088 0.0308
Echinococcus multilocularis heat shock protein 90 0.0032 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0169 0.0399 0.1463
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0053 0.0077 0.0269
Onchocerca volvulus 0.0087 0.0174 0.1569
Mycobacterium ulcerans DNA topoisomerase I 0.0033 0.0022 0.0015
Echinococcus granulosus heat shock protein 0.0032 0.0019 0.0019
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0117 0.0255 0.1149
Plasmodium vivax glutathione reductase, putative 0.0057 0.009 0.0389
Echinococcus multilocularis lamin 0.0087 0.0174 0.0174
Entamoeba histolytica DNA topoisomerase II, putative 0.0608 0.1619 0.3763
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0033 0.0022 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0034 0.0025 0.003
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0019 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0077 0.0269
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0053 0.0077 0.0077
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0034 0.0025 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0088 0.0192
Loa Loa (eye worm) hypothetical protein 0.0169 0.0399 0.1463
Loa Loa (eye worm) hypothetical protein 0.0084 0.0163 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0077 0.0269
Trypanosoma cruzi DNA topoisomerase III, putative 0.0033 0.0022 0.008
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.0077 0.0269
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0019 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0088 0.0192
Brugia malayi hypothetical protein 0.035 0.0903 0.3333
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0088 0.0381
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.0641 0.2362
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0034 0.0025 0.003
Echinococcus granulosus carboxylesterase 5A 0.0997 0.2701 0.2701
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0045 0.0185
Onchocerca volvulus 0.0033 0.0022 0.0148
Echinococcus granulosus inositol monophosphatase 1 0.0117 0.0255 0.0255
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0068 0.0068
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0144 0.0611
Echinococcus granulosus dnaJ subfamily C 6 0.0067 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0053 0.0077 0.0269
Brugia malayi TAR-binding protein 0.007 0.0125 0.0446
Echinococcus granulosus dna polymerase eta 0.0041 0.0045 0.0045
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0088 0.0192
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0045 0.0185
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0034 0.0025 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0397 0.0914
Echinococcus granulosus acetylcholinesterase 0.0997 0.2701 0.2701
Loa Loa (eye worm) hypothetical protein 0.0051 0.0073 0.0255
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0025 0.0094
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0034 0.0025 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0053 0.0077 0.0269
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0068 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0641 0.1483
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0202 0.0459
Plasmodium falciparum endoplasmin, putative 0.0032 0.0019 0.0066
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0013
Echinococcus multilocularis ras gtpase 0.0142 0.0326 0.0326
Brugia malayi Cytochrome P450 family protein 0.0034 0.0025 0.0076
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0088 0.0381
Echinococcus granulosus flap endonuclease 1 0.0027 0.0005 0.0005
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0045 0.0093
Toxoplasma gondii RNA-directed DNA polymerase 0.0088 0.0176 0.0783
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.009 0.009
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0319 0.0818 0.1895
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0378 0.0982 0.4474
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0033 0.0022 0.0078
Brugia malayi Cytochrome P450 family protein 0.0081 0.0156 0.056
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0019 0.0032
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.0429 0.1574
Brugia malayi PAS domain containing protein 0.0104 0.0221 0.0802
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0033 0.0022 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0397 0.0914
Loa Loa (eye worm) hypothetical protein 0.0997 0.2701 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0045 0.015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0007
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0006 0.0008
Chlamydia trachomatis DNA gyrase subunit A 0.0131 0.0294 0.3045
Entamoeba histolytica DNA topoisomerase III, putative 0.0033 0.0022 0.0039
Brugia malayi jmjC domain containing protein 0.0065 0.0111 0.0394
Echinococcus multilocularis sentrin specific protease 8 0.0068 0.012 0.012
Echinococcus granulosus cytochrome P450 2K1 0.0034 0.0025 0.0025
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0131 0.0294 0.0644
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0019 0.0066
Trichomonas vaginalis set domain proteins, putative 0.0243 0.0607 0.1403
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0033 0.0022 0.0022
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0158 0.037 0.1767
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0081 0.0156 0.0669
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0045 0.015
Loa Loa (eye worm) CYP4Cod1 0.0081 0.0156 0.056
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0019 0.0066
Schistosoma mansoni tar DNA-binding protein 0.007 0.0125 0.0125
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0169 0.0399 0.186
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0169 0.0399 0.0399
Schistosoma mansoni neuroligin 3 (S09 family) 0.0169 0.0399 0.0399
Plasmodium falciparum flap endonuclease 1 0.0027 0.0005 0.0003
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0034 0.0025 0.003
Toxoplasma gondii DNA topoisomerase 2, putative 0.0608 0.1619 0.7392
Brugia malayi hypothetical protein 0.0169 0.0399 0.1463
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0144 0.0611
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0641 0.1483
Leishmania major cytochrome p450-like protein 0.0034 0.0025 0.0094
Brugia malayi PHD-finger family protein 0.0027 0.0007 0.001
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0088 0.0088
Brugia malayi glutathione reductase 0.0057 0.009 0.0315
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.13 0.13
Trichomonas vaginalis esterase, putative 0.0077 0.0144 0.0323
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0202 0.0459
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0144 0.0144
Brugia malayi DNA topoisomerase I 0.0813 0.2188 0.8098
Schistosoma mansoni DNA topoisomerase type I 0.0813 0.2188 0.2188
Schistosoma mansoni glutaminase 0.0287 0.0729 0.0729
Brugia malayi hypoxia-induced factor 1 0.0323 0.0828 0.3054
Onchocerca volvulus Huntingtin homolog 0.0126 0.0281 0.2574
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0144 0.0323
Echinococcus granulosus intermediate filament protein 0.0087 0.0174 0.0174
Trypanosoma brucei DNA topoisomerase IA, putative 0.0033 0.0022 0.008
Brugia malayi Flap endonuclease-1 0.0027 0.0005 0.0003
Echinococcus multilocularis acetylcholinesterase 0.0997 0.2701 0.2701
Chlamydia trachomatis DNA gyrase subunit B 0.028 0.0709 0.7687
Loa Loa (eye worm) hypothetical protein 0.0047 0.0062 0.0211
Treponema pallidum cell division protein FtsZ 0.0311 0.0795 0.1815
Brugia malayi hypothetical protein 0.0037 0.0034 0.0108
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0202 0.0202
Schistosoma mansoni alpha-glucosidase 0.0154 0.036 0.036
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0088 0.0192
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0042 0.0084
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Mycobacterium leprae putative cytochrome p450 0.0034 0.0025 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0202 0.0459
Loa Loa (eye worm) hypothetical protein 0.0169 0.0399 0.1463
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0066
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0034 0.0025 0.003
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.009 0.0389
Leishmania major telomerase reverse transcriptase, putative 0.0088 0.0176 0.0783
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0008 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0008 0.0013
Loa Loa (eye worm) RNA binding protein 0.007 0.0125 0.0446
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0019 0.0066
Toxoplasma gondii ThiF family protein 0.0033 0.0022 0.0078
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0062 0.0211
Giardia lamblia Pms1-like protein 0.0032 0.0019 0.0032
Schistosoma mansoni DNA topoisomerase II 0.0608 0.1619 0.1619
Loa Loa (eye worm) beta-lactamase 0.0077 0.0144 0.0517
Giardia lamblia Fructose-bisphosphate aldolase 0.1571 0.4293 1
Echinococcus granulosus SUMO activating enzyme subunit 1 0.005 0.0069 0.0069
Trichomonas vaginalis protein kinase inhibitor, putative 0.0067 0.0118 0.0263
Entamoeba histolytica DNA topoisomerase III, putative 0.0033 0.0022 0.0039
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Brugia malayi glutaminase DH11.1 0.0287 0.0729 0.2686
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0053 0.0077 0.0077
Brugia malayi photoreceptor-specific nuclear receptor 0.0053 0.0077 0.0269
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0088 0.0176 0.0783
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0495 0.1305 0.4823
Brugia malayi Thioredoxin reductase 0.0057 0.009 0.0315
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0042 0.0169
Trypanosoma brucei DNA topoisomerase ii 0.0682 0.1825 0.8339
Echinococcus granulosus BC026374 protein S09 family 0.0169 0.0399 0.0399
Leishmania major DNA polymerase eta, putative 0.0041 0.0045 0.0185
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0006 0.0002
Loa Loa (eye worm) GTP-binding protein 0.0142 0.0326 0.1191
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0009 0.0019
Mycobacterium leprae cell division protein FtsZ 0.0311 0.0795 0.3836
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0333 0.1538
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0062 0.0062
Plasmodium falciparum DNA gyrase subunit B 0.0354 0.0915 0.417
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0034 0.0025 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0202 0.0459
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0059 0.0094 0.0808
Loa Loa (eye worm) hypothetical protein 0.0411 0.1073 0.3963
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0033 0.0022 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.001 0.0023
Brugia malayi Muscleblind-like protein 0.0318 0.0814 0.3001
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0034 0.0025 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0062 0.0062
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0042 0.0084
Echinococcus multilocularis survival motor neuron protein 1 0.0748 0.2008 0.2008
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0608 0.1619 0.1619
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0144 0.0517
Schistosoma mansoni heat shock protein 0.0032 0.0019 0.0019
Trypanosoma brucei heat shock protein, putative 0.0032 0.0019 0.0066
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0042 0.0084
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0144 0.0611
Echinococcus granulosus neuropeptide s receptor 0.0493 0.13 0.13
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Loa Loa (eye worm) hypothetical protein 0.0077 0.0144 0.0517
Loa Loa (eye worm) hypothetical protein 0.0997 0.2701 1
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0111 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0034 0.0025 0.003
Schistosoma mansoni tsg101-related 0.0059 0.0096 0.0096
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0077 0.0144 0.0517
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0053 0.0077 0.0077
Trichomonas vaginalis Sentrin-specific protease, putative 0.0068 0.012 0.0269
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0077 0.0077
Trypanosoma brucei unspecified product 0.0041 0.0045 0.0185
Trypanosoma brucei C-8 sterol isomerase, putative 0.0378 0.0982 0.4474
Schistosoma mansoni hypothetical protein 0.0153 0.0355 0.0355
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0005 0.0003
Onchocerca volvulus 0.0053 0.0077 0.0664
Echinococcus multilocularis microtubule associated protein 2 0.3626 1 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.0032 0.0019 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0397 0.0914
Trichomonas vaginalis sensor histidine kinase, putative 0.0032 0.0019 0.0032
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0034 0.0025 0.003
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0997 0.2701 0.2701
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0034 0.0025 0.003
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0311 0.0795 0.8658
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0053 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0067 0.0118 0.0118
Echinococcus multilocularis lamin dm0 0.0087 0.0174 0.0174
Leishmania major DNA topoisomerase ii 0.0575 0.1528 0.6975
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0034 0.0025 0.003
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Leishmania major hypothetical protein, conserved 0.0077 0.0144 0.0638
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0033 0.0022 0.0039
Schistosoma mansoni tar DNA-binding protein 0.007 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0049 0.0068 0.0236
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0032 0.0019 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0053 0.0077 0.0077
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0033 0.0022 0.0022
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.005 0.0069 0.0293
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0045 0.0045
Schistosoma mansoni lamin 0.0087 0.0174 0.0174
Mycobacterium leprae Probable two-component sensor kinase 0.0032 0.0019 0.0061
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.0019 0.0066
Trypanosoma cruzi hypothetical protein 0.0068 0.012 0.0531
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Plasmodium falciparum DNA gyrase subunit A 0.0131 0.0294 0.1325
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0019 0.0032
Schistosoma mansoni retinoic acid receptor RXR 0.0053 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0034 0.0025 0.0025
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0034 0.0025 0.0094
Loa Loa (eye worm) Ulp1 protease 0.0068 0.012 0.043
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0397 0.0914
Echinococcus multilocularis muscleblind protein 0.0318 0.0814 0.0814
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.0429 0.1574
Treponema pallidum DNA topoisomerase I (topA) 0.0033 0.0022 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0077 0.0269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0062 0.0062
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0008 0.0008
Brugia malayi Cell division protein ftsZ 0.0149 0.0346 0.1264
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0066
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0608 0.1619 0.5987
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0073 0.0255
Schistosoma mansoni inositol monophosphatase 0.0117 0.0255 0.0255
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0144 0.0323
Toxoplasma gondii DNA topoisomerase family protein 0.0033 0.0022 0.008
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0088 0.0381
Brugia malayi nuclear receptor NHR-88 0.0053 0.0077 0.0269
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0144 0.0611
Trypanosoma cruzi DNA topoisomerase II, putative 0.0575 0.1528 0.6975
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0053 0.0077 0.0077
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0411 0.1071 1
Echinococcus granulosus lamin dm0 0.0087 0.0174 0.0174
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0088 0.0381
Brugia malayi beta-lactamase 0.0077 0.0144 0.0517
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0034 0.0025 0.003
Echinococcus granulosus single minded 2 0.0077 0.0146 0.0146
Giardia lamblia DNA topoisomerase III 0.0033 0.0022 0.0039
Echinococcus granulosus tar DNA binding protein 0.007 0.0125 0.0125
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0034 0.0025 0.003
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0049 0.0066 0.0141
Mycobacterium tuberculosis Cell division protein FtsZ 0.0311 0.0795 0.3798
Loa Loa (eye worm) hypothetical protein 0.0032 0.0019 0.0053
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0144 0.0638
Loa Loa (eye worm) hypothetical protein 0.0077 0.0144 0.0517
Loa Loa (eye worm) hypothetical protein 0.0053 0.0077 0.0269
Echinococcus multilocularis DNA topoisomerase 1 0.0813 0.2188 0.2188
Brugia malayi intermediate filament protein 0.0087 0.0174 0.0627
Leishmania major protein kinase, putative 0.0028 0.0009 0.0019
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0131 0.0294 0.1325
Echinococcus multilocularis dna polymerase eta 0.0041 0.0045 0.0045
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0009 0.0019
Onchocerca volvulus 0.0169 0.0399 0.3687
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0813 0.2188 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0045 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0053 0.0077 0.0269
Echinococcus multilocularis thyroid hormone receptor alpha 0.0053 0.0077 0.0077
Plasmodium vivax DNA topoisomerase 3, putative 0.0033 0.0022 0.008
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Brugia malayi Cytochrome P450 family protein 0.0081 0.0156 0.056
Schistosoma mansoni aryl hydrocarbon receptor 0.0104 0.0221 0.0221
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0005 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0066 0.0141
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0117 0.0255 0.0583
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0034 0.0025 0.003
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0061 0.0209
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0144 0.0517
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.0077 0.0077
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0293 0.134
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0144 0.0323
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0019 0.0066
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0034 0.0025 0.003
Trypanosoma brucei heat shock protein, putative 0.0032 0.0019 0.0066
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0411 0.1071 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0068 0.012 0.0269
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0042 0.0169
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0117 0.0255 0.0583
Schistosoma mansoni alpha glucosidase 0.004 0.0042 0.0042
Trypanosoma brucei heat shock protein, putative 0.0032 0.0019 0.0066
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0034 0.0025 0.003
Mycobacterium tuberculosis Conserved protein 0.0077 0.0144 0.0611
Leishmania major ubiquitin-activating enzyme-like protein 0.0033 0.0022 0.0078
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0174 0.0627
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0033 0.0022 0.0039
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0042 0.0137
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1123 0.3048 0.7097
Loa Loa (eye worm) cytochrome P450 0.0034 0.0025 0.0076
Brugia malayi Carboxylesterase family protein 0.0169 0.0399 0.1463
Brugia malayi hypothetical protein 0.0028 0.0008 0.0013
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0068 0.012 0.012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0062 0.0211
Leishmania major DNA topoisomerase IB, large subunit 0.0813 0.2188 1
Echinococcus multilocularis neuroligin 0.0169 0.0399 0.0399
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0045 0.0093
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0117 0.0255 0.1149
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0006 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0006 0.0002
Giardia lamblia DNA topoisomerase II 0.0576 0.1531 0.3558
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0032 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0053 0.0077 0.0269
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0066
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0008 0.0013
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0354 0.0915 0.4387
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0045 0.0185
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0111 0.0111
Mycobacterium tuberculosis Conserved protein 0.0077 0.0144 0.0611
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.009 0.0346
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0073 0.0255
Echinococcus granulosus acetylcholinesterase 0.0997 0.2701 0.2701
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1571 0.4293 1
Onchocerca volvulus 0.0153 0.0355 0.327
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0088 0.0381
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0041 0.0041
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.0429 0.0429
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0005 0.0005
Mycobacterium leprae Conserved hypothetical protein 0.0034 0.0025 0.0091
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.012 0.0269
Trypanosoma cruzi cytochrome P450, putative 0.0081 0.0156 0.0692
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0144 0.0144
Mycobacterium leprae Probable lipase LipE 0.0077 0.0144 0.0669
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0045 0.0045
Trichomonas vaginalis glutaminase, putative 0.0287 0.0729 0.1687
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0045 0.0185
Brugia malayi kinase, mitochondrial precursor 0.0032 0.0019 0.0053
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0053 0.0077 0.0269
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.009 0.0389
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0048 0.0048
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0117 0.0255 0.1149
Echinococcus granulosus geminin 0.0361 0.0933 0.0933
Plasmodium vivax SET domain protein, putative 0.0031 0.0016 0.0053
Schistosoma mansoni single-minded 0.0104 0.0221 0.0221
Toxoplasma gondii DNA topoisomerase I, putative 0.0813 0.2188 1
Brugia malayi beta-lactamase family protein 0.0077 0.0144 0.0517
Echinococcus multilocularis heat shock protein 0.0032 0.0019 0.0019
Plasmodium falciparum DNA topoisomerase 2 0.0608 0.1619 0.7392
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0105 0.0221 0.1046
Brugia malayi Endoplasmin precursor 0.0032 0.0019 0.0053
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0411 0.1071 1
Leishmania major DNA topoisomerase 1A 0.0033 0.0022 0.008
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0005 0.0003
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0034 0.0025 0.003
Trypanosoma cruzi DNA topoisomerase III, putative 0.0033 0.0022 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0006 0.0002
Echinococcus granulosus ras gtpase 0.0142 0.0326 0.0326
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0293 0.134
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Loa Loa (eye worm) hypothetical protein 0.0084 0.0163 0.0587
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0378 0.0982 0.3623
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0114 0.0114
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0117 0.0117
Echinococcus granulosus lamin 0.0087 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0053 0.0077 0.0269
Echinococcus multilocularis geminin 0.0361 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0053 0.0077 0.0269
Brugia malayi GRF zinc finger family protein 0.0033 0.0022 0.0065
Brugia malayi jmjC domain containing protein 0.0067 0.0117 0.0415
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0131 0.0294 0.1346
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0013 0.0013
Giardia lamblia DINP protein human, muc B family 0.0041 0.0045 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0397 0.0914
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0422 0.0972
Loa Loa (eye worm) hypothetical protein 0.0411 0.1073 0.3963
Plasmodium vivax ubiquitin activating enzyme, putative 0.005 0.0069 0.0293
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.0129 0.0129
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0028 0.0088
Brugia malayi follicle stimulating hormone receptor 0.0495 0.1305 0.4823
Leishmania major protein kinase, putative 0.0028 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0078 0.0147 0.0529
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0608 0.1619 0.1619
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0053 0.0077 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0202 0.0459
Mycobacterium ulcerans DNA gyrase subunit B 0.0354 0.0915 0.4387
Giardia lamblia DNA repair protein RAD52 0.1123 0.3048 0.7097
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0088 0.0381
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0045 0.0185
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0042 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0641 0.1483
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0053 0.0077 0.0269
Brugia malayi beta-lactamase family protein 0.0077 0.0144 0.0517
Leishmania major C-8 sterol isomerase-like protein 0.0378 0.0982 0.4474
Brugia malayi DnaJ domain containing protein 0.0067 0.0118 0.0421
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0006 0.0008
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0202 0.0904
Leishmania major trypanothione reductase 0.0057 0.009 0.0389
Loa Loa (eye worm) endoplasmin 0.0032 0.0019 0.0053
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0333 0.1538
Plasmodium falciparum thioredoxin reductase 0.0057 0.009 0.0389
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1571 0.4293 1
Giardia lamblia Kinase, PLK 0.0098 0.0202 0.0459
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0032 0.0019 0.0032
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0045 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Echinococcus granulosus survival motor neuron protein 1 0.0748 0.2008 0.2008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.0429 0.0429
Loa Loa (eye worm) carboxylesterase 0.0169 0.0399 0.1463
Giardia lamblia Telomerase catalytic subunit 0.0088 0.0176 0.0397
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0153 0.0355 0.1298
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0042 0.0169
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0066 0.0141
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0016 0.0053
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0169 0.0399 0.0399
Trypanosoma brucei heat shock protein, putative 0.0032 0.0019 0.0066
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.1291 0.6226
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0045 0.0045
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0144 0.0611
Loa Loa (eye worm) hypothetical protein 0.005 0.0069 0.0237
Echinococcus granulosus para nitrobenzyl esterase 0.0169 0.0399 0.0399
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0575 0.1528 0.6975
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0053 0.0077 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0125 0.0446
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0032 0.0019 0.0061
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0333 0.159
Loa Loa (eye worm) carboxylesterase 0.0997 0.2701 1
Plasmodium vivax endoplasmin, putative 0.0032 0.0019 0.0066
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0034 0.0025 0.003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.001 0.0023
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0144 0.0611
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0034 0.0025 0.003
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0105 0.0221 0.0991
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0767 0.2062 1
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0019 0.0066
Loa Loa (eye worm) hypothetical protein 0.0318 0.0814 0.3001
Schistosoma mansoni survival motor neuron protein 0.0153 0.0355 0.0355
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0088 0.0381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0062 0.0062
Brugia malayi GTP-binding protein, identical 0.0142 0.0326 0.1191
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0006 0.0002
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.009 0.0315
Entamoeba histolytica hypothetical protein 0.0319 0.0818 0.1895
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0145
Mycobacterium ulcerans hypothetical protein 0.0077 0.0144 0.0611
Schistosoma mansoni tar DNA-binding protein 0.007 0.0125 0.0125
Trypanosoma cruzi DNA topoisomerase II, putative 0.0575 0.1528 0.6975
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0042 0.0084
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.0641 0.2362
Echinococcus multilocularis para nitrobenzyl esterase 0.0169 0.0399 0.0399
Onchocerca volvulus Protein ultraspiracle homolog 0.0053 0.0077 0.0664
Brugia malayi Steroid receptor seven-up type 2 0.0053 0.0077 0.0269
Brugia malayi RNA binding protein 0.007 0.0125 0.0446
Brugia malayi Carboxylesterase family protein 0.0997 0.2701 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0117 0.0255 0.1158
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0131 0.0294 0.3069
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0008 0.0008
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0202 0.0732
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0077 0.0269
Schistosoma mansoni DNA topoisomerase type I 0.0813 0.2188 0.2188
Schistosoma mansoni gliotactin 0.0169 0.0399 0.0399
Echinococcus multilocularis muscleblind protein 1 0.0318 0.0814 0.0814
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0066
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0073 0.0255
Trypanosoma brucei DNA topoisomerase III, putative 0.0033 0.0022 0.008
Loa Loa (eye worm) hypothetical protein 0.0247 0.0617 0.2273
Echinococcus multilocularis musashi 0.0087 0.0174 0.0174
Brugia malayi Inositol-1 0.0117 0.0255 0.093
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0034 0.0025 0.003
Brugia malayi Bromodomain containing protein 0.0083 0.016 0.0578
Brugia malayi DNA topoisomerase III beta-1 0.0033 0.0022 0.0065
Onchocerca volvulus 0.0169 0.0399 0.3687
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0034 0.0025 0.003
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0088 0.0176 0.1588
Loa Loa (eye worm) hypothetical protein 0.0045 0.0056 0.0189
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0117 0.0255 0.0583
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0033 0.0022 0.0065
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.0156 0.056
Toxoplasma gondii hypothetical protein 0.005 0.0069 0.0293
Echinococcus multilocularis transfer RNA-Lys 0.0077 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0126 0.0281 0.1024
Schistosoma mansoni alpha-glucosidase 0.0154 0.036 0.036
Echinococcus granulosus muscleblind protein 0.0318 0.0814 0.0814
Schistosoma mansoni microtubule-associated protein tau 0.3626 1 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.012 0.0269
Schistosoma mansoni lamin 0.0087 0.0174 0.0174
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0042 0.0042
Mycobacterium ulcerans cell division protein FtsZ 0.0311 0.0795 0.3798
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0033 0.0022 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Loa Loa (eye worm) hypoxia-induced factor 1 0.0323 0.0828 0.3054
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0813 0.2188 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0032 0.0019 0.0061
Toxoplasma gondii thioredoxin reductase 0.0057 0.009 0.0389
Brugia malayi steroid hormone receptor 0.0053 0.0077 0.0269
Brugia malayi heat shock protein 90 0.0032 0.0019 0.0053
Brugia malayi bHLH-PAS transcription factor 0.0077 0.0146 0.0523
Schistosoma mansoni pyruvate dehydrogenase 0.0032 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Loa Loa (eye worm) hypothetical protein 0.0126 0.0281 0.1024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0013
Plasmodium falciparum glutathione reductase 0.0057 0.009 0.0389
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0034 0.0025 0.003
Brugia malayi DNA topoisomerase III 0.0033 0.0022 0.0065
Schistosoma mansoni hypothetical protein 0.0361 0.0933 0.0933
Giardia lamblia DNA topoisomerase III 0.0033 0.0022 0.0039
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0042 0.0042
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0006 0.0006
Loa Loa (eye worm) DNA topoisomerase III 0.0033 0.0022 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0088 0.0088
Onchocerca volvulus 0.0169 0.0399 0.3687
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0042 0.0084
Brugia malayi Cytochrome P450 family protein 0.0034 0.0025 0.0076
Brugia malayi Carboxylesterase family protein 0.0169 0.0399 0.1463
Plasmodium vivax telomerase reverse transcriptase, putative 0.0545 0.1445 0.6595
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.0019 0.0066
Brugia malayi MAP kinase sur-1 0.0056 0.0088 0.0308
Echinococcus multilocularis 0.0034 0.0025 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1571 0.4293 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0006 0.0006
Schistosoma mansoni endoplasmin 0.0032 0.0019 0.0019
Mycobacterium tuberculosis Carboxylesterase LipT 0.0169 0.0399 0.186
Brugia malayi Carboxylesterase family protein 0.0997 0.2701 1
Brugia malayi ecdysteroid receptor 0.0053 0.0077 0.0269
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0053 0.0077 0.0077
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0575 0.1528 0.6975
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1571 0.4293 1
Trypanosoma cruzi DNA topoisomerase III, putative 0.0033 0.0022 0.008
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0033 0.0022 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0397 0.0914
Echinococcus granulosus hypothetical protein 0.0729 0.1956 0.1956
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1571 0.4293 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0034 0.0025 0.0094
Echinococcus multilocularis BC026374 protein (S09 family) 0.0169 0.0399 0.0399
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0169 0.0399 0.0399
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0088 0.0176 0.0783
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0077 0.0077
Schistosoma mansoni tar DNA-binding protein 0.007 0.0125 0.0125
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0033 0.0022 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0053 0.0077 0.0269
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0169 0.0399 0.0399
Echinococcus multilocularis FTZ F1 alpha 0.0053 0.0077 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0144 0.0144
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0053 0.0077 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1571 0.4293 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0169 0.0399 0.0918
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0045 0.0185
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.012 0.0269
Schistosoma mansoni hypothetical protein 0.0361 0.0933 0.0933
Leishmania major heat shock protein 83-1 0.0032 0.0019 0.0066
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0145
Schistosoma mansoni kinase 0.005 0.0069 0.0069
Brugia malayi GTP-binding protein 0.0142 0.0326 0.1191
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0117 0.0415
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0019 0.0032
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0019 0.0032
Trypanosoma brucei heat shock protein, putative 0.0032 0.0019 0.0066
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0006 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0034 0.0025 0.003
Loa Loa (eye worm) glutaminase 0.0287 0.0729 0.2686
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0202 0.0732
Plasmodium vivax DNA topoisomerase II, putative 0.0608 0.1619 0.7392
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.13 0.13
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0006 0.0002
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.13 0.13

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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