Detailed information for compound 1372119

Basic information

Technical information
  • TDR Targets ID: 1372119
  • Name: 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluoro phenyl)-N,N-dimethylpiperidine-1-sulfonamide
  • MW: 436.497 | Formula: C21H25FN2O5S
  • H donors: 0 H acceptors: 2 LogP: 3.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C1CCN(CC1COc1ccc2c(c1)OCO2)S(=O)(=O)N(C)C
  • InChi: 1S/C21H25FN2O5S/c1-23(2)30(25,26)24-10-9-19(15-3-5-17(22)6-4-15)16(12-24)13-27-18-7-8-20-21(11-18)29-14-28-20/h3-8,11,16,19H,9-10,12-14H2,1-2H3
  • InChiKey: LWEBIUKLNWRIHH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)-N,N-dimethyl-piperidine-1-sulfonamide
  • 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)-N,N-dimethyl-1-piperidinesulfonamide
  • MLS000083564
  • SMR000046837

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei unspecified product 0.0028 0.0015 0.0024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0044 0.0185 0.0287
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.2849 0.6265
Onchocerca volvulus 0.0085 0.0614 0.1292
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0129 0.0201
Plasmodium falciparum phd finger protein, putative 0.003 0.0037 0.1044
Echinococcus granulosus lysine specific demethylase 5A 0.0098 0.0755 0.1174
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0044 0.0185 0.0287
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0297 0.284 0.4503
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0651 0.1032
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0129 0.0129
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0146 0.0227
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0129 0.0273
Brugia malayi Latrophilin receptor protein 2 0.0044 0.0185 0.0391
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.2849 0.6265
Plasmodium vivax SET domain protein, putative 0.0057 0.0328 0.9261
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.033 0.0513
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0193 0.5
Entamoeba histolytica isopentenyl-diphosphate delta-isomerase, putative 0.0201 0.1829 0.6324
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0146 0.0231
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0413 0.0874
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0369 0.0573
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0193 0.027
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.033 0.0655
Loa Loa (eye worm) hypothetical protein 0.0095 0.0718 0.1116
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0129 0.0125
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0044 0.0185 0.0391
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0139 0.0146
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0037 0.0442
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0188 0.0536
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.0835 0.1718
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0139 0.0146
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0037 0.0442
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0106 0.0835 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0129 0.0201
Schistosoma mansoni jumonji domain containing protein 0.014 0.1189 0.1848
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0139 0.0293
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0146 0.0231
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.033 0.033
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1251 0.2029
Loa Loa (eye worm) transcription factor SMAD2 0.0223 0.207 0.3218
Leishmania major alpha glucosidase II subunit, putative 0.0106 0.0835 0.1324
Leishmania major DNA polymerase kappa, putative 0.004 0.0146 0.0231
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0146 0.0231
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0326 0.0507
Echinococcus multilocularis lysosomal alpha glucosidase 0.0477 0.4727 0.4727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.2849 0.6265
Plasmodium falciparum importin beta, putative 0.006 0.0354 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0413 0.0643
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0146 0.0231
Leishmania major isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative 0.0201 0.1829 0.2901
Trypanosoma brucei unspecified product 0.0028 0.0015 0.0024
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0129 0.0129
Trichomonas vaginalis ran, putative 0.0044 0.0188 0.0257
Giardia lamblia Fructose-bisphosphate aldolase 0.0298 0.2849 1
Mycobacterium tuberculosis Possible L-lactate dehydrogenase (cytochrome) LldD2 0.0559 0.5596 1
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.033 0.033
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0193 0.027
Trichomonas vaginalis set domain proteins, putative 0.0455 0.4504 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0627 0.6306 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0193 0.03
Echinococcus multilocularis muscleblind protein 0.031 0.298 0.298
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0235 0.0363
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0235 0.0363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0328 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0146 0.0231
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0227
Brugia malayi PHD-finger family protein 0.003 0.0037 0.0078
Schistosoma mansoni alpha glucosidase 0.0106 0.0835 0.1298
Echinococcus granulosus dna polymerase eta 0.004 0.0146 0.0227
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.2077 0.3229
Loa Loa (eye worm) hypothetical protein 0.0044 0.0185 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0015 0.0024
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.033 0.0513
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0129 0.0205
Trichomonas vaginalis rotamase, putative 0.0034 0.0082 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0835 0.1324
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0188 0.2248
Schistosoma mansoni hypothetical protein 0.0331 0.3198 0.4972
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0193 0.2315
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.2155 0.335
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0328 0.0509
Loa Loa (eye worm) MH2 domain-containing protein 0.0223 0.207 0.3218
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0614 0.0614
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0133 0.1126 0.1126
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0039 0.0139 0.022
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0146 0.0231
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0106 0.0835 0.1298
Brugia malayi jmjC domain containing protein 0.0098 0.0755 0.1598
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0146 0.0231
Echinococcus multilocularis importin subunit beta 1 0.006 0.0354 0.0354
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0044 0.0185 0.0185
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0106 0.0835 0.2743
Echinococcus multilocularis expressed protein 0.0034 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0085 0.0614 0.0954
Brugia malayi Glycosyl hydrolases family 31 protein 0.0106 0.0835 0.1767
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0188 0.5309
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0146 0.0259
Leishmania major importin beta-1 subunit, putative 0.0049 0.0235 0.0372
Loa Loa (eye worm) hypothetical protein 0.006 0.0354 0.055
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0057 0.0328 0.3921
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0129 0.0205
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0139 0.0146
Brugia malayi Inositol-1 0.0045 0.0193 0.0409
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0129 0.0201
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0037 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0627 0.6306 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.0835 0.1718
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0074 0.0117
Brugia malayi mbt repeat family protein 0.0058 0.033 0.0697
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.033 0.0513
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.2849 1
Mycobacterium ulcerans L-lactate dehydrogenase (cytochrome) LldD2 0.0559 0.5596 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0146 0.0231
Schistosoma mansoni DNA polymerase eta 0.004 0.0146 0.0227
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0146 0.0309
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0188 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.1126 0.175
Trichomonas vaginalis maltase-glucoamylase, putative 0.0106 0.0835 0.1718
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.2849 0.6265
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0159 0.1399 0.2175
Schistosoma mansoni ran 0.0044 0.0188 0.0292
Loa Loa (eye worm) hypothetical protein 0.0039 0.0139 0.0216
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0039 0.0139 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.2849 0.6265
Schistosoma mansoni rotamase 0.0034 0.0082 0.0128
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1251 0.2031
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0413 0.0643
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0193 0.0307
Echinococcus granulosus lysosomal alpha glucosidase 0.0477 0.4727 0.7348
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0088 0.0651 0.1032
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0139 0.0146
Brugia malayi Pre-SET motif family protein 0.04 0.3924 0.8301
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0835 0.1324
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0188 0.0188
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0129 0.0201
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0074 0.0117
Entamoeba histolytica Ran family GTPase 0.0044 0.0188 0.041
Echinococcus multilocularis dna polymerase eta 0.004 0.0146 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0146 0.0231
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.033 0.0513
Schistosoma mansoni hypothetical protein 0.0044 0.0185 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0015 0.0024
Schistosoma mansoni hypothetical protein 0.0355 0.3448 0.5359
Echinococcus multilocularis peregrin 0.003 0.0037 0.0037
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0129 0.0199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0133 0.1126 0.175
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0015 0.0024
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0188 0.5309
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0477 0.4727 0.7348
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0159 0.1399 0.1399
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.2849 0.6265
Plasmodium vivax importin-beta 2, putative 0.006 0.0354 1
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0193 0.0193
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0235 0.0372
Schistosoma mansoni inositol monophosphatase 0.0045 0.0193 0.03
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.0835 0.1718
Brugia malayi MH2 domain containing protein 0.0223 0.207 0.4379
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0188 0.0298
Echinococcus granulosus snurportin 1 0.0639 0.6433 1
Onchocerca volvulus 0.0455 0.4504 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0129 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0146 0.0231
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0146 0.0227
Schistosoma mansoni hypothetical protein 0.0639 0.6433 1
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0193 0.03
Schistosoma mansoni hypothetical protein 0.0095 0.0718 0.1116
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0159 0.0159
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0074 0.0885
Brugia malayi Importin beta-1 subunit 0.006 0.0354 0.0748
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0146 0.0231
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0139 0.0146
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0055 0.0305 0.0475
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0129 0.0201
Toxoplasma gondii hypothetical protein 0.0101 0.0787 0.942
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0413 0.0643
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0139 0.0233
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0037 0.0057
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0146 0.0162
Echinococcus multilocularis GPCR, family 2 0.0044 0.0185 0.0185
Schistosoma mansoni hypothetical protein 0.0044 0.0185 0.0287
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0139 0.0146
Schistosoma mansoni alpha-glucosidase 0.041 0.403 0.6265
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0193 0.0307
Loa Loa (eye worm) jmjC domain-containing protein 0.0098 0.0755 0.1174
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0651 0.1032
Loa Loa (eye worm) hypothetical protein 0.031 0.298 0.4633
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0413 0.0413
Brugia malayi RNA, U transporter 1 0.017 0.1512 0.3199
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0039 0.0139 0.022
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0138 0.1177 0.249
Loa Loa (eye worm) hypothetical protein 0.0066 0.0413 0.0643
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0129 0.0125
Brugia malayi RNA recognition motif domain containing protein 0.0057 0.0326 0.069
Schistosoma mansoni jumonji/arid domain-containing protein 0.0098 0.0755 0.1174
Echinococcus granulosus dna polymerase kappa 0.004 0.0146 0.0227
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0326 0.0507
Loa Loa (eye worm) hypothetical protein 0.031 0.298 0.4633
Brugia malayi latrophilin 2 splice variant baaae 0.0095 0.0718 0.1518
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0328 0.0328
Echinococcus multilocularis dna polymerase kappa 0.004 0.0146 0.0146
Brugia malayi TAR-binding protein 0.0057 0.0326 0.069
Echinococcus multilocularis geminin 0.0331 0.3198 0.3198
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0129 0.0129
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0146 0.0227
Schistosoma mansoni ran 0.0044 0.0188 0.0292
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0326 0.0507
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0057 0.0328 0.0509
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1251 0.2031
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0639 0.6433 1
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0326 0.0507
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0413 0.0413
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0074 0.0117
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0106 0.0835 0.1718
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0057 0.0328 0.0328
Brugia malayi RNA binding protein 0.0057 0.0326 0.069
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0139 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0326 0.0507
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0235 0.0363
Mycobacterium ulcerans hypothetical protein 0.033 0.3192 0.5589
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0129 0.0328
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0037 0.0057
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0614 0.0954
Loa Loa (eye worm) MBCTL1 0.0066 0.0413 0.0643
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0146 0.0231
Loa Loa (eye worm) hypothetical protein 0.0068 0.0434 0.0674
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0133 0.1126 0.175
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0146 0.0231
Mycobacterium ulcerans isopentenyl pyrophosphate isomerase 0.0201 0.1829 0.3089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0133 0.1126 0.1126
Plasmodium vivax hypothetical protein, conserved 0.003 0.0037 0.1044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0133 0.1126 0.175
Schistosoma mansoni hypothetical protein 0.003 0.0037 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0146 0.0231
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0614 0.1299
Echinococcus multilocularis muscleblind protein 1 0.031 0.298 0.298
Brugia malayi Muscleblind-like protein 0.031 0.298 0.6305
Schistosoma mansoni hypothetical protein 0.0044 0.0185 0.0287
Echinococcus multilocularis lysine specific demethylase 5A 0.0098 0.0755 0.0755
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0044 0.0185 0.0185
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0146 0.0003
Loa Loa (eye worm) hypothetical protein 0.0057 0.0328 0.0509
Onchocerca volvulus 0.0058 0.033 0.0655
Trypanosoma brucei glycosyl hydrolase-like protein 0.0039 0.0139 0.022
Echinococcus granulosus neutral alpha glucosidase AB 0.0106 0.0835 0.1298
Schistosoma mansoni jumonji/arid domain-containing protein 0.0098 0.0755 0.1174
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.0835 0.1718
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0082 0.0128
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0193 0.027
Echinococcus granulosus importin subunit beta 1 0.006 0.0354 0.055
Schistosoma mansoni hypothetical protein 0.0044 0.0185 0.0287
Brugia malayi Calcitonin receptor-like protein seb-1 0.0138 0.1177 0.249
Leishmania major mitochondrial DNA polymerase beta 0.0627 0.6306 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0193 0.0087
Onchocerca volvulus 0.0276 0.2618 0.5778
Brugia malayi Glycosyl hydrolases family 31 protein 0.0477 0.4727 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0129 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0201
Entamoeba histolytica hypothetical protein 0.0049 0.0235 0.058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0138 0.1177 0.183
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0193 0.0307
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0057 0.0326 0.0507
Treponema pallidum hypothetical protein 0.0559 0.5596 1
Echinococcus granulosus geminin 0.0331 0.3198 0.4972
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.04 0.3924 0.61
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.033 0.0513
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0188 0.0397
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0146 0.0003
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0193 0.043
Loa Loa (eye worm) hypothetical protein 0.0058 0.033 0.0513
Trypanosoma brucei glucosidase, putative 0.0106 0.0835 0.1324
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.0853 0.1353
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0074 0.0117
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.0835 0.1718
Leishmania major glycosyl hydrolase-like protein 0.0039 0.0139 0.022
Echinococcus granulosus GPCR family 2 0.0044 0.0185 0.0287
Echinococcus granulosus muscleblind protein 0.031 0.298 0.4633
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0146 0.0227
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0354 0.0561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.2849 0.6265
Trypanosoma brucei isopentenyl-diphosphate delta-isomerase (type II) 0.0201 0.1829 0.2901
Echinococcus granulosus expressed protein 0.0034 0.0082 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0328 0.0509
Leishmania major DNA polymerase eta, putative 0.004 0.0146 0.0231
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0328 0.0509
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0146 0.0231
Schistosoma mansoni importin beta-1 0.006 0.0354 0.055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.1126 0.175
Echinococcus multilocularis tar DNA binding protein 0.0057 0.0326 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0146 0.0231
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0146 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0082 0.0019
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0297 0.284 0.4503
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0082 0.0174
Mycobacterium tuberculosis Conserved hypothetical protein 0.033 0.3192 0.559
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0614 0.0954
Echinococcus multilocularis snurportin 1 0.0639 0.6433 0.6433
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0188 0.0292
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0129 0.0205
Echinococcus multilocularis neutral alpha glucosidase AB 0.0106 0.0835 0.0835
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0188 0.0298
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0146 0.0309
Trichomonas vaginalis sucrase-isomaltase, putative 0.0106 0.0835 0.1718
Brugia malayi jmjC domain containing protein 0.0159 0.1399 0.2959
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.2849 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.1126 0.175
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0146 0.0231
Onchocerca volvulus 0.0057 0.0328 0.0651
Mycobacterium leprae POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 0.0559 0.5596 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.1177 0.183
Mycobacterium ulcerans L-lactate dehydrogenase (cytochrome) LldD1 0.0201 0.1829 0.3089
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0188 0.0298
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.033 0.0513
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0133 0.1126 0.2382
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0146 0.0231
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0037 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.2849 0.6265
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0088 0.0651 0.1032
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0146 0.0231
Brugia malayi Bromodomain containing protein 0.003 0.0037 0.0078
Loa Loa (eye worm) inositol-1 0.0045 0.0193 0.03
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.2155 0.2155
Leishmania major GTP-binding protein, putative 0.0044 0.0188 0.0298
Schistosoma mansoni hypothetical protein 0.0331 0.3198 0.4972
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0146 0.0162
Echinococcus granulosus peregrin 0.003 0.0037 0.0057
Echinococcus granulosus tar DNA binding protein 0.0057 0.0326 0.0507
Trypanosoma brucei unspecified product 0.004 0.0146 0.0231
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0106 0.0835 0.2743
Loa Loa (eye worm) latrophilin receptor protein 2 0.0044 0.0185 0.0287
Loa Loa (eye worm) TAR-binding protein 0.0057 0.0326 0.0507
Echinococcus multilocularis lysosomal alpha glucosidase 0.0477 0.4727 0.4727
Brugia malayi Pre-SET motif family protein 0.0057 0.0328 0.0693
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0106 0.0835 0.1718
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0354 0.0561
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0354 0.4234
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0159 0.0247
Brugia malayi mbt repeat family protein 0.0058 0.033 0.0697
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0297 0.284 0.4503
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0139 0.0146
Loa Loa (eye worm) RNA binding protein 0.0057 0.0326 0.0507
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0057
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0193 0.0307
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0627 0.6306 1
Schistosoma mansoni alpha-glucosidase 0.041 0.403 0.6265
Giardia lamblia DINP protein human, muc B family 0.004 0.0146 0.0387
Brugia malayi follicle stimulating hormone receptor 0.0224 0.2077 0.4394

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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