Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.6285 | 0.6285 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.09 | 0.09 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.6285 | 0.6285 |
Onchocerca volvulus | 0.0033 | 0.6285 | 1 | |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.6285 | 0.6285 |
Schistosoma mansoni | lamin | 0.0033 | 0.6285 | 0.6285 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 1 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.1084 | 0.1084 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.1618 | 0.1618 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.6285 | 0.6285 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1084 | 0.1084 |
Echinococcus multilocularis | lamin | 0.0033 | 0.6285 | 0.6285 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.8557 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.6285 | 0.6285 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.6101 | 0.6101 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.6285 | 0.6285 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.6285 | 0.6285 |
Onchocerca volvulus | 0.0033 | 0.6285 | 1 | |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.8557 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.6285 | 0.6285 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.6285 | 0.6285 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.6285 | 0.6285 |
Echinococcus multilocularis | musashi | 0.0033 | 0.6285 | 0.6285 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 1 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 1 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.1084 | 0.1084 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 1 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 1 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 1 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.09 | 0.09 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1618 | 0.1618 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.6285 | 0.6285 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0355 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.9285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.