Detailed information for compound 1372567

Basic information

Technical information
  • TDR Targets ID: 1372567
  • Name: 2-methyl-5-nitro-N-pyridin-2-ylbenzenesulfona mide
  • MW: 293.298 | Formula: C12H11N3O4S
  • H donors: 1 H acceptors: 5 LogP: 1.9 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1S(=O)(=O)Nc1ccccn1)[N+](=O)[O-]
  • InChi: 1S/C12H11N3O4S/c1-9-5-6-10(15(16)17)8-11(9)20(18,19)14-12-4-2-3-7-13-12/h2-8H,1H3,(H,13,14)
  • InChiKey: DQQOMEKCVFTQMA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-methyl-5-nitro-N-(2-pyridyl)benzenesulfonamide
  • 2-Methyl-5-nitro-N-pyridin-2-yl-benzenesulfonamide
  • BAS 00463407
  • MLS000713364
  • SMR000272845

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0084 0.1556 0.514
Onchocerca volvulus 0.0074 0.1242 0.7984
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.1622
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0084 0.1556 0.2527
Entamoeba histolytica hypothetical protein 0.005 0.0491 0.5
Echinococcus granulosus glycine receptor subunit beta 0.0084 0.1556 0.2527
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0074 0.1242 0.1242
Brugia malayi G-protein coupled receptor 0.0074 0.1242 0.4104
Echinococcus multilocularis neuropeptide s receptor 0.0074 0.1242 0.2017
Onchocerca volvulus 0.0084 0.1556 1
Brugia malayi AKH receptor 0.0074 0.1242 0.4104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Brugia malayi putative neuropeptide receptor 0.0074 0.1242 0.4104
Onchocerca volvulus 0.0084 0.1556 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Schistosoma mansoni amine GPCR 0.0074 0.1242 0.1242
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0074 0.1242 0.2017
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus granulosus acetylcholinesterase 0.0131 0.3027 0.4916
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1242 0.1242
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.1242 0.2017
Brugia malayi follicle stimulating hormone receptor 0.0074 0.1242 0.4104
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni opsin-like receptor 0.0074 0.1242 0.1242
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0732 0.1188
Onchocerca volvulus 0.0074 0.1242 0.7984
Onchocerca volvulus 0.0074 0.1242 0.7984
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0084 0.1556 0.2527
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0084 0.1556 0.514
Schistosoma mansoni nAChR subunit 0.0084 0.1556 0.1556
Echinococcus granulosus neuropeptide receptor 0.0074 0.1242 0.2017
Echinococcus granulosus dro:myosuppressin receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0074 0.1242 0.2017
Echinococcus granulosus neuropeptide s receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.098 0.1592
Brugia malayi Carboxylesterase family protein 0.0131 0.3027 1
Echinococcus granulosus hypothetical protein 0.0074 0.1242 0.2017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Echinococcus multilocularis sex peptide receptor 0.0074 0.1242 0.2017
Onchocerca volvulus Putative nachr subunit 0.0084 0.1556 1
Brugia malayi hypothetical protein 0.0074 0.1242 0.4104
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.098 0.1592
Schistosoma mansoni hypothetical protein 0.0074 0.1242 0.1242
Echinococcus granulosus glycine receptor subunit alpha 1 0.0084 0.1556 0.2527
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0491 0.1622
Brugia malayi hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Schistosoma mansoni myosin xvIII 0.0074 0.1242 0.1242
Echinococcus multilocularis neuropeptide receptor A26 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.1622
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0084 0.1556 0.514
Brugia malayi hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0084 0.1556 0.1556
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0084 0.1556 0.2527
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) MBCTL1 0.0066 0.098 0.3239
Onchocerca volvulus 0.0074 0.1242 0.7984
Loa Loa (eye worm) ACC-1 protein 0.0084 0.1556 0.514
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0074 0.1242 0.4104
Schistosoma mansoni opsin-like receptor 0.0074 0.1242 0.1242
Brugia malayi Dopamine receptor protein 1 0.0074 0.1242 0.4104
Echinococcus granulosus sex peptide receptor 0.0074 0.1242 0.2017
Onchocerca volvulus 0.0074 0.1242 0.7984
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0084 0.1556 0.514
Brugia malayi G-protein coupled receptor 0.0074 0.1242 0.4104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1242 0.1242
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0084 0.1556 0.2527
Schistosoma mansoni nAChR subunit 0.0084 0.1556 0.1556
Echinococcus granulosus carboxylesterase 5A 0.0131 0.3027 0.4916
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.1556 0.514
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1242 0.1242
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0084 0.1556 0.514
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.005 0.0491 0.1622
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.1242 0.2017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.1242 0.2017
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.1242 0.2017
Brugia malayi hypothetical protein 0.0074 0.1242 0.4104
Brugia malayi putative neuropeptide receptor NPR1 0.0074 0.1242 0.4104
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.1242 0.1242
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1242 0.1242
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.1242 0.2017
Schistosoma mansoni neuropeptide receptor 0.0074 0.1242 0.1242
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) acetylcholinesterase 1 0.0131 0.3027 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Echinococcus granulosus neuropeptide receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0084 0.1556 0.514
Loa Loa (eye worm) GABA receptor subunit 0.005 0.0491 0.1622
Schistosoma mansoni nAChR subunit 0.0084 0.1556 0.1556
Brugia malayi Serotonin receptor 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0066 0.098 0.3239
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni hypothetical protein 0.0074 0.1242 0.1242
Schistosoma mansoni hypothetical protein 0.0074 0.1242 0.1242
Echinococcus granulosus serotonin receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Loa Loa (eye worm) hypothetical protein 0.0131 0.3027 1
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.1242 0.1242
Schistosoma mansoni neuropeptide receptor 0.0074 0.1242 0.1242
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.098 0.1592
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0074 0.1242 0.1242
Echinococcus granulosus neuropeptide receptor A26 0.0074 0.1242 0.2017
Brugia malayi Dopamine receptor 0.0074 0.1242 0.4104
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0058 0.0732 0.2417
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0074 0.1242 0.1242
Schistosoma mansoni opsin-like receptor 0.0074 0.1242 0.1242
Brugia malayi hypothetical protein 0.0074 0.1242 0.4104
Onchocerca volvulus 0.0074 0.1242 0.7984
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0491 0.0491
Echinococcus granulosus glycine receptor subunit beta 0.0084 0.1556 0.2527
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Brugia malayi G protein-coupled receptor 0.0074 0.1242 0.4104
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.1556 0.514
Onchocerca volvulus 0.0074 0.1242 0.7984
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.098 0.3239
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Brugia malayi Tachykinin-like peptides receptor 99D 0.0074 0.1242 0.4104
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0084 0.1556 0.514
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0084 0.1556 0.514
Brugia malayi G protein-coupled receptor F59B2.13 0.0074 0.1242 0.4104
Echinococcus granulosus g protein coupled receptor 0.0074 0.1242 0.2017
Brugia malayi Serotonin receptor 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Onchocerca volvulus 0.0074 0.1242 0.7984
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0084 0.1556 0.2527
Brugia malayi Cation transporter family protein 0.0084 0.1556 0.514
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Brugia malayi mbt repeat family protein 0.0058 0.0732 0.2417
Brugia malayi Dopamine receptor protein 2 0.0074 0.1242 0.4104
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0074 0.1242 0.4104
Schistosoma mansoni amine GPCR 0.0074 0.1242 0.1242
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0084 0.1556 0.1556
Brugia malayi excitatory GABA receptor EXP-1A 0.0084 0.1556 0.514
Echinococcus granulosus tachykinin peptides receptor 99D 0.0074 0.1242 0.2017
Loa Loa (eye worm) ACC-1 protein 0.0084 0.1556 0.514
Onchocerca volvulus 0.0084 0.1556 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.1556 0.514
Echinococcus granulosus 7tm_1 domain containing protein 0.0074 0.1242 0.2017
Schistosoma mansoni amine GPCR 0.0074 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.1622
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0084 0.1556 0.514
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus granulosus neuropeptide FF receptor 2 0.0074 0.1242 0.2017
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0084 0.1556 0.2527
Echinococcus multilocularis serotonin receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis allatostatin A receptor 0.0074 0.1242 0.2017
Echinococcus granulosus glycine receptor subunit alpha 1 0.0084 0.1556 0.2527
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0074 0.1242 0.2017
Echinococcus granulosus orexin receptor type 2 0.0074 0.1242 0.2017
Echinococcus multilocularis somatostatin receptor 0.0074 0.1242 0.2017
Schistosoma mansoni nAChR subunit 0.0084 0.1556 0.1556
Onchocerca volvulus 0.0074 0.1242 0.7984
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.1242 0.2017
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.1242 0.1242
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.1242 0.1242
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0074 0.1242 0.2017
Onchocerca volvulus 0.0074 0.1242 0.7984
Echinococcus multilocularis glycine receptor subunit beta 0.0084 0.1556 0.2527
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.1242 0.2017
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0084 0.1556 0.2527
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0084 0.1556 0.514
Schistosoma mansoni neuropeptide receptor 0.0074 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.1622
Echinococcus granulosus nAChR subunit 0.0084 0.1556 0.2527
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.1242 0.2017
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0084 0.1556 0.1556
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Brugia malayi hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni biogenic amine receptor 0.0074 0.1242 0.1242
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.6158 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0074 0.1242 0.4104
Schistosoma mansoni growth hormone secretagogue receptor 0.0074 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni biogenic amine receptor 0.0074 0.1242 0.1242
Schistosoma mansoni adenoreceptor 0.0074 0.1242 0.1242
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Brugia malayi larval opioid receptor 0.0074 0.1242 0.4104
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0074 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Echinococcus multilocularis g protein coupled receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1242 0.1242
Schistosoma mansoni histamine h1 receptor 0.0074 0.1242 0.1242
Brugia malayi hypothetical protein 0.0074 0.1242 0.4104
Brugia malayi Melatonin receptor type 1A 0.0074 0.1242 0.4104
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0084 0.1556 0.2527
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0084 0.1556 0.514
Echinococcus granulosus peptide allatostatin:somatostatin 0.0074 0.1242 0.2017
Echinococcus granulosus glycine receptor subunit alpha 1 0.0084 0.1556 0.2527
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0084 0.1556 0.2527
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0084 0.1556 0.1556
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.1556 0.514
Schistosoma mansoni nAChR subunit 0.0084 0.1556 0.1556
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus granulosus g protein coupled receptor 0.0074 0.1242 0.2017
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.1242 0.2017
Schistosoma mansoni hypothetical protein 0.0074 0.1242 0.1242
Brugia malayi hypothetical protein 0.0074 0.1242 0.4104
Onchocerca volvulus 0.005 0.0491 0.3156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1242 0.1242
Onchocerca volvulus 0.005 0.0491 0.3156
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0732 0.0732
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.1622
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0074 0.1242 0.1242
Brugia malayi mbt repeat family protein 0.0058 0.0732 0.2417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Brugia malayi neuropeptide F receptor 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.1622
Echinococcus multilocularis neuropeptide receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis g-protein coupled receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.1242 0.4104
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.1242 0.1242
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0732 0.1188
Echinococcus multilocularis acetylcholinesterase 0.0131 0.3027 0.4916
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0084 0.1556 0.2527
Onchocerca volvulus 0.0084 0.1556 1
Brugia malayi ORL1-like opioid receptor 0.0074 0.1242 0.4104
Echinococcus multilocularis G-protein coupled receptor, putative 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0732 0.2417
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0491 0.1622
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Echinococcus granulosus 7TM GPCR rhodopsin 0.0074 0.1242 0.2017
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0084 0.1556 0.2527
Echinococcus granulosus allatostatin A receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0131 0.3027 0.3027
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0074 0.1242 0.4104
Echinococcus multilocularis orexin receptor type 2 0.0074 0.1242 0.2017
Schistosoma mansoni nAChR subunit 0.0084 0.1556 0.1556
Loa Loa (eye worm) TYRA-2 protein 0.0074 0.1242 0.4104
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0074 0.1242 0.1242
Echinococcus granulosus g protein coupled receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus multilocularis neuropeptide FF receptor 2 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.1622
Onchocerca volvulus Neuropeptide F receptor homolog 0.0074 0.1242 0.7984
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0084 0.1556 0.514
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0084 0.1556 0.2527
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0084 0.1556 0.1556
Schistosoma mansoni amine GPCR 0.0074 0.1242 0.1242
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0084 0.1556 0.2527
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1242 0.1242
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0084 0.1556 0.2527
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0084 0.1556 0.2527
Brugia malayi Cation transporter family protein 0.0084 0.1556 0.514
Onchocerca volvulus 0.0074 0.1242 0.7984
Onchocerca volvulus 0.0074 0.1242 0.7984
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.1556 0.514
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.1242 0.2017
Echinococcus granulosus G protein coupled receptor 139 0.0074 0.1242 0.2017
Schistosoma mansoni neurotransmitter gated ion channel 0.005 0.0491 0.0491
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.1556 0.514
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0074 0.1242 0.2017
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0084 0.1556 0.2527
Onchocerca volvulus 0.0074 0.1242 0.7984
Schistosoma mansoni alpha-1 adrenergic receptor 0.0074 0.1242 0.1242
Loa Loa (eye worm) melatonin receptor type 1A 0.0074 0.1242 0.4104
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0732 0.4703
Echinococcus multilocularis glycine receptor subunit beta 0.0084 0.1556 0.2527
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0084 0.1556 0.1556
Brugia malayi neuropeptide F receptor 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni biogenic amine receptor 0.0074 0.1242 0.1242
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Brugia malayi Cation transporter family protein 0.0084 0.1556 0.514
Schistosoma mansoni amine GPCR 0.0074 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Onchocerca volvulus 0.0074 0.1242 0.7984
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus multilocularis G protein coupled receptor 139 0.0074 0.1242 0.2017
Onchocerca volvulus 0.0074 0.1242 0.7984
Brugia malayi Carboxylesterase family protein 0.0131 0.3027 1
Brugia malayi hypothetical protein 0.0074 0.1242 0.4104
Onchocerca volvulus 0.0058 0.0732 0.4703
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.1242 0.1242
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0084 0.1556 0.514
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Echinococcus multilocularis nAChR subunit 0.005 0.0491 0.0797
Echinococcus granulosus g-protein coupled receptor 0.0074 0.1242 0.2017
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0732 0.1188
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0074 0.1242 0.1242
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Brugia malayi RE15519p 0.0074 0.1242 0.4104
Onchocerca volvulus 0.0074 0.1242 0.7984
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.005 0.0491 0.1622
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0084 0.1556 0.514
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.005 0.0491 0.0491
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0074 0.1242 0.4104
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0732 0.0732
Schistosoma mansoni neuropeptide receptor 0.0074 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.1622
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.1242 0.2017
Schistosoma mansoni nAChR subunit 0.0084 0.1556 0.1556
Brugia malayi hypothetical protein 0.0074 0.1242 0.4104
Echinococcus granulosus somatostatin receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.1622
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.1242 0.2017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Loa Loa (eye worm) LGC-31 protein 0.0084 0.1556 0.514
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0084 0.1556 0.2527
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.098 0.1592
Echinococcus granulosus acetylcholinesterase 0.0131 0.3027 0.4916
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis fmrfamide receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis dro:myosuppressin receptor 0.0074 0.1242 0.2017
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0074 0.1242 0.1242
Echinococcus multilocularis serotonin receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis fmrfamide receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Echinococcus multilocularis carboxylesterase 5A 0.0131 0.3027 0.4916
Echinococcus granulosus fmrfamide receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus multilocularis g protein coupled receptor 0.0074 0.1242 0.2017
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.1242 0.2017
Echinococcus multilocularis neuropeptide receptor 0.0074 0.1242 0.2017
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.098 0.098
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.1242 0.2017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0084 0.1556 0.514
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus multilocularis g protein coupled receptor 0.0074 0.1242 0.2017
Schistosoma mansoni neuropeptide f receptor 76f 0.0074 0.1242 0.1242
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.1242 0.4104
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0074 0.1242 0.2017
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0074 0.1242 0.7984
Brugia malayi sulfakinin receptor protein 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.1242 0.2017
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0084 0.1556 0.514
Onchocerca volvulus 0.0084 0.1556 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.6158 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0131 0.3027 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0732 0.1188
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Onchocerca volvulus 0.0074 0.1242 0.7984
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0732 0.0732
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Echinococcus multilocularis nAChR subunit 0.0084 0.1556 0.2527
Brugia malayi GnHR receptor homolog 0.0074 0.1242 0.4104
Loa Loa (eye worm) hypothetical protein 0.0084 0.1556 0.514
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0084 0.1556 0.2527
Echinococcus granulosus alpha 1A adrenergic receptor 0.0074 0.1242 0.2017
Loa Loa (eye worm) hypothetical protein 0.0074 0.1242 0.4104
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1242 0.2017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1242 0.1242
Loa Loa (eye worm) carboxylesterase 0.0131 0.3027 1
Echinococcus granulosus nAChR subunit 0.005 0.0491 0.0797
Echinococcus multilocularis acetylcholinesterase 0.0131 0.3027 0.4916
Onchocerca volvulus 0.0084 0.1556 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0126 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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