TDR Targets

Basic information

Technical information

TDR Targets ID: 1372829
Name: 2-(methylsulfonyl-phenylamino)-N-(4-morpholin -4-ylsulfonylphenyl)propanamide
MW: 467.559 | Formula: C20H25N3O6S2
H donors: 1 H acceptors: 5 LogP: 1.15 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC(N(S(=O)(=O)C)c1ccccc1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1
InChi: 1S/C20H25N3O6S2/c1-16(23(30(2,25)26)18-6-4-3-5-7-18)20(24)21-17-8-10-19(11-9-17)31(27,28)22-12-14-29-15-13-22/h3-11,16H,12-15H2,1-2H3,(H,21,24)
InChiKey: DSUWHOWCJSAOTN-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-(methylsulfonyl-phenyl-amino)-N-(4-morpholinosulfonylphenyl)propanamide
2-(methylsulfonyl-phenylamino)-N-(4-morpholinosulfonylphenyl)propanamide
2-(mesyl-phenyl-amino)-N-(4-morpholinosulfonylphenyl)propionamide
2-(methylsulfonyl-phenyl-amino)-N-(4-morpholin-4-ylsulfonylphenyl)propanamide
STK066366
BAS 03448649
2-(Methanesulfonyl-phenyl-amino)-N-[4-(morpholine-4-sulfonyl)-phenyl]-propionamide
MLS000072433
SMR000012377
MLS000888397
EU-0045695

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Peroxidase homolog	0.0052	0.8622	1
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.8622	0.8622
Echinococcus granulosus	neuropeptide s receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.6483	0.1757
Echinococcus granulosus	7tm_1 domain containing protein	0.0047	0.6483	0.1757
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0047	0.6483	0.6483
Schistosoma mansoni	amine GPCR	0.0047	0.6483	0.1757
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0047	0.6483	0.1757
Brugia malayi	G-protein coupled receptor	0.0047	0.6483	0.6483
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.8622	0.8622
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0047	0.6483	0.1757
Brugia malayi	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Brugia malayi	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Schistosoma mansoni	opsin-like receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Schistosoma mansoni	amine GPCR	0.0047	0.6483	0.1757
Schistosoma mansoni	hypothetical protein	0.0047	0.6483	0.1757
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.6483	0.1757
Brugia malayi	G protein-coupled receptor F59B2.13	0.0047	0.6483	0.6483
Brugia malayi	follicle stimulating hormone receptor	0.0047	0.6483	0.6483
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.8622	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Brugia malayi	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus granulosus	fmrfamide receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0047	0.6483	0.1757
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Onchocerca volvulus		0.0052	0.8622	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	peroxidasin	0.0052	0.8622	0.6771
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	hypothetical protein	0.0047	0.6483	0.1757
Onchocerca volvulus	Peroxidasin homolog	0.0052	0.8622	1
Echinococcus granulosus	orexin receptor type 2	0.0047	0.6483	0.1757
Schistosoma mansoni	amine GPCR	0.0047	0.6483	0.1757
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.6483	0.1757
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.6483	0.1757
Brugia malayi	neuropeptide F receptor	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus granulosus	neuropeptide receptor A26	0.0047	0.6483	0.1757
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.6483	0.6483
Brugia malayi	Melatonin receptor type 1A	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.5733	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0047	0.6483	0.1757
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0047	0.6483	0.1757
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	peroxidasin	0.0052	0.8622	0.6771
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.5733	1
Echinococcus multilocularis	g-protein coupled receptor	0.0047	0.6483	0.1757
Brugia malayi	Peroxidasin	0.0052	0.8622	0.8622
Brugia malayi	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Onchocerca volvulus	Dual oxidase homolog	0.0052	0.8622	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0	0.5
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Echinococcus granulosus	serotonin receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	TYRA-2 protein	0.0047	0.6483	0.6483
Schistosoma mansoni	histamine h1 receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	opsin-like receptor	0.0047	0.6483	0.1757
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.6483	0.1757
Brugia malayi	G protein-coupled receptor	0.0047	0.6483	0.6483
Schistosoma mansoni	myosin xvIII	0.0047	0.6483	0.1757
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.6483	0.1757
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0047	0.6483	0.6483
Brugia malayi	Blistered cuticle protein 3	0.0052	0.8622	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	1	1
Brugia malayi	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus granulosus	G protein coupled receptor 139	0.0047	0.6483	0.1757
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.5733	0.5733
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Brugia malayi	Dopamine receptor protein 1	0.0047	0.6483	0.6483
Brugia malayi	Dopamine receptor protein 2	0.0047	0.6483	0.6483
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.6483	0.1757
Brugia malayi	larval opioid receptor	0.0047	0.6483	0.6483
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.6483	0.1757
Echinococcus granulosus	neuropeptide receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus granulosus	g protein coupled receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.6483	0.1757
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.6483	0.1757
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	1	1
Brugia malayi	ORL1-like opioid receptor	0.0047	0.6483	0.6483
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.5733	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	somatostatin receptor	0.0047	0.6483	0.1757
Brugia malayi	putative neuropeptide receptor NPR1	0.0047	0.6483	0.6483
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.6483	0.1757
Echinococcus granulosus	dro:myosuppressin receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Echinococcus multilocularis	neuropeptide s receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0047	0.6483	0.1757
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.6483	0.1757
Onchocerca volvulus	Peroxidasin homolog	0.0052	0.8622	1
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.8622	0.8622
Schistosoma mansoni	neuropeptide f receptor 76f	0.0047	0.6483	0.1757
Schistosoma mansoni	neuropeptide receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0047	0.6483	0.1757
Schistosoma mansoni	growth hormone secretagogue receptor	0.0047	0.6483	0.1757
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.5733	1
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	neuropeptide receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Schistosoma mansoni	amine GPCR	0.0047	0.6483	0.1757
Brugia malayi	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.6483	0.1757
Echinococcus granulosus	g protein coupled receptor	0.0047	0.6483	0.1757
Brugia malayi	hypothetical protein	0.0052	0.8622	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0047	0.6483	0.6483
Echinococcus granulosus	neuropeptide receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Schistosoma mansoni	amine GPCR	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus granulosus	7TM GPCR rhodopsin	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0047	0.6483	0.6483
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0047	0.6483	0.1757
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0047	0.6483	0.1757
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	serotonin receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	neuropeptide receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.8622	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.6483	0.1757
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Brugia malayi	putative neuropeptide receptor	0.0047	0.6483	0.6483
Brugia malayi	Serotonin receptor	0.0047	0.6483	0.6483
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.8622	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0047	0.6483	0.6483
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0047	0.6483	0.6483
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	1	1
Brugia malayi	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.6483	0.1757
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.5733	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.6483	0.1757
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.5733	0.5
Echinococcus granulosus	g protein coupled receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.6483	0.1757
Brugia malayi	G-protein coupled receptor	0.0047	0.6483	0.6483
Echinococcus granulosus	neuropeptide FF receptor 2	0.0047	0.6483	0.1757
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0047	0.6483	0.1757
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	1	1
Echinococcus granulosus	hypothetical protein	0.0047	0.6483	0.1757
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.8622	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.6483	0.6483
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Brugia malayi	RE15519p	0.0047	0.6483	0.6483
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.5733	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.6483	0.1757
Brugia malayi	GnHR receptor homolog	0.0047	0.6483	0.6483
Echinococcus granulosus	g-protein coupled receptor	0.0047	0.6483	0.1757
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Echinococcus multilocularis	neuropeptide receptor A26	0.0047	0.6483	0.1757
Brugia malayi	Serotonin receptor	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.5733	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0047	0.6483	0.6483
Brugia malayi	hypothetical protein	0.0047	0.6483	0.6483
Schistosoma mansoni	neuropeptide receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	biogenic amine receptor	0.0047	0.6483	0.1757
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.8622	0.8622
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.6483	0.1757
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	orexin receptor type 2	0.0047	0.6483	0.1757
Onchocerca volvulus	Chorion peroxidase homolog	0.0052	0.8622	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0047	0.6483	0.1757
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0047	0.6483	0.1757
Brugia malayi	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	blistered cuticle protein 3	0.0052	0.8622	0.8622
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	hypothetical protein	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Brugia malayi	neuropeptide F receptor	0.0047	0.6483	0.6483
Brugia malayi	hypothetical protein	0.0047	0.6483	0.6483
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	sex peptide receptor	0.0047	0.6483	0.1757
Onchocerca volvulus		0.0052	0.8622	1
Echinococcus granulosus	allatostatin A receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.6483	0.1757
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.6483	0.6483
Schistosoma mansoni	biogenic amine receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0052	0.8622	0.8622
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.6483	0.1757
Brugia malayi	AKH receptor	0.0047	0.6483	0.6483
Schistosoma mansoni	opsin-like receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.6483	0.1757
Schistosoma mansoni	peroxidasin	0.0052	0.8622	0.6771
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	1	1
Brugia malayi	sulfakinin receptor protein	0.0047	0.6483	0.6483
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.6483	0.1757
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.5733	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0047	0.6483	0.6483
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.6483	0.1757
Echinococcus granulosus	peroxidasin	0.0052	0.8622	0.6771
Echinococcus multilocularis	dro:myosuppressin receptor	0.0047	0.6483	0.1757
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.6483	0.1757
Onchocerca volvulus		0.0052	0.8622	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0045	0.5733	0.5733
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0047	0.6483	0.1757
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus multilocularis	allatostatin A receptor	0.0047	0.6483	0.1757
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0047	0.6483	0.6483
Echinococcus granulosus	somatostatin receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	biogenic amine receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.6483	0.1757
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.6483	0.1757
Echinococcus granulosus	sex peptide receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	hypothetical protein	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Onchocerca volvulus	Peroxidase homolog	0.0052	0.8622	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.6483	0.6483
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0047	0.6483	0.1757
Schistosoma mansoni	adenoreceptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.8622	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0047	0.6483	0.1757
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.6483	0.1757
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0047	0.6483	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0047	0.6483	0.6483
Brugia malayi	Dopamine receptor	0.0047	0.6483	0.6483
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.9953 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1498928

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1372829