Detailed information for compound 1372878

Basic information

Technical information
  • TDR Targets ID: 1372878
  • Name: 2-fluoro-N-[[1-(4-methylbenzoyl)-2,3-dihydroi ndol-5-yl]methyl]benzamide
  • MW: 388.434 | Formula: C24H21FN2O2
  • H donors: 1 H acceptors: 2 LogP: 4.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C(=O)N1CCc2c1ccc(c2)CNC(=O)c1ccccc1F
  • InChi: 1S/C24H21FN2O2/c1-16-6-9-18(10-7-16)24(29)27-13-12-19-14-17(8-11-22(19)27)15-26-23(28)20-4-2-3-5-21(20)25/h2-11,14H,12-13,15H2,1H3,(H,26,28)
  • InChiKey: WVZDJAGQMOQSPF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-fluoro-N-[[1-(4-methylbenzoyl)indolin-5-yl]methyl]benzamide
  • 2-fluoro-N-[[1-[(4-methylphenyl)-oxomethyl]-5-indolinyl]methyl]benzamide
  • 2-fluoro-N-[[1-(4-methylphenyl)carbonyl-2,3-dihydroindol-5-yl]methyl]benzamide
  • G883-0313
  • NCGC00137789-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyroid hormone receptor alpha 0.0065 0.2606 0.2222
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0065 0.2606 0.328
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0215 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0065 0.2606 0.2222
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Schistosoma mansoni intermediate filament proteins 0.0033 0.0824 0.0382
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0727 0.027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.061 0.5
Brugia malayi intermediate filament protein 0.0033 0.0824 0.1037
Loa Loa (eye worm) hypothetical protein 0.0065 0.2606 0.2606
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0727 0.0246
Echinococcus granulosus lamin dm0 0.0033 0.0824 0.0348
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0065 0.2606 0.2437
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.061 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0928 0.0928
Onchocerca volvulus 0.0029 0.061 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.2606 0.328
Brugia malayi nuclear receptor RXR 0.0034 0.0928 0.1168
Loa Loa (eye worm) steroid hormone receptor 0.0065 0.2606 0.2606
Schistosoma mansoni RAR-like nuclear receptor 0.0065 0.2606 0.2437
Onchocerca volvulus 0.0033 0.0824 0.1567
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0201 1 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0026 0.0493 0.0621
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0727 0.0727
Echinococcus granulosus intermediate filament protein 0.0033 0.0824 0.0348
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0727 0.0915
Onchocerca volvulus 0.0033 0.0824 0.1567
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.0727 0.0727
Echinococcus granulosus ecdysone induced protein 78C 0.0065 0.2606 0.2222
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0824 0.0824
Loa Loa (eye worm) hypothetical protein 0.0029 0.061 0.061
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0065 0.2606 0.2437
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.061 1
Schistosoma mansoni coup transcription factor 0.0065 0.2606 0.2437
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.0727 0.0915
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0727 0.1107
Loa Loa (eye worm) hypothetical protein 0.0065 0.2606 0.2606
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.061 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0792 0.0792
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0824 0.1037
Loa Loa (eye worm) hypothetical protein 0.0065 0.2606 0.2606
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.061 0.5
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.0727 0.0915
Schistosoma mansoni zinc finger protein 0.0031 0.0727 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.061 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0034 0.0928 0.0928
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0928 0.0458
Echinococcus multilocularis lamin 0.0033 0.0824 0.0348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.2606 0.2222
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.2606 0.2222
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.061 0.5
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0148 0.7108 0.8947
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0065 0.2606 0.328
Brugia malayi Receptor family ligand binding region containing protein 0.0042 0.1329 0.1673
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.061 1
Brugia malayi hypothetical protein 0.0031 0.0727 0.0915
Mycobacterium ulcerans hypothetical protein 0.0029 0.061 1
Brugia malayi tailless protein 0.0031 0.0727 0.0915
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0065 0.2606 0.2437
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.2606 0.2437
Brugia malayi metabotropic glutamate receptor type 2 0.008 0.3385 0.4261
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0824 0.0824
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.0727 0.0915
Loa Loa (eye worm) hypothetical protein 0.0029 0.061 0.061
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0065 0.2606 0.328
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.061 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0065 0.2606 0.2437
Echinococcus multilocularis ecdysone induced protein 78C 0.0065 0.2606 0.2222
Brugia malayi nuclear hormone receptor 0.0031 0.0727 0.0915
Brugia malayi steroid hormone receptor 0.0065 0.2606 0.328
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0186 0.9164 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0727 0.0246
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0727 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0065 0.2606 0.328
Brugia malayi nuclear receptor RXR 0.0031 0.0727 0.0915
Loa Loa (eye worm) hypothetical protein 0.0029 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0033 0.0824 0.0824
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0928 0.0502
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0065 0.2606 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.2606 0.2606
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.061 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0727 0.0246
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Brugia malayi AMP-binding enzyme family protein 0.0029 0.061 0.0767
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0065 0.2606 0.2606
Brugia malayi AMP-binding enzyme family protein 0.0029 0.061 0.0767
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0727 0.0246
Schistosoma mansoni nuclear receptor 0.0031 0.0727 0.027
Onchocerca volvulus 0.0031 0.0727 0.1107
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0727 0.0246
Loa Loa (eye worm) hypothetical protein 0.0065 0.2606 0.2606
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.2606 0.328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0065 0.2606 0.2606
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0065 0.2606 0.328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0727 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.2606 0.328
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.2606 0.328
Schistosoma mansoni lamin 0.0033 0.0824 0.0382
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0215 0.139
Loa Loa (eye worm) hypothetical protein 0.0065 0.2606 0.2606
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0065 0.2606 0.2437
Loa Loa (eye worm) glutamate receptor 0.0163 0.7944 0.7944
Schistosoma mansoni retinoic acid receptor RXR 0.0065 0.2606 0.2437
Loa Loa (eye worm) hypothetical protein 0.0065 0.2606 0.2606
Loa Loa (eye worm) DR-78 0.0031 0.0727 0.0727
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0065 0.2606 0.2606
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.061 0.5
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0727 0.0915
Brugia malayi nuclear receptor NHR-88 0.0031 0.0727 0.0915
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.061 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.061 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0065 0.2606 0.2606
Loa Loa (eye worm) hypothetical protein 0.0026 0.0493 0.0493
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.0727 0.0915
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Brugia malayi ecdysone receptor 0.0031 0.0727 0.0915
Schistosoma mansoni thyroid hormone receptor 0.0065 0.2606 0.2437
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0928 0.1168
Echinococcus granulosus metabotropic glutamate receptor 2 0.0137 0.6501 0.6319
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0928 0.0502
Schistosoma mansoni metabotropic glutamate receptor 0.008 0.3385 0.3335
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.2606 0.2222
Brugia malayi Metabotropic glutamate receptor precursor. 0.0163 0.7944 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0065 0.2606 0.2222
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.2606 0.328
Brugia malayi hypothetical protein 0.0034 0.0928 0.1168
Echinococcus multilocularis FTZ F1 alpha 0.0065 0.2606 0.2222
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0065 0.2606 0.2222
Loa Loa (eye worm) hypothetical protein 0.0034 0.0928 0.0928
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0042 0.1329 0.1329
Brugia malayi ecdysteroid receptor 0.0065 0.2606 0.328
Brugia malayi nuclear hormone receptor 0.0065 0.2606 0.328
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0727 0.0246
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.061 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0065 0.2606 0.328
Loa Loa (eye worm) hypothetical protein 0.0042 0.1329 0.1329
Loa Loa (eye worm) hypothetical protein 0.0034 0.0928 0.0928
Brugia malayi hypothetical protein 0.0031 0.0727 0.0915
Loa Loa (eye worm) hypothetical protein 0.0065 0.2606 0.2606
Loa Loa (eye worm) hypothetical protein 0.0034 0.0928 0.0928
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.2606 0.328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0065 0.2606 0.2606
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0727 0.027
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0727 0.0246
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0042 0.1329 0.1329
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0065 0.2606 0.2222
Echinococcus multilocularis lamin dm0 0.0033 0.0824 0.0348
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0727 0.0246
Brugia malayi nuclear receptor NHR-88 0.0065 0.2606 0.328
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0928 0.0458
Onchocerca volvulus 0.0031 0.0727 0.1107
Schistosoma mansoni nuclear receptor 0.0031 0.0727 0.027
Echinococcus multilocularis musashi 0.0033 0.0824 0.0348
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0727 0.0246
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Onchocerca volvulus 0.0065 0.2606 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Schistosoma mansoni thyroid hormone receptor 0.0065 0.2606 0.2437
Loa Loa (eye worm) hypothetical protein 0.0021 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.061 1
Brugia malayi hypothetical protein 0.0034 0.0928 0.1168
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0065 0.2606 0.2437
Brugia malayi AMP-binding enzyme family protein 0.0029 0.061 0.0767
Loa Loa (eye worm) hypothetical protein 0.0021 0.0215 0.0215
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.0727 0.027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0065 0.2606 0.2222
Onchocerca volvulus Bile acid receptor homolog 0.0065 0.2606 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0031 0.0727 0.027
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0727 0.0246
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0065 0.2606 0.2222
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0215 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0928 0.1168
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.0727 0.027
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0215 0.5
Loa Loa (eye worm) hypothetical protein 0.0201 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0065 0.2606 0.328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.2606 0.2222
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0137 0.6501 0.6319
Brugia malayi photoreceptor-specific nuclear receptor 0.0065 0.2606 0.328
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0065 0.2606 0.2222
Schistosoma mansoni metabotropic glutamate receptor 0.0137 0.6501 0.6929
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.061 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.2606 0.328
Loa Loa (eye worm) hypothetical protein 0.0021 0.0215 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0065 0.2606 0.2606
Onchocerca volvulus Protein ultraspiracle homolog 0.0065 0.2606 1
Brugia malayi conserved hypotetical protein 0.0031 0.0727 0.0915
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.061 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0065 0.2606 0.2222
Loa Loa (eye worm) hypothetical protein 0.0031 0.0727 0.0727
Echinococcus granulosus lamin 0.0033 0.0824 0.0348
Brugia malayi Steroid receptor seven-up type 2 0.0065 0.2606 0.328
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0727 0.1107
Loa Loa (eye worm) glutamate receptor 0.0064 0.2549 0.2549
Loa Loa (eye worm) hypothetical protein 0.0021 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0021 0.0215 0.0215
Echinococcus granulosus FTZ F1 alpha 0.0065 0.2606 0.2222
Schistosoma mansoni lamin 0.0033 0.0824 0.0382
Brugia malayi nuclear receptor NHR-67 0.0031 0.0727 0.0915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0065 0.2606 0.2606
Schistosoma mansoni nuclear hormone receptor 0.0065 0.2606 0.2437
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0065 0.2606 0.2222
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0727 0.0727

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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