Detailed information for compound 1372939

Basic information

Technical information
  • TDR Targets ID: 1372939
  • Name: ethyl 3-cyano-6-methyl-2-oxo-1H-pyridine-4-ca rboxylate
  • MW: 206.198 | Formula: C10H10N2O3
  • H donors: 1 H acceptors: 4 LogP: 1.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cc(C)nc(c1C#N)O
  • InChi: 1S/C10H10N2O3/c1-3-15-10(14)7-4-6(2)12-9(13)8(7)5-11/h4H,3H2,1-2H3,(H,12,13)
  • InChiKey: RJJRKBMJIICKDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-cyano-6-methyl-2-oxo-1H-pyridine-4-carboxylic acid ethyl ester
  • 3-cyano-2-keto-6-methyl-1H-pyridine-4-carboxylic acid ethyl ester
  • 18619-97-1
  • NSC17505
  • SR-01000636859-1
  • MLS000737828
  • SMR000528179
  • Maybridge1_006054

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Saccharomyces cerevisiae Ste24p Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis caax prenyl protease 1 Get druggable targets OG5_127953 All targets in OG5_127953
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei gambiense CAAX prenyl protease 1, putative,metallo- peptidase, Clan M- Family M48 Get druggable targets OG5_127953 All targets in OG5_127953
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans likely metallopeptidase similar to S. cerevisiae STE24 (YJR117W) involved in the proteolytic maturation of a-factor Get druggable targets OG5_127953 All targets in OG5_127953
Entamoeba histolytica CAAX prenyl protease, putative Get druggable targets OG5_127953 All targets in OG5_127953
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni farnesylated-protein converting enzyme 1 (M48 family) Get druggable targets OG5_127953 All targets in OG5_127953
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 Get druggable targets OG5_127953 All targets in OG5_127953
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Peptidase family M48 containing protein Get druggable targets OG5_127953 All targets in OG5_127953
Toxoplasma gondii CAAX metallo endopeptidase Get druggable targets OG5_127953 All targets in OG5_127953
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei metallo- peptidase, Clan M- Family M48 Get druggable targets OG5_127953 All targets in OG5_127953
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva CAAX prenyl protease 1, putative Get druggable targets OG5_127953 All targets in OG5_127953
Trypanosoma cruzi CAAX prenyl protease 1, putative Get druggable targets OG5_127953 All targets in OG5_127953
Trypanosoma congolense metallo- peptidase, Clan M- Family M48 Get druggable targets OG5_127953 All targets in OG5_127953
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) peptidase family M48 containing protein Get druggable targets OG5_127953 All targets in OG5_127953
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase Get druggable targets OG5_127953 All targets in OG5_127953
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans likely metallopeptidase similar to S. cerevisiae STE24 (YJR117W) involved in the proteolytic maturation of a-factor Get druggable targets OG5_127953 All targets in OG5_127953
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 Get druggable targets OG5_127953 All targets in OG5_127953
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus caax prenyl protease 1 Get druggable targets OG5_127953 All targets in OG5_127953
Schistosoma japonicum ko:K06013 STE24 endopeptidase [EC3.4.24.84], putative Get druggable targets OG5_127953 All targets in OG5_127953
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Neospora caninum peptidase family M48 domain-containing protein, putative Get druggable targets OG5_127953 All targets in OG5_127953
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi metallo- peptidase, Clan M- Family M48 Get druggable targets OG5_127953 All targets in OG5_127953
Babesia bovis CAAX metallo endopeptidase, putative Get druggable targets OG5_127953 All targets in OG5_127953
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania donovani metallo- peptidase, Clan M- Family M48 Get druggable targets OG5_127953 All targets in OG5_127953
Leishmania infantum CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 Get druggable targets OG5_127953 All targets in OG5_127953
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania major CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 Get druggable targets OG5_127953 All targets in OG5_127953
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_127953 All targets in OG5_127953
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase Get druggable targets OG5_127953 All targets in OG5_127953
Cryptosporidium hominis CAAX prenyl protease Get druggable targets OG5_127953 All targets in OG5_127953
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.5323 1
Loa Loa (eye worm) hypothetical protein 0.018 1 1
Toxoplasma gondii CAAX metallo endopeptidase 0.0082 0.3815 0.7146
Brugia malayi PHD-finger family protein 0.003 0.0555 0.052
Echinococcus multilocularis muscleblind protein 0.018 1 1
Brugia malayi cell division control protein 2 homolog 0.0048 0.1704 0.1673
Echinococcus granulosus cyclins 0.0034 0.0807 0.0807
Brugia malayi Peptidase family M48 containing protein 0.0082 0.3815 0.3792
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0048 0.1704 0.1699
Trichomonas vaginalis cyclins, putative 0.0034 0.0807 0.1455
Schistosoma mansoni bromodomain containing protein 0.0076 0.3467 0.6488
Giardia lamblia Hypothetical protein 0.0034 0.0807 0.1455
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0106 0.5323 0.5321
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0048 0.1704 0.3152
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.055 0.097
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0048 0.1704 0.3152
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0376 0.0376
Trichomonas vaginalis cyclin D, putative 0.0034 0.0807 0.1455
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.1704 0.3152
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0037 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.1704 0.3152
Echinococcus granulosus cyclins 0.0034 0.0807 0.0807
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0376 0.064
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.3273 0.3273
Echinococcus granulosus muscleblind protein 0.018 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.1704 0.1699
Giardia lamblia Kinase, CMGC CDK 0.0048 0.1704 0.3152
Brugia malayi jmjC domain containing protein 0.0073 0.3273 0.3248
Echinococcus granulosus caax prenyl protease 1 0.0082 0.3815 0.3815
Entamoeba histolytica CAAX prenyl protease, putative 0.0082 0.3815 0.7146
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0037 0.0037
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.3195 0.3195
Echinococcus multilocularis cyclins 0.0034 0.0807 0.0807
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.055 0.097
Loa Loa (eye worm) hypothetical protein 0.0048 0.1661 0.1656
Schistosoma mansoni hypothetical protein 0.0025 0.0231 0.0366
Trypanosoma brucei protein kinase, putative 0.0106 0.5323 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0106 0.5323 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0082 0.3802 0.3779
Loa Loa (eye worm) hypothetical protein 0.0082 0.3802 0.3799
Schistosoma mansoni jumonji domain containing protein 0.0071 0.3128 0.5847
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.018 1 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0034 0.0807 0.0801
Echinococcus granulosus cyclins 0.0034 0.0807 0.0807
Giardia lamblia G2/mitotic-specific cyclin B 0.0082 0.3802 0.7123
Trichomonas vaginalis cyclin B, putative 0.0082 0.3802 0.7123
Echinococcus granulosus cyclin dependent kinase 1 0.0048 0.1704 0.1704
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0082 0.3815 0.7146
Trichomonas vaginalis cyclin B, putative 0.0082 0.3802 0.7123
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0366 0.0623
Entamoeba histolytica protein kinase, putative 0.0106 0.5323 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.1704 0.1673
Toxoplasma gondii hypothetical protein 0.0026 0.029 0.0478
Toxoplasma gondii FATC domain-containing protein 0.003 0.055 0.097
Brugia malayi Bromodomain containing protein 0.0091 0.4356 0.4335
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0106 0.5323 0.5323
Echinococcus granulosus serine protein kinase ATM 0.003 0.055 0.055
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1392 0.1392
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0037 0.0037
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.3128 0.3128
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.055 0.097
Echinococcus multilocularis protein kinase shaggy 0.0106 0.5323 0.5323
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.1704 0.3152
Trichomonas vaginalis cyclin B, putative 0.0034 0.0807 0.1455
Brugia malayi Cyclin, N-terminal domain containing protein 0.0034 0.0807 0.0772
Echinococcus multilocularis cyclins 0.0034 0.0807 0.0807
Trypanosoma brucei metallo- peptidase, Clan M- Family M48 0.0082 0.3815 0.7146
Trypanosoma cruzi CAAX prenyl protease 1, putative 0.0082 0.3815 0.7146
Onchocerca volvulus 0.0106 0.5323 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0048 0.1704 0.1704
Echinococcus granulosus protein kinase shaggy 0.0106 0.5323 0.5323
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.1704 0.3152
Trichomonas vaginalis cyclins, putative 0.0082 0.3802 0.7123
Schistosoma mansoni cyclin B 0.0082 0.3802 0.7123
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.3128 0.3128
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.1704 0.3152
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0082 0.3815 0.7146
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0106 0.5323 1
Echinococcus granulosus cyclin b3 0.0034 0.0807 0.0807
Echinococcus granulosus cyclin dependent kinase 5 0.0048 0.1704 0.1704
Giardia lamblia Cyclin A 0.0034 0.0807 0.1455
Trichomonas vaginalis cyclins, putative 0.0056 0.2178 0.4049
Leishmania major cyclin 0.0082 0.3802 0.7123
Loa Loa (eye worm) hypothetical protein 0.0047 0.1608 0.1604
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.3273 0.6121
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.3273 0.6121
Echinococcus multilocularis muscleblind protein 1 0.018 1 1
Trichomonas vaginalis cyclin B, putative 0.0082 0.3802 0.7123
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.055 0.097
Echinococcus granulosus cyclin B 0.0082 0.3802 0.3802
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0037 0.0037
Trypanosoma cruzi CYC2-like cyclin, putative 0.0082 0.3802 0.7123
Loa Loa (eye worm) hypothetical protein 0.0052 0.1901 0.1897
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0106 0.5323 0.5323
Echinococcus multilocularis serine protein kinase ATM 0.003 0.055 0.055
Trichomonas vaginalis cyclin B, putative 0.0082 0.3802 0.7123
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0034 0.0807 0.0807
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0231 0.0225
Echinococcus multilocularis cyclins 0.0034 0.0807 0.0807
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.5323 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.055 0.0515
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0037 0.0032
Trypanosoma cruzi cyclin, putative 0.0082 0.3802 0.7123
Trichomonas vaginalis cyclins, putative 0.0082 0.3802 0.7123
Giardia lamblia Kinase, CMGC GSK 0.0106 0.5323 1
Echinococcus multilocularis cyclins 0.0034 0.0807 0.0807
Echinococcus multilocularis cyclin B 0.0082 0.3802 0.3802
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1392 0.1392
Loa Loa (eye worm) peptidase family M48 containing protein 0.0082 0.3815 0.3811
Trypanosoma cruzi metallo- peptidase, Clan M- Family M48 0.0082 0.3815 0.7146
Schistosoma mansoni zinc finger protein 0.0024 0.015 0.0214
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.1704 0.3152
Echinococcus granulosus cyclin B3 1 0.0034 0.0807 0.0807
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0082 0.3802 0.7123
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0366 0.0623
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0106 0.5323 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.004 0.0005
Echinococcus multilocularis cyclin dependent kinase 5 0.0048 0.1704 0.1704
Echinococcus multilocularis cyclin B3 1 0.0034 0.0807 0.0807
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.3195 0.3195
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.1704 0.3152
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0037 0.0032
Brugia malayi intracellular kinase 0.0106 0.5323 0.5306
Echinococcus multilocularis cyclins 0.0034 0.0807 0.0807
Trypanosoma cruzi cyclin, putative 0.0082 0.3802 0.7123
Plasmodium vivax glycogen synthase kinase 3, putative 0.0106 0.5323 1
Trichomonas vaginalis cyclin D, putative 0.0034 0.0807 0.1455
Echinococcus granulosus cyclins 0.0034 0.0807 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0807 0.1455
Echinococcus multilocularis zinc finger protein 0.0024 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0046 0.1576 0.1572
Trichomonas vaginalis cyclin A, putative 0.0082 0.3802 0.7123
Entamoeba histolytica cyclin family protein 0.0034 0.0807 0.1455
Echinococcus granulosus zinc finger protein 0.0024 0.015 0.015
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.5323 1
Trypanosoma brucei mitotic cyclin 6 0.0082 0.3802 0.7123
Trichomonas vaginalis cyclins, putative 0.0082 0.3802 0.7123
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.3128 0.3128
Schistosoma mansoni farnesylated-protein converting enzyme 1 (M48 family) 0.0082 0.3815 0.7146
Entamoeba histolytica hypothetical protein 0.003 0.055 0.097
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.1704 0.1699
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.004 0.0005
Trypanosoma cruzi cyclin 6, putative 0.0082 0.3802 0.7123
Echinococcus multilocularis cyclin dependent kinase 0.0048 0.1704 0.1704
Echinococcus granulosus cyclin dependent kinase 0.0048 0.1704 0.1704
Trichomonas vaginalis cyclin B3, putative 0.0034 0.0807 0.1455
Leishmania major CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 0.0082 0.3815 0.7146
Echinococcus multilocularis cyclins 0.0034 0.0807 0.0807
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0048 0.1704 0.3152
Schistosoma mansoni cyclins 0.0034 0.0807 0.1455
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.1704 0.3152
Trypanosoma brucei cdc2-related kinase 3 0.0048 0.1704 0.3152
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.1704 0.1704
Brugia malayi Bromodomain containing protein 0.0046 0.1571 0.154
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0106 0.5323 0.5321
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.1704 0.3152
Plasmodium falciparum protein kinase 5 0.0048 0.1704 0.1986
Echinococcus multilocularis cyclin b3 0.0034 0.0807 0.0807
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0286 0.047
Schistosoma mansoni cyclin B3 0.0034 0.0807 0.1455
Loa Loa (eye worm) hypothetical protein 0.0085 0.4031 0.4028
Trypanosoma brucei cdc2-related kinase 1 0.0048 0.1704 0.3152
Echinococcus granulosus cyclins 0.0034 0.0807 0.0807
Echinococcus multilocularis cyclins 0.0034 0.0807 0.0807
Giardia lamblia Kinase, CMGC CDK 0.0048 0.1704 0.3152
Plasmodium falciparum glycogen synthase kinase 3 0.0106 0.5323 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.3273 0.3269
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.1704 0.1704
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.1704 0.3152
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.1704 0.3152
Loa Loa (eye worm) hypothetical protein 0.0049 0.1756 0.1752
Loa Loa (eye worm) hypothetical protein 0.0026 0.0286 0.0281
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.5323 1
Brugia malayi jmjC domain containing protein 0.0071 0.3128 0.3102
Trichomonas vaginalis cyclins, putative 0.0082 0.3802 0.7123
Entamoeba histolytica cyclin, putative 0.0082 0.3802 0.7123
Giardia lamblia Kinase, CMGC GSK 0.0106 0.5323 1
Echinococcus multilocularis caax prenyl protease 1 0.0082 0.3815 0.3815
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0034 0.0807 0.0807
Entamoeba histolytica cyclin family protein 0.0034 0.0807 0.1455
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0106 0.5323 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.3802 0.3799
Entamoeba histolytica cyclin, putative 0.0034 0.0807 0.1455
Brugia malayi Cyclin, N-terminal domain containing protein 0.0082 0.3802 0.3779

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 12.27 uM PUBCHEM_BIOASSAY: Ste24 Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-03_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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