Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0591 | 1 | 1 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.01 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0591 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.01 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0591 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.01 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0591 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.01 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0591 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0591 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0591 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0591 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.01 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0591 | 1 | 1 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0591 | 1 | 1 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.01 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0591 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0591 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.