Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | nucleotide-binding oligomerization domain containing 1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | tumor necrosis factor | Starlite/ChEMBL | No references |
Streptococcus pyogenes serotype M1 | Streptokinase A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.697 | 0.697 |
Echinococcus granulosus | transcription factor btf3 | 0.0042 | 0.3627 | 0.3627 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0042 | 0.3627 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.7156 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.1437 | 0.3961 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.7156 | 0.7156 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.3429 | 0.3429 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1437 | 0.3961 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0037 | 0.2715 | 0.2715 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1437 | 0.3961 |
Echinococcus granulosus | caspase 2 | 0.0037 | 0.2715 | 0.2715 |
Onchocerca volvulus | 0.0037 | 0.2715 | 0.5 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1437 | 0.3961 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.126 | 0.126 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | beta-NAC-like protein | 0.0042 | 0.3627 | 0.3627 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.3627 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1437 | 0.2008 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.3429 | 0.3429 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.2715 | 0.2715 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0037 | 0.2715 | 0.2715 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.7156 | 0.7156 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.697 | 0.697 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1437 | 0.1437 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.3627 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.2715 | 0.2715 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0042 | 0.3627 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.7156 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.3627 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.1437 | 0.2008 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.3627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.2715 | 0.2715 |
Brugia malayi | hypothetical protein | 0.0037 | 0.2715 | 0.2715 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.7156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3429 | 0.3429 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.3627 | 1 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0037 | 0.2715 | 0.2715 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1437 | 0.3961 |
Schistosoma mansoni | transcription factor btf3 | 0.0042 | 0.3627 | 0.3627 |
Toxoplasma gondii | NAC domain-containing protein | 0.0042 | 0.3627 | 0.5069 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.7156 | 0.7156 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0042 | 0.3627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.697 | 0.697 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3627 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.7156 | 0.7156 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0042 | 0.3627 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0037 | 0.2715 | 0.2715 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0037 | 0.2715 | 0.2715 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.7156 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.1437 | 0.1437 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.7156 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.697 | 0.697 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Leishmania major | basic transcription factor 3a, putative | 0.0042 | 0.3627 | 0.5069 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0037 | 0.2715 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.7156 | 1 |
Echinococcus multilocularis | transcription factor btf3 | 0.0042 | 0.3627 | 0.3627 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1437 | 0.3961 |
Loa Loa (eye worm) | ICD-1 protein | 0.0042 | 0.3627 | 0.3627 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 6.474 um | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] | ChEMBL. | No reference |
EC50 (functional) | = 8.18 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD1. uHTS luminescence assay for the identification of compounds that inhibit NOD1, utilizing an NF-kB-mediated luciferase reporter gene activity as a measure of NOD1 modulation (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1849, AID1852, AID2250, AID2255, AID2260, AID2261, AID2264, AID2333, AID2334, AID2335, AID2337, AID2466, AID2469, AID2475, AID2483, AID2485, AID2503, AID2505, AID2789, AID2792, AID2793, AID2798, AID2799, AID2800, AID2801] | ChEMBL. | No reference |
EC50 (functional) | > 150 um | PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] | ChEMBL. | No reference |
IC50 (functional) | = 4.28 uM | PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD1 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID2335, AID2466, AID2469, AID2505, AID2798, AID2800] | ChEMBL. | No reference |
IC50 (functional) | = 5.97 uM | PUBCHEM_BIOASSAY: HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2337] | ChEMBL. | No reference |
IC50 (functional) | = 6.22 uM | PUBCHEM_BIOASSAY: SAR analysis of inhibitors of TNFa specific NF-kB induction revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2469, AID2483, AID2485, AID2800, AID2801] | ChEMBL. | No reference |
IC50 (functional) | = 6.776 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1579, AID1849, AID2260, AID2335, AID2469, AID2503, AID2800] | ChEMBL. | No reference |
IC50 (functional) | = 7.209928 uM | PUBCHEM_BIOASSAY: uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD1 cell inhibition assay. Cytotoxicity counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1852, AID2001, AID2260, AID2264, AID2334, AID2335, AID2466, AID2469, AID2475, AID2503, AID2793, AID2798, AID2799, AID2800] | ChEMBL. | No reference |
Potency (functional) | 0.4467 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.5858 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.0621 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.8584 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Saccharomyces cerevisiae | ChEMBL23 | ||
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.