TDR Targets

Basic information

Technical information

TDR Targets ID: 1373571
Name: N-(2,3-dimethylphenyl)-2-[[2-(5-fluoro-2-nitr ophenoxy)acetyl]amino]acetamide
MW: 375.351 | Formula: C18H18FN3O5
H donors: 2 H acceptors: 4 LogP: 2.8 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(COc1cc(F)ccc1[N+](=O)[O-])NCC(=O)Nc1cccc(c1C)C
InChi: 1S/C18H18FN3O5/c1-11-4-3-5-14(12(11)2)21-17(23)9-20-18(24)10-27-16-8-13(19)6-7-15(16)22(25)26/h3-8H,9-10H2,1-2H3,(H,20,24)(H,21,23)
InChiKey: YKSWZIFCESBMDK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,3-dimethylphenyl)-2-[[2-(5-fluoro-2-nitro-phenoxy)acetyl]amino]acetamide
N-(2,3-dimethylphenyl)-2-[[2-(5-fluoro-2-nitrophenoxy)-1-oxoethyl]amino]acetamide
N-(2,3-dimethylphenyl)-2-[2-(5-fluoro-2-nitro-phenoxy)ethanoylamino]ethanamide
T5340880
MLS000771111
SMR000375990
ZINC03431314

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	regulator of G-protein signaling 4	Starlite/ChEMBL	No references
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	expressed protein	Get druggable targets OG5_141764	All targets in OG5_141764
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	expressed protein	Get druggable targets OG5_141764	All targets in OG5_141764
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Fructose-bisphosphate aldolase	0.0323	0.7073	1
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0068	0.1282	0.1942
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0275	0.1129
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0222	0.0233
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0243	0.1869
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0014	0.0064	0.0006
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0014	0.0064	0.0096
Brugia malayi	Pre-SET motif family protein	0.0034	0.0511	0.0774
Echinococcus granulosus	chromobox protein 1	0.0084	0.1656	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0064	0.0096
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0511	0.0511
Brugia malayi	hypoxia-induced factor 1	0.0166	0.3521	0.5335
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0022	0.0243	0.0243
Echinococcus multilocularis	lysine specific demethylase 6a	0.0029	0.0398	0.0398
Onchocerca volvulus		0.0046	0.0779	0.1367
Onchocerca volvulus		0.0262	0.57	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0222	0.0233
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0029	0.0398	0.1657
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0272	0.0412
Plasmodium vivax	hypothetical protein, conserved	0.0049	0.0856	1
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.0726	0.0741
Brugia malayi	Protein kinase domain containing protein	0.0065	0.1213	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0586	0.0887
Brugia malayi	jmjC domain containing protein	0.0029	0.0398	0.0603
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0023	0.0272	0.0272
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0049	0.0856	0.1135
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0014	0.0064	0.0219
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0856	0.1135
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.1269	0.1269
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0222	0.0233
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0504	0.0635
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0776	0.3302
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0022	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0272	0.0412
Plasmodium falciparum	heterochromatin protein 1	0.0014	0.0059	0.0093
Schistosoma mansoni	caspase-7 (C14 family)	0.0129	0.2679	0.2679
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0817	0.108
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0275	0.0791
Schistosoma mansoni	caspase-3 (C14 family)	0.0129	0.2679	0.2679
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0243	0.0369
Echinococcus multilocularis	dna polymerase eta	0.0016	0.0109	0.0109
Onchocerca volvulus		0.0022	0.0241	0.0423
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0218	0.2071
Schistosoma mansoni	hypothetical protein	0.0012	0.003	0.003
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.1269	0.1269
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0029	0.0398	0.1675
Schistosoma mansoni	chromobox protein	0.0084	0.1656	0.1656
Echinococcus multilocularis	Chromobox protein 3	0.0014	0.0059	0.0059
Echinococcus multilocularis	regulator of G protein signaling 3	0.0023	0.0272	0.0272
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0024	0.028	0.028
Mycobacterium leprae	Possible regulatory protein	0.0014	0.0064	0.0153
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0776	0.3287
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0243	0.0369
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0021	0.0232	0.0333
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0398	0.0603
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1888	0.2861
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0323	0.7073	1
Leishmania major	hypothetical protein, conserved	0.0028	0.0379	0.1575
Trypanosoma cruzi	DNA polymerase eta, putative	0.0016	0.0109	0.0416
Schistosoma mansoni	tyrosine kinase	0.0065	0.1213	0.1213
Echinococcus multilocularis	insulin receptor	0.0065	0.1213	0.1213
Echinococcus granulosus	JmjC domain containing protein 4	0.0029	0.0398	0.0398
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.1269	0.3791
Trypanosoma cruzi	metacaspase, putative	0.0049	0.0856	0.3629
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0467	0.0467
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0275	0.0083
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0776	0.3302
Echinococcus granulosus	apoptotic protease activating factor 1	0.0046	0.0779	0.0779
Echinococcus granulosus	caspase 2	0.0094	0.1888	0.1888
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2335	0.3244
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0158	0.3326	0.503
Brugia malayi	chromobox protein homolog 3	0.0047	0.0817	0.1238
Echinococcus multilocularis	axis inhibition protein axin	0.0023	0.0272	0.0272
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0158	0.3326	1
Echinococcus multilocularis	peregrin	0.0039	0.0634	0.0634
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0545	0.4264
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0014	0.0064	0.0006
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0545	0.4264
Echinococcus granulosus	dna polymerase eta	0.0016	0.0109	0.0109
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0014	0.0059	0.0059
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0014	0.0059	0.0407
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0545	0.0545
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0014	0.0064	0.0064
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0511	0.0511
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0024	0.028	0.028
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0129	0.2679	0.2679
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0511	0.0511
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0014	0.0064	0.0219
Schistosoma mansoni	axis inhibition protein axin	0.0023	0.0272	0.0272
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0047	0.0815	0.6403
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0323	0.7073	1
Plasmodium falciparum	metacaspase 1	0.0049	0.0856	1
Loa Loa (eye worm)	acetyltransferase	0.016	0.338	0.5122
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0061	0.1131	0.1131
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0014	0.0064	0.5
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0218	0.033
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.009
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0068	0.1282	0.383
Onchocerca volvulus		0.004	0.0649	0.1139
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0129	0.2679	0.2679
Brugia malayi	Cytochrome P450 family protein	0.0054	0.0969	0.1469
Echinococcus granulosus	bloom syndrome protein	0.0022	0.0243	0.0243
Echinococcus granulosus	peregrin	0.0039	0.0634	0.0634
Schistosoma mansoni	jumonji domain containing protein	0.0029	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.009
Brugia malayi	hypothetical protein	0.018	0.3838	0.5816
Echinococcus granulosus	cytochrome P450 2K1	0.0012	0.0013	0.0013
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0858	0.0858
Echinococcus granulosus	caspase 8	0.0049	0.0856	0.0856
Schistosoma mansoni	chromobox protein	0.0084	0.1656	0.1656
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0024	0.028	0.0425
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0014	0.0072	0.0255
Trypanosoma brucei	metacaspase 5, putative	0.0049	0.0856	0.3643
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0231	0.498	0.7546
Schistosoma mansoni	DNA helicase recq1	0.0022	0.0243	0.0243
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0024	0.028	0.0425
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0059	0.00000000029206
Trypanosoma brucei	DNA polymerase eta, putative	0.0016	0.0109	0.0437
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0817	0.1433
Echinococcus multilocularis	caspase	0.0129	0.2679	0.2679
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0065	0.1213	0.1213
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0023	0.0272	0.0412
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.1401	0.5989
Schistosoma mansoni	thyroid hormone receptor	0.015	0.3156	0.3156
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0779	0.1181
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0059	0.0093
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0046	0.0779	0.0779
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0069	0.1301	0.1301
Onchocerca volvulus		0.0014	0.0059	0.0104
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0064	0.0006
Echinococcus multilocularis	JmjC domain containing protein 4	0.0029	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.009
Echinococcus multilocularis		0.0064	0.1193	0.1193
Trypanosoma brucei	unspecified product	0.0038	0.0611	0.2591
Schistosoma mansoni	DNA polymerase eta	0.0016	0.0109	0.0109
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0059	0.00000000029206
Brugia malayi	jmjC domain containing protein	0.0029	0.0398	0.0603
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0024	0.028	0.0425
Schistosoma mansoni	hypothetical protein	0.0046	0.0779	0.0779
Echinococcus multilocularis	regulator of G protein signaling	0.0023	0.0272	0.0272
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0068	0.1282	0.1282
Schistosoma mansoni	polycystin 1-related	0.0022	0.0241	0.0241
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0068	0.1282	0.1943
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0059	0.00000000029206
Echinococcus multilocularis	chromobox protein 1	0.0084	0.1656	0.1656
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0776	0.3302
Plasmodium vivax	SET domain protein, putative	0.0034	0.0511	0.571
Echinococcus multilocularis		0.0012	0.0013	0.0013
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0031	0.0439	0.0439
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0029	0.0398	0.1657
Brugia malayi	hypothetical protein	0.0023	0.0272	0.0412
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0218	0.2071
Echinococcus granulosus	dna polymerase kappa	0.0045	0.0776	0.0776
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0323	0.7073	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.2335	0.3538
Entamoeba histolytica	hypothetical protein	0.0023	0.0272	0.0303
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0545	0.0827
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0379	0.4066
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0016	0.0109	0.0109
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0162	0.0664
Loa Loa (eye worm)	cytochrome P450 family protein	0.0054	0.0969	0.1469
Leishmania major	protein kinase, putative	0.0014	0.0072	0.0255
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0379	0.4066
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0139	0.2902	0.2902
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.009
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0049	0.0856	0.1135
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0014	0.0059	0.0407
Brugia malayi	Valyl-tRNA synthetase	0.0014	0.0059	0.009
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1269	0.1907
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0776	0.3302
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0272	0.0303
Brugia malayi	ImpB/MucB/SamB family protein	0.0016	0.0109	0.0166
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0218	0.0904
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0059	0.00000000029206
Brugia malayi	A-kinase anchor protein 10, precursor	0.0023	0.0272	0.0412
Brugia malayi	PAS domain containing protein	0.0054	0.0966	0.1464
Loa Loa (eye worm)	glutaminase	0.0302	0.6599	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0218	0.0218
Echinococcus granulosus	axis inhibition protein axin	0.0023	0.0272	0.0272
Brugia malayi	ImpB/MucB/SamB family protein	0.0016	0.0109	0.0166
Echinococcus granulosus	caspase	0.0129	0.2679	0.2679
Echinococcus granulosus	aryl hydrocarbon receptor	0.0014	0.0064	0.0064
Loa Loa (eye worm)	cytochrome P450 family protein	0.0021	0.0232	0.0352
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0218	0.0227
Echinococcus granulosus	Polycystic kidney disease protein	0.0022	0.0241	0.0241
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0029	0.0398	0.0398
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.018	0.3837	0.3837
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.1269	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.016	0.338	0.338
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0776	0.3287
Loa Loa (eye worm)	RGS-3 protein	0.0023	0.0272	0.0412
Trichomonas vaginalis	DNA helicase recq, putative	0.0022	0.0243	0.0263
Echinococcus multilocularis	dna polymerase kappa	0.0045	0.0776	0.0776
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0218	0.0884
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0275	0.1148
Schistosoma mansoni	phosphatidylserine receptor	0.0029	0.0398	0.0398
Echinococcus granulosus	chromobox protein 1	0.0084	0.1656	0.1656
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0218	0.5
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.1269	0.1269
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0218	0.0884
Trypanosoma cruzi	metacaspase, putative	0.0049	0.0856	0.3629
Trichomonas vaginalis	DNA helicase recq1, putative	0.0022	0.0243	0.0263
Brugia malayi	Bloom's syndrome protein homolog	0.0022	0.0243	0.0369
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0898	0.1196
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0272	0.0303
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.1028	0.1381
Echinococcus multilocularis	RUN	0.0022	0.0241	0.0241
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.0726	0.0951
Onchocerca volvulus	Alhambra homolog	0.0035	0.0545	0.0957
Entamoeba histolytica	recQ family helicase, putative	0.0022	0.0243	0.0263
Echinococcus multilocularis	thyroid hormone receptor alpha	0.015	0.3156	0.3156
Brugia malayi	PXA domain containing protein	0.0023	0.0272	0.0412
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0205	0.4393	0.6657
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0017	0.0135	0.0108
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0013	0.0019
Trypanosoma cruzi	cytochrome P450, putative	0.0021	0.0232	0.0946
Loa Loa (eye worm)	helicase	0.0014	0.0059	0.009
Echinococcus multilocularis	expressed protein	0.0451	0.9974	0.9974
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0016	0.0109	0.0072
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0023	0.0272	0.0412
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0059	0.0093
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.1028	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0856	0.1296
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0858	0.0858
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2335	0.3244
Trypanosoma brucei	metacaspase MCA3	0.0049	0.0856	0.3643
Echinococcus multilocularis	regulator of G protein signaling 7	0.0023	0.0272	0.0272
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0068	0.1282	0.5464
Echinococcus multilocularis	Polycystic kidney disease protein	0.0022	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0241	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0398	0.0603
Brugia malayi	jmjC domain containing protein	0.0109	0.2229	0.3378
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0545	0.6143
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0379	0.4066
Brugia malayi	jmjC domain containing protein	0.018	0.3837	0.5815
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.018	0.3837	0.3837
Brugia malayi	DnaJ domain containing protein	0.0068	0.1282	0.1943
Echinococcus multilocularis	caspase 3	0.008	0.157	0.157
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0776	0.3302
Schistosoma mansoni	protein phosphatase 2C	0.0029	0.0398	0.0398
Echinococcus multilocularis	epidermal growth factor receptor	0.0205	0.4393	0.4393
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0526	0.2226
Schistosoma mansoni	hypothetical protein	0.0068	0.1282	0.1282
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0073	0.1401	0.598
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0014	0.0064	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0545	0.0827
Giardia lamblia	Sgs1 DNA helicase, putative	0.0022	0.0243	0.0037
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0059	0.0059
Schistosoma mansoni	hypothetical protein	0.0035	0.0545	0.0545
Brugia malayi	F/Y-rich N-terminus family protein	0.0022	0.0255	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1509	0.2287
Echinococcus multilocularis	lysine specific demethylase 5A	0.0108	0.2188	0.2188
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0398	0.0603
Echinococcus granulosus	insulin receptor	0.0065	0.1213	0.1213
Echinococcus granulosus	single minded 2	0.004	0.0649	0.0649
Trypanosoma brucei	Metacaspase-4	0.0049	0.0856	0.3643
Echinococcus granulosus	epidermal growth factor receptor	0.0205	0.4393	0.4393
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0014	0.0059	0.009
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0014	0.0059	0.0059
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0047	0.0815	0.9497
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0272	0.0303
Echinococcus granulosus	regulator of G protein signaling 7	0.0023	0.0272	0.0272
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0047	0.0823	0.0823
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1269	0.1907
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0856	0.1135
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0029	0.0398	0.3092
Schistosoma mansoni	hypothetical protein	0.0014	0.0059	0.0059
Echinococcus granulosus	regulator of G protein signaling 3	0.0023	0.0272	0.0272
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0029	0.0398	0.4304
Brugia malayi	Cytochrome P450 family protein	0.0021	0.0232	0.0352
Plasmodium falciparum	LCCL domain-containing protein	0.0022	0.0241	0.2354
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.1656	0.2509
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0068	0.1282	0.1282
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0243	0.1013
Loa Loa (eye worm)	glutaminase 2	0.0302	0.6599	1
Brugia malayi	M-phase phosphoprotein, mpp8	0.0014	0.0059	0.009
Mycobacterium ulcerans	DNA polymerase IV	0.0045	0.0776	0.1159
Trichomonas vaginalis	guanylate cyclase, putative	0.0014	0.0064	0.0006
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0023	0.0272	0.0272
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0014	0.0059	0.0059
Echinococcus granulosus	regulator of G protein signaling 7	0.0023	0.0272	0.0272
Echinococcus multilocularis	bloom syndrome protein	0.0022	0.0243	0.0243
Brugia malayi	PXA domain containing protein	0.0023	0.0272	0.0412
Trichomonas vaginalis	DNA helicase recq, putative	0.0022	0.0243	0.0263
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.0072	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0856	0.1135
Trichomonas vaginalis	glutaminase, putative	0.0302	0.6599	0.9324
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0016	0.01	0.01
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0021	0.0214	0.0214
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.0072	0.0255
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0068	0.1282	0.1282
Brugia malayi	PHD-finger family protein	0.0035	0.0545	0.0827
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0049	0.0856	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0243	0.0369
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0147	0.0125
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0898	0.1196
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0511	0.0511
Onchocerca volvulus		0.0022	0.0241	0.0423
Mycobacterium ulcerans	DNA polymerase IV	0.0045	0.0776	0.1159
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0526	0.0797
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2335	0.3244
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0222	0.0233
Loa Loa (eye worm)	CHromoDomain protein family member	0.0016	0.01	0.0152
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0243	0.2386
Trypanosoma cruzi	metacaspase 5, putative	0.0049	0.0856	0.3629
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0222	0.0233
Onchocerca volvulus		0.0032	0.0467	0.0819
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0856	0.1135
Mycobacterium ulcerans	glutaminase	0.0302	0.6599	1
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0073	0.1401	0.2124
Leishmania major	DNA polymerase eta, putative	0.0016	0.0109	0.0416
Schistosoma mansoni	z-protein (S1r protein)	0.0023	0.0272	0.0272
Schistosoma mansoni	cpg binding protein	0.0034	0.0508	0.0508
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0114	0.2335	0.2335
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0379	0.1593
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0023	0.0272	0.0272
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0014	0.0064	0.0219
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0162	0.0664
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0014	0.0059	0.0093
Brugia malayi	Associated with TFs and helicases family protein	0.0014	0.0059	0.009
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0467	0.0707
Schistosoma mansoni	axis inhibition protein axin	0.0023	0.0272	0.0272
Brugia malayi	hypothetical protein	0.0046	0.0779	0.1181
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0016	0.0109	0.0109
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0272	0.0272
Trichomonas vaginalis	adenylate cyclase, putative	0.0014	0.0064	0.0006
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0156	0.3278	0.3278
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0023	0.0272	0.0272
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2335	0.3244
Brugia malayi	hypothetical protein	0.0028	0.0379	0.0574
Schistosoma mansoni	tyrosine kinase	0.0109	0.2231	0.2231
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0272	0.0412
Schistosoma mansoni	glutaminase	0.0302	0.6599	0.6599
Schistosoma mansoni	loxhd1	0.0022	0.0241	0.0241
Schistosoma mansoni	rab6-interacting	0.0022	0.0241	0.0241
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0022	0.0243	0.0243
Echinococcus multilocularis	regulator of G protein signaling 7	0.0023	0.0272	0.0272
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0016	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.009
Echinococcus granulosus	regulator of G protein signaling 3	0.0023	0.0272	0.0272
Brugia malayi	CHD4 protein	0.0016	0.01	0.0152
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0049	0.0856	0.1135
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0109	0.2229	0.2229
Schistosoma mansoni	ap endonuclease	0.0021	0.0218	0.0218
Schistosoma mansoni	hypothetical protein	0.0452	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0147	0.0125
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.1282	0.1926
Trypanosoma brucei	cytochrome P450, putative	0.0021	0.0232	0.0965
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0114	0.2335	0.3244
Schistosoma mansoni	cpg binding protein	0.0034	0.0508	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0241	0.0365
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0139	0.2902	0.2902
Echinococcus multilocularis	caspase 8	0.0049	0.0856	0.0856
Echinococcus granulosus	Chromobox protein 3	0.0014	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0817	0.1238
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0073	0.1401	0.2124
Echinococcus multilocularis	chromobox protein 2	0.0014	0.0059	0.0059
Trypanosoma brucei	metacaspase MCA2	0.0049	0.0856	0.3643
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.1656	0.2276
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0014	0.0064	0.0006
Brugia malayi	hypothetical protein	0.0022	0.0241	0.0365
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0545	0.0545
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0109	0.2231	0.2231
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.1401	0.598
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0049	0.0856	0.6723
Loa Loa (eye worm)	doublecortin family protein	0.0022	0.0241	0.0365
Leishmania major	metacaspase, putative	0.0049	0.0856	0.3629
Giardia lamblia	PHD finger protein 15	0.0035	0.0545	0.0478
Brugia malayi	hypothetical protein	0.0022	0.0241	0.0365
Brugia malayi	polk-prov protein	0.0034	0.0526	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0272	0.0412
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0014	0.0059	0.0059
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0114	0.2335	0.4096
Loa Loa (eye worm)	PXA domain-containing protein	0.0023	0.0272	0.0412
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0323	0.7073	1
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0014	0.0072	0.0255
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0023	0.0272	0.0412
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.003	0.003
Treponema pallidum	fructose-bisphosphate aldolase	0.0323	0.7073	1
Schistosoma mansoni	single-minded	0.0054	0.0966	0.0966
Leishmania major	protein kinase, putative	0.0014	0.0072	0.0255
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0272	0.0272
Brugia malayi	acetyltransferase, GNAT family protein	0.016	0.338	0.5122
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0065	0.1213	0.1213
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0064	0.0006
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0776	0.3302
Giardia lamblia	Kinase, PLK	0.0114	0.2335	0.3088
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0218	0.0227
Echinococcus multilocularis	chromobox protein 1	0.0084	0.1656	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.009
Entamoeba histolytica	hypothetical protein	0.0023	0.0272	0.0303
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0379	0.1575
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0022	0.0243	0.0243
Brugia malayi	glutaminase DH11.1	0.0302	0.6599	1
Brugia malayi	SET domain containing protein	0.0016	0.0102	0.0155
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0323	0.7073	1
Plasmodium falciparum	metacaspase-like protein	0.0049	0.0856	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0022	0.0241	0.2354
Schistosoma mansoni	cytochrome P450	0.0012	0.0013	0.0013
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.1269	0.5409
Brugia malayi	bHLH-PAS transcription factor	0.004	0.0649	0.0984
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0014	0.0059	0.0093
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0776	0.3287
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0014	0.0064	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.028	0.028
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0016	0.0109	0.0109
Trypanosoma brucei	DNA polymerase IV, putative	0.0045	0.0776	0.3302
Echinococcus multilocularis	jumonji domain containing 1A	0.0029	0.0398	0.0398
Echinococcus granulosus	epidermal growth factor receptor	0.0109	0.2231	0.2231
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0272	0.0272
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0776	0.3302
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0012	0.0013	0.004
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0379	0.294
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0504	0.0635
Brugia malayi	jmjC domain containing protein	0.0029	0.0398	0.0603
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0272	0.0303
Onchocerca volvulus		0.0014	0.0064	0.0112
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0073	0.1401	0.1914
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.028	0.028
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0379	0.1575
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0222	0.0233
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0166	0.3521	0.5335
Schistosoma mansoni	cpg binding protein	0.0032	0.0467	0.0467
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0047	0.0815	0.1078
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0059	0.00000000029206
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0049	0.0856	0.1135
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.016	0.338	0.338
Brugia malayi	hypothetical protein	0.0014	0.0059	0.009
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0218	0.0227
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0241	0.0241
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0029	0.0398	0.3092
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0049	0.0856	0.1135
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.1401	0.598
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1269	0.1907
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0222	0.0233
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0049	0.0856	0.1296
Trichomonas vaginalis	guanylate cyclase, putative	0.0014	0.0064	0.0006
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0114	0.2335	0.2335
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0109	0.0166
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0776	0.3287
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0023	0.0272	0.0303
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0241	0.0241
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0218	0.062
Schistosoma mansoni	phd/f-box containing protein	0.0029	0.0398	0.0398
Trypanosoma brucei	polo-like protein kinase	0.0114	0.2335	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0162	0.0664
Schistosoma mansoni	tyrosine kinase	0.0109	0.2231	0.2231
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0526	0.2226
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0379	0.0574
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0241	0.0241
Echinococcus granulosus	chromobox protein 2	0.0014	0.0059	0.0059
Loa Loa (eye worm)	TK/INSR protein kinase	0.0065	0.1213	0.1839
Brugia malayi	cytochrome P450	0.0012	0.0013	0.0019
Echinococcus multilocularis	epidermal growth factor receptor	0.0109	0.2231	0.2231
Echinococcus granulosus	phd:f box containing protein	0.0029	0.0398	0.0398
Trypanosoma cruzi	metacaspase 5, putative	0.0049	0.0856	0.3629
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0014	0.0064	0.0064
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0114	0.2335	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0016	0.0109	0.0109
Schistosoma mansoni	chromobox protein	0.0014	0.0059	0.0059
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0023	0.0272	0.0272
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0856	0.1135
Brugia malayi	Pre-SET motif family protein	0.0231	0.498	0.7546
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0398	0.0603
Mycobacterium ulcerans	putative regulatory protein	0.004	0.0649	0.0966
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0073	0.1401	0.1401
Schistosoma mansoni	jumonji domain containing protein	0.0157	0.33	0.33
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0049	0.0856	0.1135
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0243	0.0993
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0047	0.0815	0.1078
Entamoeba histolytica	hypothetical protein	0.0014	0.0059	0.00000000029206
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0323	0.7073	1
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.1656	0.2276
Echinococcus granulosus	RUN	0.0022	0.0241	0.0241
Loa Loa (eye worm)	cytochrome P450	0.0012	0.0013	0.0019
Schistosoma mansoni	hypothetical protein	0.0012	0.0008	0.0008
Echinococcus granulosus	dnaJ subfamily C 6	0.0068	0.1282	0.1282
Loa Loa (eye worm)	CYP4Cod1	0.0021	0.0232	0.0352
Echinococcus multilocularis	axis inhibition protein axin	0.0023	0.0272	0.0272
Brugia malayi	regulator of G-protein signaling egl-10	0.0023	0.0272	0.0412
Schistosoma mansoni	tyrosine kinase	0.0109	0.2231	0.2231
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0022	0.0243	0.0369
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0545	0.0545
Trypanosoma brucei	metacaspase	0.0049	0.0856	0.3643
Schistosoma mansoni	hypothetical protein	0.0022	0.0241	0.0241
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0323	0.7073	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0611	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0049	0.0074
Brugia malayi	PHD-finger family protein	0.0013	0.0049	0.0074
Schistosoma mansoni	thyroid hormone receptor	0.015	0.3156	0.3156
Schistosoma mansoni	tyrosine kinase	0.0065	0.1213	0.1213
Schistosoma mansoni	kinase	0.0058	0.1062	0.1062
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0511	0.0511
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0049	0.0856	0.1135
Brugia malayi	Cell death protein 3 precursor	0.0094	0.1888	0.2861
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0511	0.3988
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0218	0.033
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0222	0.0233
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0023	0.0272	0.0272
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0047	0.0815	0.6403
Echinococcus multilocularis	Chromo domain	0.0014	0.0059	0.0059
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0049	0.0856	0.6723
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0065	0.1227	0.967
Echinococcus granulosus	lysine specific demethylase 5A	0.0109	0.2229	0.2229
Echinococcus multilocularis	regulator of G protein signaling 3	0.0023	0.0272	0.0272
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0016	0.0109	0.0292
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.2335	1
Plasmodium vivax	JmjC domain containing protein	0.0029	0.0398	0.4304
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.2335	0.3538
Brugia malayi	Cytochrome P450 family protein	0.0021	0.0232	0.0352
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0545	0.6143
Brugia malayi	regulator of G-protein signaling rgs-7	0.0023	0.0272	0.0412
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0398	0.0603
Echinococcus granulosus	lysine specific demethylase 6a	0.0029	0.0398	0.0398
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0272	0.0303
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0014	0.0064	0.0064
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0068	0.1282	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.009
Brugia malayi	hypothetical protein	0.0018	0.0155	0.0234
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0022	0.0243	0.2386
Echinococcus multilocularis	transcription factor Dp 1	0.0042	0.0704	0.0704
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0064	0.0006
Onchocerca volvulus	Cell death protein 3 homolog	0.0094	0.1888	0.3313
Echinococcus multilocularis	transfer RNA-Lys	0.004	0.0649	0.0649
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0158	0.3326	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0272	0.0412
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.2335	0.2335
Echinococcus granulosus	transcription factor Dp 1	0.0042	0.0704	0.0704
Loa Loa (eye worm)	jmjC domain-containing protein	0.0109	0.2229	0.3378
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0047	0.0815	0.0815
Echinococcus granulosus	Chromo domain	0.0014	0.0059	0.0059
Trypanosoma brucei	DNA polymerase IV, putative	0.0045	0.0776	0.3302
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0109	0.2229	0.2229
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0467	0.0707
Entamoeba histolytica	hypothetical protein	0.0023	0.0272	0.0303
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0511	0.0774
Plasmodium vivax	metacaspase 1, putative	0.0049	0.0856	1
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0016	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0272	0.0412
Leishmania major	cytochrome p450-like protein	0.0021	0.0232	0.0946
Schistosoma mansoni	ap endonuclease	0.0021	0.0218	0.0218
Schistosoma mansoni	aryl hydrocarbon receptor	0.0054	0.0966	0.0966
Loa Loa (eye worm)	cytochrome P450 family protein	0.0021	0.0232	0.0352
Echinococcus granulosus	jumonji domain containing 1A	0.0029	0.0398	0.0398
Echinococcus granulosus	expressed protein	0.0451	0.9974	0.9974
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.0898	0.1575
Brugia malayi	Protein cec-1.	0.0014	0.0059	0.009
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0275	0.1129
Schistosoma mansoni	caspase-7 (C14 family)	0.0094	0.1888	0.1888
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0014	0.0059	0.0407
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0059	0.00000000029206
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0817	0.108
Echinococcus granulosus	axis inhibition protein axin	0.0023	0.0272	0.0272
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.1282	0.1926
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.2335	1
Schistosoma mansoni	tyrosine kinase	0.0109	0.2231	0.2231
Onchocerca volvulus		0.0037	0.0586	0.1027
Schistosoma mansoni	tyrosine kinase	0.0109	0.2231	0.2231
Schistosoma mansoni	lipoxygenase	0.0022	0.0241	0.0241
Echinococcus multilocularis	caspase 2	0.0094	0.1888	0.1888
Brugia malayi	AF-10 protein	0.0012	0.0008	0.0012
Loa Loa (eye worm)	RecQ helicase	0.0022	0.0243	0.0369
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.1088	0.1649
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0012	0.0013	0.0022
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0061	0.1131	0.1131
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2335	0.3244
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0323	0.7073	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0243	0.1869
Trichomonas vaginalis	set domain proteins, putative	0.0262	0.57	0.8043
Schistosoma mansoni	lipoxygenase	0.0061	0.1131	0.1131
Trypanosoma cruzi	cytochrome P450, putative	0.0021	0.0232	0.0946
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0218	0.0884
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0323	0.7073	1
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2335	0.3244
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0049	0.0856	0.6723
Schistosoma mansoni	hypothetical protein	0.0139	0.2902	0.2902
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0323	0.7073	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0049	0.0856	0.1135
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.1269	0.1269
Echinococcus granulosus	cpg binding protein	0.0034	0.0508	0.0508
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0776	0.3302
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0031	0.0439	0.0439
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0049	0.0856	0.0856
Echinococcus multilocularis	cpg binding protein	0.0034	0.0508	0.0508
Plasmodium vivax	heterochromatin protein 1, putative	0.0014	0.0059	0.0093
Brugia malayi	jmjC domain containing protein	0.0029	0.0398	0.0603
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0045	0.0776	0.1022
Onchocerca volvulus		0.0014	0.0059	0.0104
Trichomonas vaginalis	DNA polymerase eta, putative	0.0045	0.0776	0.1022
Leishmania major	hypothetical protein, conserved	0.0029	0.0398	0.1657
Echinococcus multilocularis	dnaJ subfamily B	0.0452	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0856	0.1135
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0073	0.1401	0.1401
Schistosoma mansoni	regulator of G protein signaling	0.0023	0.0272	0.0272
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0511	0.0511
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.003	0.003
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0073	0.1401	0.1401
Schistosoma mansoni	hypothetical protein	0.0012	0.0013	0.0013
Brugia malayi	Heterochromatin protein 1	0.0084	0.1656	0.2509
Brugia malayi	Furin-like cysteine rich region family protein	0.0205	0.4393	0.6657
Brugia malayi	Doublecortin family protein	0.0022	0.0241	0.0365
Schistosoma mansoni	DNA helicase recq5	0.0022	0.0243	0.0243
Echinococcus multilocularis	phd:f box containing protein	0.0029	0.0398	0.0398
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0012	0.0025	0.0134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0776	0.3302
Schistosoma mansoni	rab6-interacting	0.0022	0.0241	0.0241
Echinococcus granulosus	caspase 3	0.008	0.157	0.157
Schistosoma mansoni	chromobox protein	0.0014	0.0059	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0272	0.0303
Echinococcus granulosus	Regulator of G protein signaling 20	0.0023	0.0272	0.0272
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2335	0.3244
Echinococcus multilocularis	dnaJ subfamily C 6	0.0068	0.1282	0.1282
Trypanosoma cruzi	metacaspase, putative	0.0049	0.0856	0.3629
Toxoplasma gondii	exonuclease III APE	0.0021	0.0218	0.1668
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0218	0.0312
Schistosoma mansoni	tyrosine kinase	0.0205	0.4393	0.4393
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.0726	0.839
Brugia malayi	hypothetical protein	0.0023	0.0272	0.0412
Onchocerca volvulus		0.0047	0.0823	0.1444
Brugia malayi	Bromodomain containing protein	0.0039	0.0634	0.0961
Loa Loa (eye worm)	hypothetical protein	0.018	0.3838	0.5816
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0243	0.0993
Trypanosoma cruzi	metacaspase, putative	0.0049	0.0856	0.3629
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0016	0.0109	0.0166
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.1396	0.2115

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	15.003 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ]	ChEMBL.	No reference
Potency (functional)	25.929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	58.4789 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1499070

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1373571