Detailed information for compound 1373617
Basic information
Technical information
- TDR Targets ID: 1373617
- Name: N-(3-chloro-4-methylphenyl)-4,5-dihydro-3H-py rrol-2-amine
- MW: 208.687 | Formula: C11H13ClN2
-
H donors: 1
H acceptors: 0
LogP: 2.07
Rotable bonds: 2
Rule of 5 violations (Lipinski): 1 - SMILES: Cc1ccc(cc1Cl)NC1=NCCC1
- InChi: 1S/C11H13ClN2/c1-8-4-5-9(7-10(8)12)14-11-3-2-6-13-11/h4-5,7H,2-3,6H2,1H3,(H,13,14)
- InChiKey: OEDDJDFKTNJJKN-UHFFFAOYSA-N
Network
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Synonyms
- N-(3-chloro-4-methyl-phenyl)-4,5-dihydro-3H-pyrrol-2-amine
- (3-chloro-4-methyl-phenyl)-(1-pyrrolin-2-yl)amine
- MLS000594550
- N-(3-chloro-4-methylphenyl)-N-(2-pyrrolidinylidene)amine
- SMR000114320
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
| Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
| Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
| Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Predicted pathogen targets for this compound
By orthology
By sequence similarity to non orthologous known druggable targets
| Species | Potential target | Known druggable target | Length | Alignment span | Identity |
|---|---|---|---|---|---|
| Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Echinococcus multilocularis | fmrfamide receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0998 | 0.5 |
| Brugia malayi | Serotonin receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | biogenic amine receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0128 | 1 | 1 |
| Echinococcus granulosus | biogenic amine 5HT receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0128 | 1 | 1 |
| Echinococcus granulosus | neuropeptides capa receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | neuropeptide F receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | neuropeptide s receptor | 0.0128 | 1 | 1 |
| Brugia malayi | sulfakinin receptor protein | 0.0128 | 1 | 1 |
| Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0128 | 1 | 0.5 |
| Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0128 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide s receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0128 | 1 | 1 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.0128 | 1 | 1 |
| Brugia malayi | Bromodomain containing protein | 0.0046 | 0.246 | 0.246 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.0128 | 1 | 1 |
| Brugia malayi | putative neuropeptide receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0128 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Schistosoma mansoni | biogenic amine receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.07 | 0.0618 |
| Brugia malayi | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3291 | 0.3232 |
| Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0128 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0128 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0128 | 1 | 0.5 |
| Brugia malayi | follicle stimulating hormone receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | melatonin receptor type 1A | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3291 | 0.3232 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0128 | 1 | 1 |
| Schistosoma mansoni | histamine h1 receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | g-protein coupled receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | neuropeptides capa receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | g protein coupled receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | sex peptide receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | orexin receptor type 2 | 0.0128 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2732 | 0.2668 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0128 | 1 | 1 |
| Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | serotonin receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0128 | 1 | 1 |
| Brugia malayi | G protein-coupled receptor | 0.0128 | 1 | 1 |
| Brugia malayi | G-protein coupled receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0128 | 1 | 1 |
| Schistosoma mansoni | biogenic amine receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0998 | 0.0918 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Brugia malayi | larval opioid receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0128 | 1 | 1 |
| Brugia malayi | Dopamine receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | g-protein coupled receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | serotonin receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0128 | 1 | 1 |
| Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3291 | 0.3232 |
| Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2195 | 0.2127 |
| Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0369 | 0.0284 |
| Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0128 | 1 | 1 |
| Brugia malayi | neuropeptide F receptor | 0.0128 | 1 | 1 |
| Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0998 | 0.5 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Echinococcus granulosus | g protein coupled receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | neuropeptide Y receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | g protein coupled receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | neuropeptide f receptor 76f | 0.0128 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0128 | 1 | 1 |
| Brugia malayi | ORL1-like opioid receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Echinococcus multilocularis | serotonin receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.485 | 0.4804 |
| Schistosoma mansoni | growth hormone secretagogue receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | neuropeptide F receptor | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | TYRA-2 protein | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Echinococcus multilocularis | neuropeptide Y receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor A26 | 0.0128 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | orexin receptor type 2 | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3291 | 0.3232 |
| Echinococcus multilocularis | sex peptide receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.0128 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide Y receptor | 0.0128 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0487 | 0.0403 |
| Schistosoma mansoni | amine GPCR | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2945 | 0.2883 |
| Echinococcus granulosus | allatostatin A receptor | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | neuropeptides capa receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | G protein coupled receptor 139 | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | fmrfamide receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | biogenic amine 5HT receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.608 | 0.6046 |
| Echinococcus granulosus | fmrfamide receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0369 | 0.0284 |
| Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0128 | 1 | 1 |
| Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0369 | 0.0284 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | dro:myosuppressin receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.5249 | 0.5208 |
| Schistosoma mansoni | amine GPCR | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2468 | 0.2401 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | G protein coupled receptor 139 | 0.0128 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 2 | 0.0128 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0156 | 0.0069 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.003 | 0.0998 | 0.0998 |
| Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0998 | 0.5 |
| Brugia malayi | GnHR receptor homolog | 0.0128 | 1 | 1 |
| Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Schistosoma mansoni | neuropeptide F-like receptor | 0.0128 | 1 | 1 |
| Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0128 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0128 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0128 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 1 | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0487 | 0.0403 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | G-protein coupled receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.0128 | 1 | 1 |
| Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0128 | 1 | 1 |
| Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0998 | 0.5 |
| Echinococcus multilocularis | neuropeptides capa receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0128 | 1 | 1 |
| Brugia malayi | G-protein coupled receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor A26 | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Brugia malayi | Serotonin receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0128 | 1 | 1 |
| Brugia malayi | AKH receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0128 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.003 | 0.0998 | 0.5 |
| Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0128 | 1 | 1 |
| Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0998 | 0.5 |
| Schistosoma mansoni | myosin xvIII | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.0128 | 1 | 1 |
| Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0998 | 0.5 |
| Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3291 | 0.3232 |
| Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Brugia malayi | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | dro:myosuppressin receptor | 0.0128 | 1 | 1 |
| Brugia malayi | putative neuropeptide receptor NPR1 | 0.0128 | 1 | 1 |
| Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3291 | 0.3232 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Brugia malayi | PHD-finger family protein | 0.003 | 0.0965 | 0.0965 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | neuropeptide F-like receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | somatostatin receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.3291 | 0.3232 |
| Echinococcus multilocularis | allatostatin A receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3291 | 0.3232 |
| Brugia malayi | RE15519p | 0.0128 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0128 | 1 | 1 |
| Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.3291 | 0.3291 |
| Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.07 | 0.0618 |
| Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.485 | 0.4804 |
| Echinococcus granulosus | 7tm_1 domain containing protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0128 | 1 | 1 |
| Brugia malayi | Bromodomain containing protein | 0.0091 | 0.6558 | 0.6558 |
| Echinococcus granulosus | neuropeptide Y receptor | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | somatostatin receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.07 | 0.0618 |
| Schistosoma mansoni | neuropeptide receptor | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | adenoreceptor | 0.0128 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.0128 | 1 | 1 |
| Brugia malayi | neuropeptide F receptor | 0.0128 | 1 | 1 |
| Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2195 | 0.2127 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Brugia malayi | Melatonin receptor type 1A | 0.0128 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0128 | 1 | 1 |
| Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0998 | 0.5 |
| Echinococcus multilocularis | g protein coupled receptor | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0128 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0128 | 1 | 1 |
| Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
| Loa Loa (eye worm) | G-protein coupled receptor | 0.0128 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
| Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (binding) | = 112.2018 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
| Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1507044
Bibliographic References
No literature references available for this target.
If you have references for this compound, please enter them in a user comment (below) or Contact us.