Detailed information for compound 1373647

Basic information

Technical information
  • TDR Targets ID: 1373647
  • Name: 6-(amino-methylamino)-N,N'-di(propan-2-yl)-1, 3,5-triazine-2,4-diamine
  • MW: 239.321 | Formula: C10H21N7
  • H donors: 3 H acceptors: 3 LogP: 1.92 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Nc1nc(NC(C)C)nc(n1)N(N)C)C
  • InChi: 1S/C10H21N7/c1-6(2)12-8-14-9(13-7(3)4)16-10(15-8)17(5)11/h6-7H,11H2,1-5H3,(H2,12,13,14,15,16)
  • InChiKey: PSTAMZMBSQUCPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(amino-methyl-amino)-N,N'-diisopropyl-1,3,5-triazine-2,4-diamine
  • 6-(amino-methylamino)-N,N'-diisopropyl-1,3,5-triazine-2,4-diamine
  • [4-(amino-methyl-amino)-6-(isopropylamino)-s-triazin-2-yl]-isopropyl-amine
  • 6-(amino-methyl-amino)-N,N'-di(propan-2-yl)-1,3,5-triazine-2,4-diamine
  • MLS000324667
  • N-isopropyl-N-[4-(isopropylamino)-6-(1-methylhydrazino)-1,3,5-triazin-2-yl]amine
  • SMR000163991
  • ZINC00477505
  • AJ-292/13330051

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0552 0.0619
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0029 0.0003
Schistosoma mansoni pyruvate kinase 0.0037 0.0552 0.054
Plasmodium vivax SET domain protein, putative 0.0037 0.0537 0.7674
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0552 0.0773
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0229 0.048
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0661 0.0864
Echinococcus multilocularis pyruvate kinase 0.0037 0.0552 0.0527
Schistosoma mansoni hypothetical protein 0.0368 1 1
Mycobacterium ulcerans hypothetical protein 0.004 0.0626 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0073 0.0061
Brugia malayi jmjC domain containing protein 0.0019 0.0026 0.0034
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0552 0.1711
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0552 0.069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0946 0.0923
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.026 0.0307
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.026 0.0235
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0634 0.0622
Onchocerca volvulus 0.004 0.0626 0.0613
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.1638 0.1628
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.1626 0.1616
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0029 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0027 0.026 0.0248
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0692 1
Schistosoma mansoni ap endonuclease 0.0021 0.008 0.0068
Echinococcus multilocularis transcription factor btf3 0.0042 0.0692 0.0668
Loa Loa (eye worm) hypothetical protein 0.0053 0.1014 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.026 0.034
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0692 0.0873
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.026 0.0235
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0626 0.1946
Loa Loa (eye worm) hypothetical protein 0.004 0.0626 0.0787
Brugia malayi beta-lactamase family protein 0.004 0.0626 0.0818
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0165 0.2092
Schistosoma mansoni lipoxygenase 0.01 0.2332 0.2323
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0026 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.008 0.0216
Entamoeba histolytica hypothetical protein 0.0042 0.0692 0.1982
Loa Loa (eye worm) hypothetical protein 0.004 0.0626 0.0787
Plasmodium vivax hypothetical protein, conserved 0.004 0.0626 0.9012
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.026 0.034
Schistosoma mansoni thyroid hormone receptor 0.0027 0.026 0.0248
Loa Loa (eye worm) hypothetical protein 0.0037 0.0552 0.069
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0626 0.0883
Onchocerca volvulus 0.0027 0.026 0.0126
Chlamydia trachomatis pyruvate kinase 0.0037 0.0552 0.5
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0129 0.3164 0.3147
Brugia malayi Pre-SET motif family protein 0.0252 0.6695 0.8749
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0129 0.3164 0.3147
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0725 0.0701
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0552 0.0721
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0552 0.069
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0165 0.014
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0016
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0552 0.0619
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0221 0.5816 0.5805
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0148 0.0123
Brugia malayi PHD-finger family protein 0.0032 0.0401 0.0524
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1206 0.1576
Brugia malayi beta-lactamase family protein 0.004 0.0626 0.0818
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0552 0.0514
Brugia malayi Bromodomain containing protein 0.0046 0.0807 0.1054
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.7653 0.7647
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0307
Echinococcus granulosus zinc finger protein 0.0026 0.0217 0.0192
Leishmania major hypothetical protein, conserved 0.004 0.0626 0.1946
Schistosoma mansoni pyruvate kinase 0.0037 0.0552 0.054
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0626 0.0717
Schistosoma mansoni hypothetical protein 0.0024 0.0165 0.0153
Brugia malayi nuclear hormone receptor 0.0027 0.026 0.034
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0197 0.0224
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0626 0.1946
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.003 0.006
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0319 0.0294
Loa Loa (eye worm) beta-lactamase 0.004 0.0626 0.0787
Schistosoma mansoni hypothetical protein 0.0368 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.026 0.034
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0073 0.0061
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.026 0.0235
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.026 0.0235
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.008 0.0216
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.3164 1
Mycobacterium leprae conserved hypothetical protein 0.004 0.0626 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1927 0.2493
Loa Loa (eye worm) hypothetical protein 0.004 0.0626 0.0787
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0626 0.0602
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0129 0.3164 0.3156
Leishmania major pyruvate kinase 0.0037 0.0552 0.1711
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0165 0.2092
Echinococcus multilocularis GPCR, family 2 0.0019 0.0029 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0283 0.1768
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.026 0.0235
Schistosoma mansoni pyruvate kinase 0.0019 0.0032 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.026 0.034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.026 0.0235
Schistosoma mansoni hypothetical protein 0.004 0.0634 0.0622
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0165 0.0183
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0552 0.0514
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0626 0.0883
Loa Loa (eye worm) hypothetical protein 0.0049 0.0891 0.1135
Echinococcus multilocularis pyruvate kinase 0.0019 0.0032 0.0006
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0026 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0946 0.1207
Echinococcus multilocularis RUN 0.0024 0.0165 0.014
Brugia malayi steroid hormone receptor 0.0027 0.026 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.026 0.0307
Schistosoma mansoni rab6-interacting 0.0024 0.0165 0.0153
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.3164 1
Brugia malayi nuclear receptor NHR-88 0.0027 0.026 0.034
Brugia malayi Pre-SET motif family protein 0.0037 0.0537 0.0701
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0537 0.0525
Entamoeba histolytica hypothetical protein 0.004 0.0634 0.1795
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0552 0.069
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.1638 0.2114
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.026 0.0248
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.008 0.0072
Leishmania major basic transcription factor 3a, putative 0.0042 0.0692 0.2155
Schistosoma mansoni cpg binding protein 0.0039 0.0599 0.0587
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0283 0.086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.1126 0.1115
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0016
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.7653 0.7647
Loa Loa (eye worm) hypothetical protein 0.0046 0.0809 0.1028
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0552 0.3609
Plasmodium falciparum pyruvate kinase 0.0037 0.0552 0.7898
Brugia malayi jmjC domain containing protein 0.0019 0.0026 0.0034
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.026 0.034
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0129 0.3164 0.4135
Echinococcus granulosus pyruvate kinase 0.0019 0.0032 0.0006
Loa Loa (eye worm) hypothetical protein 0.006 0.1206 0.1548
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.026 0.0126
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0283 0.086
Schistosoma mansoni jumonji domain containing protein 0.0071 0.1516 0.1505
Loa Loa (eye worm) hypothetical protein 0.004 0.0626 0.0787
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.026 0.034
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.003 0.0027
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0032 0.0043
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0307
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0626 1
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0032 0.0094
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0626 0.0883
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0207 0.5405 0.5394
Entamoeba histolytica hypothetical protein 0.004 0.0634 0.1795
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0537 0.3507
Echinococcus granulosus pyruvate kinase 0.0037 0.0552 0.0527
Brugia malayi hypothetical protein 0.0028 0.0283 0.037
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.003 0.0005
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.026 0.034
Brugia malayi beta-NAC-like protein 0.0042 0.0692 0.0904
Schistosoma mansoni survival motor neuron protein 0.0058 0.115 0.1139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.026 0.0235
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0026 0.0013
Loa Loa (eye worm) hypothetical protein 0.0286 0.7653 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0129 0.3164 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0283 0.0338
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.008 0.0055
Schistosoma mansoni zinc finger protein 0.0026 0.0217 0.0205
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0552 0.864
Mycobacterium ulcerans lipase LipD 0.004 0.0626 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1206 0.1576
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0004
Brugia malayi beta-lactamase 0.004 0.0626 0.0818
Schistosoma mansoni coup transcription factor 0.0027 0.026 0.0248
Echinococcus granulosus transcription factor Dp 1 0.0074 0.1614 0.1593
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0307
Brugia malayi jmjC domain containing protein 0.0075 0.1638 0.2141
Schistosoma mansoni hypothetical protein 0.0041 0.0661 0.065
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0165 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0626 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0692 0.0803
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.008 0.0932
Mycobacterium ulcerans beta-lactamase 0.004 0.0626 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.026 0.0235
Onchocerca volvulus 0.0035 0.0476 0.0413
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0552 0.0721
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0692 0.4569
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0026 0.0013
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0626 0.0883
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.026 0.034
Brugia malayi ecdysteroid receptor 0.0027 0.026 0.034
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0552 0.1711
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0016
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0552 0.7898
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0946 0.0935
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.008 0.0216
Brugia malayi Bromodomain containing protein 0.0093 0.2131 0.2785
Echinococcus multilocularis pyruvate kinase 0.0019 0.0032 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0626 0.1946
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.008 0.0822
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.003 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1206 0.1548
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0073 0.0047
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.026 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.026 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0692 0.0803
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.026 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0946 0.0923
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.1516 0.1494
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.003 0.0027
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.026 0.0248
Loa Loa (eye worm) hypothetical protein 0.0041 0.0661 0.0833
Brugia malayi jmjC domain containing protein 0.0019 0.0026 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0692 0.0803
Loa Loa (eye worm) hypothetical protein 0.0024 0.0165 0.0183
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.026 0.0235
Onchocerca volvulus 0.0287 0.7689 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0283 0.086
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.1603 0.1581
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.026 0.034
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0552 0.1711
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.3558 0.3542
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.026 0.0235
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0026 0.0042
Schistosoma mansoni hypothetical protein 0.0058 0.115 0.1139
Entamoeba histolytica hypothetical protein 0.004 0.0634 0.1795
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0946 0.0923
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.026 0.0235
Schistosoma mansoni rab6-interacting 0.0024 0.0165 0.0153
Echinococcus multilocularis cpg binding protein 0.0039 0.0599 0.0574
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0319 0.0294
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.6695 0.8744
Echinococcus multilocularis transcription factor Dp 1 0.0074 0.1614 0.1593
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0552 0.0514
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0476 0.059
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.3558 0.3542
Trichomonas vaginalis set domain proteins, putative 0.0287 0.7689 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.026 0.0126
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0029 0.0004
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.003 0.0055
Echinococcus granulosus RUN 0.0024 0.0165 0.014
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.1126 0.1103
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.026 0.0248
Mycobacterium tuberculosis Conserved protein 0.004 0.0626 0.0883
Mycobacterium tuberculosis Conserved protein 0.004 0.0626 0.0883
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.026 0.0248
Echinococcus granulosus pyruvate kinase 0.0019 0.0032 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.026 0.0248
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.026 0.0235
Echinococcus granulosus pyruvate kinase 0.0037 0.0552 0.0527
Echinococcus multilocularis pyruvate kinase 0.0037 0.0552 0.0527
Leishmania major pyruvate kinase 0.0037 0.0552 0.1711
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.003 0.0055
Schistosoma mansoni bromodomain containing protein 0.0078 0.1727 0.1716
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0129 0.3164 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0476 0.0622
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0026 0.0042
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.008 0.0105
Entamoeba histolytica hypothetical protein 0.004 0.0634 0.1795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.026 0.0307
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0165 0.014
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0032 0.0094
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0626 1
Onchocerca volvulus 0.0058 0.115 0.1309
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.026 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.026 0.034
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.003 0.0055
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0692 0.2155
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0634 0.061
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.026 0.0307
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.1483 1
Onchocerca volvulus 0.004 0.0626 0.0613
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.003 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.008 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0165 0.0183
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0626 0.0883
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.1638 0.1628
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0026 0.0042
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0029 0.0038
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.026 0.0307
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.1603 0.1581
Giardia lamblia Pyruvate kinase 0.0037 0.0552 1
Schistosoma mansoni cpg binding protein 0.0039 0.0599 0.0587
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.008 0.0075
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.026 0.0235
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0148 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.026 0.034
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0307
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0029 0.0038
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.003 0.0055
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.008 0.0822
Onchocerca volvulus 0.004 0.0626 0.0613
Loa Loa (eye worm) hypothetical protein 0.004 0.0626 0.0787
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0477 0.0453
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.026 0.0235
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0029 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0626 0.0602
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0634 0.061
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.1126 0.1103
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0283 0.387
Echinococcus granulosus transcription factor btf3 0.0042 0.0692 0.0668
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0946 0.0935
Brugia malayi Doublecortin family protein 0.0024 0.0165 0.0216
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0094 0.009
Echinococcus multilocularis zinc finger protein 0.0026 0.0217 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.026 0.0307
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0626 0.0787
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0029 0.0003
Schistosoma mansoni ap endonuclease 0.0021 0.008 0.0068
Brugia malayi hypothetical protein 0.0024 0.0165 0.0216
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0626 0.0614
Schistosoma mansoni hypothetical protein 0.0025 0.0197 0.0185
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0626 0.0717
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.3164 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0626 0.0883
Schistosoma mansoni cpg binding protein 0.0035 0.0476 0.0464
Schistosoma mansoni retinoic acid receptor RXR 0.0221 0.5816 0.581
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.008 0.0055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0946 0.0923
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.1638 0.1617
Brugia malayi hypothetical protein 0.0024 0.0165 0.0216
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0165 0.014
Brugia malayi jmjC domain containing protein 0.0019 0.0026 0.0034
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.008 0.5
Brugia malayi isocitrate dehydrogenase 0.0019 0.003 0.0039
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0129 0.3164 0.4115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.026 0.0307
Echinococcus granulosus GPCR family 2 0.0019 0.0029 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.026 0.0307
Toxoplasma gondii exonuclease III APE 0.0021 0.008 0.0376
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.026 0.034
Schistosoma mansoni thyroid hormone receptor 0.0027 0.026 0.0248
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0626 0.0883
Schistosoma mansoni polycystin 1-related 0.0024 0.0165 0.0153
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0283 0.387
Mycobacterium leprae Probable lipase LipE 0.004 0.0626 1
Echinococcus multilocularis pyruvate kinase 0.0029 0.0327 0.0302
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0537 0.0512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0946 0.0935
Brugia malayi Isocitrate dehydrogenase 0.0019 0.003 0.0039
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.1516 0.1494
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.0004
Schistosoma mansoni lipoxygenase 0.0142 0.3558 0.355
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.026 0.0235
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0692 0.2155
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.003 0.006
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0165 0.014
Echinococcus multilocularis pyruvate kinase 0.0019 0.0032 0.0006
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0026 0.0013
Echinococcus multilocularis geminin 0.0368 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0307
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.1126 0.1115
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0692 0.1982
Leishmania major hypothetical protein, conserved 0.0028 0.0283 0.086
Schistosoma mansoni transcription factor btf3 0.0042 0.0692 0.068
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0229 0.0266
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0626 0.0818
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0552 0.1711
Loa Loa (eye worm) hypothetical protein 0.0057 0.1126 0.1443
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.115 0.1503
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0626 0.0717
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0283 0.387
Trichomonas vaginalis esterase, putative 0.004 0.0626 0.0717
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0626 0.0614
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.026 0.0126
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.008 0.5
Brugia malayi hypothetical protein 0.004 0.0634 0.0828
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.026 0.034
Loa Loa (eye worm) hypothetical protein 0.004 0.0626 0.0787
Leishmania major hypothetical protein, conserved 0.0019 0.0026 0.0042
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0692 0.2155
Echinococcus granulosus FTZ F1 alpha 0.0027 0.026 0.0235
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0073 0.0047
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0626 0.0883
Echinococcus granulosus cpg binding protein 0.0039 0.0599 0.0574
Brugia malayi hypothetical protein 0.0286 0.7653 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0032 0.0006
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0692 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0165 0.014
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0319 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0229 0.0266
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0537 0.0525
Schistosoma mansoni loxhd1 0.0024 0.0165 0.0153
Onchocerca volvulus 0.0037 0.0537 0.0494
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.026 0.0248
Toxoplasma gondii ABC1 family protein 0.004 0.0626 0.4118
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.003 0.0004
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.003 0.0055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0946 0.1236
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.1516 0.1494
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0307
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0725 0.0701
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0626 0.0717
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0307
Loa Loa (eye worm) hypothetical protein 0.0027 0.026 0.0307
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.026 0.034
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.026 0.034
Brugia malayi jmjC domain containing protein 0.0071 0.1516 0.198
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.678 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 3.066 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.0517 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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