Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Onchocerca volvulus | Huntingtin homolog | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Onchocerca volvulus | Huntingtin homolog | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Brugia malayi | Peroxidasin | 0.0085 | 0.2868 | 0.2868 |
Echinococcus multilocularis | peroxidasin | 0.0085 | 0.2868 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0085 | 0.2868 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.2868 | 0.2868 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Echinococcus granulosus | peroxidasin | 0.0085 | 0.2868 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.2868 | 0.2868 |
Brugia malayi | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Brugia malayi | Blistered cuticle protein 3 | 0.0085 | 0.2868 | 0.2868 |
Schistosoma mansoni | peroxidasin | 0.0085 | 0.2868 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2868 | 0.2868 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.4467 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 0.4654 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.