Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | tyrosyl-DNA phosphodiesterase 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.029 | 0.0274 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.029 | 0.0786 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.029 | 0.0274 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.1086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.029 | 0.0786 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.029 | 0.0406 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.029 | 0.0274 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.029 | 0.5 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.1086 | 0.3077 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.029 | 0.0786 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.1086 | 0.3077 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.029 | 0.0786 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0012 | 0.0278 | 0.0753 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.029 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2966 | 0.2955 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.029 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.029 | 0.0274 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.029 | 0.0274 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0012 | 0.0278 | 0.0753 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.029 | 0.0406 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.029 | 0.0274 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0012 | 0.0278 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.008 | 0.3492 | 0.5167 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0069 | 0.2966 | 0.8486 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.029 | 0.0406 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0278 | 0.0262 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.002 | 0.0641 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1772 | 0.2609 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.029 | 0.0274 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.2966 | 0.4384 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.029 | 0.0274 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1772 | 0.5073 |
Echinococcus multilocularis | GPCR, family 2 | 0.0069 | 0.2966 | 0.8486 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0797 | 0.1159 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0012 | 0.0278 | 0.0262 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0012 | 0.0278 | 0.0753 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.008 | 0.3492 | 0.3482 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.029 | 0.0274 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1772 | 0.1758 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.029 | 0.0274 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.1086 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.029 | 0.0786 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.029 | 0.0786 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.029 | 0.0786 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.029 | 0.0406 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0046 | 0.19 | 0.5418 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.029 | 0.0406 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1772 | 0.505 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.1086 | 0.1071 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0278 | 0.4422 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0217 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.029 | 0.0274 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0012 | 0.0278 | 0.0753 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.029 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.3492 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.029 | 0.0274 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0069 | 0.2966 | 0.8486 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.029 | 0.0274 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.029 | 0.0406 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.029 | 0.0786 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.029 | 0.0274 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.029 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.029 | 0.0406 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.029 | 0.0786 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.029 | 0.0786 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.029 | 0.0406 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.0445 | 0.1275 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.029 | 0.0274 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1772 | 0.505 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1772 | 0.5073 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.063 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.029 | 0.0274 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0148 | 0.6744 | 0.6739 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.029 | 0.0274 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0046 | 0.19 | 0.5418 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.029 | 0.0786 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0069 | 0.2966 | 0.2955 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.029 | 0.0274 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0217 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.008 | 0.3492 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.029 | 0.0406 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.029 | 0.0274 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.3492 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.008 | 0.3492 | 0.3482 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.3492 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0278 | 0.0262 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.029 | 0.0274 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1772 | 0.2609 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0069 | 0.2966 | 0.8486 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0278 | 0.0262 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.029 | 0.0274 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.029 | 0.0786 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.1086 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.029 | 0.0274 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.029 | 0.0274 |
Schistosoma mansoni | DNA helicase recq5 | 0.0012 | 0.0278 | 0.0389 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.2966 | 0.4384 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.029 | 0.0786 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0069 | 0.2966 | 0.2955 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.0919 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.3492 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.029 | 0.0274 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1772 | 0.5073 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.029 | 0.0786 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.029 | 0.0274 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.008 | 0.3492 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0148 | 0.6744 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.6633 | 0.6628 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.6744 | 0.6739 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0069 | 0.2966 | 0.8486 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.029 | 0.0406 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.029 | 0.0274 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0278 | 0.4422 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.029 | 0.0274 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.029 | 0.0406 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.029 | 0.0786 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.029 | 0.0274 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.3492 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.029 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.029 | 0.0274 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.029 | 0.0406 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.029 | 0.0274 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.029 | 0.0274 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.029 | 0.0274 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.2966 | 0.4384 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1772 | 0.5073 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.029 | 0.0274 |
Schistosoma mansoni | DNA helicase recq1 | 0.0012 | 0.0278 | 0.0389 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.029 | 0.0274 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.2966 | 0.4384 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.029 | 0.0406 |
Onchocerca volvulus | 0.0012 | 0.029 | 0.5 | |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.029 | 0.0274 |
Echinococcus granulosus | GPCR family 2 | 0.0069 | 0.2966 | 0.8486 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0069 | 0.2966 | 0.2955 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.029 | 0.0274 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 7.032 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD1. uHTS luminescence assay for the identification of compounds that inhibit NOD1, utilizing an NF-kB-mediated luciferase reporter gene activity as a measure of NOD1 modulation (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1849, AID1852, AID2250, AID2255, AID2260, AID2261, AID2264, AID2333, AID2334, AID2335, AID2337, AID2466, AID2469, AID2475, AID2483, AID2485, AID2503, AID2505, AID2789, AID2792, AID2793, AID2798, AID2799, AID2800, AID2801] | ChEMBL. | No reference |
EC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2001, AID2260, AID2264, AID2334, AID2335, AID2337, AID2466, AID2475, AID2485, AID2503, AID2793, AID2798, AID2799] | ChEMBL. | No reference |
IC50 (functional) | = 6.536 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1579, AID1849, AID2260, AID2335, AID2469, AID2503, AID2800] | ChEMBL. | No reference |
IC50 (functional) | = 16.0665 uM | PUBCHEM_BIOASSAY: HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2337] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD1 cell inhibition assay. Cytotoxicity counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1852, AID2001, AID2260, AID2264, AID2334, AID2335, AID2466, AID2469, AID2475, AID2503, AID2793, AID2798, AID2799, AID2800] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD2 cell inhibition assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1579, AID2260, AID2334, AID2335, AID2475, AID2503, AID2799, AID2800] | ChEMBL. | No reference |
IC50 (functional) | = 33.2 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule antagonists of the CCR6 receptor: a luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159] | ChEMBL. | No reference |
IC50 (functional) | > 66.6 uM | PUBCHEM_BIOASSAY: HTS Dose response counterscreen for assays utilizing the enzyme, beta-galactosidase - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159] | ChEMBL. | No reference |
Potency (binding) | = 0.0708 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.5623 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.