Detailed information for compound 1373956
Basic information
Technical information
- TDR Targets ID: 1373956
- Name: 2,2-dibromo-N-[3,5-dimethyl-1-[(4-methylpheny l)methyl]pyrazol-4-yl]-1-methylcyclopropane-1 -carboxamide
- MW: 455.187 | Formula: C18H21Br2N3O
-
H donors: 1
H acceptors: 2
LogP: 4.13
Rotable bonds: 5
Rule of 5 violations (Lipinski): 1 - SMILES: Cc1ccc(cc1)Cn1nc(c(c1C)NC(=O)C1(C)CC1(Br)Br)C
- InChi: 1S/C18H21Br2N3O/c1-11-5-7-14(8-6-11)9-23-13(3)15(12(2)22-23)21-16(24)17(4)10-18(17,19)20/h5-8H,9-10H2,1-4H3,(H,21,24)
- InChiKey: RSBBQBFBXCXNPT-UHFFFAOYSA-N
Network
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Synonyms
- 2,2-dibromo-N-[3,5-dimethyl-1-[(4-methylphenyl)methyl]pyrazol-4-yl]-1-methyl-cyclopropane-1-carboxamide
- 2,2-dibromo-N-[3,5-dimethyl-1-[(4-methylphenyl)methyl]-4-pyrazolyl]-1-methyl-1-cyclopropanecarboxamide
- 2,2-dibromo-N-[3,5-dimethyl-1-(4-methylbenzyl)pyrazol-4-yl]-1-methyl-cyclopropane-1-carboxamide
- STK316276
- MLS000594535
- AK-968/15609831
- SMR000114855
- 2,2-dibromo-N-[3,5-dimethyl-1-(4-methylbenzyl)-1H-pyrazol-4-yl]-1-methylcyclopropanecarboxamide
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Echinococcus granulosus | 3 ketodihydrosphingosine reductase | 0.0045 | 1 | 0.5 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 1 homolog | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0045 | 1 | 1 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0045 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase | 0.0045 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0045 | 1 | 0.5 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein | 0.0045 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0045 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenases/reductase, putative | 0.0045 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | oxidoreductase | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0045 | 1 | 1 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0045 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0045 | 1 | 1 |
| Entamoeba histolytica | 3-ketodihydrosphingosine reductase protein, putative | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0045 | 1 | 1 |
| Brugia malayi | Dehydrogenases, short chain protein 30 | 0.0045 | 1 | 1 |
| Giardia lamblia | Oxidoreductase, short chain dehydrogenase/reductase family | 0.0045 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Brugia malayi | Hypothetical oxidoreductase F56D1.5 | 0.0045 | 1 | 1 |
| Echinococcus granulosus | Dehydrogenase:reductase SDR family | 0.0045 | 1 | 0.5 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0045 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Brugia malayi | dehydrogenases, short chain protein 9 | 0.0045 | 1 | 1 |
| Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0045 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Leishmania major | short chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Leishmania major | pteridine reductase 1 | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable shortchain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible iron-regulated short-chain dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Leishmania major | dehydrogenase-like protein | 0.0045 | 1 | 1 |
| Brugia malayi | D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor | 0.0045 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | carbonyl reductase | 0.0045 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0045 | 1 | 1 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0045 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0045 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short-chain membrane-associated dehydrogenase | 0.0045 | 1 | 0.5 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Schistosoma mansoni | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0045 | 1 | 0.5 |
| Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0045 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0045 | 1 | 0.5 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0045 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | retinal dehydrogenase | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Schistosoma mansoni | short-chain dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Echinococcus multilocularis | oxidoreductase | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0045 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0045 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Leishmania major | oxidoreductase-like protein | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0045 | 1 | 0.5 |
| Echinococcus multilocularis | 3 ketodihydrosphingosine reductase | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0045 | 1 | 0.5 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Toxoplasma gondii | carbonyl reductase 1, putative | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | carveol-like dehydrogenase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | oxidoreductase short chain dehydrogenase/reductase family | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Echinococcus granulosus | hypothetical protein | 0.0045 | 1 | 0.5 |
| Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0045 | 1 | 0.5 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Echinococcus multilocularis | epidermal retinal dehydrogenase 2 | 0.0045 | 1 | 0.5 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Mycobacterium ulcerans | oxidoreductase | 0.0045 | 1 | 0.5 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | carbonyl reductase | 0.0045 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0045 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium leprae | Probable oxidoreductase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Trypanosoma brucei | oxidoreductase-like protein | 0.0045 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0045 | 1 | 0.5 |
| Trichomonas vaginalis | hydroxyacyl dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Mycobacterium ulcerans | short-chain type oxidoreductase | 0.0045 | 1 | 0.5 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0045 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Brugia malayi | Dehydrogenases, short chain protein 2 | 0.0045 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Giardia lamblia | Hypothetical protein | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | dehydrogenase | 0.0045 | 1 | 1 |
| Echinococcus granulosus | oxidoreductase | 0.0045 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0045 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Loa Loa (eye worm) | dehydrogenase | 0.0045 | 1 | 1 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0045 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Decaprenylphosphoryl-D-2-keto erythro pentose reductase | 0.0045 | 1 | 0.5 |
| Trichomonas vaginalis | steroid dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0045 | 1 | 1 |
| Echinococcus granulosus | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0045 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Plasmodium falciparum | oxidoreductase, short-chain dehydrogenase family, putative | 0.0045 | 1 | 1 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0045 | 1 | 0.5 |
| Echinococcus multilocularis | Dehydrogenase:reductase SDR family | 0.0045 | 1 | 0.5 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible fatty acyl-CoA reductase | 0.0045 | 1 | 0.5 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0045 | 1 | 0.5 |
| Echinococcus multilocularis | estradiol 17 beta dehydrogenase 12 | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Brugia malayi | dehydrogenases, short chain protein 2 | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Possible ketoacyl reductase | 0.0045 | 1 | 0.5 |
| Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0045 | 1 | 0.5 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0045 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Echinococcus multilocularis | conserved hypothetical protein | 0.0045 | 1 | 0.5 |
| Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0045 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Onchocerca volvulus | Sepiapterin reductase homolog | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable dehydrogenase | 0.0045 | 1 | 0.5 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 3, putative | 0.0045 | 1 | 1 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Leishmania major | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0045 | 1 | 1 |
| Plasmodium vivax | steroid dehydrogenase, putative | 0.0045 | 1 | 1 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0045 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0045 | 1 | 1 |
| Giardia lamblia | Reductase, putative | 0.0045 | 1 | 0.5 |
| Plasmodium falciparum | steroid dehydrogenase, putative | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0045 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/decarboxylase protein | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Trypanosoma brucei | 3-ketoacyl-CoA reductase, putative | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium leprae | PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE | 0.0045 | 1 | 0.5 |
| Toxoplasma gondii | 3-ketoacyl-CoA reductase, putative | 0.0045 | 1 | 1 |
| Leishmania major | 3-keto-dihydrosphingosine reductase | 0.0045 | 1 | 1 |
| Trypanosoma cruzi | quinonoid dihydropteridine reductase, putative | 0.0045 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short chain alcohol dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Brugia malayi | Retinol dehydrogenase 12 | 0.0045 | 1 | 1 |
| Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0045 | 1 | 1 |
| Schistosoma mansoni | 3-keto-dihydrosphingosine reductase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0045 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0045 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Trichomonas vaginalis | estradiol 17 beta-dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
| Schistosoma mansoni | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Echinococcus granulosus | epidermal retinal dehydrogenase 2 | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Echinococcus multilocularis | retinol dehydrogenase 13 | 0.0045 | 1 | 0.5 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 2 | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium leprae | ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE | 0.0045 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0045 | 1 | 0.5 |
| Brugia malayi | hypothetical protein | 0.0045 | 1 | 1 |
| Trypanosoma brucei | 3-keto-dihydrosphingosine reductase | 0.0045 | 1 | 1 |
| Giardia lamblia | Short-chain dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0045 | 1 | 0.5 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0045 | 1 | 1 |
| Mycobacterium tuberculosis | Possible short-chain dehydrogenase EphD | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Trypanosoma brucei | beta-D-hydroxybutyrate dehydrogenase | 0.0045 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0045 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0045 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0045 | 1 | 1 |
| Entamoeba histolytica | oxidoreductase, short chain dehydrogenase/reductase family | 0.0045 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0045 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type oxidoreductase | 0.0045 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0045 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0045 | 1 | 0.5 |
| Leishmania major | short chain dehydrogenase-like protein | 0.0045 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0045 | 1 | 0.5 |
| Echinococcus multilocularis | transient receptor potential cation channel | 0.0045 | 1 | 0.5 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0045 | 1 | 0.5 |
| Echinococcus granulosus | WW domain containing oxidoreductase | 0.0045 | 1 | 0.5 |
| Schistosoma mansoni | carbonyl reductase | 0.0045 | 1 | 0.5 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Potency (functional) | 0.0282 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1501525
Bibliographic References
No literature references available for this target.
If you have references for this compound, please enter them in a user comment (below) or Contact us.