Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0105 | 0.5543 | 0.8444 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.2577 | 0.3926 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.3598 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.6564 | 0.6564 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0057 | 0.2577 | 0.4649 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0568 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0105 | 0.5543 | 0.5543 |
Brugia malayi | TAR-binding protein | 0.0105 | 0.5543 | 0.5543 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2498 | 0.3806 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.3598 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0568 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.3598 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0568 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2498 | 0.2498 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.3598 | 0.649 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.2577 | 0.3926 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2498 | 0.4507 |
Schistosoma mansoni | tar DNA-binding protein | 0.0105 | 0.5543 | 0.8444 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2498 | 0.3806 |
Echinococcus granulosus | tar DNA binding protein | 0.0105 | 0.5543 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.2577 | 0.3926 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2498 | 0.2498 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2498 | 0.4507 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0057 | 0.2577 | 0.4649 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.3598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.3598 | 0.548 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.3598 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0105 | 0.5543 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0105 | 0.5543 | 0.5543 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0179 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0105 | 0.5543 | 0.8444 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0122 | 0.6564 | 0.6564 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2498 | 0.4507 |
Echinococcus granulosus | GPCR family 2 | 0.0057 | 0.2577 | 0.4649 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0063 | 0.0063 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0568 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0057 | 0.2577 | 0.4649 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2498 | 0.4507 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0057 | 0.2577 | 0.2577 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0057 | 0.2577 | 0.4649 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.3598 | 0.649 |
Loa Loa (eye worm) | TAR-binding protein | 0.0105 | 0.5543 | 0.5543 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.2577 | 0.3926 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0568 | 0.0568 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.3598 | 0.548 |
Schistosoma mansoni | tar DNA-binding protein | 0.0105 | 0.5543 | 0.8444 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0057 | 0.2577 | 0.2577 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2498 | 0.3806 |
Brugia malayi | RNA binding protein | 0.0105 | 0.5543 | 0.5543 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0105 | 0.5543 | 0.5543 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0.0568 | 0.158 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2577 | 0.2577 |
Schistosoma mansoni | tar DNA-binding protein | 0.0105 | 0.5543 | 0.8444 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0023 | 0.0568 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0179 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0023 | 0.0568 | 0.158 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0023 | 0.0568 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.6564 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0568 | 0.0568 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0057 | 0.2577 | 0.4649 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0057 | 0.2577 | 0.2577 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.3598 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.