Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0.0182 | 0.0676 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0116 | 0.0226 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0182 | 0.0329 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.2745 | 0.2745 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0116 | 0.0226 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0659 | 0.1192 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1092 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 1 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0182 | 0.0676 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0116 | 0.0226 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.5129 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0989 | 0.179 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0776 | 0.0776 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0116 | 0.0116 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0116 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0021 | 0.0378 | 0.0736 |
Brugia malayi | hypothetical protein | 0.0028 | 0.1092 | 0.1092 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3016 | 0.3016 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0378 | 0.0683 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0378 | 0.0683 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2481 | 0.4837 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0116 | 0.0226 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0021 | 0.0378 | 0.0736 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0446 | 0.0446 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0182 | 0.0676 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.6833 | 0.6833 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1092 | 0.1092 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1092 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1767 | 0.1767 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2752 | 0.2752 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0116 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0378 | 0.0378 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.1253 | 0.1253 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0989 | 0.1929 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.1092 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0182 | 0.0676 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1767 | 0.1767 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0165 | 0.0165 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1092 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3229 | 0.3229 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1767 | 0.3196 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.1092 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0116 | 0.0226 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0182 | 0.0329 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.1092 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.5129 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0378 | 0.0683 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0116 | 0.0116 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0021 | 0.0378 | 0.0736 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0776 | 0.1405 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.5528 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0659 | 0.1284 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0116 | 0.0116 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0989 | 0.1929 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.1092 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.3289 | 0.3289 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0659 | 0.1284 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.6357 | 0.6357 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1092 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0378 | 0.0683 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0116 | 0.0226 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0021 | 0.0378 | 0.0736 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2481 | 0.4837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.