TDR Targets

Basic information

Technical information

TDR Targets ID: 1374134
Name: 1-(3,4-dihydro-2H-quinolin-1-yl)-2-(1-methyli ndol-3-yl)ethane-1,2-dione
MW: 318.369 | Formula: C20H18N2O2
H donors: 0 H acceptors: 2 LogP: 3.29 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(=O)c1cn(c2c1cccc2)C)N1CCCc2c1cccc2
InChi: 1S/C20H18N2O2/c1-21-13-16(15-9-3-5-11-18(15)21)19(23)20(24)22-12-6-8-14-7-2-4-10-17(14)22/h2-5,7,9-11,13H,6,8,12H2,1H3
InChiKey: FKFMXRRJFGMUEQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(3,4-dihydro-2H-quinolin-1-yl)-2-(1-methyl-3-indolyl)ethane-1,2-dione
1-(3,4-Dihydro-2H-quinolin-1-yl)-2-(1-methyl-1H-indol-3-yl)-ethane-1,2-dione
BAS 13090491
A3577/0151854
ZINC04414670
MLS000719118
SMR000291386

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Human immunodeficiency virus 1	Aberrant vpr protein	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tubulin subunit TubB	0.0033	0.1025	0.1025
Trichomonas vaginalis	tubulin beta chain, putative	0.0033	0.1025	0.6577
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2926	0.2926
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0405	0.0405
Trichomonas vaginalis	cyclins, putative	0.0018	0.037	0.2207
Trichomonas vaginalis	cyclins, putative	0.0044	0.1492	0.9689
Echinococcus granulosus	tubulin subunit beta	0.0025	0.0653	0.0653
Trichomonas vaginalis	cyclins, putative	0.0044	0.1492	0.9689
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0045	0.1538	0.1538
Schistosoma mansoni	tubulin subunit gamma	0.0025	0.0653	0.0653
Trichomonas vaginalis	tubulin beta chain, putative	0.0033	0.1025	0.6577
Echinococcus multilocularis	cyclin B3 1	0.0018	0.037	0.037
Brugia malayi	Tubulin beta-1 chain	0.0025	0.0653	0.0653
Trichomonas vaginalis	cyclin B, putative	0.0044	0.1492	0.9689
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0018	0.037	0.037
Loa Loa (eye worm)	tubulin beta chain	0.0025	0.0653	0.0653
Echinococcus granulosus	tubulin alpha chain	0.0033	0.1025	0.1025
Echinococcus multilocularis	tubulin alpha	0.0025	0.0653	0.0653
Loa Loa (eye worm)	hypothetical protein	0.006	0.221	0.221
Giardia lamblia	Alpha-tubulin	0.0033	0.1025	0.6577
Trypanosoma cruzi	cdc2-related kinase 3	0.0045	0.1538	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0033	0.1025	0.6577
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0238	1	1
Brugia malayi	alpha-tubulin	0.0033	0.1025	0.1025
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0019	0.0412	0.2483
Trichomonas vaginalis	tubulin alpha chain, putative	0.0014	0.0182	0.0952
Plasmodium vivax	tubulin alpha chain, putative	0.0033	0.1025	0.6577
Trypanosoma cruzi	cyclin 6, putative	0.0044	0.1492	0.9689
Plasmodium falciparum	alpha tubulin 1	0.0033	0.1025	0.6577
Trypanosoma cruzi	cyclin, putative	0.0044	0.1492	0.9689
Schistosoma mansoni	unc-13 (munc13)	0.001	0.0012	0.0012
Loa Loa (eye worm)	tubulin beta chain	0.0011	0.004	0.004
Trypanosoma brucei	alpha tubulin	0.0033	0.1025	0.6577
Trypanosoma brucei	alpha tubulin	0.0033	0.1025	0.6577
Entamoeba histolytica	tubulin family protein	0.0025	0.0653	0.2421
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Trichomonas vaginalis	tubulin gamma chain, putative	0.0025	0.0653	0.4094
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Echinococcus granulosus	cyclin dependent kinase 1	0.0045	0.1538	0.1538
Loa Loa (eye worm)	tubulin alpha chain	0.0033	0.1025	0.1025
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Echinococcus multilocularis	tubulin gamma 1 chain	0.0025	0.0653	0.0653
Trichomonas vaginalis	cyclin B, putative	0.0044	0.1492	0.9689
Echinococcus granulosus	raf serine:threonine protein kinase	0.0224	0.9402	0.9402
Brugia malayi	Cell division protein ftsZ	0.0011	0.004	0.004
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0406	0.0406
Loa Loa (eye worm)	tubulin gamma chain	0.0025	0.0653	0.0653
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0406	0.0406
Onchocerca volvulus		0.0182	0.7576	1
Schistosoma mansoni	hypothetical protein	0.0205	0.8548	0.8548
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2926	0.2926
Leishmania major	epsilon tubulin, putative	0.0025	0.0653	0.4094
Schistosoma mansoni	cyclin B	0.0044	0.1492	0.1492
Trypanosoma brucei	alpha tubulin	0.0033	0.1025	0.6577
Echinococcus granulosus	tubulin delta chain	0.0011	0.004	0.004
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.2926	0.2926
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Plasmodium falciparum	tubulin beta chain	0.0025	0.0653	0.4094
Echinococcus granulosus	Tubulin beta 2C chain	0.0025	0.0653	0.0653
Trichomonas vaginalis	tubulin beta chain, putative	0.0033	0.1025	0.6577
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0653	0.0653
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0405	0.0405
Trichomonas vaginalis	cyclin A, putative	0.0044	0.1492	0.9689
Echinococcus multilocularis	tubulin alpha 1C chain	0.0033	0.1025	0.1025
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1375	0.1375
Echinococcus multilocularis	cyclins	0.0018	0.037	0.037
Giardia lamblia	Gamma tubulin	0.0025	0.0653	0.4094
Trypanosoma brucei	tubulin gamma chain	0.0025	0.0653	0.4094
Loa Loa (eye worm)	tubulin beta-1 chain	0.0025	0.0653	0.0653
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.2926	0.2926
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0406	0.2445
Schistosoma mansoni	tubulin subunit beta	0.0011	0.004	0.004
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0033	0.1025	0.6577
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.221	0.221
Echinococcus multilocularis	tubulin alpha 3 chain	0.0033	0.1025	0.1025
Echinococcus multilocularis	tubulin alpha chain	0.0033	0.1025	0.1025
Schistosoma mansoni	hypothetical protein	0.0019	0.0405	0.0405
Loa Loa (eye worm)	BEN-1 protein	0.0025	0.0653	0.0653
Echinococcus granulosus	tar DNA binding protein	0.0076	0.2926	0.2926
Trichomonas vaginalis	tubulin alpha chain, putative	0.0014	0.0182	0.0952
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0025	0.0653	0.4094
Schistosoma mansoni	serine/threonine protein kinase	0.0238	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0033	0.1025	0.1025
Entamoeba histolytica	tubulin family protein	0.0025	0.0653	0.2421
Echinococcus multilocularis	tubulin epsilon chain	0.0025	0.0653	0.0653
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0405	0.0405
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0022	0.0554	0.3435
Echinococcus granulosus	tubulin alpha 1C chain	0.0033	0.1025	0.1025
Loa Loa (eye worm)	tubulin beta-2A chain	0.0025	0.0653	0.0653
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0033	0.1025	0.6577
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0025	0.0653	0.4094
Schistosoma mansoni	hypothetical protein	0.0019	0.0405	0.0405
Echinococcus multilocularis	hypothetical protein	0.0033	0.1025	0.1025
Brugia malayi	tubulin alpha-2 chain	0.0033	0.1025	0.1025
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.221	0.221
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0033	0.1025	0.1025
Trypanosoma brucei	epsilon tubulin	0.0025	0.0653	0.4094
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2926	0.2926
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0011	0.0042	0.0042
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Trypanosoma cruzi	alpha tubulin, putative	0.0033	0.1025	0.6577
Echinococcus granulosus	Tubulin beta 2C chain	0.0025	0.0653	0.0653
Echinococcus multilocularis	Tubulin beta 2C chain	0.0025	0.0653	0.0653
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.0406	0.2445
Entamoeba histolytica	cyclin, putative	0.0044	0.1492	0.9601
Brugia malayi	Tubulin beta chain	0.0011	0.004	0.004
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.1538	0.1538
Trichomonas vaginalis	tubulin, putative	0.0014	0.0182	0.0952
Loa Loa (eye worm)	tubulin alpha 2	0.0022	0.0554	0.0554
Trichomonas vaginalis	tubulin beta chain, putative	0.0033	0.1025	0.6577
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0406	0.0406
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Brugia malayi	Tubulin gamma chain	0.0025	0.0653	0.0653
Schistosoma mansoni	alpha tubulin	0.0033	0.1025	0.1025
Echinococcus multilocularis	tubulin beta 1 chain	0.0025	0.0653	0.0653
Schistosoma mansoni	tubulin subunit alpha	0.0033	0.1025	0.1025
Echinococcus multilocularis	cyclin dependent kinase 1	0.0045	0.1538	0.1538
Echinococcus multilocularis	cyclins	0.0018	0.037	0.037
Echinococcus granulosus	tubulin beta 4A class IVa	0.0025	0.0653	0.0653
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0018	0.037	0.037
Echinococcus granulosus	cyclin dependent kinase	0.0045	0.1538	0.1538
Trypanosoma brucei	epsilon tubulin	0.0025	0.0653	0.4094
Schistosoma mansoni	cyclins	0.0018	0.037	0.037
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2926	0.2926
Giardia lamblia	Beta tubulin	0.0025	0.0653	0.4094
Toxoplasma gondii	alpha tubulin TUBA1	0.0033	0.1025	0.6577
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0018	0.037	0.037
Brugia malayi	Raf kinase	0.0216	0.9061	0.9061
Echinococcus granulosus	cyclin B	0.0044	0.1492	0.1492
Loa Loa (eye worm)	hypothetical protein	0.0026	0.069	0.069
Trypanosoma brucei	beta tubulin	0.0025	0.0653	0.4094
Plasmodium falciparum	protein kinase 5	0.0045	0.1538	1
Mycobacterium leprae	cell division protein FtsZ	0.0011	0.004	0.5
Schistosoma mansoni	tubulin subunit alpha	0.0033	0.1025	0.1025
Loa Loa (eye worm)	beta-tubulin	0.0025	0.0653	0.0653
Echinococcus multilocularis	cyclin b3	0.0018	0.037	0.037
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1492	0.1492
Toxoplasma gondii	beta-1 tubulin, putative	0.0025	0.0653	0.4094
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Echinococcus granulosus	tubulin alpha chain	0.0033	0.1025	0.1025
Giardia lamblia	Kinase, CMGC CDK	0.0045	0.1538	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0025	0.0653	0.4094
Giardia lamblia	Cyclin A	0.0018	0.037	0.2207
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0011	0.004	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0224	0.9402	0.9402
Brugia malayi	RNA binding protein	0.0076	0.2926	0.2926
Echinococcus multilocularis	cyclin dependent kinase	0.0045	0.1538	0.1538
Plasmodium vivax	tubulin epsilon chain, putative	0.0025	0.0653	0.4094
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0653	0.0653
Echinococcus multilocularis	cyclin B	0.0044	0.1492	0.1492
Trypanosoma brucei	beta tubulin	0.0025	0.0653	0.4094
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Schistosoma mansoni	tubulin subunit alpha	0.0011	0.004	0.004
Echinococcus multilocularis	tubulin alpha 1C chain	0.0033	0.1025	0.1025
Schistosoma mansoni	tubulin subunit alpha	0.0033	0.1025	0.1025
Echinococcus multilocularis	tubulin alpha chain	0.0033	0.1025	0.1025
Brugia malayi	hypothetical protein	0.0182	0.7576	0.7576
Brugia malayi	Tubulin beta chain	0.0014	0.0182	0.0182
Echinococcus multilocularis	beta tubulin	0.0025	0.0653	0.0653
Trichomonas vaginalis	tubulin alpha chain, putative	0.0014	0.0182	0.0952
Echinococcus granulosus	peroxisome assembly protein 26	0.0033	0.1025	0.1025
Brugia malayi	Tubulin alpha-2 chain	0.0033	0.1025	0.1025
Trypanosoma brucei	cdc2-related kinase 3	0.0045	0.1538	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0406	0.0406
Schistosoma mansoni	tubulin subunit epsilon	0.0025	0.0653	0.0653
Toxoplasma gondii	alpha-tubulin I, putative	0.0033	0.1025	0.6577
Echinococcus granulosus	tubulin alpha	0.0025	0.0653	0.0653
Echinococcus granulosus	N chimaerin	0.0012	0.008	0.008
Trichomonas vaginalis	cyclins, putative	0.0044	0.1492	0.9689
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0012	0.008	0.008
Echinococcus granulosus	Tubulin alpha 1 chain	0.0033	0.1025	0.1025
Plasmodium falciparum	alpha tubulin 2	0.0033	0.1025	0.6577
Entamoeba histolytica	tubulin gamma chain	0.0025	0.0653	0.2421
Trichomonas vaginalis	tubulin alpha chain, putative	0.0025	0.0653	0.4094
Onchocerca volvulus		0.0044	0.1492	0.1771
Echinococcus multilocularis	tubulin alpha 3 chain	0.0033	0.1025	0.1025
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0019	0.0412	0.0412
Plasmodium vivax	tubulin alpha chain, putative	0.0033	0.1025	0.6577
Echinococcus multilocularis	Tubulin beta 2C chain	0.0025	0.0653	0.0653
Brugia malayi	Protein kinase domain containing protein	0.0045	0.1538	0.1538
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.1375	0.1375
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0019	0.0406	0.2445
Toxoplasma gondii	hypothetical protein	0.0014	0.0177	0.0916
Brugia malayi	cell division control protein 2 homolog	0.0045	0.1538	0.1538
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1025	0.1025
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0019	0.0406	1
Trichomonas vaginalis	cyclin B, putative	0.0044	0.1492	0.9689
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0012	0.008	0.008
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Echinococcus granulosus	c-Jun N-terminal kinases	0.0238	1	1
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Trypanosoma brucei	cdc2-related kinase 1	0.0045	0.1538	1
Schistosoma mansoni	vav2	0.0012	0.008	0.008
Trypanosoma cruzi	cdc2-related kinase 1	0.0045	0.1538	1
Toxoplasma gondii	beta-tubulin, putative	0.0025	0.0653	0.4094
Schistosoma mansoni	hypothetical protein	0.0041	0.1375	0.1375
Leishmania major	cyclin	0.0044	0.1492	0.9689
Echinococcus granulosus	tubulin beta 1 chain	0.0025	0.0653	0.0653
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0653	0.0653
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0405	0.0405
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0045	0.1538	0.1538
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0653	0.0653
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.2926	0.2926
Echinococcus multilocularis	tubulin delta chain	0.0011	0.004	0.004
Entamoeba histolytica	tubulin alpha chain, putative	0.0033	0.1025	0.5607
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0406	0.0406
Echinococcus granulosus	cyclins	0.0018	0.037	0.037
Echinococcus granulosus	tubulin alpha chain	0.0033	0.1025	0.1025
Giardia lamblia	Alpha-tubulin	0.0033	0.1025	0.6577
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0045	0.1538	0.1538
Echinococcus granulosus	tubulin gamma 1 chain	0.0025	0.0653	0.0653
Echinococcus multilocularis	beta tubulin	0.0025	0.0653	0.0653
Brugia malayi	Tubulin alpha chain	0.0011	0.004	0.004
Trichomonas vaginalis	cyclin B, putative	0.0018	0.037	0.2207
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0406	0.0406
Trichomonas vaginalis	tubulin, putative	0.0025	0.0653	0.4094
Echinococcus multilocularis	geminin	0.0205	0.8548	0.8548
Trichomonas vaginalis	tubulin gamma chain, putative	0.0025	0.0653	0.4094
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0045	0.1538	1
Schistosoma mansoni	serine/threonine protein kinase	0.0224	0.9402	0.9402
Loa Loa (eye worm)	RNA binding protein	0.0076	0.2926	0.2926
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0044	0.1492	0.1492
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0406	0.0406
Echinococcus multilocularis	tubulin subunit beta	0.0025	0.0653	0.0653
Brugia malayi	Tubulin alpha-2 chain	0.0033	0.1025	0.1025
Echinococcus multilocularis	cyclins	0.0018	0.037	0.037
Echinococcus granulosus	cyclin dependent kinase 5	0.0045	0.1538	0.1538
Echinococcus granulosus	alpha tubulin	0.0033	0.1025	0.1025
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0025	0.0653	0.4094
Loa Loa (eye worm)	hypothetical protein	0.0182	0.7576	0.7576
Giardia lamblia	Beta tubulin	0.0025	0.0653	0.4094
Trichomonas vaginalis	CMGC family protein kinase	0.0045	0.1538	1
Echinococcus multilocularis	cyclin dependent kinase 1	0.0045	0.1538	0.1538
Echinococcus multilocularis	Tubulin beta 2C chain	0.0025	0.0653	0.0653
Echinococcus granulosus	cyclins	0.0018	0.037	0.037
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1492	0.1492
Echinococcus granulosus	Tubulin beta 2C chain	0.0025	0.0653	0.0653
Schistosoma mansoni	hypothetical protein	0.0019	0.0405	0.0405
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.037	0.2207
Echinococcus granulosus	cyclins	0.0018	0.037	0.037
Echinococcus granulosus	GPCR family 2	0.0019	0.0405	0.0405
Echinococcus granulosus	Tubulin alpha 1 chain	0.0033	0.1025	0.1025
Loa Loa (eye worm)	BEN-1 protein	0.0025	0.0653	0.0653
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2926	0.2926
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.221	0.221
Trypanosoma cruzi	epsilon tubulin, putative	0.0025	0.0653	0.4094
Trichomonas vaginalis	tubulin alpha chain, putative	0.0025	0.0653	0.4094
Echinococcus multilocularis	cyclins	0.0018	0.037	0.037
Plasmodium vivax	tubulin gamma chain, putative	0.0025	0.0653	0.4094
Echinococcus granulosus	Tubulin beta 2C chain	0.0025	0.0653	0.0653
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Trichomonas vaginalis	cyclin B3, putative	0.0018	0.037	0.2207
Brugia malayi	beta-tubulin, identical	0.0025	0.0653	0.0653
Plasmodium vivax	tubulin beta chain, putative	0.0025	0.0653	0.4094
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0405	0.0405
Trypanosoma brucei	alpha tubulin	0.0033	0.1025	0.6577
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.1538	0.1538
Schistosoma mansoni	alpha tubulin	0.0033	0.1025	0.1025
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0019	0.0406	0.2445
Echinococcus multilocularis	Tubulin beta 2C chain	0.0025	0.0653	0.0653
Trichomonas vaginalis	CMGC family protein kinase	0.0045	0.1538	1
Giardia lamblia	Hypothetical protein	0.0018	0.037	0.2207
Echinococcus granulosus	cyclin B3 1	0.0018	0.037	0.037
Leishmania major	gamma-tubulin	0.0025	0.0653	0.4094
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0406	0.0406
Loa Loa (eye worm)	tubulin alpha chain	0.0033	0.1025	0.1025
Schistosoma mansoni	tubulin subunit delta	0.0011	0.004	0.004
Echinococcus multilocularis	tubulin alpha chain	0.0033	0.1025	0.1025
Schistosoma mansoni	cyclin B3	0.0018	0.037	0.037
Schistosoma mansoni	alpha tubulin	0.0033	0.1025	0.1025
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Trypanosoma cruzi	cdc2-related kinase 1	0.0045	0.1538	1
Echinococcus granulosus	cyclins	0.0018	0.037	0.037
Trichomonas vaginalis	cyclin D, putative	0.0018	0.037	0.2207
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0406	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0554	0.0554
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0033	0.1025	0.1025
Trypanosoma cruzi	cyclin, putative	0.0044	0.1492	0.9689
Trichomonas vaginalis	cyclin B, putative	0.0044	0.1492	0.9689
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0406	0.2445
Plasmodium falciparum	cyclin	0.0018	0.037	0.2207
Entamoeba histolytica	cell division protein kinase 2, putative	0.0045	0.1538	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0025	0.0653	0.0653
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Trichomonas vaginalis	tubulin beta chain, putative	0.0033	0.1025	0.6577
Brugia malayi	RhoGAP domain containing protein	0.0012	0.008	0.008
Entamoeba histolytica	tubulin alpha-1 chain	0.0033	0.1025	0.5607
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0033	0.1025	0.1025
Echinococcus multilocularis	tubulin alpha chain	0.0033	0.1025	0.1025
Trichomonas vaginalis	tubulin gamma chain, putative	0.0025	0.0653	0.4094
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0012	0.008	0.008
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Loa Loa (eye worm)	cyclin domain-containing protein	0.0018	0.037	0.037
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0405	0.0405
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0405	0.0405
Trypanosoma brucei	beta tubulin	0.0025	0.0653	0.4094
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0405	0.0405
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Echinococcus granulosus	beta tubulin	0.0025	0.0653	0.0653
Giardia lamblia	Beta tubulin	0.0025	0.0653	0.4094
Brugia malayi	Tubulin alpha chain	0.0033	0.1025	0.1025
Brugia malayi	TAR-binding protein	0.0076	0.2926	0.2926
Treponema pallidum	cell division protein FtsZ	0.0011	0.004	0.5
Loa Loa (eye worm)	tubulin beta-4 chain	0.0025	0.0653	0.0653
Echinococcus multilocularis	cyclins	0.0018	0.037	0.037
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0012	0.008	0.008
Trichomonas vaginalis	cyclin D, putative	0.0018	0.037	0.2207
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0406	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0412	0.0412
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.0406	0.2445
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0044	0.1492	0.1492
Entamoeba histolytica	cell division protein kinase 2, putative	0.0045	0.1538	1
Loa Loa (eye worm)	alpha-tubulin	0.0033	0.1025	0.1025
Schistosoma mansoni	hypothetical protein	0.0205	0.8548	0.8548
Trichomonas vaginalis	tubulin beta chain, putative	0.0025	0.0653	0.4094
Echinococcus granulosus	tubulin alpha 3 chain	0.0033	0.1025	0.1025
Echinococcus granulosus	tubulin subunit TubB	0.0033	0.1025	0.1025
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0022	0.0554	0.0554
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.2926	0.2926
Trichomonas vaginalis	cyclins, putative	0.0044	0.1492	0.9689
Trypanosoma cruzi	beta tubulin, putative	0.0025	0.0653	0.4094
Plasmodium falciparum	tubulin epsilon chain, putative	0.0025	0.0653	0.4094
Plasmodium vivax	protein kinase Crk2	0.0045	0.1538	1
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0238	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0014	0.0182	0.0952
Mycobacterium ulcerans	cell division protein FtsZ	0.0011	0.004	0.5
Trichomonas vaginalis	tubulin, putative	0.0014	0.0182	0.0952
Trypanosoma brucei	mitotic cyclin 6	0.0044	0.1492	0.9689
Echinococcus multilocularis	cyclins	0.0018	0.037	0.037
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0406	0.0406
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0128	0.5165	0.5165
Trichomonas vaginalis	tubulin beta chain, putative	0.0014	0.0182	0.0952
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Echinococcus granulosus	tubulin alpha chain	0.0033	0.1025	0.1025
Trypanosoma brucei	beta tubulin	0.0025	0.0653	0.4094
Plasmodium falciparum	tubulin gamma chain	0.0025	0.0653	0.4094
Echinococcus multilocularis	N chimaerin	0.0012	0.008	0.008
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0045	0.1538	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0045	0.1538	1
Echinococcus granulosus	cyclins	0.0018	0.037	0.037
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1497	0.1497
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0653	0.0653
Echinococcus granulosus	tubulin epsilon chain	0.0025	0.0653	0.0653
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0033	0.1025	0.1025
Echinococcus granulosus	tubulin alpha chain	0.0033	0.1025	0.1025
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0025	0.0653	0.0653
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0406	0.2445
Echinococcus granulosus	Tubulin alpha 1 chain	0.0033	0.1025	0.1025
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0012	0.008	0.008
Echinococcus granulosus	tubulin alpha 3 chain	0.0033	0.1025	0.1025
Trypanosoma brucei	beta tubulin	0.0025	0.0653	0.4094
Echinococcus granulosus	tubulin alpha 1C chain	0.0033	0.1025	0.1025
Brugia malayi	tubulin alpha chain - mouse	0.0033	0.1025	0.1025
Echinococcus multilocularis	cyclin dependent kinase 5	0.0045	0.1538	0.1538
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0045	0.1538	1
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0653	0.0653
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0044	0.1492	0.9689
Trichomonas vaginalis	tubulin beta chain, putative	0.0033	0.1025	0.6577
Giardia lamblia	Kinase, CMGC CDK	0.0045	0.1538	1
Echinococcus granulosus	geminin	0.0205	0.8548	0.8548
Echinococcus granulosus	beta tubulin	0.0025	0.0653	0.0653
Echinococcus granulosus	Tubulin beta 2C chain	0.0025	0.0653	0.0653
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.008	0.008
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Echinococcus granulosus	cyclin b3	0.0018	0.037	0.037
Trypanosoma brucei	alpha tubulin, putative	0.0014	0.0182	0.0952
Trichomonas vaginalis	CMGC family protein kinase	0.0045	0.1538	1
Trypanosoma brucei	epsilon tubulin	0.0025	0.0653	0.4094
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0045	0.1538	0.1538
Giardia lamblia	G2/mitotic-specific cyclin B	0.0044	0.1492	0.9689
Echinococcus multilocularis	peroxisome assembly protein 26	0.0033	0.1025	0.1025
Toxoplasma gondii	beta tubulin	0.0025	0.0653	0.4094
Leishmania major	beta tubulin	0.0025	0.0653	0.4094
Loa Loa (eye worm)	alpha-tubulin	0.0033	0.1025	0.1025
Loa Loa (eye worm)	tubulin alpha 2	0.0022	0.0554	0.0554
Trichomonas vaginalis	cyclins, putative	0.003	0.0884	0.5631
Schistosoma mansoni	hypothetical protein	0.0019	0.0405	0.0405
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0405	0.0405
Trypanosoma cruzi	tubulin gamma chain	0.0025	0.0653	0.4094
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0406	0.0406
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Leishmania major	alpha tubulin	0.0033	0.1025	0.6577
Loa Loa (eye worm)	raf kinase	0.0222	0.9306	0.9306
Echinococcus multilocularis	cyclins	0.0018	0.037	0.037
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0044	0.1492	0.9689

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.5733 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1507223

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1374134