Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.13 | 0 | 0.5 | |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.4666 | 0.5262 | 0.5262 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.13 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.13 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.7697 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.7697 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.7697 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.13 | 0 | 0.5 |
Onchocerca volvulus | 0.13 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.7697 | 1 | 1 |
Onchocerca volvulus | 0.13 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.7697 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.13 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.13 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.7697 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.7697 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.13 | 0 | 0.5 |
Onchocerca volvulus | 0.13 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.7697 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.7697 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.7697 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.7697 | 1 | 1 |
Onchocerca volvulus | 0.13 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.7697 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1158 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.