Detailed information for compound 1374262

Basic information

Technical information
  • TDR Targets ID: 1374262
  • Name: N-(furan-2-ylmethyl)-3-[3-(2-methylphenyl)-1, 2,4-oxadiazol-5-yl]propanamide
  • MW: 311.335 | Formula: C17H17N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.31 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccco1)CCc1onc(n1)c1ccccc1C
  • InChi: 1S/C17H17N3O3/c1-12-5-2-3-7-14(12)17-19-16(23-20-17)9-8-15(21)18-11-13-6-4-10-22-13/h2-7,10H,8-9,11H2,1H3,(H,18,21)
  • InChiKey: RGHSWQSXVKVRCM-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(2-furylmethyl)-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide
  • N-(2-furylmethyl)-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]propionamide
  • ZINC02390645
  • MLS000763066
  • N-Furan-2-ylmethyl-3-(3-o-tolyl-[1,2,4]oxadiazol-5-yl)-propionamide
  • SMR000438296

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0066 0.3586 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0066 0.3586 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Leishmania major quinonoid dihydropteridine reductase 0.0066 0.3586 0.5
Mycobacterium ulcerans dehydrogenase/reductase 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0066 0.3586 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0066 0.3586 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.3586 0.3586
Mycobacterium tuberculosis Probable oxidoreductase 0.0066 0.3586 0.5
Loa Loa (eye worm) oxidoreductase 0.0066 0.3586 0.3586
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Echinococcus granulosus tar DNA binding protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0066 0.3586 0.5
Loa Loa (eye worm) oxidoreductase 0.0066 0.3586 0.3586
Brugia malayi hypothetical protein 0.0066 0.3586 0.3586
Onchocerca volvulus 0.0066 0.3586 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0066 0.3586 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0066 0.3586 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0066 0.3586 0.5
Onchocerca volvulus 0.0066 0.3586 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0066 0.3586 0.5
Giardia lamblia Hypothetical protein 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0066 0.3586 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0066 0.3586 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.3586 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0066 0.3586 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0066 0.3586 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Brugia malayi Dehydrogenases, short chain protein 2 0.0066 0.3586 0.3586
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0066 0.3586 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0066 0.3586 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0076 1 1
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0066 0.3586 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0066 0.3586 0.3586
Leishmania major hypothetical protein, conserved 0.0066 0.3586 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0066 0.3586 0.5
Onchocerca volvulus 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Mycobacterium ulcerans ketoacyl reductase 0.0066 0.3586 0.5
Leishmania major hypothetical protein, conserved 0.0066 0.3586 0.5
Brugia malayi oxidoreductase 0.0066 0.3586 0.3586
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0066 0.3586 0.3586
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0066 0.3586 0.5
Loa Loa (eye worm) dehydrogenase 0.0066 0.3586 0.3586
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0066 0.3586 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0066 0.3586 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0066 0.3586 0.5
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0066 0.3586 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0066 0.3586 0.5
Onchocerca volvulus 0.0066 0.3586 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0066 0.3586 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0066 0.3586 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.3586 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Mycobacterium ulcerans ketoacyl reductase 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Onchocerca volvulus 0.0066 0.3586 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Brugia malayi TAR-binding protein 0.0076 1 1
Brugia malayi Retinol dehydrogenase 12 0.0066 0.3586 0.3586
Leishmania major hypothetical protein, conserved 0.0066 0.3586 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0066 0.3586 0.5
Loa Loa (eye worm) oxidoreductase 0.0066 0.3586 0.3586
Brugia malayi dehydrogenases, short chain protein 9 0.0066 0.3586 0.3586
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0066 0.3586 0.3586
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Loa Loa (eye worm) oxidoreductase 0.0066 0.3586 0.3586
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Toxoplasma gondii oxidoreductase, putative 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0066 0.3586 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0066 0.3586 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0066 0.3586 0.5
Leishmania major short chain dehydrogenase-like protein 0.0066 0.3586 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Onchocerca volvulus Sepiapterin reductase homolog 0.0066 0.3586 0.5
Leishmania major hypothetical protein, conserved 0.0066 0.3586 0.5
Leishmania major oxidoreductase-like protein 0.0066 0.3586 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0066 0.3586 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.5
Mycobacterium ulcerans oxidoreductase 0.0066 0.3586 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0066 0.3586 0.5
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0066 0.3586 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.0066 0.3586 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.5
Brugia malayi hypothetical protein 0.0066 0.3586 0.3586
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0066 0.3586 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0066 0.3586 0.5
Onchocerca volvulus 0.0066 0.3586 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0066 0.3586 0.5
Loa Loa (eye worm) dehydrogenase 0.0066 0.3586 0.3586
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0066 0.3586 0.5
Entamoeba histolytica hypothetical protein 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0066 0.3586 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.3586 0.5
Leishmania major short chain dehydrogenase, putative 0.0066 0.3586 0.5
Leishmania major pteridine reductase 1 0.0066 0.3586 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0066 0.3586 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Trypanosoma brucei short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.0066 0.3586 0.3586
Echinococcus multilocularis tar DNA binding protein 0.0076 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Loa Loa (eye worm) RNA binding protein 0.0076 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0066 0.3586 0.5
Loa Loa (eye worm) oxidoreductase 0.0066 0.3586 0.3586
Onchocerca volvulus 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Onchocerca volvulus 0.0066 0.3586 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0066 0.3586 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0066 0.3586 0.5
Onchocerca volvulus 0.0066 0.3586 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0066 0.3586 0.5
Loa Loa (eye worm) oxidoreductase 0.0066 0.3586 0.3586
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0066 0.3586 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0066 0.3586 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0066 0.3586 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0066 0.3586 0.5
Loa Loa (eye worm) oxidoreductase 0.0066 0.3586 0.3586
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0066 0.3586 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0066 0.3586 0.5
Plasmodium vivax hypothetical protein, conserved 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Loa Loa (eye worm) TAR-binding protein 0.0076 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0066 0.3586 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Toxoplasma gondii oxidoreductase, putative 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Onchocerca volvulus 0.0066 0.3586 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Leishmania major short chain dehydrogenase, putative 0.0066 0.3586 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Loa Loa (eye worm) oxidoreductase 0.0066 0.3586 0.3586
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0066 0.3586 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0066 0.3586 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Leishmania major dehydrogenase-like protein 0.0066 0.3586 0.5
Trypanosoma brucei oxidoreductase-like protein 0.0066 0.3586 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0066 0.3586 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0066 0.3586 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0066 0.3586 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Onchocerca volvulus 0.0066 0.3586 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0066 0.3586 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.3586 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Brugia malayi dehydrogenases, short chain protein 2 0.0066 0.3586 0.3586
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0066 0.3586 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.3586 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0066 0.3586 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0066 0.3586 0.5
Onchocerca volvulus 0.0066 0.3586 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.3586 0.3586
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0066 0.3586 0.5
Loa Loa (eye worm) oxidoreductase 0.0066 0.3586 0.3586
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.3586 0.3586
Giardia lamblia Reductase, putative 0.0066 0.3586 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0066 0.3586 0.5
Leishmania major hypothetical protein, conserved 0.0066 0.3586 0.5
Mycobacterium ulcerans dehydrogenase 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0066 0.3586 0.5
Mycobacterium leprae Probable oxidoreductase 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.3586 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.3586 0.5
Mycobacterium ulcerans oxidoreductase 0.0066 0.3586 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0066 0.3586 0.5
Mycobacterium ulcerans carveol-like dehydrogenase 0.0066 0.3586 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0066 0.3586 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0066 0.3586 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0066 0.3586 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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