Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1555 | 0.1555 |
Onchocerca volvulus | 0.0185 | 0.1555 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.1093 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0185 | 0.1555 | 0.1434 |
Schistosoma mansoni | gliotactin | 0.0185 | 0.1555 | 0.1434 |
Onchocerca volvulus | 0.0185 | 0.1555 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0185 | 0.1555 | 0.1555 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1555 | 0.1555 |
Onchocerca volvulus | 0.0185 | 0.1555 | 1 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.0185 | 0.1555 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.1093 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0185 | 0.1555 | 0.1434 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.1555 | 0.1555 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.052 | 0.0384 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0185 | 0.1555 | 0.1434 |
Loa Loa (eye worm) | hypothetical protein | 0.1093 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1093 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1093 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1093 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1093 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0185 | 0.1555 | 0.1434 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0185 | 0.1555 | 0.5 |
Onchocerca volvulus | 0.0185 | 0.1555 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0185 | 0.1555 | 0.1434 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0185 | 0.1555 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.1555 | 0.1555 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0185 | 0.1555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1555 | 0.1555 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0185 | 0.1555 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.174 | 0.1623 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0141 | 0.0141 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.174 | 0.1623 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.1555 | 0.1555 |
Echinococcus multilocularis | neuroligin | 0.0185 | 0.1555 | 0.1434 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.052 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.052 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0185 | 0.1555 | 0.1555 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.052 | 0.0384 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0185 | 0.1555 | 0.1434 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1555 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1555 | 0.1555 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0185 | 0.1555 | 0.1434 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1555 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.1093 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1093 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0185 | 0.1555 | 0.1434 |
Brugia malayi | hypothetical protein | 0.0185 | 0.1555 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1555 | 0.1555 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.052 | 0.0384 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0185 | 0.1555 | 0.1434 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0141 | 0.0141 |
Echinococcus multilocularis | geminin | 0.0205 | 0.174 | 0.1623 |
Echinococcus multilocularis | acetylcholinesterase | 0.1093 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.174 | 0.1623 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0185 | 0.1555 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0185 | 0.1555 | 0.1434 |
Echinococcus granulosus | neuroligin | 0.0185 | 0.1555 | 0.1434 |
Echinococcus multilocularis | acetylcholinesterase | 0.1093 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.052 | 0.0384 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0185 | 0.1555 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0185 | 0.1555 | 0.1434 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1093 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.1555 | 0.1555 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0185 | 0.1555 | 0.1434 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5858 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.