TDR Targets

Basic information

Technical information

TDR Targets ID: 1375149
Name: N,N'-bis(4-methylphenyl)pyridine-2,3-dicarbox amide
MW: 345.394 | Formula: C21H19N3O2
H donors: 2 H acceptors: 3 LogP: 3.58 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)NC(=O)c1ncccc1C(=O)Nc1ccc(cc1)C
InChi: 1S/C21H19N3O2/c1-14-5-9-16(10-6-14)23-20(25)18-4-3-13-22-19(18)21(26)24-17-11-7-15(2)8-12-17/h3-13H,1-2H3,(H,23,25)(H,24,26)
InChiKey: ZQARKRXBMJQCRF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N,N'-bis(4-methylphenyl)quinolinamide
ZINC00611666
MLS000671971
N,N'-bis(4-methylphenyl)-2,3-pyridinedicarboxamide
SMR000294482

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0064	0.0055
Echinococcus multilocularis	serotonin transporter	0.0165	0.0232	0.7765
Echinococcus granulosus	geminin	0.0205	0.0299	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0118	0.0152	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0098	0.2905
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0165	0.0232	0.687
Brugia malayi	Pre-SET motif family protein	0.0033	0.0007	0.0209
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0165	0.0232	1
Mycobacterium leprae	Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX	0.0812	0.1329	0.1313
Trichomonas vaginalis	glucosaminephosphotransferase, putative	0.0034	0.0009	0.0243
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0045	0.1519
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0131	0.0174	0.0156
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0165	0.0232	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0232	0.687
Mycobacterium ulcerans	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0812	0.1329	0.1321
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0086	0.0098	0.3121
Treponema pallidum	phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY)	0.0308	0.0475	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0045	0.1314
Brugia malayi	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0034	0.0009	0.0281
Mycobacterium ulcerans	thymidylate synthase	0.0118	0.0151	0.0142
Wolbachia endosymbiont of Brugia malayi	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0812	0.1329	1
Brugia malayi	dihydrofolate reductase family protein	0.0048	0.0033	0.0976
Echinococcus multilocularis	geminin	0.0205	0.0299	1
Brugia malayi	glutathione reductase	0.0052	0.0039	0.1167
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0064	0.1963
Giardia lamblia	Cysteinyl-tRNA synthetase	0.0086	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0009	0.0281
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0045	0.1344
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0007	0.0304
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0045	0.1314
Schistosoma mansoni	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0034	0.0009	0.0083
Plasmodium falciparum	thioredoxin reductase	0.0052	0.0039	0.1696
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0064	0.1963
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.0064	0.2153
Entamoeba histolytica	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	1
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.5919	1	1
Treponema pallidum	sodium- and chloride- dependent transporter	0.0165	0.0232	0.3553
Mycobacterium tuberculosis	Probable oxidoreductase	0.0131	0.0174	0.0156
Plasmodium vivax	cysteine--tRNA ligase, putative	0.0086	0.0098	0.4223
Leishmania major	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0408
Toxoplasma gondii	cysteine-tRNA synthetase (CysRS)	0.0086	0.0098	0.4223
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0165	0.0232	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0052	0.0039	0.1696
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	0.4223
Echinococcus granulosus	serotonin transporter	0.0165	0.0232	0.7765
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0118	0.0151	0.4934
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0064	0.0055
Chlamydia trachomatis	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0308	0.0475	1
Echinococcus granulosus	thymidylate synthase	0.0118	0.0151	0.5054
Trypanosoma brucei	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0408
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0045	0.1519
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0007	0.0237
Echinococcus multilocularis	cysteinyl tRNA synthetase	0.0086	0.0098	0.3283
Loa Loa (eye worm)	cysteinyl tRNA synthetase 1	0.0086	0.0098	0.2905
Mycobacterium tuberculosis	Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC	0.5919	1	1
Leishmania major	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	0.4223
Echinococcus multilocularis	thymidylate synthase	0.0118	0.0151	0.5054
Toxoplasma gondii	thioredoxin reductase	0.0052	0.0039	0.1696
Loa Loa (eye worm)	thymidylate synthase	0.0118	0.0151	0.4471
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0005	0.0168
Echinococcus granulosus	cysteinyl tRNA synthetase	0.0086	0.0098	0.3283
Onchocerca volvulus		0.0165	0.0232	0.5858
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	0.0187	0.027	0.1393
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0045	0.1519
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0165	0.0232	0.687
Trichomonas vaginalis	set domain proteins, putative	0.0259	0.0391	1
Loa Loa (eye worm)	glutathione reductase	0.0052	0.0039	0.1167
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	0.4223
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0007	0.0237
Loa Loa (eye worm)	dihydrofolate reductase	0.0048	0.0033	0.0976
Echinococcus granulosus	UDP N acetylglucosamine dolichyl phosphate	0.0034	0.0009	0.0318
Loa Loa (eye worm)	norepinephrine transporter	0.0165	0.0232	0.687
Brugia malayi	hypothetical protein	0.0056	0.0047	0.1377
Mycobacterium tuberculosis	Probable dehydrogenase	0.0118	0.0152	0.0133
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0118	0.0151	0.0132
Trypanosoma brucei	trypanothione reductase	0.0052	0.0039	0.1696
Brugia malayi	Pre-SET motif family protein	0.0228	0.0338	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.0064	0.2769
Entamoeba histolytica	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0967
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.0086	0.0098	0.0089
Onchocerca volvulus		0.0259	0.0391	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0045	0.1314
Plasmodium vivax	N-acetylglucosamine-1-phosphate transferase, putative	0.0034	0.0009	0.0408
Mycobacterium tuberculosis	Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX	0.0812	0.1329	0.1313
Schistosoma mansoni	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0034	0.0009	0.0083
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0118	0.0152	0.0133
Schistosoma mansoni	hypothetical protein	0.0205	0.0299	1
Plasmodium vivax	thioredoxin reductase, putative	0.0052	0.0039	0.1696
Plasmodium vivax	SET domain protein, putative	0.0033	0.0007	0.0304
Schistosoma mansoni	dihydrofolate reductase	0.0048	0.0033	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0232	0.687
Mycobacterium tuberculosis	Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG	0.0137	0.0185	0.0166
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0048	0.0033	0.0014
Brugia malayi	cysteinyl tRNA synthetase protein 1	0.0086	0.0098	0.2905
Mycobacterium leprae	ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG	0.0137	0.0185	0.0166
Onchocerca volvulus		0.0086	0.0098	0.2371
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0086	0.0098	0.3121
Loa Loa (eye worm)	serotonin transporter b	0.0165	0.0232	0.687
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0131	0.0174	0.0156
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0048	0.0033	0.0014
Mycobacterium ulcerans	glycosyltransferase	0.004	0.0019	0.001
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0118	0.0152	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0232	0.687
Loa Loa (eye worm)	thioredoxin reductase	0.0052	0.0039	0.1167
Treponema pallidum	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	0.0187	0.027	0.4547
Trypanosoma brucei	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	0.4223
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0048	0.0033	0.0024
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0165	0.0232	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0118	0.0152	0.0133
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0052	0.0039	0.1319
Trichomonas vaginalis	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	0.2509
Onchocerca volvulus		0.0118	0.0151	0.3748
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0007	0.0237
Echinococcus multilocularis	dihydrofolate reductase	0.0048	0.0033	0.1103
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.0064	0.2769
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0045	0.1519
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0165	0.0232	1
Trypanosoma cruzi	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0408
Chlamydia trachomatis	cysteine--tRNA ligase	0.0086	0.0098	0.1474
Mycobacterium tuberculosis	Hypothetical protein	0.0056	0.0047	0.0028
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.0064	0.2153
Schistosoma mansoni	sodium/chloride dependent transporter	0.0165	0.0232	0.7711
Echinococcus granulosus	leucyl tRNA synthetase	0.0086	0.0098	0.3283
Plasmodium falciparum	glutathione reductase	0.0052	0.0039	0.1696
Chlamydia trachomatis	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	0.0187	0.027	0.535
Plasmodium falciparum	cysteine--tRNA ligase	0.0086	0.0098	0.4223
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0131	0.0174	0.0156
Plasmodium falciparum	cysteine--tRNA ligase	0.0086	0.0098	0.4223
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0165	0.0232	0.7711
Schistosoma mansoni	hypothetical protein	0.0205	0.0299	1
Echinococcus multilocularis	UDP N acetylglucosamine dolichyl phosphate	0.0034	0.0009	0.0318
Brugia malayi	Dihydrofolate reductase	0.0048	0.0033	0.0976
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0118	0.0151	0.0132
Giardia lamblia	UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase	0.0034	0.0009	0.0967
Mycobacterium tuberculosis	Probable reductase	0.0118	0.0152	0.0133
Mycobacterium ulcerans	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	0.0187	0.027	0.026
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0064	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0007	0.0209
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0165	0.0232	1
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0047	0.1189
Brugia malayi	thymidylate synthase	0.0118	0.0151	0.4471
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0118	0.0152	0.0133
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0045	0.1344
Plasmodium falciparum	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0408
Brugia malayi	Thioredoxin reductase	0.0052	0.0039	0.1167
Echinococcus granulosus	dihydrofolate reductase	0.0048	0.0033	0.1103
Leishmania major	trypanothione reductase	0.0052	0.0039	0.1696
Trypanosoma cruzi	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0408
Echinococcus granulosus	thioredoxin glutathione reductase	0.0052	0.0039	0.1319
Plasmodium vivax	glutathione reductase, putative	0.0052	0.0039	0.1696
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.0064	0.0045
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0228	0.0338	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0056	0.0047	0.2002
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0052	0.0039	0.002
Toxoplasma gondii	glycosyl transferase, group 4 family protein	0.0034	0.0009	0.0408
Onchocerca volvulus		0.0034	0.0009	0.0063

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.5821 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1505949

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1375149