Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0222 | 0.1421 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0222 | 0.1421 | 0.1421 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 0.1421 | 0.1421 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1283 | 0.1273 |
Schistosoma mansoni | acetylcholinesterase | 0.0222 | 0.1421 | 0.1421 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1421 | 0.1421 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0222 | 0.1421 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0222 | 0.1421 | 0.1421 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0222 | 0.1421 | 0.1411 |
Schistosoma mansoni | gliotactin | 0.0222 | 0.1421 | 0.1421 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.015 | 0.015 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0222 | 0.1421 | 0.1411 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0222 | 0.1421 | 0.1411 |
Echinococcus granulosus | acetylcholinesterase | 0.1315 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.0396 | 0.0396 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0151 | 0.0151 |
Brugia malayi | hypothetical protein | 0.0222 | 0.1421 | 0.1421 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.015 | 0.015 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0222 | 0.1421 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.1421 | 0.1421 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1421 | 0.1421 |
Brugia malayi | Carboxylesterase family protein | 0.1315 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.1421 | 0.1421 |
Echinococcus multilocularis | acetylcholinesterase | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1421 | 0.1421 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.7365 | 0.7362 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 0.1421 | 0.1421 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1421 | 0.1421 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0062 | 0.005 |
Loa Loa (eye worm) | carboxylesterase | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1315 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0062 | 0.005 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0011 | 0.0011 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1283 | 0.1283 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0222 | 0.1421 | 0.1421 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.0582 | 0.0571 |
Onchocerca volvulus | 0.0222 | 0.1421 | 0.5 | |
Onchocerca volvulus | 0.0222 | 0.1421 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1421 | 0.1421 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0222 | 0.1421 | 0.1411 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1315 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.1421 | 0.1421 |
Echinococcus granulosus | carboxylesterase 5A | 0.1315 | 1 | 1 |
Onchocerca volvulus | 0.0222 | 0.1421 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 0.1421 | 0.1421 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0222 | 0.1421 | 0.1411 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.0248 | 0.0248 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.0582 | 0.0582 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0222 | 0.1421 | 0.1411 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0222 | 0.1421 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0222 | 0.1421 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.015 | 0.015 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0222 | 0.1421 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0222 | 0.1421 | 0.1421 |
Echinococcus multilocularis | neuroligin | 0.0222 | 0.1421 | 0.1411 |
Echinococcus granulosus | acetylcholinesterase | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1421 | 0.1421 |
Echinococcus multilocularis | acetylcholinesterase | 0.1315 | 1 | 1 |
Onchocerca volvulus | 0.0222 | 0.1421 | 0.5 | |
Echinococcus granulosus | geminin | 0.0205 | 0.1283 | 0.1273 |
Onchocerca volvulus | 0.0222 | 0.1421 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.0222 | 0.1421 | 0.1411 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1283 | 0.1283 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0011 | 0.0011 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 0.1421 | 0.1421 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1315 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1421 | 0.1421 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.0582 | 0.0571 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1315 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.9362 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3535 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.