TDR Targets

Basic information

Technical information

TDR Targets ID: 1375427
Name: (E)-N-cyclohexyl-N-ethyl-3-phenylprop-2-enami de
MW: 257.371 | Formula: C17H23NO
H donors: 0 H acceptors: 1 LogP: 3.98 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCN(C(=O)/C=C/c1ccccc1)C1CCCCC1
InChi: 1S/C17H23NO/c1-2-18(16-11-7-4-8-12-16)17(19)14-13-15-9-5-3-6-10-15/h3,5-6,9-10,13-14,16H,2,4,7-8,11-12H2,1H3/b14-13+
InChiKey: MBEQPKQLCZOANA-BUHFOSPRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cyclohexyl-N-ethyl-3-phenylprop-2-enamide
(E)-N-cyclohexyl-N-ethyl-3-phenyl-prop-2-enamide
N-cyclohexyl-N-ethyl-3-phenyl-prop-2-enamide
(E)-N-cyclohexyl-N-ethyl-3-phenyl-acrylamide
N-cyclohexyl-N-ethyl-3-phenyl-acrylamide
MLS001185525
NSC204680
STK075717
ZINC00456532
SMR000503157

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.629	0.629
Loa Loa (eye worm)	neuropeptide F receptor	0.0052	0.629	0.629
Echinococcus multilocularis	g-protein coupled receptor	0.0052	0.629	0.629
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.629	0.629
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.629	0.629
Echinococcus multilocularis	dro:myosuppressin receptor	0.0052	0.629	0.629
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.1291	0.1291
Treponema pallidum	DNA ligase (lig)	0.0012	0.0206	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Brugia malayi	larval opioid receptor	0.0052	0.629	0.629
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Echinococcus multilocularis	neuropeptide receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0052	0.629	0.629
Brugia malayi	Serotonin receptor	0.0052	0.629	0.629
Entamoeba histolytica	hypothetical protein	0.0043	0.499	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.629	0.629
Plasmodium vivax	replication factor C subunit 1, putative	0.0012	0.0206	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0206	0.0206
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0052	0.629	0.629
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0012	0.0206	0.5
Schistosoma mansoni	hypothetical protein	0.0041	0.4642	0.4642
Schistosoma mansoni	biogenic amine receptor	0.0052	0.629	0.629
Schistosoma mansoni	hypothetical protein	0.0052	0.629	0.629
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.629	0.629
Echinococcus granulosus	neuropeptide Y receptor	0.0052	0.629	0.629
Echinococcus granulosus	hypothetical protein	0.0052	0.629	0.629
Echinococcus multilocularis	neuropeptide Y receptor	0.0052	0.629	0.629
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0052	0.629	0.629
Schistosoma mansoni	opsin-like receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Toxoplasma gondii	ATPase, AAA family protein	0.0012	0.0206	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0052	0.629	0.629
Echinococcus multilocularis	tar DNA binding protein	0.0076	1	1
Echinococcus granulosus	replication factor c subunit 1	0.0012	0.0206	0.0206
Schistosoma mansoni	biogenic amine receptor	0.0052	0.629	0.629
Echinococcus multilocularis	G protein coupled receptor 139	0.0052	0.629	0.629
Brugia malayi	GnHR receptor homolog	0.0052	0.629	0.629
Brugia malayi	putative neuropeptide receptor	0.0052	0.629	0.629
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.629	0.629
Echinococcus granulosus	neuropeptide FF receptor 2	0.0052	0.629	0.629
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0052	0.629	0.629
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0052	0.629	0.629
Plasmodium falciparum	replication factor C subunit 1, putative	0.0012	0.0206	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.499	0.499
Schistosoma mansoni	opsin-like receptor	0.0052	0.629	0.629
Echinococcus granulosus	tm gpcr rhodopsin	0.0052	0.629	0.629
Brugia malayi	hypothetical protein	0.0052	0.629	0.629
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0052	0.629	0.629
Echinococcus multilocularis	g protein coupled receptor	0.0052	0.629	0.629
Echinococcus granulosus	biogenic amine 5HT receptor	0.0052	0.629	0.629
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0052	0.629	0.629
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0052	0.629	0.629
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0052	0.629	0.629
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.753	0.753
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.499	0.499
Echinococcus granulosus	fmrfamide receptor	0.0052	0.629	0.629
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0052	0.629	0.629
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0052	0.629	0.629
Brugia malayi	TAR-binding protein	0.0076	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0206	0.0206
Brugia malayi	putative neuropeptide receptor NPR1	0.0052	0.629	0.629
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.4419	0.4419
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0052	0.629	0.629
Brugia malayi	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.3913	0.3913
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0052	0.629	0.629
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0012	0.0206	0.5
Brugia malayi	ORL1-like opioid receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0032	0.3185	0.3185
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Chlamydia trachomatis	DNA ligase	0.0012	0.0206	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0052	0.629	0.629
Schistosoma mansoni	neuropeptide f receptor 76f	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Brugia malayi	hypothetical protein	0.0052	0.629	0.629
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0206	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.629	0.629
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Echinococcus granulosus	GPCR family 2	0.0019	0.1291	0.1291
Schistosoma mansoni	adenoreceptor	0.0052	0.629	0.629
Schistosoma mansoni	myosin xvIII	0.0052	0.629	0.629
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.4642	0.4642
Schistosoma mansoni	topbp1	0.0012	0.0206	0.0206
Schistosoma mansoni	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	G-protein coupled receptor	0.0052	0.629	0.629
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.629	0.629
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.1291	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus granulosus	neuropeptides capa receptor	0.0052	0.629	0.629
Schistosoma mansoni	hypothetical protein	0.0019	0.1291	0.1291
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0052	0.629	0.629
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.629	0.629
Echinococcus granulosus	neuropeptide s receptor	0.0052	0.629	0.629
Brugia malayi	hypothetical protein	0.0012	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Schistosoma mansoni	neuropeptide F-like receptor	0.0052	0.629	0.629
Brugia malayi	G-protein coupled receptor	0.0052	0.629	0.629
Brugia malayi	Dopamine receptor protein 2	0.0052	0.629	0.629
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Brugia malayi	G-protein coupled receptor	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Brugia malayi	Serotonin receptor	0.0052	0.629	0.629
Schistosoma mansoni	neuropeptide receptor	0.0052	0.629	0.629
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.3913	0.3913
Echinococcus multilocularis	fmrfamide receptor	0.0052	0.629	0.629
Echinococcus multilocularis	replication factor c subunit 1	0.0012	0.0206	0.0206
Loa Loa (eye worm)	RNA binding protein	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Schistosoma mansoni	opsin-like receptor	0.0052	0.629	0.629
Schistosoma mansoni	hypothetical protein	0.0052	0.629	0.629
Echinococcus multilocularis	g protein coupled receptor	0.0052	0.629	0.629
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.499	0.499
Echinococcus granulosus	nibrin	0.0012	0.0206	0.0206
Echinococcus multilocularis	g protein coupled receptor	0.0052	0.629	0.629
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	neuropeptide F receptor	0.0052	0.629	0.629
Echinococcus granulosus	neuropeptide Y receptor	0.0052	0.629	0.629
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Entamoeba histolytica	hypothetical protein	0.0043	0.499	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0012	0.0206	0.5
Schistosoma mansoni	hypothetical protein	0.0019	0.1291	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0206	0.5
Echinococcus multilocularis	somatostatin receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus multilocularis	neuropeptide s receptor	0.0052	0.629	0.629
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.4419	0.4419
Brugia malayi	Melatonin receptor type 1A	0.0052	0.629	0.629
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0052	0.629	1
Echinococcus granulosus	sex peptide receptor	0.0052	0.629	0.629
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.629	0.629
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.629	0.629
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Onchocerca volvulus		0.0052	0.629	1
Onchocerca volvulus		0.0052	0.629	1
Echinococcus granulosus	somatostatin receptor	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Brugia malayi	Pax transcription activation domain interacting protein	0.0012	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.006	0.753	0.753
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0206	0.0206
Echinococcus granulosus	serotonin receptor	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Echinococcus granulosus	tar DNA binding protein	0.0076	1	1
Echinococcus granulosus	neuropeptide receptor	0.0052	0.629	0.629
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0052	0.629	0.629
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.3913	0.3913
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus granulosus	g protein coupled receptor	0.0052	0.629	0.629
Schistosoma mansoni	amine GPCR	0.0052	0.629	0.629
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Trypanosoma cruzi	FHA domain containing protein, putative	0.0012	0.0206	0.5
Schistosoma mansoni	neuropeptide receptor	0.0052	0.629	0.629
Echinococcus multilocularis	fmrfamide receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus multilocularis	neuropeptide receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	G-protein coupled receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Entamoeba histolytica	hypothetical protein	0.0043	0.499	1
Brugia malayi	Dopamine receptor protein 1	0.0052	0.629	0.629
Brugia malayi	hypothetical protein	0.0052	0.629	0.629
Giardia lamblia	Replication factor C, subunit 1	0.0012	0.0206	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	TAR-binding protein	0.0076	1	1
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0012	0.0206	0.0206
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0052	0.629	0.629
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.355	1
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0012	0.0206	0.5
Brugia malayi	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0041	0.4642	0.4642
Brugia malayi	hypothetical protein	0.0052	0.629	0.629
Echinococcus granulosus	g protein coupled receptor	0.0052	0.629	0.629
Schistosoma mansoni	amine GPCR	0.0052	0.629	0.629
Echinococcus multilocularis	sex peptide receptor	0.0052	0.629	0.629
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0052	0.629	0.629
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.629	0.629
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0052	0.629	0.629
Echinococcus granulosus	7TM GPCR rhodopsin	0.0052	0.629	0.629
Brugia malayi	hypothetical protein	0.0043	0.499	0.499
Schistosoma mansoni	neuropeptide receptor	0.0052	0.629	0.629
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0052	0.629	0.629
Echinococcus multilocularis	allatostatin A receptor	0.0052	0.629	0.629
Echinococcus multilocularis	neuropeptides capa receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.355	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.753	0.753
Brugia malayi	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus granulosus	tm gpcr rhodopsin	0.0052	0.629	0.629
Schistosoma mansoni	topbp1	0.0012	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Schistosoma mansoni	hypothetical protein	0.0019	0.1291	0.1291
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.1291	0.1291
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0012	0.0206	0.5
Echinococcus multilocularis	serotonin receptor	0.0052	0.629	0.629
Schistosoma mansoni	histamine h1 receptor	0.0052	0.629	0.629
Brugia malayi	G protein-coupled receptor	0.0052	0.629	0.629
Echinococcus granulosus	neuropeptide receptor	0.0052	0.629	0.629
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0052	0.629	0.629
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0206	0.0206
Echinococcus multilocularis	GPCR, family 2	0.0019	0.1291	0.1291
Brugia malayi	neuropeptide F receptor	0.0052	0.629	0.629
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0052	0.629	0.629
Brugia malayi	sulfakinin receptor protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus granulosus	orexin receptor type 2	0.0052	0.629	0.629
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.629	0.629
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.629	0.629
Echinococcus multilocularis	neuropeptide Y receptor	0.0052	0.629	0.629
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.629	0.629
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.1291	0.1291
Brugia malayi	RNA recognition motif domain containing protein	0.0076	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0052	0.629	0.629
Echinococcus granulosus	biogenic amine 5HT receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0052	0.629	0.629
Brugia malayi	G protein-coupled receptor F59B2.13	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus granulosus	tm gpcr rhodopsin	0.0052	0.629	0.629
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0206	0.0206
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.1291	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0052	0.629	0.629
Schistosoma mansoni	hypothetical protein	0.0052	0.629	0.629
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0052	0.629	0.629
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0052	0.629	0.629
Brugia malayi	neuropeptide F receptor	0.0052	0.629	0.629
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0052	0.629	0.629
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0012	0.0206	0.5
Schistosoma mansoni	neuropeptide receptor	0.0052	0.629	0.629
Brugia malayi	topoisomerase	0.0012	0.0206	0.0206
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.629	0.629
Brugia malayi	hypothetical protein	0.0012	0.0206	0.0206
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0052	0.629	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Schistosoma mansoni	amine GPCR	0.0052	0.629	0.629
Loa Loa (eye worm)	TYRA-2 protein	0.0052	0.629	0.629
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.629	0.629
Brugia malayi	RE15519p	0.0052	0.629	0.629
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.629	0.629
Brugia malayi	DKFZp564C0469 protein	0.0012	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Schistosoma mansoni	DNA ligase IV	0.0012	0.0206	0.0206
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.3913	0.3913
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0052	0.629	0.629
Schistosoma mansoni	amine GPCR	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0206	0.0206
Schistosoma mansoni	hypothetical protein	0.0019	0.1291	0.1291
Echinococcus granulosus	G protein coupled receptor 139	0.0052	0.629	0.629
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.753	0.753
Entamoeba histolytica	hypothetical protein	0.0043	0.499	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0052	0.629	0.629
Schistosoma mansoni	hypothetical protein	0.0043	0.499	0.499
Echinococcus multilocularis	serotonin receptor	0.0052	0.629	0.629
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0052	0.629	0.629
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0052	0.629	0.629
Brugia malayi	Dopamine receptor	0.0052	0.629	0.629
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.1291	0.1291
Echinococcus granulosus	g-protein coupled receptor	0.0052	0.629	0.629
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0052	0.629	0.629
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0052	0.629	0.629
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	1	1
Brugia malayi	hypothetical protein	0.0052	0.629	0.629
Brugia malayi	hypothetical protein	0.0052	0.629	0.629
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.629	0.629
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.1291	0.1291
Echinococcus granulosus	allatostatin A receptor	0.0052	0.629	0.629
Echinococcus granulosus	g protein coupled receptor	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0052	0.629	0.629
Schistosoma mansoni	chromosome transmission fidelity factor	0.0012	0.0206	0.0206
Schistosoma mansoni	amine GPCR	0.0052	0.629	0.629
Echinococcus granulosus	7tm_1 domain containing protein	0.0052	0.629	0.629
Schistosoma mansoni	biogenic amine receptor	0.0052	0.629	0.629
Schistosoma mansoni	growth hormone secretagogue receptor	0.0052	0.629	0.629
Onchocerca volvulus		0.0052	0.629	1
Onchocerca volvulus		0.0052	0.629	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0052	0.629	0.629
Loa Loa (eye worm)	hypothetical protein	0.0052	0.629	0.629
Brugia malayi	hypothetical protein	0.0052	0.629	0.629
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.629	0.629
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0052	0.629	0.629
Echinococcus multilocularis	nibrin	0.0012	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1291	0.1291
Brugia malayi	AKH receptor	0.0052	0.629	0.629
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0052	0.629	0.629
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0052	0.629	0.629
Echinococcus multilocularis	neuropeptide receptor A26	0.0052	0.629	0.629
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0052	0.629	0.629

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	37.933 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1506912

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1375427