Detailed information for compound 1375461

Basic information

Technical information
  • TDR Targets ID: 1375461
  • Name: N-butyl-N-methyl-6-morpholin-4-ylsulfonyl-4-o xo-1H-quinoline-3-carboxamide
  • MW: 407.484 | Formula: C19H25N3O5S
  • H donors: 1 H acceptors: 5 LogP: 1.87 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(C(=O)c1cnc2c(c1O)cc(cc2)S(=O)(=O)N1CCOCC1)C
  • InChi: 1S/C19H25N3O5S/c1-3-4-7-21(2)19(24)16-13-20-17-6-5-14(12-15(17)18(16)23)28(25,26)22-8-10-27-11-9-22/h5-6,12-13H,3-4,7-11H2,1-2H3,(H,20,23)
  • InChiKey: XCRZZQOCHODQDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-butyl-N-methyl-6-morpholinosulfonyl-4-oxo-1H-quinoline-3-carboxamide
  • N-butyl-4-keto-N-methyl-6-morpholinosulfonyl-1H-quinoline-3-carboxamide
  • EU-0096153
  • Oprea1_078189
  • MLS000104069
  • SMR000018578

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum lysophospholipase, putative 0.0077 0.0181 0.0307
Echinococcus multilocularis transfer RNA-Thr 0.0038 0.0057 0.0096
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0036 0.0051 0.0086
Brugia malayi protein-tyrosine kinase 0.0038 0.0057 0.0057
Onchocerca volvulus 0.0038 0.0057 0.0036
Loa Loa (eye worm) hypothetical protein 0.0373 0.1126 0.1126
Echinococcus multilocularis raf serine:threonine protein kinase 0.0038 0.0057 0.0096
Echinococcus granulosus roundabout 2 0.0036 0.0051 0.0086
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0036 0.0051 0.0086
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0036 0.0051 0.0016
Schistosoma mansoni tyrosine kinase 0.1307 0.411 0.6988
Echinococcus multilocularis Phospholipase carboxylesterase 0.0077 0.0181 0.0308
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Echinococcus multilocularis c src tyrosine kinase 0.0038 0.0057 0.0096
Echinococcus multilocularis insulin receptor 0.1861 0.5881 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0181 0.0307
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1861 0.5881 1
Plasmodium vivax alpha/beta hydrolase, putative 0.0077 0.0181 0.0307
Brugia malayi Immunoglobulin I-set domain containing protein 0.0054 0.0107 0.0107
Echinococcus multilocularis 0.0548 0.1685 0.2865
Plasmodium falciparum epoxide hydrolase 2 0.0077 0.0181 0.0307
Echinococcus granulosus defective proboscis extension response 0.0062 0.0134 0.0228
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.1269 0.3989 0.6782
Entamoeba histolytica hypothetical protein 0.0043 0.0074 0.0043
Toxoplasma gondii phospholipase 0.0077 0.0181 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0038 0.0057 0.0057
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0038 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0181 0.0307
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0051 0.0051
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0169 0.018
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0036 0.0051 0.0086
Brugia malayi hypothetical protein 0.0038 0.0057 0.0057
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0077 0.0181 0.0307
Plasmodium falciparum prodrug activation and resistance esterase 0.0077 0.0181 0.0307
Plasmodium vivax PST-A protein 0.0077 0.0181 0.0307
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0077 0.0181 0.0307
Leishmania major hypothetical protein, conserved 0.0077 0.0181 0.0307
Plasmodium falciparum esterase, putative 0.0077 0.0181 0.0307
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0077 0.0181 0.0307
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0038 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Echinococcus multilocularis epidermal growth factor receptor 0.1837 0.5805 0.987
Loa Loa (eye worm) TK/ACK protein kinase 0.0038 0.0057 0.0057
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0051 0.0097 0.5
Echinococcus multilocularis activated cdc42 kinase 1 0.0038 0.0057 0.0096
Echinococcus granulosus fibroblast growth factor receptor 4 0.0038 0.0057 0.0096
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0077 0.0181 0.0307
Entamoeba histolytica hypothetical protein 0.0077 0.0181 0.0307
Schistosoma mansoni nephrin 0.0078 0.0185 0.0314
Loa Loa (eye worm) hypothetical protein 0.0373 0.1126 0.1126
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1307 0.411 1
Entamoeba histolytica hypothetical protein 0.0043 0.0074 0.0043
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0038 0.0057 0.0057
Echinococcus granulosus tyrosine protein kinase ABL1 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Brugia malayi C-terminal src kinase protein 1 0.0038 0.0057 0.0057
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0057 0.0096
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0057 0.0096
Schistosoma mansoni cell adhesion molecule 0.0083 0.0199 0.0338
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Echinococcus granulosus tyrosine protein kinase shark 0.0038 0.0057 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0169 0.018
Echinococcus granulosus MAM 0.0373 0.1126 0.1914
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.1307 0.411 1
Brugia malayi SH2 domain containing protein 0.0038 0.0057 0.0057
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0057 0.0096
Echinococcus multilocularis Immunoglobulin 0.0062 0.0134 0.0228
Echinococcus multilocularis fatty acid amide hydrolase 1 0.042 0.1279 0.2174
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0038 0.0057 0.0096
Echinococcus granulosus ephrin type A receptor 4 A 0.0038 0.0057 0.0096
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Schistosoma mansoni cell adhesion molecule 0.0036 0.0051 0.0086
Echinococcus multilocularis hemicentin 1 0.0036 0.0051 0.0086
Loa Loa (eye worm) TK protein kinase 0.0038 0.0057 0.0057
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.1269 0.3989 0.6782
Echinococcus granulosus tyrosine protein kinase HCK 0.0038 0.0057 0.0096
Loa Loa (eye worm) TK protein kinase 0.0038 0.0057 0.0057
Trypanosoma cruzi serine peptidase, putative 0.0077 0.0181 0.0307
Schistosoma mansoni titin 0.0036 0.0051 0.0086
Plasmodium falciparum alpha/beta hydrolase, putative 0.0077 0.0181 0.0307
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0038 0.0057 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Plasmodium vivax PST-A protein 0.1307 0.411 1
Brugia malayi Raf kinase 0.0038 0.0057 0.0057
Echinococcus granulosus retinal guanylyl cyclase 2 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0038 0.0057 0.0096
Toxoplasma gondii hypothetical protein 0.0077 0.0181 1
Entamoeba histolytica hypothetical protein 0.0043 0.0074 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Echinococcus multilocularis abhydrolase domain containing 3 0.0077 0.0181 0.0308
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Loa Loa (eye worm) TK protein kinase 0.0038 0.0057 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0051 0.0051
Loa Loa (eye worm) TK/RYK protein kinase 0.0038 0.0057 0.0057
Loa Loa (eye worm) amidase 0.0051 0.0097 0.0097
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0051 0.0097 0.01
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0077 0.0181 0.0308
Trypanosoma cruzi serine peptidase, putative 0.0077 0.0181 0.0307
Echinococcus multilocularis receptor type guanylyl cyclase 0.0038 0.0057 0.0096
Echinococcus granulosus retinal guanylyl cyclase 2 0.0038 0.0057 0.0096
Plasmodium falciparum exported lipase 2 0.0077 0.0181 0.0307
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0051 0.0051
Echinococcus multilocularis tyrosine protein kinase HCK 0.0038 0.0057 0.0096
Loa Loa (eye worm) TK protein kinase 0.0038 0.0057 0.0057
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0077 0.0181 0.0307
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0057 0.0096
Plasmodium vivax alpha/beta hydrolase, putative 0.0077 0.0181 0.0307
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.0057 0.0057
Schistosoma mansoni vesicular amine transporter 0.0062 0.0134 0.0228
Echinococcus granulosus kinase suppressor of Ras 1 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Brugia malayi Tyrosine-protein kinase PR2 0.0038 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) TK/CSK protein kinase 0.0038 0.0057 0.0057
Echinococcus multilocularis tyrosine kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Chlamydia trachomatis hydrolase 0.0077 0.0181 1
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0077 0.0181 0.0307
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0038 0.0057 0.0096
Toxoplasma gondii phospholipase/carboxylesterase 0.0077 0.0181 1
Toxoplasma gondii hypothetical protein 0.0077 0.0181 1
Echinococcus granulosus hemicentin 1 0.0036 0.0051 0.0086
Echinococcus multilocularis neuroglian 0.0078 0.0185 0.0314
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0077 0.0181 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0157 0.0266
Echinococcus multilocularis natriuretic peptide receptor 1 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Plasmodium vivax unspecified product 0.0077 0.0181 0.0307
Plasmodium falciparum esterase, putative 0.0077 0.0181 0.0307
Loa Loa (eye worm) hypothetical protein 0.2738 0.8684 0.8687
Echinococcus granulosus tyrosine kinase 0.0038 0.0057 0.0096
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0077 0.0181 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Toxoplasma gondii hypothetical protein 0.0077 0.0181 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.025 0.025
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Schistosoma mansoni hypothetical protein 0.0373 0.1126 0.1914
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0057 0.0096
Plasmodium vivax unspecified product 0.0077 0.0181 0.0307
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0038 0.0057 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0181 0.0307
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0051 0.0051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0074 0.0126
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0038 0.0057 0.0096
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Onchocerca volvulus 0.0038 0.0057 0.0036
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0057 0.0096
Echinococcus granulosus tyrosine kinase 0.0038 0.0057 0.0096
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0051 0.0097 0.0165
Schistosoma mansoni serine/threonine RGC 0.0038 0.0057 0.0096
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0077 0.0181 0.0307
Echinococcus granulosus receptor type guanylyl cyclase 0.0038 0.0057 0.0096
Brugia malayi putative amidase 0.0051 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.042 0.1279 0.1279
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0083 0.0199 0.0338
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Plasmodium falciparum esterase, putative 0.1307 0.411 1
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0043 0.0074 0.0043
Brugia malayi Fibronectin type III domain containing protein 0.0062 0.0134 0.0134
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0157 0.0266
Echinococcus granulosus c src tyrosine kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Brugia malayi MGC83647 protein 0.0077 0.0181 0.0181
Loa Loa (eye worm) TK protein kinase 0.0054 0.0107 0.0108
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0038 0.0057 0.0096
Schistosoma mansoni peptidase 0.0077 0.0181 0.0308
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0057 0.0096
Brugia malayi integrin-linked kinase 0.0038 0.0057 0.0057
Echinococcus multilocularis heat shock protein 70 0.0038 0.0057 0.0096
Echinococcus granulosus natriuretic peptide receptor 1 0.0038 0.0057 0.0096
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0157 0.0246
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0051 0.0097 0.0165
Schistosoma mansoni tyrosine kinase 0.1307 0.411 0.6988
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Brugia malayi Amidase family protein 0.0051 0.0097 0.0097
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0077 0.0181 0.0308
Brugia malayi Protein kinase domain containing protein 0.0842 0.2626 0.2626
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0057 0.0096
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.0829 0.0829
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1044 0.3271 0.3272
Echinococcus multilocularis integrin linked protein kinase 0.0038 0.0057 0.0096
Brugia malayi hypothetical protein 0.0373 0.1126 0.1126
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0074 0.0126
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0038 0.0057 0.0096
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1307 0.411 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0038 0.0057 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0057 0.0096
Echinococcus granulosus protein tyrosine kinase 0.0038 0.0057 0.0096
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0077 0.0181 0.0307
Loa Loa (eye worm) TK/EPH protein kinase 0.0038 0.0057 0.0057
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0169 0.0278
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0181 0.0307
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0169 0.018
Echinococcus granulosus lachesin 0.0036 0.0051 0.0086
Plasmodium falciparum lysophospholipase, putative 0.1307 0.411 1
Brugia malayi Peroxidasin 0.0036 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0373 0.1126 0.1914
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0054 0.0107 0.0183
Onchocerca volvulus 0.0038 0.0057 0.0036
Loa Loa (eye worm) hypothetical protein 0.0077 0.0181 0.0181
Echinococcus multilocularis tyrosine protein kinase Abl 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0062 0.0134 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0181 0.0307
Echinococcus multilocularis tyrosine protein kinase 0.0038 0.0057 0.0096
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0057 0.0096
Trypanosoma cruzi monoglyceride lipase, putative 0.1307 0.411 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0054 0.0107 0.0183
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0038 0.0057 0.0036
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Plasmodium falciparum alpha/beta hydrolase, putative 0.0077 0.0181 0.0307
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0057 0.0096
Leishmania major hypothetical protein, conserved 0.0077 0.0181 0.0307
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0038 0.0057 0.0096
Echinococcus granulosus tyrosine kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) serine/threonine protein kinase 0.0038 0.0057 0.0057
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0077 0.0181 0.0307
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0181 0.0307
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0051 0.0051
Loa Loa (eye worm) amidase 0.0051 0.0097 0.0097
Echinococcus multilocularis Immunoglobulin 0.0062 0.0134 0.0228
Brugia malayi Protein kinase domain containing protein 0.1861 0.5881 0.5881
Loa Loa (eye worm) TK protein kinase 0.0038 0.0057 0.0057
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0038 0.0057 0.0057
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.1837 0.5805 0.987
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0077 0.0181 0.0307
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0057 0.0096
Plasmodium vivax PST-A protein 0.0077 0.0181 0.0307
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0038 0.0057 0.0096
Plasmodium vivax PST-A protein 0.0077 0.0181 0.0307
Plasmodium vivax PST-A protein 0.0077 0.0181 0.0307
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0051 0.0051
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0038 0.0057 0.0096
Toxoplasma gondii hypothetical protein 0.0077 0.0181 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.017 0.0289
Plasmodium falciparum BEM46-like protein, putative 0.0077 0.0181 0.0307
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0038 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0181 0.0307
Loa Loa (eye worm) hypothetical protein 0.0062 0.0134 0.0134
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0062 0.0134 0.0134
Echinococcus multilocularis roundabout 2 0.0036 0.0051 0.0086
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0057 0.0096
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0038 0.0057 0.0096
Echinococcus granulosus tyrosine protein kinase Blk 0.0038 0.0057 0.0096
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.0057 0.0096
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.0134 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.1307 0.411 1
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Schistosoma mansoni septate junction protein 0.0036 0.0051 0.0086
Brugia malayi Protein C20orf22 0.0077 0.0181 0.0181
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.0057 0.0057
Echinococcus multilocularis tyrosine protein kinase pr2 0.0038 0.0057 0.0096
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0038 0.0057 0.0096
Entamoeba histolytica hypothetical protein 0.0077 0.0181 0.0307
Plasmodium vivax lysophospholipase, putative 0.0077 0.0181 0.0307
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0181 0.0307
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0169 0.018
Loa Loa (eye worm) hypothetical protein 0.0077 0.0181 0.0181
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0077 0.0181 0.0307
Loa Loa (eye worm) hypothetical protein 0.0062 0.0134 0.0134
Echinococcus granulosus integrin linked protein kinase 0.0038 0.0057 0.0096
Mycobacterium tuberculosis Possible lysophospholipase 0.1307 0.411 1
Chlamydia trachomatis acyltransferase family protein 0.0077 0.0181 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0074 0.0126
Schistosoma mansoni ephrin receptor 0.0038 0.0057 0.0096
Onchocerca volvulus 0.0038 0.0057 0.0036
Onchocerca volvulus 0.0038 0.0057 0.0036
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Echinococcus multilocularis MAM 0.0373 0.1126 0.1914
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0036 0.0051 0.0086
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0036 0.0051 0.0086
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0038 0.0057 0.0057
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1307 0.411 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0038 0.0057 0.0096
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0181 0.0307
Echinococcus granulosus raf serine:threonine protein kinase 0.0038 0.0057 0.0096
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0062 0.0134 0.0228
Onchocerca volvulus 0.0038 0.0057 0.0036
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0038 0.0057 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0057 0.0096
Brugia malayi Receptor family ligand binding region containing protein 0.0038 0.0057 0.0057
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.0057 0.0057
Onchocerca volvulus 0.0038 0.0057 0.0036
Brugia malayi SH2 domain containing protein 0.0038 0.0057 0.0057
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0077 0.0181 0.0307
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0038 0.0057 0.0096
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Echinococcus granulosus Phospholipase carboxylesterase 0.0077 0.0181 0.0308
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Echinococcus granulosus contactin 0.0036 0.0051 0.0086
Echinococcus multilocularis neuroglian 0.0036 0.0051 0.0086
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0062 0.0134 0.0228
Trypanosoma cruzi amidase, putative 0.0051 0.0097 0.01
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Schistosoma mansoni tyrosine protein kinase 0.0038 0.0057 0.0096
Echinococcus granulosus tyrosine protein kinase Srms 0.0038 0.0057 0.0096
Loa Loa (eye worm) TK/ABL protein kinase 0.0038 0.0057 0.0057
Brugia malayi hypothetical protein 0.0062 0.0134 0.0134
Brugia malayi Immunoglobulin I-set domain containing protein 0.1044 0.3271 0.3271
Schistosoma mansoni septate junction protein 0.0036 0.0051 0.0086
Trypanosoma cruzi amidase, putative 0.0051 0.0097 0.01
Schistosoma mansoni cpg binding protein 0.0037 0.0052 0.0089
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0057 0.0096
Mycobacterium ulcerans hypothetical protein 0.0077 0.0181 0.0209
Loa Loa (eye worm) SRC-1 0.0038 0.0057 0.0057
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Echinococcus granulosus neuroglian 0.0036 0.0051 0.0086
Loa Loa (eye worm) TK/ALK protein kinase 0.3149 0.9997 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0038 0.0057 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0181 0.0307
Echinococcus granulosus retinal guanylyl cyclase 2 0.0038 0.0057 0.0096
Loa Loa (eye worm) TK protein kinase 0.0038 0.0057 0.0057
Echinococcus granulosus cpg binding protein 0.0037 0.0052 0.0089
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Echinococcus granulosus protein kinase 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1307 0.411 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0051 0.0051
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Schistosoma mansoni cell adhesion molecule 0.0036 0.0051 0.0086
Echinococcus multilocularis tyrosine protein kinase shark 0.0038 0.0057 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0181 0.0307
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0077 0.0181 0.0307
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Brugia malayi amidase 0.042 0.1279 0.1279
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0077 0.0181 1
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0051 0.0097 0.0165
Brugia malayi hypothetical protein 0.0038 0.0057 0.0057
Mycobacterium tuberculosis Conserved hypothetical protein 0.0077 0.0181 0.0209
Echinococcus multilocularis protein tyrosine kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0142 0.0142
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0077 0.0181 0.0307
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0051 0.0051
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0077 0.0181 0.0307
Loa Loa (eye worm) TK protein kinase 0.0038 0.0057 0.0057
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0077 0.0181 0.0307
Echinococcus multilocularis tyrosine kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) TK/DDR protein kinase 0.0038 0.0057 0.0057
Onchocerca volvulus 0.0038 0.0057 0.0036
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0077 0.0181 0.0181
Schistosoma mansoni tyrosine kinase 0.0074 0.0172 0.0293
Schistosoma mansoni roundabout 0.0036 0.0051 0.0086
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0051 0.0097 0.01
Echinococcus granulosus roundabout 2 0.0098 0.025 0.0425
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0062 0.0134 0.0228
Schistosoma mansoni nephrin 0.0036 0.0051 0.0086
Loa Loa (eye worm) hypothetical protein 0.0077 0.0181 0.0181
Brugia malayi Guanylyl cyclase protein 23 0.0038 0.0057 0.0057
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0036 0.0051 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0181 0.0307
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0038 0.0057 0.0096
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0077 0.0181 0.0307
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0038 0.0057 0.0096
Leishmania major hypothetical protein, conserved 0.0051 0.0097 0.01
Echinococcus granulosus activin receptor type 0.0038 0.0057 0.0096
Brugia malayi CXXC zinc finger family protein 0.0035 0.0046 0.0046
Plasmodium falciparum lysophospholipase, putative 0.1307 0.411 1
Mycobacterium ulcerans hydrolase 0.0077 0.0181 0.0209
Echinococcus granulosus neuroglian 0.0078 0.0185 0.0314
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0038 0.0057 0.0057
Echinococcus granulosus fatty acid amide hydrolase 1 0.042 0.1279 0.2174
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0051 0.0097 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0169 0.0288
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0077 0.0181 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0038 0.0057 0.0096
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0169 0.0288
Onchocerca volvulus 0.0923 0.2885 0.9428
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0038 0.0057 0.0096
Brugia malayi Amidase family protein 0.0051 0.0097 0.0097
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1307 0.411 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.025 0.025
Plasmodium falciparum lysophospholipase, putative 0.1307 0.411 1
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0051 0.0097 0.01
Trichomonas vaginalis conserved hypothetical protein 0.1307 0.411 1
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Echinococcus multilocularis tyrosine protein kinase Blk 0.0038 0.0057 0.0096
Brugia malayi ephrin receptor 1 precursor 0.0038 0.0057 0.0057
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0077 0.0181 0.0307
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Onchocerca volvulus 0.0038 0.0057 0.0036
Echinococcus multilocularis tyrosine protein kinase Srms 0.0038 0.0057 0.0096
Onchocerca volvulus Tyrosine kinase homolog 0.0977 0.3058 1
Schistosoma mansoni fatty-acid amide hydrolase 0.042 0.1279 0.2174
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.0057 0.0057
Plasmodium falciparum exported lipase 1 0.0077 0.0181 0.0307
Echinococcus multilocularis activin receptor type 0.0038 0.0057 0.0096
Schistosoma mansoni protein tyrosine kinase 0.0038 0.0057 0.0096
Schistosoma mansoni cpg binding protein 0.0035 0.0046 0.0078
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0038 0.0057 0.0057
Loa Loa (eye worm) TK/Met protein kinase 0.0038 0.0057 0.0057
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Echinococcus granulosus peroxidasin 0.0036 0.0051 0.0086
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0036 0.0051 0.0086
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0077 0.0181 0.0307
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0038 0.0057 0.0057
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0038 0.0057 0.0096
Onchocerca volvulus 0.0038 0.0057 0.0036
Echinococcus multilocularis ephrin type A receptor 4 A 0.0038 0.0057 0.0096
Onchocerca volvulus 0.0038 0.0057 0.0036
Brugia malayi follicle stimulating hormone receptor 0.028 0.0829 0.0829
Echinococcus granulosus roundabout 2 0.0036 0.0051 0.0086
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Brugia malayi hypothetical protein 0.0038 0.0057 0.0057
Brugia malayi hypothetical protein 0.0043 0.0074 0.0074
Schistosoma mansoni tyrosine kinase 0.1861 0.5881 1
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Echinococcus granulosus tyrosine protein kinase 0.0038 0.0057 0.0096
Echinococcus granulosus activated cdc42 kinase 1 0.0038 0.0057 0.0096
Echinococcus multilocularis protein kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) TK/FAK protein kinase 0.0038 0.0057 0.0057
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0038 0.0057 0.0057
Plasmodium falciparum alpha/beta hydrolase, putative 0.0077 0.0181 0.0307
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0038 0.0057 0.0096
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0077 0.0181 0.0307
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0169 0.0288
Schistosoma mansoni neuroglian 0.0036 0.0051 0.0086
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0038 0.0057 0.0096
Brugia malayi Furin-like cysteine rich region family protein 0.1837 0.5805 0.5805
Brugia malayi MGC79044 protein 0.0077 0.0181 0.0181
Echinococcus granulosus abhydrolase domain containing protein 13 0.0077 0.0181 0.0308
Brugia malayi bone morphogenetic protein type 1 receptor 0.0038 0.0057 0.0057
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0038 0.0057 0.0057
Echinococcus multilocularis protein kinase 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Mycobacterium ulcerans lysophospholipase 0.1307 0.411 1
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Onchocerca volvulus 0.0038 0.0057 0.0036
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0057 0.0096
Toxoplasma gondii protein c14orf29, putative 0.0077 0.0181 1
Leishmania major monoglyceride lipase, putative 0.1307 0.411 1
Schistosoma mansoni cell adhesion molecule 0.0036 0.0051 0.0086
Echinococcus granulosus epidermal growth factor receptor 0.1837 0.5805 0.987
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0046 0.0046
Echinococcus multilocularis cpg binding protein 0.0037 0.0052 0.0089
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Echinococcus granulosus insulin receptor 0.1861 0.5881 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0077 0.0181 0.0307
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.1307 0.411 1
Onchocerca volvulus 0.0038 0.0057 0.0036
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0077 0.0181 0.0307
Loa Loa (eye worm) hypothetical protein 0.0083 0.0199 0.0199
Echinococcus granulosus epidermal growth factor receptor 0.1307 0.411 0.6988
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Brugia malayi SRC-1 0.0038 0.0057 0.0057
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0038 0.0057 0.0096
Echinococcus granulosus fatty acid amide hydrolase 1 0.042 0.1279 0.2174
Loa Loa (eye worm) hypothetical protein 0.0804 0.2504 0.2505
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Onchocerca volvulus 0.0038 0.0057 0.0036
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0038 0.0057 0.0096
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1307 0.411 0.6988
Echinococcus granulosus abhydrolase domain containing 3 0.0077 0.0181 0.0308
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Plasmodium falciparum alpha/beta hydrolase, putative 0.0077 0.0181 0.0307
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.1861 0.5881 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0036 0.0051 0.0051
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0051 0.0051
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0036 0.0051 0.0086
Loa Loa (eye worm) TK/INSR protein kinase 0.1861 0.5881 0.5883
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0157 0.0266
Loa Loa (eye worm) TK protein kinase 0.0038 0.0057 0.0057
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0169 0.9052
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0169 0.0288
Plasmodium vivax PST-A protein 0.0077 0.0181 0.0307
Loa Loa (eye worm) TK protein kinase 0.0038 0.0057 0.0057
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0157 0.0148
Mycobacterium ulcerans hypothetical protein 0.0077 0.0181 0.0209
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0038 0.0057 0.0096
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0057 0.0096
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0057 0.0096
Echinococcus multilocularis roundabout 2 0.0036 0.0051 0.0086
Schistosoma mansoni tyrosine kinase 0.1269 0.3989 0.6782
Echinococcus multilocularis epidermal growth factor receptor 0.1307 0.411 0.6988
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0057 0.0096
Toxoplasma gondii peptidase S15, putative 0.0077 0.0181 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0038 0.0057 0.0057
Schistosoma mansoni fatty-acid amide hydrolase 0.0051 0.0097 0.0165
Loa Loa (eye worm) hypothetical protein 0.0077 0.0181 0.0181
Echinococcus multilocularis fatty acid amide hydrolase 1 0.042 0.1279 0.2174
Schistosoma mansoni protein kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) TK/ROR protein kinase 0.0054 0.0107 0.0108
Echinococcus multilocularis kinase suppressor of Ras 1 0.0038 0.0057 0.0096
Loa Loa (eye worm) protein kinase domain-containing protein 0.0038 0.0057 0.0057
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0038 0.0057 0.0096
Brugia malayi Prion-like- 0.0036 0.0051 0.0051
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0157 0.0157
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Echinococcus granulosus twitchin 0.0078 0.0185 0.0314
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Echinococcus granulosus Immunoglobulin 0.0062 0.0134 0.0228
Echinococcus multilocularis FL cytokine receptor 0.0038 0.0057 0.0096
Echinococcus granulosus activated cdc42 kinase 1 0.0038 0.0057 0.0096
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0051 0.0097 0.0165
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0057 0.0096
Echinococcus multilocularis hemicentin 1 0.0036 0.0051 0.0086
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0051
Plasmodium vivax lysophospholipase, putative 0.0077 0.0181 0.0307
Schistosoma mansoni cpg binding protein 0.0037 0.0052 0.0089
Plasmodium vivax lysophospholipase, putative 0.0077 0.0181 0.0307
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Trichomonas vaginalis valacyclovir hydrolase, putative 0.1307 0.411 1
Trypanosoma brucei monoglyceride lipase, putative 0.1307 0.411 1
Onchocerca volvulus 0.0373 0.1126 0.3585
Echinococcus multilocularis tyrosine protein kinase otk 0.0036 0.0051 0.0086
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0038 0.0057 0.0096
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1861 0.5881 1
Echinococcus multilocularis roundabout 2 0.0098 0.025 0.0425
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0051 0.0051
Schistosoma mansoni amidase 0.042 0.1279 0.2174
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Entamoeba histolytica ;Alias 0.0077 0.0181 0.0307
Echinococcus granulosus tyrosine protein kinase otk 0.0036 0.0051 0.0086
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0157 0.0148
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Loa Loa (eye worm) TK/EGFR protein kinase 0.1837 0.5805 0.5807
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0062 0.0134 0.0134
Onchocerca volvulus 0.0038 0.0057 0.0036
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0038 0.0057 0.0096
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0038 0.0057 0.0036
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0057 0.0096
Echinococcus multilocularis lachesin 0.0036 0.0051 0.0086
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0077 0.0181 0.0308
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0057 0.0057
Echinococcus multilocularis peroxidasin 0.0036 0.0051 0.0086
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0038 0.0057 0.0096
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0077 0.0181 0.0308
Loa Loa (eye worm) hypothetical protein 0.0062 0.0134 0.0134
Schistosoma mansoni hypothetical protein 0.0038 0.0057 0.0096
Loa Loa (eye worm) hypothetical protein 0.0373 0.1126 0.1126
Plasmodium falciparum lysophospholipase, putative 0.0077 0.0181 0.0307
Echinococcus granulosus fatty acid amide hydrolase 1 0.0051 0.0097 0.0165
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0057 0.0096
Schistosoma mansoni hypothetical protein 0.0043 0.0074 0.0126
Trypanosoma brucei monoglyceride lipase, putative 0.1307 0.411 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0038 0.0057 0.0096
Brugia malayi Protein kinase domain containing protein 0.0038 0.0057 0.0057
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.1307 0.411 1
Onchocerca volvulus 0.0373 0.1126 0.3585
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0057 0.0096
Schistosoma mansoni ephrin receptor 0.0038 0.0057 0.0096
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0157 0.0148
Schistosoma mansoni tyrosine kinase 0.0038 0.0057 0.0096
Mycobacterium ulcerans hypothetical protein 0.1307 0.411 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0145 0.7097

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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