TDR Targets

Basic information

Technical information

TDR Targets ID: 1375794
Name: 2-(4-ethylphenoxy)-N-[2,2,2-trichloro-1-[(2,4 -dimethylphenyl)carbamothioylamino]ethyl]acet amide
MW: 488.858 | Formula: C21H24Cl3N3O2S
H donors: 2 H acceptors: 1 LogP: 6.32 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)OCC(=O)NC(C(Cl)(Cl)Cl)N=C(Nc1ccc(cc1C)C)S
InChi: 1S/C21H24Cl3N3O2S/c1-4-15-6-8-16(9-7-15)29-12-18(28)26-19(21(22,23)24)27-20(30)25-17-10-5-13(2)11-14(17)3/h5-11,19H,4,12H2,1-3H3,(H,26,28)(H2,25,27,30)
InChiKey: GQWBXOYZCDSIJC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-ethylphenoxy)-N-[2,2,2-trichloro-1-[[[(2,4-dimethylphenyl)amino]-thioxomethyl]amino]ethyl]acetamide
2-(4-ethylphenoxy)-N-[2,2,2-trichloro-1-[(2,4-dimethylphenyl)thiocarbamoylamino]ethyl]acetamide
2-(4-ethylphenoxy)-N-[2,2,2-trichloro-1-[(2,4-dimethylphenyl)carbamothioylamino]ethyl]ethanamide
2-(4-ethylphenoxy)-N-[2,2,2-trichloro-1-({[(2,4-dimethylphenyl)amino]carbonothioyl}amino)ethyl]acetamide
MLS000574370
SMR000195033

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	DNA-damage inducible transcript 3	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Streptococcus pyogenes serotype M1	Streptokinase A	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	X-box binding protein 1	Starlite/ChEMBL	No references
Homo sapiens	arachidonate 15-lipoxygenase, type B	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac	Get druggable targets OG5_134980	All targets in OG5_134980
Babesia bovis	NAC domain containing protein	Get druggable targets OG5_127333	All targets in OG5_127333
Loa Loa (eye worm)	ICD-1 protein	Get druggable targets OG5_127333	All targets in OG5_127333
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium yoelii	basic transcription factor 3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Trypanosoma brucei gambiense	nascent polypeptide associated complex alpha subunit, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac	Get druggable targets OG5_134980	All targets in OG5_134980
Leishmania mexicana	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Cryptosporidium hominis	NAC domain protein	Get druggable targets OG5_127333	All targets in OG5_127333
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Plasmodium falciparum	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania donovani	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Toxoplasma gondii	NAC domain-containing protein	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium berghei	transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma brucei	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma cruzi	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Brugia malayi	beta-NAC-like protein	Get druggable targets OG5_127333	All targets in OG5_127333
Cryptosporidium parvum	BTF domain, basal transcription factor	Get druggable targets OG5_127333	All targets in OG5_127333
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Neospora caninum	hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus multilocularis	X box binding protein 1	Get druggable targets OG5_134980	All targets in OG5_134980
Leishmania major	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium knowlesi	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_134980	All targets in OG5_134980
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Entamoeba histolytica	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania braziliensis	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus multilocularis	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Echinococcus granulosus	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Plasmodium vivax	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Theileria parva	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma cruzi	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus granulosus	X box binding protein 1	Get druggable targets OG5_134980	All targets in OG5_134980
Schistosoma japonicum	ko:K01527 nascent polypeptide-associated complex subunit beta, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania infantum	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus granulosus	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative	Get druggable targets OG5_127482	All targets in OG5_127482
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0048	0.0985	0.0985
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0096	0.2294	0.5217
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0144	0.0175
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.006	0.1318	0.0563
Plasmodium vivax	multidomain scavenger receptor, putative	0.0024	0.0318	0.0477
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2294	0.2581
Loa Loa (eye worm)	hypothetical protein	0.0079	0.184	0.2247
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0861	0.193
Echinococcus multilocularis	insulin receptor	0.0048	0.0985	0.0985
Brugia malayi	PXA domain containing protein	0.0019	0.0196	0.0271
Brugia malayi	jmjC domain containing protein	0.0036	0.0643	0.0888
Schistosoma mansoni	hypothetical protein	0.0171	0.4357	0.4735
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Echinococcus granulosus	Polycystic kidney disease protein	0.0024	0.0318	0.0318
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0172	0.4378	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0048	0.0985	0.0985
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Echinococcus granulosus	epidermal growth factor receptor	0.0081	0.1884	0.1884
Echinococcus multilocularis	lamin dm0	0.0033	0.0558	0.0558
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0218	0.0236
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0253	0.0309
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0196	0.024
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0196	0.0196
Loa Loa (eye worm)	glutaminase	0.0276	0.7234	0.8835
Trypanosoma cruzi	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Echinococcus granulosus	insulin receptor	0.0048	0.0985	0.0985
Echinococcus multilocularis	chromobox protein 1	0.007	0.1594	0.1594
Echinococcus multilocularis	peregrin	0.0029	0.0473	0.0473
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0161	0.4087	0.4991
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0558	0.0682
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0311	0.8188	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.2294	0.5217
Schistosoma mansoni	DNA polymerase eta	0.0079	0.184	0.2
Onchocerca volvulus	Hexokinase homolog	0.005	0.1049	0.2567
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0188	0.0188
Plasmodium falciparum	basic transcription factor 3b, putative	0.0042	0.0823	0.1647
Trichomonas vaginalis	ran, putative	0.0021	0.0253	0.0264
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0081	0.1884	0.1884
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0473	0.0851
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0196	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0513	0.0627
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0196	0.0199
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0387	0.084
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0142	0.3569	0.3569
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2294	0.2581
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0253	0.0309
Echinococcus granulosus	beta-adrenergic receptor kinase	0.002	0.0218	0.0218
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0643	0.0698
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0188	0.0229
Echinococcus multilocularis	hexokinase	0.008	0.1871	0.1871
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0387	0.0623
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0313	0.0671
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0387	0.0649
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0823	0.0911
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0431	0.0466
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2294	0.2581
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0861	0.193
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0643	0.0643
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0096	0.2294	0.5217
Echinococcus granulosus	geminin	0.0171	0.4357	0.4357
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0253	0.0534
Schistosoma mansoni	lipoxygenase	0.0142	0.3569	0.3879
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0558	0.0607
Echinococcus multilocularis	epidermal growth factor receptor	0.0081	0.1884	0.1884
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0021	0.0248	0.0258
Loa Loa (eye worm)	hexokinase	0.0025	0.0348	0.0425
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0196	0.0213
Echinococcus multilocularis	X box binding protein 1	0.0348	0.9201	0.9201
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0063	0.1395	0.3155
Schistosoma mansoni	hypothetical protein	0.0019	0.0188	0.0204
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0196	0.0196
Echinococcus granulosus	chromobox protein 1	0.007	0.1594	0.1594
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0021	0.0248	0.0258
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0063	0.1395	0.3155
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0464	0.1017
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0122	0.0232
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2294	0.2581
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.3617	0.4417
Schistosoma mansoni	lamin	0.0033	0.0558	0.0607
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.2294	0.5217
Brugia malayi	hexokinase	0.008	0.1871	0.2586
Brugia malayi	polk-prov protein	0.0044	0.0858	0.1186
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Echinococcus multilocularis	chromobox protein 1	0.007	0.1594	0.1594
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0196	0.0196
Schistosoma mansoni	tyrosine kinase	0.008	0.1861	0.2022
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1315	0.1607
Brugia malayi	glutaminase DH11.1	0.0276	0.7234	1
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0161	0.4087	0.4087
Trypanosoma brucei	polo-like protein kinase	0.0096	0.2294	0.5217
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0334	0.8828	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0054	0.1135	0.1233
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0196	0.0213
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0172	0.4378	0.4947
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0196	0.0213
Trypanosoma brucei	unspecified product	0.0074	0.1688	0.3828
Trichomonas vaginalis	glutaminase, putative	0.0276	0.7234	0.8191
Echinococcus granulosus	GPCR family 2	0.0019	0.0188	0.0188
Schistosoma mansoni	chromobox protein	0.007	0.1594	0.1733
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.2309	0.2309
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0823	0.0911
Brugia malayi	Hexokinase family protein	0.0025	0.0348	0.0481
Onchocerca volvulus		0.008	0.1871	0.4578
Onchocerca volvulus		0.005	0.1049	0.2567
Echinococcus multilocularis	expressed protein	0.0377	1	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0042	0.0827	0.1681
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0387	0.0472
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0464	0.0464
Brugia malayi	hexokinase type II	0.0026	0.0367	0.0507
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1315	0.1818
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0464	0.0819
Schistosoma mansoni	hypothetical protein	0.0041	0.0793	0.0862
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Leishmania major	basic transcription factor 3a, putative	0.0042	0.0823	0.1841
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.0318	0.0318
Plasmodium falciparum	phosphoglycerate kinase	0.0172	0.4378	1
Brugia malayi	hypothetical protein	0.0019	0.0196	0.0271
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Toxoplasma gondii	hexokinase	0.008	0.1871	0.4126
Schistosoma mansoni	tyrosine kinase	0.008	0.1861	0.2022
Brugia malayi	Importin beta-1 subunit	0.0029	0.0464	0.0641
Leishmania major	hexokinase, putative	0.008	0.1871	0.4246
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0096	0.2294	0.2801
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0253	0.035
Plasmodium vivax	hexokinase, putative	0.008	0.1871	0.4119
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.002	0.0218	0.0266
Trypanosoma cruzi	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0196	0.0199
Plasmodium vivax	phosphoglycerate kinase, putative	0.0172	0.4378	1
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0063	0.1395	0.3155
Echinococcus multilocularis	transcription factor btf3	0.0042	0.0823	0.0823
Brugia malayi	intermediate filament protein	0.0033	0.0558	0.0771
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0196	0.0196
Schistosoma mansoni	hypothetical protein	0.0019	0.0188	0.0204
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0172	0.4378	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0643	0.0698
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.1332	0.1627
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0096	0.2294	0.2294
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Brugia malayi	PHD-finger family protein	0.0029	0.0473	0.0653
Trypanosoma cruzi	DNA damage repair protein, putative	0.0017	0.0122	0.0232
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0172	0.4378	1
Trypanosoma brucei	DNA polymerase IV, putative	0.008	0.1871	0.4247
Loa Loa (eye worm)	hexokinase	0.005	0.1049	0.1281
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0122	0.0232
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0829	0.2028
Schistosoma mansoni	importin beta-1	0.0029	0.0464	0.0504
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Trypanosoma brucei	hypothetical protein, conserved	0.0017	0.0122	0.0232
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.033	0.0351
Echinococcus granulosus	phosphoglycerate kinase 1	0.0172	0.4378	0.4378
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0023	0.0304	0.0456
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0313	0.0332
Giardia lamblia	Kinase, PLK	0.0096	0.2294	0.5103
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0161	0.4087	1
Loa Loa (eye worm)	hypothetical protein	0.0122	0.3011	0.3677
Leishmania major	GTP-binding protein, putative	0.0021	0.0253	0.0534
Echinococcus granulosus	X box binding protein 1	0.0348	0.9201	0.9201
Brugia malayi	RNA, U transporter 1	0.0083	0.1936	0.2676
Schistosoma mansoni	tyrosine kinase	0.0048	0.0985	0.1071
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0196	0.024
Leishmania major	DNA damage repair protein, putative	0.0017	0.0122	0.0232
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.0318	0.0318
Brugia malayi	hypothetical protein	0.0019	0.0196	0.0271
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0017	0.0122	0.0028
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0063	0.1395	0.3155
Brugia malayi	Protein kinase domain containing protein	0.0161	0.4087	0.5649
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0096	0.2294	0.5612
Giardia lamblia	PHD finger protein 15	0.0029	0.0473	0.0825
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0196	0.0199
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.002	0.0218	0.0301
Trypanosoma brucei	hexokinase, putative	0.008	0.1871	0.4246
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0188	0.0188
Loa Loa (eye worm)	hexokinase	0.008	0.1871	0.2285
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0096	0.2294	0.2294
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0558	0.0682
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Schistosoma mansoni	tyrosine kinase	0.0048	0.0985	0.1071
Mycobacterium ulcerans	DNA polymerase IV	0.008	0.1871	0.246
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0861	0.193
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0473	0.0577
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.002	0.0218	0.0266
Onchocerca volvulus		0.0031	0.0513	0.1256
Loa Loa (eye worm)	hypothetical protein	0.0055	0.117	0.1428
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0188	0.0188
Schistosoma mansoni	kinase	0.0049	0.1007	0.1095
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Echinococcus multilocularis	snurportin 1	0.0311	0.8188	0.8188
Schistosoma mansoni	lipoxygenase	0.01	0.2394	0.2602
Entamoeba histolytica	hypothetical protein	0.0024	0.0313	0.0671
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Schistosoma mansoni	hexokinase	0.008	0.1871	0.2033
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0196	0.0213
Brugia malayi	jmjC domain containing protein	0.0096	0.2309	0.3192
Brugia malayi	ImpB/MucB/SamB family protein	0.0079	0.184	0.2544
Echinococcus granulosus	transcription factor btf3	0.0042	0.0823	0.0823
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0172	0.4378	0.4947
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Loa Loa (eye worm)	glutaminase 2	0.0276	0.7234	0.8835
Schistosoma mansoni	chromobox protein	0.007	0.1594	0.1733
Trypanosoma brucei	hexokinase	0.008	0.1871	0.4246
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0218	0.0236
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0973	0.1081
Chlamydia trachomatis	phosphoglycerate kinase	0.0172	0.4378	0.5
Schistosoma mansoni	glutaminase	0.0276	0.7234	0.7862
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0021	0.0248	0.0258
Plasmodium falciparum	LCCL domain-containing protein	0.0024	0.0318	0.0462
Trypanosoma brucei	DNA damage repair protein, putative	0.0017	0.0122	0.0232
Echinococcus multilocularis	Polycystic kidney disease protein	0.0024	0.0318	0.0318
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0747	0.0825
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0643	0.0643
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0464	0.0464
Schistosoma mansoni	polycystin 1-related	0.0024	0.0318	0.0346
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2294	0.2581
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0789	0.0789
Trypanosoma brucei	transcription factor BTF3, putative	0.0042	0.0823	0.1841
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0387	0.084
Schistosoma mansoni	hypothetical protein	0.0029	0.0473	0.0514
Schistosoma mansoni	phosphoglycerate kinase	0.0172	0.4378	0.4758
Brugia malayi	Doublecortin family protein	0.0024	0.0318	0.044
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0196	0.024
Schistosoma mansoni	rab6-interacting	0.0024	0.0318	0.0346
Trypanosoma brucei	DNA polymerase IV, putative	0.008	0.1871	0.4247
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0318	0.0388
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0196	0.024
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0196	0.0213
Loa Loa (eye worm)	hypothetical protein	0.006	0.1315	0.1607
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0172	0.4378	1
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0823	0.0911
Entamoeba histolytica	hypothetical protein	0.0019	0.0196	0.0403
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0253	0.0534
Entamoeba histolytica	transcription factor BTF3, putative	0.0042	0.0823	0.1841
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.3617	0.4417
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0985	0.1362
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0196	0.0213
Plasmodium falciparum	hexokinase	0.008	0.1871	0.411
Trichomonas vaginalis	DNA polymerase eta, putative	0.008	0.1871	0.2101
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0054	0.1135	0.1386
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0188	0.0259
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.033	0.033
Plasmodium falciparum	importin beta, putative	0.0029	0.0464	0.0804
Trypanosoma brucei	DNA damage repair protein, putative	0.0017	0.0122	0.0232
Brugia malayi	serine/threonine-protein kinase plk-2	0.0096	0.2294	0.3171
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2294	0.2581
Loa Loa (eye worm)	doublecortin family protein	0.0024	0.0318	0.0388
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0196	0.0199
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0253	0.0309
Brugia malayi	MH2 domain containing protein	0.0144	0.3617	0.5
Schistosoma mansoni	hypothetical protein	0.0311	0.8188	0.8899
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0789	0.0789
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0196	0.0213
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0313	0.0332
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0161	0.4087	0.4991
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0313	0.0332
Trypanosoma brucei	chrX additional, unordered contigs	0.0017	0.0122	0.0232
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0144	0.0199
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.1594	0.1947
Schistosoma mansoni	lamin	0.0033	0.0558	0.0607
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0313	0.0671
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Echinococcus granulosus	chromobox protein 1	0.007	0.1594	0.1594
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0096	0.0096
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0196	0.0213
Plasmodium vivax	basic transcription factor 3b, putative	0.0042	0.0823	0.166
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0249	0.03
Onchocerca volvulus		0.008	0.1871	0.4578
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1315	0.1818
Schistosoma mansoni	rab6-interacting	0.0024	0.0318	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0196	0.024
Schistosoma mansoni	tyrosine kinase	0.0151	0.3795	0.4124
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0188	0.0229
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0196	0.0271
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0021	0.0248	0.0521
Plasmodium vivax	DNA repair protein REV1, putative	0.0017	0.0122	0.0016
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0172	0.4378	0.5
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.0196	0.0199
Loa Loa (eye worm)	RecQ helicase	0.0024	0.033	0.0403
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0196	0.0196
Mycobacterium ulcerans	DNA polymerase IV	0.008	0.1871	0.246
Entamoeba histolytica	hypothetical protein	0.0021	0.0248	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0196	0.024
Giardia lamblia	NADPH oxidoreductase, putative	0.0021	0.0248	0.0297
Brugia malayi	chromobox protein homolog 3	0.0039	0.0747	0.1032
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0253	0.0253
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0793	0.1097
Trypanosoma brucei	phosphoglycerate kinase	0.0172	0.4378	1
Echinococcus multilocularis	dna polymerase kappa	0.008	0.1871	0.1871
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0172	0.4378	1
Trypanosoma brucei	unspecified product	0.0037	0.0679	0.1511
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0196	0.0196
Entamoeba histolytica	Ran family GTPase	0.0021	0.0253	0.0534
Brugia malayi	Heterochromatin protein 1	0.007	0.1594	0.2204
Entamoeba histolytica	hypothetical protein	0.0019	0.0196	0.0403
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0196	0.0196
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0063	0.1395	0.3155
Brugia malayi	Phosphoglycerate kinase	0.0063	0.1395	0.1929
Schistosoma mansoni	hypothetical protein	0.0019	0.0188	0.0204
Trypanosoma cruzi	hexokinase, putative	0.008	0.1871	0.4246
Trypanosoma brucei	hypothetical protein, conserved	0.0017	0.0122	0.0232
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0172	0.4378	0.4378
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0196	0.0196
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0161	0.4087	0.4087
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0464	0.0566
Trypanosoma cruzi	DNA damage repair protein, putative	0.0017	0.0122	0.0232
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0253	0.0336
Schistosoma mansoni	hypothetical protein	0.0348	0.9201	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0196	0.0196
Echinococcus multilocularis	beta adrenergic receptor kinase	0.002	0.0218	0.0218
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0196	0.0271
Echinococcus granulosus	dna polymerase kappa	0.008	0.1871	0.1871
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0063	0.1395	0.3155
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.2309	0.2309
Schistosoma mansoni	ran	0.0021	0.0253	0.0275
Leishmania major	DNA polymerase kappa, putative	0.006	0.1318	0.2977
Trypanosoma brucei	phosphoglycerate kinase	0.0063	0.1395	0.3155
Trichomonas vaginalis	chromobox protein, putative	0.007	0.1594	0.1787
Echinococcus granulosus	lamin dm0	0.0033	0.0558	0.0558
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.008	0.1871	0.2101
Trypanosoma cruzi	hexokinase, putative	0.008	0.1871	0.4246
Schistosoma mansoni	flap endonuclease-1	0.0024	0.0317	0.0345
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0473	0.0473
Treponema pallidum	phosphoglycerate kinase	0.0172	0.4378	1
Schistosoma mansoni	tyrosine kinase	0.008	0.1861	0.2022
Brugia malayi	beta-NAC-like protein	0.0042	0.0823	0.1137
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0172	0.4378	1
Schistosoma mansoni	phosphoglycerate kinase	0.0172	0.4378	0.4758
Brugia malayi	Hexokinase family protein	0.008	0.1871	0.2586
Echinococcus multilocularis	lamin	0.0033	0.0558	0.0558
Schistosoma mansoni	loxhd1	0.0024	0.0318	0.0346
Echinococcus multilocularis	RUN	0.0024	0.0318	0.0318
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2294	0.2581
Echinococcus granulosus	dna polymerase eta	0.0079	0.184	0.184
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0643	0.0785
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0387	0.084
Entamoeba histolytica	hexokinase 1	0.008	0.1871	0.4246
Schistosoma mansoni	tyrosine kinase	0.0081	0.1884	0.2048
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0473	0.0473
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0021	0.0248	0.0258
Brugia malayi	PXA domain containing protein	0.0019	0.0196	0.0271
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0387	0.0387
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0367	0.0448
Loa Loa (eye worm)	hypothetical protein	0.005	0.1049	0.1282
Leishmania major	DNA polymerase eta, putative	0.0042	0.0827	0.185
Trypanosoma brucei	hexokinase	0.008	0.1871	0.4246
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Trypanosoma cruzi	transcription factor btf3, putative	0.0042	0.0823	0.1841
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0172	0.4378	0.5346
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0054	0.1135	0.1135
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0253	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0747	0.0912
Trypanosoma brucei	phosphoglycerate kinase	0.0172	0.4378	1
Echinococcus multilocularis	hexokinase	0.008	0.1871	0.1871
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0196	0.0199
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0196	0.0196
Schistosoma mansoni	hypothetical protein	0.0019	0.0188	0.0204
Echinococcus multilocularis		0.0047	0.0944	0.0944
Onchocerca volvulus	Alhambra homolog	0.0029	0.0473	0.1157
Echinococcus multilocularis	hexokinase type 2	0.008	0.1871	0.1871
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0196	0.0196
Giardia lamblia	Phosphoglycerate kinase	0.0172	0.4378	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0054	0.1135	0.2557
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0196	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0188	0.0259
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0196	0.0199
Schistosoma mansoni	DNA polymerase IV / kappa	0.0017	0.0122	0.0132
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0473	0.0851
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0142	0.3569	0.3569
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0218	0.0236
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0747	0.1827
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0063	0.1395	0.3155
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0196	0.0196
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0473	0.0839
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0196	0.0196
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.019	0.0207
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0431	0.0466
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.1318	0.2977
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0196	0.0196
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0387	0.084
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0196	0.0271
Mycobacterium ulcerans	phosphoglycerate kinase	0.0172	0.4378	0.5984
Brugia malayi	Bromodomain containing protein	0.0029	0.0473	0.0653
Echinococcus granulosus	hexokinase	0.008	0.1871	0.1871
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0196	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0196	0.024
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0464	0.1017
Mycobacterium ulcerans	glutaminase	0.0276	0.7234	1
Echinococcus granulosus	hexokinase	0.008	0.1871	0.1871
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Leishmania major	DNA polymerase eta, putative	0.0079	0.184	0.4176
Echinococcus multilocularis	musashi	0.0033	0.0558	0.0558
Trypanosoma brucei	unspecified product	0.0037	0.0679	0.1511
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0318	0.0388
Loa Loa (eye worm)	TK/INSR protein kinase	0.0048	0.0985	0.1203
Echinococcus granulosus	bloom syndrome protein	0.0024	0.033	0.033
Schistosoma mansoni	ran	0.0021	0.0253	0.0275
Brugia malayi	Phosphoglycerate kinase	0.0172	0.4378	0.6051
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0196	0.0213
Toxoplasma gondii	NAC domain-containing protein	0.0042	0.0823	0.1671
Loa Loa (eye worm)	ICD-1 protein	0.0042	0.0823	0.1005
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0473	0.0514
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.006	0.1318	0.2977
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0196	0.0196
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0973	0.1081
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0858	0.1921
Echinococcus granulosus	epidermal growth factor receptor	0.0151	0.3795	0.3795
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0253	0.0253
Entamoeba histolytica	hypothetical protein	0.0019	0.0196	0.0403
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0196	0.0213
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0196	0.024
Leishmania major	DNA polymerase kappa, putative	0.0017	0.0122	0.0232
Brugia malayi	Furin-like cysteine rich region family protein	0.0151	0.3795	0.5246
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0021	0.0248	0.0521
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0747	0.0825
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.033	0.0456
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0248	0.0258
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0387	0.0623
Loa Loa (eye worm)	hexokinase type II	0.008	0.1871	0.2285
Leishmania major	hexokinase, putative	0.008	0.1871	0.4246
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0473	0.0825
Giardia lamblia	DINP protein human, muc B family	0.006	0.1318	0.281
Giardia lamblia	NADPH oxidoreductase, putative	0.0021	0.0248	0.0297
Echinococcus multilocularis	hexokinase	0.008	0.1871	0.1871
Echinococcus multilocularis	dna polymerase eta	0.0079	0.184	0.184
Trypanosoma cruzi	DNA polymerase eta, putative	0.0079	0.184	0.4176
Onchocerca volvulus		0.0024	0.0318	0.0778
Schistosoma mansoni	tyrosine kinase	0.0081	0.1884	0.2048
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0096	0.0118
Echinococcus granulosus	snurportin 1	0.0311	0.8188	0.8188
Onchocerca volvulus		0.0024	0.0318	0.0778
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0387	0.0637
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0188	0.0188
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0196	0.0271
Echinococcus granulosus	lamin	0.0033	0.0558	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0558	0.0682
Echinococcus multilocularis	geminin	0.0171	0.4357	0.4357
Schistosoma mansoni	hypothetical protein	0.0171	0.4357	0.4735
Trypanosoma cruzi	DNA polymerase eta, putative	0.0042	0.0827	0.185
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.0318	0.0318
Loa Loa (eye worm)	hexokinase	0.008	0.1871	0.2285
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.2294	0.2493
Trypanosoma cruzi	transcription factor btf3, putative	0.0042	0.0823	0.1841
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0793	0.0969
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0151	0.3795	0.4634
Brugia malayi	hypothetical protein	0.0024	0.0318	0.044
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0464	0.083
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0558	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0542	0.0662
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.0096	0.0096
Echinococcus multilocularis	epidermal growth factor receptor	0.0151	0.3795	0.3795
Onchocerca volvulus		0.0033	0.0558	0.1365
Echinococcus granulosus	hexokinase	0.008	0.1871	0.1871
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0188	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0196	0.024
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0334	0.8828	1
Brugia malayi	Hexokinase family protein	0.005	0.1049	0.145
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0172	0.4378	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0074	0.1688	0.3828
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0858	0.1048
Echinococcus granulosus	peregrin	0.0029	0.0473	0.0473
Brugia malayi	ImpB/MucB/SamB family protein	0.0054	0.1135	0.1569
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0054	0.1135	0.1135
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0172	0.4378	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0318	0.0346
Onchocerca volvulus		0.0033	0.0558	0.1365
Trichomonas vaginalis	chromobox protein, putative	0.007	0.1594	0.1787
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0196	0.0196
Trypanosoma brucei	DNA polymerase eta, putative	0.0079	0.184	0.4176
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.0098
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0858	0.1921
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0161	0.4087	0.5649
Brugia malayi	hypothetical protein	0.0024	0.0318	0.044
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0172	0.4378	0.5
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0054	0.1135	0.1233
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.033	0.0351
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Trypanosoma cruzi	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0829	0.0918
Schistosoma mansoni	serine/threonine protein kinase	0.0161	0.4087	0.4442
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0829	0.0918
Onchocerca volvulus		0.008	0.1871	0.4578
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0248	0.0258
Echinococcus granulosus	intermediate filament protein	0.0033	0.0558	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.0098
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.1766	0.1919
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0367	0.0448
Trypanosoma cruzi	DNA polymerase kappa, putative	0.008	0.1871	0.4247
Giardia lamblia	NADPH oxidoreductase, putative	0.0021	0.0248	0.0297
Echinococcus granulosus	hexokinase type 2	0.008	0.1871	0.1871
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.0318	0.0318
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0253	0.0534
Entamoeba histolytica	hypothetical protein	0.0042	0.0823	0.1841
Brugia malayi	Flap endonuclease-1	0.0026	0.0387	0.0534
Echinococcus granulosus	RUN	0.0024	0.0318	0.0318
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0387	0.0415
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0473	0.0577
Entamoeba histolytica	hexokinase 2	0.008	0.1871	0.4246
Schistosoma mansoni	transcription factor btf3	0.0042	0.0823	0.0894

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 4.441 um	PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)]	ChEMBL.	No reference
IC50 (functional)	= 7.23 uM	PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217]	ChEMBL.	No reference
IC50 (functional)	= 8.46 uM	PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217]	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1511795

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1375794