Detailed information for compound 1375883

Basic information

Technical information
  • TDR Targets ID: 1375883
  • Name: 2-(3,4-dimethoxyphenyl)-N-[(1-propanoyl-2,3-d ihydroindol-5-yl)methyl]acetamide
  • MW: 382.453 | Formula: C22H26N2O4
  • H donors: 1 H acceptors: 2 LogP: 2.44 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N1CCc2c1ccc(c2)CNC(=O)Cc1ccc(c(c1)OC)OC
  • InChi: 1S/C22H26N2O4/c1-4-22(26)24-10-9-17-11-16(5-7-18(17)24)14-23-21(25)13-15-6-8-19(27-2)20(12-15)28-3/h5-8,11-12H,4,9-10,13-14H2,1-3H3,(H,23,25)
  • InChiKey: PEXKPOQEPXSZQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3,4-dimethoxyphenyl)-N-[(1-propanoylindolin-5-yl)methyl]acetamide
  • 2-(3,4-dimethoxyphenyl)-N-[[1-(1-oxopropyl)-5-indolinyl]methyl]acetamide
  • 2-(3,4-dimethoxyphenyl)-N-[(1-propionylindolin-5-yl)methyl]acetamide
  • 2-(3,4-dimethoxyphenyl)-N-[(1-propanoyl-2,3-dihydroindol-5-yl)methyl]ethanamide
  • G883-0163
  • NCGC00137759-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1028 0.0938
Schistosoma mansoni nuclear receptor 0.0084 0.4203 0.4203
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.6143 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0179 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0179 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0084 0.4203 0.4203
Echinococcus granulosus FTZ F1 alpha 0.0179 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0094 0.4824 0.4824
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0179 1 1
Brugia malayi steroid hormone receptor 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Onchocerca volvulus 0.0084 0.4203 0.3539
Loa Loa (eye worm) hypothetical protein 0.0179 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.1028 0.0938
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.5429 0.8837
Loa Loa (eye worm) hypothetical protein 0.0094 0.4824 0.4772
Echinococcus granulosus nuclear receptor nhr 48 0.0084 0.4203 0.4203
Echinococcus multilocularis musashi 0.0033 0.1028 0.1028
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0 0.5
Plasmodium falciparum thioredoxin reductase 0.0046 0.1834 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0179 1 1
Brugia malayi nuclear receptor NHR-67 0.0084 0.4203 0.4203
Brugia malayi Steroid receptor seven-up type 2 0.0179 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0084 0.4203 0.4203
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0084 0.4203 0.4203
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0179 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.4203 0.4203
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0094 0.4824 0.4824
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0084 0.4203 0.3539
Schistosoma mansoni nuclear hormone receptor 0.0084 0.4203 0.4203
Brugia malayi hypothetical protein 0.0084 0.4203 0.4203
Plasmodium falciparum glutathione reductase 0.0046 0.1834 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 1 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0094 0.4824 0.4772
Schistosoma mansoni thyroid hormone receptor 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0094 0.4824 0.4824
Brugia malayi glutathione reductase 0.0046 0.1834 0.1834
Echinococcus granulosus thyroid hormone receptor alpha 0.0084 0.4203 0.4203
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Onchocerca volvulus 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Echinococcus multilocularis ecdysone induced protein 78C 0.0179 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0084 0.4203 0.4203
Echinococcus granulosus Nuclear hormone receptor HR96 0.0084 0.4203 0.4203
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0094 0.4824 0.4824
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0179 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0179 1 1
Schistosoma mansoni zinc finger protein 0.0084 0.4203 0.4203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Brugia malayi Thioredoxin reductase 0.0046 0.1834 0.1834
Onchocerca volvulus Bile acid receptor homolog 0.0179 1 1
Brugia malayi hypothetical protein 0.0094 0.4824 0.4824
Loa Loa (eye worm) hypothetical protein 0.0094 0.4824 0.4772
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0179 1 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.4203 0.4203
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0179 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0179 1 1
Schistosoma mansoni lamin 0.0033 0.1028 0.1028
Echinococcus multilocularis nuclear receptor nhr 48 0.0084 0.4203 0.4203
Schistosoma mansoni coup transcription factor 0.0179 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0084 0.4203 0.4203
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Brugia malayi Nuclear hormone receptor E75 0.0084 0.4203 0.4203
Loa Loa (eye worm) glutathione reductase 0.0046 0.1834 0.1752
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0179 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0179 1 1
Brugia malayi ecdysone receptor 0.0084 0.4203 0.4203
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 1 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.1834 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0179 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.6143 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.5429 0.8837
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1834 0.2985
Schistosoma mansoni RAR-like nuclear receptor 0.0179 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1871 0.1871
Leishmania major trypanothione reductase 0.0046 0.1834 1
Treponema pallidum NADH oxidase 0.0016 0 0.5
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0099 0.0099
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0179 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.6143 1
Trichomonas vaginalis mercuric reductase, putative 0.0016 0 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0179 1 1
Schistosoma mansoni thyroid hormone receptor 0.0179 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0084 0.4203 0.4203
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.6143 1
Loa Loa (eye worm) hypothetical protein 0.0179 1 1
Brugia malayi intermediate filament protein 0.0033 0.1028 0.1028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0179 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0179 1 1
Brugia malayi hypothetical protein 0.0094 0.4824 0.4824
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Echinococcus granulosus Nuclear hormone receptor HR96 0.0084 0.4203 0.4203
Loa Loa (eye worm) hypothetical protein 0.0094 0.4824 0.4772
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0179 1 1
Schistosoma mansoni lamin 0.0033 0.1028 0.1028
Brugia malayi hypothetical protein 0.0084 0.4203 0.4203
Schistosoma mansoni steroid hormone receptor ad4bp 0.0179 1 1
Brugia malayi Nuclear hormone receptor E75 0.0084 0.4203 0.4203
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0084 0.4203 0.4203
Echinococcus multilocularis lamin dm0 0.0033 0.1028 0.1028
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1871 0.1871
Brugia malayi conserved hypotetical protein 0.0084 0.4203 0.4203
Echinococcus granulosus lamin 0.0033 0.1028 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0179 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0084 0.4203 0.4203
Echinococcus granulosus ecdysone induced protein 78C 0.0179 1 1
Trichomonas vaginalis glutathione reductase, putative 0.0016 0 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0179 1 1
Onchocerca volvulus 0.0084 0.4203 0.3539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 1 1
Brugia malayi nuclear receptor RXR 0.0094 0.4824 0.4824
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0179 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0179 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0179 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0 0.5
Brugia malayi nuclear receptor NHR-88 0.0084 0.4203 0.4203
Plasmodium vivax glutathione reductase, putative 0.0046 0.1834 1
Echinococcus multilocularis FTZ F1 alpha 0.0179 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0094 0.4824 0.4824
Schistosoma mansoni nuclear receptor 0.0084 0.4203 0.4203
Brugia malayi nuclear receptor NHR-88 0.0179 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0084 0.4203 0.4203
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Schistosoma mansoni nuclear hormone receptor 0.0179 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0084 0.4203 0.4203
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0179 1 1
Echinococcus multilocularis lamin 0.0033 0.1028 0.1028
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0084 0.4203 0.4203
Brugia malayi nuclear hormone receptor 0.0084 0.4203 0.4203
Loa Loa (eye worm) hypothetical protein 0.0179 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0084 0.4203 0.4145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.4824 0.4772
Loa Loa (eye worm) hypothetical protein 0.0032 0.0991 0.0901
Trypanosoma brucei trypanothione reductase 0.0046 0.1834 1
Brugia malayi tailless protein 0.0084 0.4203 0.4203
Echinococcus granulosus lamin dm0 0.0033 0.1028 0.1028
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.5429 0.8837
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0179 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0179 1 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1028 0.0938
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0179 1 1
Loa Loa (eye worm) DR-78 0.0084 0.4203 0.4145
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1834 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0179 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Echinococcus granulosus intermediate filament protein 0.0033 0.1028 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.4824 0.4772
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0179 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0084 0.4203 0.4145
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0179 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0084 0.4203 0.4145
Brugia malayi Nuclear hormone receptor-like 1 0.0094 0.4824 0.4824
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Brugia malayi Nuclear hormone receptor-like 1 0.0179 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0179 1 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0 0.5
Schistosoma mansoni nuclear hormone receptor 0.0084 0.4203 0.4203
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1834 0.1752
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0179 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0179 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0179 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0179 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0179 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Brugia malayi nuclear receptor RXR 0.0084 0.4203 0.4203
Brugia malayi orphan nuclear receptor NR2E1 0.0084 0.4203 0.4203
Mycobacterium tuberculosis Probable reductase 0.0104 0.5429 0.8837
Brugia malayi nuclear hormone receptor 0.0179 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 1 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1834 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0084 0.4203 0.4145
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.5429 0.8837
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.5429 0.8837
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0084 0.4203 0.3539

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0794 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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