TDR Targets

Basic information

Technical information

TDR Targets ID: 1376164
Name: (Z)-4-(4-ethylpiperazin-1-yl)-4-oxobut-2-enoi c acid
MW: 212.246 | Formula: C10H16N2O3
H donors: 1 H acceptors: 3 LogP: -2.61 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CCN(CC1)C(=O)/C=C\C(=O)O
InChi: 1S/C10H16N2O3/c1-2-11-5-7-12(8-6-11)9(13)3-4-10(14)15/h3-4H,2,5-8H2,1H3,(H,14,15)/b4-3-
InChiKey: RZWNXLICCRVKFW-ARJAWSKDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(Z)-4-(4-ethylpiperazin-1-yl)-4-oxo-but-2-enoic acid
(Z)-4-(4-ethyl-1-piperazinyl)-4-oxobut-2-enoic acid
(Z)-4-(4-ethylpiperazin-1-yl)-4-keto-but-2-enoic acid
MLS000541123
SMR000161849
SBB015210
AF-399/15286623
4-(4-ethyl-1-piperazinyl)-4-oxo-2-butenoic acid
(Z)-4-(4-ethylpiperazin-4-ium-1-yl)-4-oxobut-2-enoate
(Z)-4-(4-ethylpiperazin-4-ium-1-yl)-4-oxo-but-2-enoate
(Z)-4-(4-ethyl-1-piperazin-4-iumyl)-4-oxobut-2-enoate
(Z)-4-(4-ethylpiperazin-4-ium-1-yl)-4-keto-but-2-enoate

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0644	0.0615	0.3687
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0008	0.0007
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0073	0.0045	0.1122
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0029	0.0001	0.0001
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0094	0.0066	0.211
Brugia malayi	Carboxylesterase family protein	1.0047	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0525	0.0497	0.0497
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0385	0.0357	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0045	0.0017	0.01
Onchocerca volvulus		0.0043	0.0016	0.0091
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0004	0.0003
Leishmania major	DNA topoisomerase ii	0.0153	0.0125	0.3481
Loa Loa (eye worm)	carboxylesterase	0.1698	0.1667	0.1667
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.007	0.0042	0.0243
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0016	0.0087
Onchocerca volvulus		0.1698	0.1667	1
Trypanosoma brucei	DNA topoisomerase IB, large subunit	0.0216	0.0188	0.5256
Brugia malayi	beta-lactamase family protein	0.0043	0.0016	0.0015
Loa Loa (eye worm)	steroid hormone receptor	0.0045	0.0017	0.0017
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0081	0.0054	0.1473
Brugia malayi	beta-lactamase family protein	0.0043	0.0016	0.0015
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0109	0.0081	0.0486
Leishmania major	hypothetical protein, conserved	0.0043	0.0016	0.0409
Schistosoma mansoni	gliotactin	0.1698	0.1667	0.1666
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0045	0.0017	0.0017
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0073	0.0045	0.0229
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0109	0.0081	0.0486
Plasmodium falciparum	DNA gyrase subunit A	0.0035	0.0007	0.0096
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0045	0.0017	0.0017
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0315	0.0286	0.1683
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0029	0.0002	0.0001
Trypanosoma cruzi	cytochrome P450, putative	0.0039	0.0011	0.0284
Echinococcus multilocularis	muscleblind protein	0.0156	0.0128	0.0128
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0024	0.0024
Brugia malayi	Cytochrome P450 family protein	0.0039	0.0011	0.0011
Echinococcus multilocularis	p2X purinoceptor 4	0.0256	0.0228	0.0227
Echinococcus granulosus	para nitrobenzyl esterase	0.1698	0.1667	0.1666
Toxoplasma gondii	RNA-directed DNA polymerase	0.0098	0.0071	0.3698
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0162	0.0134	0.0133
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0016	0.0052
Schistosoma mansoni	inositol monophosphatase	0.0081	0.0054	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.1698	0.1667	0.1667
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0045	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0128	0.01	0.01
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.0017	0.0017
Echinococcus granulosus	microtubule associated protein 2	0.1521	0.149	0.149
Echinococcus multilocularis	acetylcholinesterase	1.0047	1	1
Brugia malayi	hypothetical protein	0.1698	0.1667	0.1666
Schistosoma mansoni	hypothetical protein	0.0036	0.0008	0.0007
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0029	0.0001	0.0001
Brugia malayi	Cell division protein ftsZ	0.0156	0.0128	0.0128
Echinococcus granulosus	X box binding protein 1	0.0256	0.0228	0.0227
Giardia lamblia	DNA repair protein RAD52	0.0364	0.0336	0.5445
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0016	0.0052
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0045	0.0017	0.0017
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0081	0.0054	0.1473
Schistosoma mansoni	DNA topoisomerase II	0.0162	0.0134	0.0133
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.1698	0.1667	0.1666
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0045	0.0017	0.0017
Trypanosoma cruzi	cytochrome P450, putative	0.0039	0.0011	0.0284
Schistosoma mansoni	P2X receptor subunit	0.0256	0.0228	0.0227
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0045	0.0017	0.0017
Trichomonas vaginalis	chaperonin, putative	0.0029	0.0002	0.0002
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.007	0.0042	0.0041
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.1698	0.1667	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.01	0.01
Brugia malayi	ecdysteroid receptor	0.0045	0.0017	0.0017
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.001	0.0009
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0045	0.0017	0.0017
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0644	0.0615	0.3687
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0016	0.0052
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0106	0.0078	0.0078
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0104	0.0076	0.1213
Entamoeba histolytica	hypothetical protein	0.0038	0.001	0.0143
Plasmodium vivax	DNA topoisomerase II, putative	0.0162	0.0134	0.2284
Echinococcus multilocularis	survival motor neuron protein 1	0.0521	0.0493	0.0492
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0045	0.0017	0.0017
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0016	0.0053
Onchocerca volvulus		0.0042	0.0014	0.008
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1698	0.1667	0.1666
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0035	0.0007	0.0297
Echinococcus multilocularis	DNA topoisomerase 1	0.0216	0.0188	0.0188
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0004	0.0108
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.0017	0.0017
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0016	0.0052
Loa Loa (eye worm)	hypothetical protein	0.1698	0.1667	0.1667
Loa Loa (eye worm)	T-complex protein 1	0.0029	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0029	0.0001	0.0001
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	1.0047	1	1
Echinococcus multilocularis	sentrin specific protease 8	0.007	0.0042	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0045	0.0017	0.0017
Trypanosoma brucei	cytochrome P450, putative	0.0039	0.0011	0.0284
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0317	0.0289	0.1697
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0027	0.0027
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0364	0.0336	0.5445
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0045	0.0017	0.0017
Echinococcus multilocularis	FTZ F1 alpha	0.0045	0.0017	0.0017
Echinococcus granulosus	p2X purinoceptor 4	0.0256	0.0228	0.0227
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0644	0.0615	0.3687
Mycobacterium tuberculosis	Carboxylesterase LipT	0.1698	0.1667	1
Leishmania major	cytochrome p450-like protein	0.0039	0.0011	0.0284
Brugia malayi	Pre-SET motif family protein	0.0031	0.0004	0.0003
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.025	0.1461
Loa Loa (eye worm)	cytochrome P450 family protein	0.0039	0.0011	0.0011
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0109	0.0081	0.0486
Giardia lamblia	Telomerase catalytic subunit	0.0098	0.0071	0.113
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0644	0.0615	0.3687
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0182	0.0154	0.4281
Schistosoma mansoni	survival motor neuron protein	0.0106	0.0078	0.0078
Echinococcus multilocularis	carboxylesterase 5A	1.0047	1	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0016	0.0015
Mycobacterium ulcerans	DNA gyrase subunit B	0.0094	0.0066	0.0358
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0045	0.0017	0.0017
Onchocerca volvulus	Huntingtin homolog	0.0128	0.01	0.0599
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0098	0.0071	0.042
Leishmania major	telomerase reverse transcriptase, putative	0.0098	0.0071	0.195
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0161	0.0161
Echinococcus granulosus	FTZ F1 alpha	0.0045	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0385	0.0357	0.0357
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0385	0.0357	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0644	0.0615	0.3687
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0045	0.0017	0.0017
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1698	0.1667	0.1666
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0016	0.0015
Schistosoma mansoni	DNA topoisomerase type I	0.0216	0.0188	0.0188
Trypanosoma brucei	DNA topoisomerase ii	0.0182	0.0154	0.4281
Loa Loa (eye worm)	hypothetical protein	0.0197	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.1698	0.1667	0.1667
Loa Loa (eye worm)	hypothetical protein	0.1698	0.1667	0.1667
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0029	0.0002	0.0009
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0027	0.0027
Trichomonas vaginalis	set domain proteins, putative	0.0248	0.022	0.1313
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.007	0.0042	0.066
Leishmania major	C-8 sterol isomerase-like protein	0.0385	0.0357	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0016	0.0052
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0016	0.0016
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0017	0.0017
Onchocerca volvulus	Huntingtin homolog	0.0128	0.01	0.0599
Brugia malayi	Muscleblind-like protein	0.0156	0.0128	0.0128
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0218	0.019	0.019
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0315	0.0286	0.1683
Echinococcus granulosus	p2X purinoceptor 4	0.0256	0.0228	0.0227
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0016	0.0052
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0045	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.1698	0.1667	0.1667
Brugia malayi	beta-lactamase	0.0043	0.0016	0.0015
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.0017	0.0017
Onchocerca volvulus		0.0031	0.0004	0.0018
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0094	0.0066	0.0358
Plasmodium falciparum	DNA topoisomerase 2	0.0162	0.0134	0.2284
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0081	0.0054	0.028
Echinococcus granulosus	acetylcholinesterase	1.0047	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0525	0.0497	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0038	0.0038
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0081	0.0054	0.0315
Loa Loa (eye worm)	hypothetical protein	0.1698	0.1667	0.1667
Brugia malayi	T-complex protein 1, beta subunit	0.0029	0.0002	0.0001
Brugia malayi	Carboxylesterase family protein	0.1698	0.1667	0.1666
Brugia malayi	PAS domain containing protein	0.0056	0.0029	0.0028
Giardia lamblia	DNA topoisomerase II	0.0153	0.0125	0.2022
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0004	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0521	0.0493	0.0493
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0081	0.0054	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0128	0.01	0.01
Loa Loa (eye worm)	carboxylesterase	1.0047	1	1
Schistosoma mansoni	acetylcholinesterase	0.1698	0.1667	0.1666
Echinococcus granulosus	DNA topoisomerase 1	0.0216	0.0188	0.0188
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0081	0.0054	0.2789
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.0017	0.0017
Echinococcus multilocularis	acetylcholinesterase	1.0047	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0024	0.0024
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0016	0.0053
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0004	0.0003
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0039	0.0011	0.0025
Trichomonas vaginalis	spcc417.12 protein, putative	0.1698	0.1667	1
Onchocerca volvulus	Bile acid receptor homolog	0.0045	0.0017	0.01
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0016	0.0052
Chlamydia trachomatis	DNA gyrase subunit B	0.0094	0.0066	1
Brugia malayi	Steroid receptor seven-up type 2	0.0045	0.0017	0.0017
Echinococcus multilocularis	p2X purinoceptor 4	0.0256	0.0228	0.0227
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0174	0.0146	0.0146
Schistosoma mansoni	thyroid hormone receptor	0.0045	0.0017	0.0017
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0162	0.0134	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0017	0.0017
Schistosoma mansoni	coup transcription factor	0.0045	0.0017	0.0017
Loa Loa (eye worm)	Ulp1 protease	0.007	0.0042	0.0042
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0024	0.0024
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0016	0.0052
Brugia malayi	photoreceptor-specific nuclear receptor	0.0045	0.0017	0.0017
Onchocerca volvulus		0.0248	0.022	0.1316
Brugia malayi	DNA topoisomerase I	0.0216	0.0188	0.0188
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.1698	0.1667	0.1666
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0182	0.0154	0.4281
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0045	0.0017	0.0017
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0029	0.0002	0.0001
Plasmodium vivax	DNA gyrase subunit A, putative	0.0035	0.0007	0.0096
Brugia malayi	Carboxylesterase family protein	0.1698	0.1667	0.1666
Brugia malayi	Inositol-1	0.0081	0.0054	0.0053
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0162	0.0134	0.0133
Loa Loa (eye worm)	cytochrome P450 family protein	0.0039	0.0011	0.0011
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0644	0.0615	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0045	0.0017	0.0017
Plasmodium falciparum	telomerase reverse transcriptase	0.0609	0.0581	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0008	0.0008
Brugia malayi	Pre-SET motif family protein	0.0218	0.019	0.0189
Echinococcus multilocularis	ecdysone induced protein 78C	0.0045	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0045	0.0017	0.0017
Onchocerca volvulus		0.0106	0.0078	0.0468
Trypanosoma cruzi	DNA topoisomerase IB, large subunit, putative	0.0216	0.0188	0.5256
Entamoeba histolytica	hypothetical protein	0.0104	0.0076	0.1213
Echinococcus multilocularis	para nitrobenzyl esterase	0.1698	0.1667	0.1666
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0045	0.0017	0.0017
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0045	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0038	0.0038
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0098	0.0071	0.195
Schistosoma mansoni	BC026374 protein (S09 family)	0.1698	0.1667	0.1666
Brugia malayi	hypothetical protein	0.0038	0.001	0.0009
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0094	0.0066	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0017	0.0017
Onchocerca volvulus		0.1698	0.1667	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0016	0.0015
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0644	0.0615	0.3687
Leishmania major	T-complex protein 1, beta subunit, putative	0.0029	0.0002	0.0009
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0045	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.0017	0.0017
Loa Loa (eye worm)	DNA topoisomerase I	0.0216	0.0188	0.0188
Schistosoma mansoni	RAR-like nuclear receptor	0.0045	0.0017	0.0017
Brugia malayi	Carboxylesterase family protein	0.1698	0.1667	0.1666
Schistosoma mansoni	P2X receptor subunit	0.0256	0.0228	0.0227
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0029	0.0002	0.0005
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0162	0.0134	0.0796
Echinococcus granulosus	neuroligin	0.1698	0.1667	0.1666
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0081	0.0054	0.1473
Schistosoma mansoni	single-minded	0.0056	0.0029	0.0028
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0016	0.0246
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0002	0.0002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0045	0.0017	0.0017
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0153	0.0125	0.3481
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.0017	0.0017
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0004	0.0003
Echinococcus granulosus	sentrin specific protease 8	0.007	0.0042	0.0041
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.0017	0.0017
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.001	0.0009
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0016	0.0052
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0016	0.0016
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1698	0.1667	0.1666
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0004	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0024	0.0024
Brugia malayi	bHLH-PAS transcription factor	0.0042	0.0014	0.0013
Loa Loa (eye worm)	carboxylesterase	0.1698	0.1667	0.1667
Brugia malayi	nuclear hormone receptor	0.0045	0.0017	0.0017
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0385	0.0357	0.0357
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0016	0.0015
Treponema pallidum	fructose-bisphosphate aldolase	0.0644	0.0615	1
Loa Loa (eye worm)	CYP4Cod1	0.0039	0.0011	0.0011
Onchocerca volvulus		0.1698	0.1667	1
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0029	0.0002	0.0001
Brugia malayi	Probable DNA topoisomerase II	0.0162	0.0134	0.0133
Schistosoma mansoni	inositol monophosphatase	0.0081	0.0054	0.0053
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0094	0.0066	0.3479
Loa Loa (eye worm)	hypothetical protein	1.0047	1	1
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.007	0.0042	0.0243
Echinococcus multilocularis	conserved hypothetical protein	0.0722	0.0693	0.0693
Mycobacterium ulcerans	cell division protein FtsZ	0.0317	0.0289	0.1697
Echinococcus granulosus	inositol monophosphatase 1	0.0081	0.0054	0.0053
Mycobacterium ulcerans	putative regulatory protein	0.0042	0.0014	0.0041
Echinococcus multilocularis	transfer RNA-Lys	0.0042	0.0014	0.0013
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0004	0.0003
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0029	0.0002	0.0002
Schistosoma mansoni	microtubule-associated protein tau	0.1521	0.149	0.149
Schistosoma mansoni	hypothetical protein	0.0106	0.0078	0.0078
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0001	0.0001
Echinococcus granulosus	hypothetical protein	0.0741	0.0712	0.0711
Brugia malayi	hypothetical protein	0.0189	0.0161	0.016
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0029	0.0002	0.0005
Brugia malayi	hypothetical protein	0.0521	0.0493	0.0492
Schistosoma mansoni	thyroid hormone receptor	0.0045	0.0017	0.0017
Plasmodium vivax	topoisomerase I, putative	0.0216	0.0188	0.3225
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0001	0.0001
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0045	0.0017	0.0017
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0001	0.0001
Schistosoma mansoni	retinoic acid receptor RXR	0.0045	0.0017	0.0017
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0016	0.0087
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0317	0.0289	1
Schistosoma mansoni	DNA topoisomerase type I	0.0216	0.0188	0.0188
Entamoeba histolytica	hypothetical protein	0.0038	0.001	0.0143
Schistosoma mansoni	P2X receptor subunit	0.0256	0.0228	0.0227
Trypanosoma cruzi	hypothetical protein	0.007	0.0042	0.1139
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0162	0.0134	0.7083
Echinococcus multilocularis	p2X purinoceptor 4	0.0256	0.0228	0.0227
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.007	0.0042	0.0243
Onchocerca volvulus		0.0043	0.0016	0.0091
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0029	0.0002	0.0001
Brugia malayi	steroid hormone receptor	0.0045	0.0017	0.0017
Trypanosoma brucei	telomerase reverse transcriptase	0.0098	0.0071	0.195
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0045	0.0017	0.0017
Plasmodium vivax	DNA gyrase subunit B, putative	0.0094	0.0066	0.1122
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.0017	0.0017
Loa Loa (eye worm)	TOPoisomerase family member	0.0162	0.0134	0.0134
Echinococcus granulosus	carboxylesterase 5A	1.0047	1	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0016	0.0052
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0315	0.0286	0.9916
Toxoplasma gondii	ABC1 family protein	0.0043	0.0016	0.0761
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0153	0.0125	0.3481
Echinococcus multilocularis	muscleblind protein 1	0.0156	0.0128	0.0128
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0081	0.0054	0.1473
Mycobacterium ulcerans	lipase LipD	0.0043	0.0016	0.0052
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0045	0.0017	0.0017
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0029	0.0002	0.0009
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.0017	0.0017
Onchocerca volvulus		0.1698	0.1667	1
Loa Loa (eye worm)	hypothetical protein	1.0047	1	1
Echinococcus granulosus	survival motor neuron protein 1	0.0521	0.0493	0.0492
Schistosoma mansoni	hypothetical protein	0.0256	0.0228	0.0227
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0016	0.0087
Echinococcus granulosus	single minded 2	0.0042	0.0014	0.0013
Onchocerca volvulus		0.1698	0.1667	1
Schistosoma mansoni	hypothetical protein	0.006	0.0032	0.0032
Giardia lamblia	Fructose-bisphosphate aldolase	0.0644	0.0615	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0017	0.0017
Entamoeba histolytica	hypothetical protein	0.0038	0.001	0.0143
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0027	0.0027
Brugia malayi	T-complex protein 1, beta subunit	0.0029	0.0002	0.0001
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0849	0.082	0.0819
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0016	0.0016
Echinococcus multilocularis	X box binding protein 1	0.0256	0.0228	0.0227
Onchocerca volvulus	Protein ultraspiracle homolog	0.0045	0.0017	0.01
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0045	0.0017	0.0017
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0153	0.0125	0.3481
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0644	0.0615	0.3687
Plasmodium vivax	SET domain protein, putative	0.0031	0.0004	0.0035
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.1698	0.1667	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0045	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0082	0.0082
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0045	0.0017	0.0017
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.1698	0.1667	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0644	0.0615	0.3687
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0017	0.0017
Entamoeba histolytica	DNA topoisomerase II, putative	0.0162	0.0134	0.2159
Leishmania major	mitochondrial DNA topoisomerase II	0.0182	0.0154	0.4281
Echinococcus multilocularis	inositol monophosphatase 1	0.0081	0.0054	0.0053
Echinococcus multilocularis	neuroligin	0.1698	0.1667	0.1666
Brugia malayi	Cell division protein ftsZ	0.0152	0.0124	0.0124
Loa Loa (eye worm)	acetylcholinesterase 1	1.0047	1	1
Echinococcus granulosus	acetylcholinesterase	1.0047	1	1
Echinococcus granulosus	BC026374 protein S09 family	0.1698	0.1667	0.1666
Trichomonas vaginalis	inositol monophosphatase, putative	0.0081	0.0054	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0016	0.0016
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0045	0.0017	0.0017
Trichomonas vaginalis	Sentrin-specific protease, putative	0.007	0.0042	0.0243
Schistosoma mansoni	hypothetical protein	0.0038	0.001	0.0009
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0081	0.0054	0.1652
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0016	0.0409
Plasmodium falciparum	DNA gyrase subunit B	0.0094	0.0066	0.1122
Brugia malayi	Carboxylesterase family protein	0.1698	0.1667	0.1666
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0045	0.0017	0.0017
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0016	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0082	0.0082
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0045	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0128	0.0128
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0016	0.0087
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0016	0.0016
Mycobacterium leprae	cell division protein FtsZ	0.0317	0.0289	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0004	0.0003
Onchocerca volvulus		0.0045	0.0017	0.01
Echinococcus multilocularis	microtubule associated protein 2	0.1521	0.149	0.149
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.007	0.0042	0.0041
Loa Loa (eye worm)	inositol-1	0.0081	0.0054	0.0054
Schistosoma mansoni	neuroligin 3 (S09 family)	0.1698	0.1667	0.1666
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0016	0.0409
Schistosoma mansoni	P2X receptor subunit	0.0256	0.0228	0.0227
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0016	0.0016
Leishmania major	DNA topoisomerase IB, large subunit	0.0216	0.0188	0.5256
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0017	0.0017
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0016	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0016	0.0016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0027	0.0027
Mycobacterium ulcerans	carboxylesterase, LipT	0.1698	0.1667	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.1698	0.1667	0.1667
Plasmodium falciparum	topoisomerase I	0.0216	0.0188	0.3225
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0016	0.0052
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0029	0.0002	0.0001
Toxoplasma gondii	DNA topoisomerase I, putative	0.0216	0.0188	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.001	0.0009
Onchocerca volvulus		0.0043	0.0016	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0017	0.0017
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0016	0.0015
Schistosoma mansoni	aryl hydrocarbon receptor	0.0056	0.0029	0.0028
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0098	0.0071	0.195
Echinococcus multilocularis	BC026374 protein (S09 family)	0.1698	0.1667	0.1666
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0153	0.0125	0.3481
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0045	0.0017	0.0017
Brugia malayi	hypoxia-induced factor 1	0.0174	0.0146	0.0146
Brugia malayi	Cytochrome P450 family protein	0.0039	0.0011	0.0011
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0162	0.0134	0.0133
Chlamydia trachomatis	DNA gyrase subunit B	0.0075	0.0047	0.6674
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0644	0.0615	1
Trichomonas vaginalis	esterase, putative	0.0043	0.0016	0.0087
Entamoeba histolytica	hypothetical protein	0.0038	0.001	0.0143
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0027	0.0027
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0016	0.0409
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0081	0.0054	0.0315
Echinococcus granulosus	muscleblind protein	0.0156	0.0128	0.0128
Schistosoma mansoni	DNA topoisomerase type I	0.0216	0.0188	0.0188
Brugia malayi	nuclear receptor NHR-88	0.0045	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0016	0.0016
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0016	0.0052
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0016	0.0052
Treponema pallidum	cell division protein FtsZ	0.0317	0.0289	0.4631
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0609	0.0581	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0045	0.0017	0.0017
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0027	0.0027
Echinococcus granulosus	p2X purinoceptor 4	0.0256	0.0228	0.0227
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0045	0.0017	0.0017

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.5858 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 0.7079 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	0.7943 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1509907

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1376164