Detailed information for compound 1376268

Basic information

Technical information
  • TDR Targets ID: 1376268
  • Name: 1-cyclopentyl-4-[1-[1-(furan-2-ylmethyl)tetra zol-5-yl]-3-methylbutyl]piperazine hydrochlor ide
  • MW: 408.969 | Formula: C20H33ClN6O
  • H donors: 0 H acceptors: 3 LogP: 3.74 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(c1nnnn1Cc1ccco1)N1CCN(CC1)C1CCCC1)C.Cl
  • InChi: 1S/C20H32N6O.ClH/c1-16(2)14-19(20-21-22-23-26(20)15-18-8-5-13-27-18)25-11-9-24(10-12-25)17-6-3-4-7-17;/h5,8,13,16-17,19H,3-4,6-7,9-12,14-15H2,1-2H3;1H
  • InChiKey: VXVGFZHZHXOMTF-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-cyclopentyl-4-[1-[1-(2-furylmethyl)tetrazol-5-yl]-3-methyl-butyl]piperazine hydrochloride
  • 1-cyclopentyl-4-[1-[1-(2-furylmethyl)-5-tetrazolyl]-3-methylbutyl]piperazine hydrochloride
  • 1-cyclopentyl-4-[1-[1-(2-furfuryl)tetrazol-5-yl]-3-methyl-butyl]piperazine hydrochloride
  • 1-cyclopentyl-4-[1-[1-(furan-2-ylmethyl)-1,2,3,4-tetrazol-5-yl]-3-methyl-butyl]piperazine hydrochloride
  • 1-Cyclopentyl-4-[1-(1-furan-2-ylmethyl-1H-tetrazol-5-yl)-3-methyl-butyl]-piperazine
  • MLS000070789
  • SMR000005013

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0263 0.3007 0.7062
Trypanosoma cruzi cytochrome P450, putative 0.0183 0.1988 0.4669
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0175 0.1896 0.4449
Leishmania major proteasome alpha 7 subunit, putative 0.0194 0.2133 0.5008
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0194 0.2133 0.3384
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0031 0.0071 0.0053
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0028 0.0038 0.0013
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0042 0.0207 0.0481
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0601 0.0909
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0269 0.0373
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0194 0.2133 0.3093
Toxoplasma gondii tat-binding family protein, putative 0.0028 0.0038 0.0066
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0031 0.0071 0.016
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0133 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0138 0.02
Brugia malayi proteasome subunit alpha type 4 0.0168 0.1804 0.2617
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0028 0.0038 0.0089
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0043 0.0217 0.0509
Loa Loa (eye worm) proteasome 26S subunit 0.0028 0.0038 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0287 0.0372
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0031 0.0071 0.0166
Echinococcus multilocularis Niemann Pick C1 protein 0.0199 0.2202 0.2182
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0031 0.0071 0.0123
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0029 0.0048 0.0084
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0031 0.0071 0.0166
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0263 0.3007 0.299
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0287 0.0372
Giardia lamblia 26S protease regulatory subunit 6A 0.0031 0.0071 0.016
Leishmania major proteasome beta 3 subunit, putative 0.0183 0.1997 0.4689
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0191 0.2093 0.3321
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0203 0.2241 0.3559
Giardia lamblia Proteasome subunit beta type 2 0.0183 0.1997 0.4686
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0287 0.0589
Entamoeba histolytica proteasome regulatory subunit, putative 0.0057 0.0397 0.085
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0044 0.0235 0.0553
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0029 0.0048 0.0114
Brugia malayi 26S proteasome subunit P45 family protein 0.0029 0.0048 0.007
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0056 0.0383 0.0898
Loa Loa (eye worm) hypothetical protein 0.048 0.5745 0.8333
Toxoplasma gondii proteasome subunit beta type, putative 0.0362 0.4258 0.7412
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0075 0.0624 0.1465
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0029 0.0048 0.0108
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0027 0.0025 0.0058
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0208 0.2312 0.3353
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0223 0.2502 0.2483
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0031 0.0071 0.0074
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0181 0.1966 0.4568
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0044 0.0232 0.0546
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0181 0.1966 0.3115
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0057 0.0397 0.06
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0031 0.0071 0.0053
Leishmania major hypothetical protein, conserved 0.025 0.2838 0.6666
Schistosoma mansoni hypothetical protein 0.0311 0.3619 0.5786
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0056 0.0383 0.0359
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0362 0.4258 1
Plasmodium falciparum 26S protease regulatory subunit 10B, putative 0.0028 0.0038 0.0089
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0057 0.0397 0.0932
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0263 0.3007 0.7035
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0127 0.1284 0.1262
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0053 0.0346 0.0519
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0192 0.2103 0.4938
Plasmodium vivax proteasome subunit beta type-2, putative 0.0183 0.1997 0.4689
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0056 0.0383 0.0577
Echinococcus multilocularis adhesion regulating molecule 1 0.048 0.5745 0.5734
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0029 0.0048 0.0038
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0146 0.1529 0.3424
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0044 0.0232 0.0541
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0146 0.1529 0.3385
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0208 0.2312 0.5429
Loa Loa (eye worm) hypothetical protein 0.0048 0.0287 0.0416
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0175 0.1896 0.4452
Loa Loa (eye worm) hypothetical protein 0.0029 0.0048 0.007
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0183 0.1997 0.4686
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0146 0.1529 0.3385
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0042 0.0207 0.0487
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0181 0.1966 0.4617
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0044 0.0235 0.034
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0044 0.0235 0.0468
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0029 0.0048 0.0025
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0175 0.1896 0.4449
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0208 0.2312 0.5426
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0029 0.0048 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0193
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0029 0.0048 0.0108
Loa Loa (eye worm) cytochrome P450 family protein 0.0183 0.1988 0.2884
Onchocerca volvulus 0.0029 0.0048 0.003
Loa Loa (eye worm) proteasome subunit alpha type 6 0.021 0.2329 0.3378
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0044 0.0235 0.0341
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0056 0.0383 0.0557
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0183 0.1997 0.4689
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0269 0.0394
Echinococcus multilocularis proteasome subunit alpha type 6 0.021 0.2329 0.231
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0263 0.3007 0.7062
Brugia malayi Proteasome/cyclosome repeat family protein 0.0032 0.0082 0.0118
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0029 0.0048 0.0114
Toxoplasma gondii proteasome 26S regulatory subunit 0.003 0.0059 0.0103
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0044 0.0235 0.0468
Echinococcus granulosus proteasome subunit beta t family 0.0183 0.1997 0.3179
Echinococcus multilocularis proteasome subunit beta type 6 0.0192 0.2111 0.2091
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0032 0.0082 0.0118
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0057 0.0397 0.0932
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0146 0.1529 0.3385
Loa Loa (eye worm) cytochrome P450 family protein 0.057 0.6894 1
Brugia malayi CHE-14 protein 0.0086 0.0762 0.1105
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0287 0.0416
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0191 0.2093 0.4916
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0181 0.1966 0.4617
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0031 0.0069 0.0051
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0194 0.2133 0.5008
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0056 0.0383 0.0898
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0029 0.0048 0.0038
Brugia malayi Proteasome A-type and B-type family protein 0.0518 0.6227 0.9032
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0048 0.0283 0.0395
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0044 0.0235 0.0547
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0175 0.1896 0.4452
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0199 0.2194 0.5153
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0199 0.2194 0.3819
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0044 0.0232 0.0335
Leishmania major proteasome alpha 3 subunit, putative 0.0192 0.2103 0.4938
Entamoeba histolytica proteasome regulatory subunit, putative 0.0044 0.0232 0.0461
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0183 0.1997 0.4689
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0191 0.2093 0.3037
Toxoplasma gondii proteasome subunit alpha type, putative 0.0118 0.1177 0.2049
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0027 0.0025 0.0058
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0181 0.1966 0.1946
Trichomonas vaginalis 26S proteasome subunit, putative 0.0044 0.0232 0.0541
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0056 0.0383 0.0555
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0192 0.2111 0.4954
Toxoplasma gondii hypothetical protein 0.0039 0.0167 0.029
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.021 0.2329 0.3702
Schistosoma mansoni hypothetical protein 0.0083 0.0723 0.1106
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0146 0.1529 0.3424
Schistosoma mansoni hypothetical protein 0.0127 0.1284 0.2013
Echinococcus granulosus proteasome subunit alpha type 6 0.021 0.2329 0.3715
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0175 0.1896 0.4452
Loa Loa (eye worm) cytochrome P450 0.0146 0.1529 0.2218
Giardia lamblia 20S proteasome alpha subunit 1 0.021 0.2329 0.5467
Echinococcus granulosus 26S protease regulatory subunit 8 0.0028 0.0038 0.0021
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0053 0.0346 0.0814
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0194 0.2133 0.4963
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0193
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0044 0.0235 0.041
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.025 0.2838 0.6666
Brugia malayi Cytochrome P450 family protein 0.0183 0.1988 0.2884
Leishmania major cytochrome p450-like protein 0.0183 0.1988 0.4669
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0183 0.1997 0.3164
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0287 0.0416
Trypanosoma brucei proteasome alpha 7 subunit 0.0194 0.2133 0.5008
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0146 0.1529 0.3385
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0181 0.1966 0.4617
Giardia lamblia 20S proteasome alpha subunit 3 0.0192 0.2103 0.4935
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0044 0.0235 0.0547
Echinococcus granulosus proteasome prosome macropain 0.0362 0.4258 0.6826
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0192 0.2111 0.4956
Brugia malayi Cytochrome P450 family protein 0.0183 0.1988 0.2884
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0029 0.0048 0.0024
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0762 0.1105
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0208 0.2312 0.4024
Leishmania major proteasome beta 2 subunit, putative 0.0175 0.1896 0.4452
Leishmania major proteasome alpha 7 subunit, putative 0.0263 0.3007 0.7062
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0183 0.1997 0.3164
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.003 0.0059 0.0139
Schistosoma mansoni 26S proteasome subunit S9 0.0053 0.0346 0.0498
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0145 0.1509 0.3078
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0223 0.2502 0.3981
Brugia malayi proteasome subunit beta type 3 0.0183 0.1997 0.2896
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0146 0.1529 0.3385
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0048 0.0285 0.0261
Brugia malayi Probable 26S protease regulatory subunit 4 0.0029 0.0048 0.007
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0048 0.0283 0.0659
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0263 0.3007 0.299
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0056 0.0383 0.0555
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0208 0.2312 0.5429
Onchocerca volvulus Notchless protein homolog 0.0194 0.2133 0.5998
Schistosoma mansoni multiubiquitin binding protein S5a 0.0031 0.0069 0.0051
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0025 0.0052
Giardia lamblia Proteasome subunit beta type 1 0.0223 0.2502 0.5874
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0053 0.0346 0.0814
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0175 0.1896 0.275
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0027 0.0025 0.0052
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0192 0.2103 0.4935
Schistosoma mansoni hypothetical protein 0.0083 0.0723 0.1106
Toxoplasma gondii proteasome subunit alpha1, putative 0.021 0.2329 0.4054
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0048 0.0283 0.0664
Brugia malayi Cytochrome P450 family protein 0.057 0.6894 1
Schistosoma mansoni 26S protease regulatory subunit 0.0029 0.0048 0.0017
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0042 0.0207 0.0487
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0269 0.039
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0175 0.1896 0.4452
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0053 0.0346 0.0503
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0362 0.4258 1
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0028 0.0038 0.0089
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0032 0.0082 0.0186
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0048 0.0285 0.0669
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0287 0.0372
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0044 0.0235 0.0341
Loa Loa (eye worm) hypothetical protein 0.0048 0.0287 0.0416
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0055
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0048 0.0283 0.0664
Giardia lamblia 26S protease regulatory subunit 8 0.0028 0.0038 0.0084
Loa Loa (eye worm) cytochrome P450 family protein 0.0183 0.1988 0.2884
Toxoplasma gondii cytochrome p450 superfamily protein 0.0146 0.1529 0.2662
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0028 0.0038 0.0089
Toxoplasma gondii peptidase, T1 family protein 0.0194 0.2133 0.3712
Trypanosoma cruzi 20S proteasome subunit 0.0183 0.1997 0.4689
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0181 0.1966 0.4617
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0146 0.1529 0.3424
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0287 0.043
Echinococcus multilocularis proteasome subunit alpha type 2 0.0199 0.2194 0.2175
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0031 0.0071 0.0103
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0146 0.1529 0.3385
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0146 0.1529 0.3424
Schistosoma mansoni hypothetical protein 0.0083 0.0723 0.1106
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0183 0.1997 0.3164
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0223 0.2502 0.5876
Plasmodium vivax 26S protease regulatory subunit 8, putative 0.0028 0.0038 0.0089
Loa Loa (eye worm) PCI domain-containing protein 0.0044 0.0232 0.0337
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0223 0.2502 0.3994
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0362 0.4258 1
Mycobacterium leprae Conserved hypothetical protein 0.0146 0.1529 0.3129
Toxoplasma gondii proteasome beta subunit 0.0183 0.1997 0.3475
Toxoplasma gondii proteasome regulatory subunit 0.0044 0.0235 0.041
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0183 0.1988 0.4497
Echinococcus granulosus subfamily T1A non peptidase ue 0.0208 0.2312 0.3687
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0029 0.0048 0.0114
Giardia lamblia Hypothetical protein 0.0053 0.0346 0.0808
Entamoeba histolytica hypothetical protein 0.0036 0.0135 0.023
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0025 0.0052
Brugia malayi Proteasome/cyclosome repeat family protein 0.0032 0.0082 0.0118
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0057 0.0397 0.0576
Plasmodium vivax proteasome subunit beta type-7, putative 0.0175 0.1896 0.4452
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0146 0.1529 0.3385
Echinococcus multilocularis proteasome subunit beta type 7 0.0518 0.6227 0.6217
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0048 0.0285 0.0664
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0042 0.0207 0.0294
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0223 0.2502 0.4355
Loa Loa (eye worm) hypothetical protein 0.0199 0.2202 0.3194
Echinococcus granulosus expressed conserved protein 0.0187 0.2049 0.3263
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0146 0.1529 0.3385
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0044 0.0235 0.0341
Entamoeba histolytica 19S cap proteasome S2 subunit 0.003 0.0059 0.005
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0146 0.1529 0.3385
Echinococcus multilocularis expressed conserved protein 0.0187 0.2049 0.2029
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.048 0.5745 0.9221
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0199 0.2194 0.3183
Leishmania major cytochrome p450-like protein 0.0146 0.1529 0.3591
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0029 0.0048 0.0114
Echinococcus granulosus Niemann Pick C1 protein 0.0199 0.2202 0.351
Leishmania major proteasome beta 5 subunit, putative 0.0362 0.4258 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0146 0.1529 0.3591
Brugia malayi proteasome subunit alpha type 1 0.0191 0.2093 0.3037
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0175 0.1896 0.33
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0146 0.1529 0.3591
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0762 0.0739
Loa Loa (eye worm) proteasome regulatory particle 0.0053 0.0346 0.0503
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0263 0.3007 0.299
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0146 0.1529 0.3385
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0146 0.1529 0.3424
Plasmodium vivax 26S protease regulatory subunit 10B, putative 0.0028 0.0038 0.0089
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0031 0.0071 0.0166
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0133 0.0312
Brugia malayi Probable 26S protease regulatory subunit S10B 0.0028 0.0038 0.0055
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0194 0.2133 0.5008
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0075 0.0624 0.1465
Loa Loa (eye worm) proteasome subunit beta type 1 0.0223 0.2502 0.3629
Leishmania major proteasome alpha 1 subunit, putative 0.0191 0.2093 0.4916
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0146 0.1529 0.3424
Giardia lamblia 20S proteasome alpha subunit 5 0.0208 0.2312 0.5426
Schistosoma mansoni hypothetical protein 0.0146 0.1529 0.2409
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0263 0.3007 0.7062
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0362 0.4258 0.6177
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.021 0.2329 0.547
Loa Loa (eye worm) RPT-2 protein 0.0029 0.0048 0.007
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0146 0.1529 0.3424
Brugia malayi proteasome subunit beta type 1 0.0223 0.2502 0.3629
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0075 0.0624 0.1465
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0146 0.1529 0.3424
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0025 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0269 0.0245
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0048 0.0283 0.041
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0192 0.2111 0.4956
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0044 0.0235 0.0341
Onchocerca volvulus 0.0029 0.0048 0.003
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0146 0.1529 0.3424
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0057 0.0397 0.0373
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0056 0.0383 0.0898
Toxoplasma gondii PCI domain-containing protein 0.0044 0.0232 0.0405
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0031 0.007 0.0159
Brugia malayi Proteasome A-type and B-type family protein 0.0192 0.2111 0.3061
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0183 0.1997 0.4689
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0181 0.1966 0.4617
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0192 0.2111 0.3349
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0175 0.1896 0.4449
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0028 0.0038 0.0089
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0145 0.1509 0.3544
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0029 0.0048 0.0024
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0762 0.1188
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0192 0.2111 0.4956
Leishmania major proteasome beta-1 subunit, putative 0.0192 0.2111 0.4956
Echinococcus multilocularis Niemann Pick C1 protein 0.0285 0.3284 0.3267
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0031 0.0069 0.0072
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0208 0.2312 0.5429
Loa Loa (eye worm) proteasome subunit beta type 2 0.0183 0.1997 0.2896
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0042 0.0207 0.0301
Trypanosoma cruzi cytochrome P450, putative 0.0183 0.1988 0.4669
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0269 0.0373
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0208 0.2312 0.5429
Schistosoma mansoni hypothetical protein 0.0083 0.0723 0.1106
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0146 0.1529 0.3424
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0044 0.0235 0.0211
Plasmodium vivax proteasome subunit beta type-6, putative 0.0192 0.2111 0.4956
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0146 0.1529 0.3424
Toxoplasma gondii heat shock protein hslv, putative 0.0145 0.1509 0.2627
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0025 0.0052
Brugia malayi proteasome subunit alpha type 3 0.0194 0.2133 0.3093
Mycobacterium ulcerans proteasome PrcA 0.0145 0.1509 0.3336
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0145 0.1509 0.3544
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.021 0.2329 0.5429
Plasmodium vivax proteasome subunit alpha type-6, putative 0.021 0.2329 0.547
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0044 0.0235 0.0553
Echinococcus multilocularis protein dispatched 1 0.0098 0.0915 0.0892
Entamoeba histolytica proteasome regulatory subunit, putative 0.0053 0.0346 0.0731
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0287 0.0673
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0056 0.0383 0.0898
Toxoplasma gondii PCI domain-containing protein 0.0057 0.0397 0.0691
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0183 0.1997 0.4641
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0183 0.1997 0.3164
Giardia lamblia 20S proteasome alpha subunit 7 0.0194 0.2133 0.5005
Schistosoma mansoni cytochrome P450 0.0146 0.1529 0.2409
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0192 0.2103 0.3336
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0044 0.0235 0.0341
Toxoplasma gondii proteasome subunit 0.0192 0.2111 0.3674
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0146 0.1529 0.3385
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0146 0.1529 0.3424
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0199 0.2202 0.5127
Brugia malayi proteasome subunit alpha type 6 0.021 0.2329 0.3378
Plasmodium vivax proteasome subunit beta type-4, putative 0.0181 0.1966 0.4617
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0191 0.2093 0.4913
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0036 0.0135 0.0178
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0031 0.0069 0.0045
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0208 0.2312 0.3674
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0146 0.1529 0.3385
Giardia lamblia Proteasome subunit beta type 3 0.0183 0.1997 0.4686
Echinococcus granulosus Niemann Pick C1 protein 0.0285 0.3284 0.5255
Leishmania major proteasome beta 7 subunit, putative 0.0181 0.1966 0.4617
Entamoeba histolytica hypothetical protein 0.0073 0.0601 0.1334
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0192 0.2103 0.335
Entamoeba histolytica hypothetical protein 0.0073 0.0601 0.1334
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0146 0.1529 0.3591
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0192 0.2103 0.4938
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0042 0.0207 0.0273
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0036 0.0135 0.0318
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0029 0.0048 0.0114
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0183 0.1997 0.3179
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0031 0.0069 0.0163
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0044 0.0235 0.0553
Echinococcus granulosus adhesion regulating molecule 1 0.048 0.5745 0.9222
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0208 0.2312 0.2292
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0287 0.0589
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0053 0.0346 0.0814
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0036 0.0135 0.0236
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0183 0.1997 0.4689
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0193
Brugia malayi 26S protease regulatory subunit 6A 0.0031 0.0071 0.0103
Brugia malayi hypothetical protein 0.0073 0.0601 0.0872
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.021 0.2329 0.5467
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0181 0.1966 0.3422
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0185 0.2013 0.3191
Plasmodium falciparum proteasome subunit beta type-4 0.0181 0.1966 0.4617
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0208 0.2312 0.5429
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0183 0.1997 0.4689
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0146 0.1529 0.3385
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0044 0.0235 0.0553
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0194 0.2133 0.5005
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0146 0.1529 0.3424
Giardia lamblia 20S proteasome alpha subunit 2 0.0199 0.2194 0.515
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0146 0.1529 0.3424
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0762 0.1188
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0133 0.0312
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0183 0.1997 0.1977
Echinococcus granulosus proteasome subunit beta type 7 0.0518 0.6227 1
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0145 0.1509 0.3544
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0183 0.1997 0.4686
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0053 0.0346 0.0814
Loa Loa (eye worm) hypothetical protein 0.0105 0.1005 0.1458
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0223 0.2502 0.5876
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0048 0.0283 0.0492
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0192 0.2103 0.4938
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0056 0.0383 0.0557
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0075 0.0624 0.1465
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0192 0.2111 0.3061
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0133 0.006
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0223 0.2502 0.5839
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0048 0.0285 0.0669
Brugia malayi Proteasome A-type and B-type family protein 0.0362 0.4258 0.6177
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0053 0.0346 0.0808
Brugia malayi Proteasome subunit alpha type 7-1 0.0263 0.3007 0.4362
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0601 0.0578
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0192 0.2111 0.4956
Echinococcus multilocularis protein patched 0.0086 0.0762 0.0739
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0048 0.0285 0.0669
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0192 0.2103 0.4892
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0287 0.0372
Plasmodium vivax proteasome subunit beta type-5, putative 0.0362 0.4258 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0223 0.2502 0.5876
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0029 0.0048 0.0114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0269 0.0373
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0311 0.3619 0.5249
Echinococcus granulosus Proteasome subunit alpha beta 0.0194 0.2133 0.3398
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0057 0.0397 0.058
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0048 0.0283 0.0416
Mycobacterium ulcerans hypothetical protein 0.0048 0.0287 0.0372
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0183 0.1997 0.3475
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0146 0.1529 0.3424
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0146 0.1529 0.3424
Brugia malayi follicle stimulating hormone receptor 0.028 0.3217 0.4666
Leishmania major proteasome alpha 1 subunit, putative 0.021 0.2329 0.547
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0057 0.0397 0.058
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0036 0.0135 0.0318
Echinococcus granulosus Proteasome subunit alpha type 7 0.0263 0.3007 0.4808
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0183 0.1997 0.4641
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0199 0.2194 0.5153
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0145 0.1509 0.5
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0044 0.0232 0.0546
Giardia lamblia 26S protease regulatory subunit 7 0.0028 0.0038 0.0084
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0029 0.0048 0.0017
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0056 0.0383 0.0557
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0287 0.0372
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0194 0.2133 0.5008
Loa Loa (eye worm) proteasome subunit beta type 3 0.0183 0.1997 0.2896
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0199 0.2194 0.5153
Brugia malayi Adhesion regulating molecule conserved region family protein 0.048 0.5745 0.8333
Leishmania major cytochrome p450-like protein 0.0146 0.1529 0.3591
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0263 0.3007 0.7062
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0044 0.0232 0.0546
Plasmodium falciparum proteasome subunit beta type-5 0.0362 0.4258 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0601 0.0929
Giardia lamblia 26S protease regulatory subunit 6B 0.0029 0.0048 0.0108
Schistosoma mansoni hypothetical protein 0.0073 0.0601 0.0909
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0031 0.0071 0.0166
Leishmania major proteasome regulatory ATPase subunit 0.0028 0.0038 0.0089
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0044 0.0235 0.0553
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0362 0.4258 1
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0192 0.2111 0.4954
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0036 0.0135 0.0111
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0181 0.1966 0.4617
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0069 0.0157
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0223 0.2502 0.5876
Loa Loa (eye worm) hypothetical protein 0.0042 0.0207 0.0301
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0031 0.0071 0.0166
Plasmodium vivax proteasome subunit beta type-3, putative 0.0183 0.1997 0.4689
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0027 0.0025 0.0058
Echinococcus granulosus proteasome subunit beta type 6 0.0192 0.2111 0.3363
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0181 0.1966 0.4617
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0029 0.0048 0.0114
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0048 0.0285 0.0419
Toxoplasma gondii SAC3/GANP family protein 0.0042 0.0207 0.0361
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0042 0.0207 0.0487
Plasmodium vivax proteasome subunit beta type-1, putative 0.0223 0.2502 0.5876
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0181 0.1966 0.4613
Toxoplasma gondii proteasome subunit alpha type, putative 0.0192 0.2103 0.366
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0362 0.4258 1
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0208 0.2312 0.5429
Brugia malayi Proteasome A-type and B-type family protein 0.0181 0.1966 0.2851
Brugia malayi proteasome subunit beta type 2 0.0183 0.1997 0.2896
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0287 0.0372
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0146 0.1529 0.3385
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0191 0.2093 0.2074
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0362 0.4258 0.6819
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0044 0.0232 0.0546
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0044 0.0235 0.034
Echinococcus multilocularis proteasome (prosome, macropain) 0.0362 0.4258 0.4244
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.021 0.2329 0.547
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0042 0.0207 0.0487
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0031 0.0071 0.0166
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0208 0.2312 0.3674
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0263 0.3007 0.4797
Brugia malayi 20S proteasome alpha5 subunit 0.0208 0.2312 0.3353
Brugia malayi Ubiquitin interaction motif family protein 0.0031 0.0069 0.0101
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0191 0.2093 0.4916
Echinococcus granulosus proteasome subunit alpha type 2 0.0199 0.2194 0.3498
Loa Loa (eye worm) hypothetical protein 0.0042 0.0207 0.0301
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0029 0.0048 0.0114
Loa Loa (eye worm) hypothetical protein 0.0029 0.0048 0.007
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0146 0.1529 0.3385
Toxoplasma gondii PCI domain-containing protein 0.0053 0.0346 0.0603
Brugia malayi proteasome subunit alpha type 2 0.0199 0.2194 0.3183
Toxoplasma gondii 26S proteasome regulatory subunit 0.0028 0.0038 0.0066
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0075 0.0624 0.1465
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0287 0.0372
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0044 0.0235 0.0553
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.021 0.2329 0.547
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0263 0.3007 0.7062
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0028 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0287 0.0416
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0145 0.1509 0.3544
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0029 0.0048 0.0114
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0175 0.1896 0.4402
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0048 0.0285 0.0669
Loa Loa (eye worm) hypothetical protein 0.0039 0.0167 0.0242
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0183 0.1997 0.4689
Loa Loa (eye worm) hypothetical protein 0.0311 0.3619 0.5249
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0199 0.2194 0.3484
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0191 0.2093 0.4916
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0057 0.0397 0.0932
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0048 0.0283 0.0664
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0146 0.1529 0.3385
Leishmania major proteasome beta 2 subunit, putative 0.0183 0.1997 0.4689
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0168 0.1808 0.4242
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0048 0.0283 0.0664
Mycobacterium leprae putative cytochrome p450 0.0146 0.1529 0.3129
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0146 0.1529 0.3424
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3217 0.4666
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0208 0.2312 0.5387
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0042 0.0207 0.0487
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0044 0.0235 0.0553
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0146 0.1529 0.3591
Schistosoma mansoni proteasome regulatory subunit-related 0.0048 0.0285 0.0399
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0518 0.6227 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0269 0.0245
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0287 0.0589
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0028 0.0038 0.0021
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0181 0.1966 0.2851
Giardia lamblia 20S proteasome alpha subunit 4 0.0263 0.3007 0.706
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0044 0.0235 0.0211
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0194 0.2133 0.4963
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0029 0.0048 0.0114
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0028 0.0038 0.0089
Trypanosoma brucei cytochrome P450, putative 0.0183 0.1988 0.4669
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0263 0.3007 0.706
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0044 0.0232 0.0546
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0191 0.2093 0.4871
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0269 0.039
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0287 0.0673
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0192 0.2103 0.4892
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0075 0.0624 0.1465
Loa Loa (eye worm) PAS-3 protein 0.0168 0.1804 0.2617
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0146 0.1529 0.3424
Echinococcus granulosus cytochrome P450 2K1 0.0146 0.1529 0.2426
Brugia malayi Niemann-Pick C1 protein precursor 0.0199 0.2202 0.3194
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0287 0.043
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0192 0.2103 0.4938
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.048 0.5745 1
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0127 0.1284 0.2031
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0183 0.1997 0.4686
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0199 0.2194 0.5109
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0192 0.2111 0.4911
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0028 0.0038 0.0013
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0145 0.1509 0.3376
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0056 0.0383 0.0898
Schistosoma mansoni hypothetical protein 0.0044 0.0232 0.0314
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0031 0.0071 0.0077
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0053 0.0346 0.0814
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0146 0.1529 0.3385
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0029 0.0048 0.0114
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0044 0.0235 0.0553
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.021 0.2329 0.547
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0362 0.4258 1
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0362 0.4258 1
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0031 0.0069 0.0163
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0029 0.0048 0.0084
Trypanosoma brucei proteasome beta 6 subunit 0.0223 0.2502 0.5876
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0762 0.1784
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0146 0.1529 0.3385
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0193
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0192 0.2103 0.2083
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0029 0.0048 0.0108
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0362 0.4258 1
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0145 0.1509 0.3544
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0145 0.1509 0.3544
Mycobacterium ulcerans proteasome PrcB 0.0362 0.4258 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0193
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0194 0.2133 0.2113
Brugia malayi PCI domain containing protein 0.0048 0.0285 0.0413
Onchocerca volvulus 0.0048 0.0287 0.0712
Entamoeba histolytica hypothetical protein 0.0073 0.0601 0.1334
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0146 0.1529 0.3591
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0146 0.1529 0.3424
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0048 0.0283 0.0659
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0191 0.2093 0.3335
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0181 0.1966 0.4613
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0208 0.2312 0.5387
Echinococcus multilocularis 0.0146 0.1529 0.1508
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0053 0.0346 0.0323
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0199 0.2194 0.5153
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0048 0.0283 0.0259
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0075 0.0624 0.1465
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0042 0.0207 0.0481
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0048 0.0283 0.0664
Loa Loa (eye worm) proteasome 26S subunit 0.0027 0.0025 0.0036
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0194 0.2133 0.5008
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0056 0.0383 0.0893
Schistosoma mansoni patched 1 0.0086 0.0762 0.1169
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0191 0.2093 0.3644
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0028 0.0038 0.0089
Entamoeba histolytica proteasome regulatory subunit, putative 0.0048 0.0285 0.0585
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0287 0.0416
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0145 0.1509 0.3486
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0036 0.0135 0.0157
Brugia malayi 26S protease regulatory subunit 8 0.0028 0.0038 0.0055
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0036 0.0135 0.0318
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0223 0.2502 0.5874
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0069 0.0074
Loa Loa (eye worm) CYP4Cod1 0.0183 0.1988 0.2884
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0263 0.3007 0.4362
Entamoeba histolytica proteasome regulatory subunit, putative 0.0042 0.0207 0.0401
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0146 0.1529 0.3385
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0042 0.0207 0.0301
Brugia malayi Cytochrome P450 family protein 0.0146 0.1529 0.2218
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0181 0.1966 0.313
Loa Loa (eye worm) PCI domain-containing protein 0.0048 0.0285 0.0413
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0056 0.0383 0.0893
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0146 0.1529 0.3424
Brugia malayi PCI domain containing protein 0.0044 0.0232 0.0337
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0029 0.0048 0.0114
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0042 0.0207 0.0183
Trypanosoma brucei proteasome beta 7 subunit 0.0181 0.1966 0.4617
Loa Loa (eye worm) RPN-3 protein 0.0057 0.0397 0.0576
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0044 0.0232 0.0208
Entamoeba histolytica hypothetical protein 0.0073 0.0601 0.1334
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0145 0.1509 0.2377
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0027 0.0025 0.0058
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0304 0.353 1
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0028 0.0038 0.0084
Brugia malayi Proteasome subunit alpha type 1 0.0167 0.1795 0.2604
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0183 0.1997 0.1977
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0192 0.2103 0.4938
Brugia malayi cytochrome P450 0.0146 0.1529 0.2218
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0191 0.2093 0.4916
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0031 0.0071 0.0053
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0048 0.0285 0.0496
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0029 0.0048 0.0108
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0028 0.0038 0.0084
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0057 0.0397 0.0932
Entamoeba histolytica proteasome regulatory subunit, putative 0.0048 0.0283 0.058
Loa Loa (eye worm) proteasome Regulatory Particle 0.0048 0.0283 0.041
Plasmodium falciparum 26S protease regulatory subunit 8, putative 0.0028 0.0038 0.0089
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0048 0.0285 0.0669
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0031 0.0071 0.0046
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0146 0.1529 0.3385
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0263 0.3007 0.7035
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0183 0.1997 0.4689
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0042 0.0207 0.0481
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0044 0.0235 0.0319
Leishmania major proteasome alpha 2 subunit, putative 0.0199 0.2194 0.5153
Giardia lamblia 20S proteasome alpha subunit 6 0.0191 0.2093 0.4913
Loa Loa (eye worm) hypothetical protein 0.0086 0.0762 0.1105
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0287 0.0673
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0269 0.0394

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 50 uM PUBCHEM_BIOASSAY: Factor XIIa Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID684] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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