Detailed information for compound 1376271

Basic information

Technical information
  • TDR Targets ID: 1376271
  • Name: (2,3-dioxoindol-1-yl)methyl 4-chlorobenzoate
  • MW: 315.708 | Formula: C16H10ClNO4
  • H donors: 0 H acceptors: 3 LogP: 3.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)OCN1c2ccccc2C(=O)C1=O
  • InChi: 1S/C16H10ClNO4/c17-11-7-5-10(6-8-11)16(21)22-9-18-13-4-2-1-3-12(13)14(19)15(18)20/h1-8H,9H2
  • InChiKey: QYGHMWWBRHIOBW-UHFFFAOYSA-N  

Network

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Synonyms

  • (2,3-dioxoindolin-1-yl)methyl 4-chlorobenzoate
  • 4-chlorobenzoic acid (2,3-dioxo-1-indolinyl)methyl ester
  • 4-chlorobenzoic acid (2,3-diketoindolin-1-yl)methyl ester
  • ZINC02709440
  • 4-Chloro-benzoic acid 2,3-dioxo-2,3-dihydro-indol-1-ylmethyl ester
  • BAS 08980375
  • ST5038020

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0127 0.307 0.5429
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0111 0.2624 0.4641
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0088 0.1971 0.3486
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0111 0.2624 0.2624
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0118 0.2806 0.4963
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0127 0.307 0.5429
Brugia malayi Probable 26S protease regulatory subunit 4 0.0018 0.0014 0.0014
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.022 0.5654 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0111 0.2624 0.2624
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0126 0.3046 0.5387
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0032 0.0413 0.0731
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0315 0.8292 0.8292
Leishmania major proteasome beta 7 subunit, putative 0.011 0.2583 0.4568
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0038 0.0583 0.0583
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.022 0.5654 1
Toxoplasma gondii PCI domain-containing protein 0.0027 0.026 0.026
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0111 0.2624 0.2624
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0019 0.0044 0.0077
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.022 0.5654 0.5654
Toxoplasma gondii peptidase, T1 family protein 0.0118 0.2806 0.2806
Brugia malayi proteasome subunit alpha type 3 0.0118 0.2806 0.2806
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0073 0.013
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0027 0.026 0.026
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0034 0.0481 0.0481
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0126 0.3046 0.5387
Leishmania major proteasome alpha 1 subunit, putative 0.0116 0.2754 0.4871
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0264 0.0468
Loa Loa (eye worm) hypothetical protein 0.0376 1 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0136 0.3301 0.5839
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0264 0.0468
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0583 0.0583
Entamoeba histolytica hypothetical protein 0.0034 0.0466 0.0824
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0196 0.4978 0.8804
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0118 0.2806 0.4963
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0019 0.0042 0.0042
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0019 0.0044 0.0044
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0029 0.0331 0.0585
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0117 0.2777 0.4911
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0116 0.2766 0.4892
Loa Loa (eye worm) proteasome subunit beta type 2 0.0111 0.2624 0.2624
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0088 0.1971 0.1971
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0413 0.0731
Loa Loa (eye worm) hypothetical protein 0.0025 0.0227 0.0227
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0227 0.0227
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0044 0.0077
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0027 0.0264 0.0264
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0027 0.0264 0.0264
Plasmodium vivax proteasome subunit beta type-1, putative 0.0136 0.3301 0.5839
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0227 0.0227
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0027 0.0264 0.0468
Giardia lamblia 20S proteasome alpha subunit 1 0.0127 0.307 0.5429
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0328 0.058
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0136 0.3301 0.3301
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0126 0.3046 0.3046
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0126 0.3046 0.5387
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0121 0.2889 0.5109
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0136 0.3301 0.3301
Brugia malayi Ubiquitin interaction motif family protein 0.0019 0.0042 0.0042
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0116 0.2754 0.2754
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0583 0.0583
Toxoplasma gondii proteasome subunit beta type, putative 0.022 0.5654 0.5654
Brugia malayi proteasome subunit alpha type 4 0.0102 0.2366 0.2366
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0042 0.0042
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0018 0.0014 0.0025
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0038 0.0583 0.1031
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0014 0.0025
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0034 0.0481 0.0481
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0127 0.307 0.5429
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0111 0.2624 0.4641
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0014
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0029 0.0328 0.058
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0027 0.0264 0.0264
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0117 0.2777 0.4911
Brugia malayi PCI domain containing protein 0.0029 0.0331 0.0331
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0126 0.3046 0.3046
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.011 0.2583 0.2583
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0032 0.0413 0.0731
Plasmodium vivax proteasome subunit beta type-2, putative 0.0111 0.2624 0.4641
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0029 0.0328 0.058
Brugia malayi proteasome subunit beta type 1 0.0136 0.3301 0.3301
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.011 0.2583 0.4568
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0106 0.2489 0.4402
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0136 0.3301 0.5839
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0106 0.2489 0.4402
Leishmania major proteasome alpha 3 subunit, putative 0.0116 0.2766 0.4892
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0029 0.0328 0.0328
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0042 0.0074
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0038 0.0583 0.1031
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0018 0.0014 0.0025
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0116 0.2766 0.4892
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0018 0.0014 0.0025
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0227 0.0227
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0111 0.2624 0.4641
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0264 0.0468
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0481 0.0481
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.016 0.3978 0.3978
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0073 0.013
Brugia malayi 26S protease regulatory subunit 6A 0.0019 0.0044 0.0044
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0034 0.0481 0.085
Giardia lamblia Proteasome subunit beta type 5 precursor 0.022 0.5654 1
Toxoplasma gondii proteasome subunit alpha1, putative 0.0127 0.307 0.307
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0106 0.2489 0.4402
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0027 0.026 0.0461
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0018 0.0014 0.0025
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.011 0.2583 0.4568
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0264 0.0468
Loa Loa (eye worm) hypothetical protein 0.0189 0.4798 0.4798
Leishmania major proteasome alpha 7 subunit, putative 0.0118 0.2806 0.4963
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0027 0.0264 0.0264
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0059 0.1152 0.2037
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0029 0.0328 0.0328
Schistosoma mansoni hypothetical protein 0.0027 0.026 0.026
Brugia malayi proteasome subunit alpha type 1 0.0116 0.2754 0.2754
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0264 0.0468
Brugia malayi proteasome subunit beta type 3 0.0111 0.2624 0.2624
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0027 0.026 0.0461
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.011 0.2583 0.4568
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0059 0.1152 0.2037
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0044 0.0044
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.011 0.2583 0.2583
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0014 0.0025
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0126 0.3046 0.5387
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0136 0.3301 0.3301
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0077 0.167 0.167
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0029 0.0328 0.058
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0116 0.2754 0.4871
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0038 0.0583 0.0583
Giardia lamblia Proteasome subunit beta type 4 precursor 0.011 0.2583 0.4568
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0376 1 1
Plasmodium vivax proteasome subunit alpha type-7, putative 0.016 0.3978 0.7035
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.022 0.5654 0.5654
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0029 0.0331 0.0331
Echinococcus multilocularis proteasome subunit alpha type 6 0.0127 0.307 0.307
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0227 0.0401
Brugia malayi proteasome subunit alpha type 2 0.0121 0.2889 0.2889
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0118 0.2806 0.4963
Brugia malayi 26S proteasome subunit P45 family protein 0.0018 0.0014 0.0014
Loa Loa (eye worm) PCI domain-containing protein 0.0029 0.0331 0.0331
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0116 0.2766 0.4892
Leishmania major proteasome beta 3 subunit, putative 0.0111 0.2624 0.4641
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0044 0.0077
Giardia lamblia Proteasome subunit beta type 3 0.0111 0.2624 0.4641
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0116 0.2766 0.4892
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0034 0.0466 0.0466
Brugia malayi PCI domain containing protein 0.0027 0.026 0.026
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0042 0.0042
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0014 0.0025
Loa Loa (eye worm) RPT-2 protein 0.0018 0.0014 0.0014
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0126 0.3046 0.5387
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0044 0.0044
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0027 0.026 0.0461
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0116 0.2754 0.2754
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0264 0.0264
Brugia malayi proteasome subunit alpha type 6 0.0127 0.307 0.307
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0025 0.0227 0.0227
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0038 0.0583 0.1031
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0029 0.0328 0.0328
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.016 0.3978 0.7035
Toxoplasma gondii proteasome beta subunit 0.0111 0.2624 0.2624
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0127 0.307 0.307
Echinococcus multilocularis proteasome (prosome, macropain) 0.022 0.5654 0.5654
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0264 0.0264
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0116 0.2766 0.4892
Leishmania major proteasome beta-1 subunit, putative 0.0117 0.2777 0.4911
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0027 0.026 0.0461
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0034 0.0466 0.0466
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0038 0.0583 0.0583
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0136 0.3301 0.5839
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0029 0.0328 0.0328
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0227 0.0227
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0038 0.0583 0.1031
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0118 0.2806 0.4963
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0126 0.3046 0.5387
Echinococcus multilocularis adhesion regulating molecule 1 0.0376 1 1
Leishmania major proteasome alpha 1 subunit, putative 0.0127 0.307 0.5429
Toxoplasma gondii proteasome regulatory subunit 0.0027 0.0264 0.0264
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0121 0.2889 0.5109
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0116 0.2754 0.4871
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0136 0.3301 0.5839
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0264 0.0468
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0038 0.0583 0.1031
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0106 0.2489 0.4402
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.022 0.5654 1
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0118 0.2806 0.2806
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0111 0.2624 0.2624
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0088 0.1971 0.3486
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0331 0.0585
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0018 0.0014 0.0025
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0111 0.2624 0.4641
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0102 0.2371 0.4193
Schistosoma mansoni 26S proteasome subunit S9 0.0032 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0014
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0029 0.0331 0.0331
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0126 0.3046 0.3046
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0059 0.1152 0.2037
Plasmodium vivax proteasome subunit beta type-5, putative 0.022 0.5654 1
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0018 0.0014 0.0014
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0111 0.2624 0.4641
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0118 0.2806 0.2806
Plasmodium falciparum proteasome subunit beta type-5 0.022 0.5654 1
Echinococcus granulosus proteasome subunit beta type 7 0.0315 0.8292 0.8292
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0029 0.0331 0.0331
Loa Loa (eye worm) PAS-3 protein 0.0102 0.2366 0.2366
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0018 0.0014 0.0025
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0027 0.0264 0.0468
Brugia malayi 20S proteasome alpha5 subunit 0.0126 0.3046 0.3046
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.016 0.3978 0.7035
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0106 0.2489 0.2489
Plasmodium vivax proteasome subunit beta type-6, putative 0.0117 0.2777 0.4911
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0027 0.0264 0.0264
Loa Loa (eye worm) proteasome subunit beta type 3 0.0111 0.2624 0.2624
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0116 0.2754 0.2754
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0027 0.0264 0.0264
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.011 0.2583 0.4568
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0029 0.0328 0.0328
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0111 0.2624 0.4641
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0014 0.0025
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0376 1 1
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0038 0.0583 0.1031
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0044 0.0077
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0077 0.167 0.167
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0018 0.0014 0.0014
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0117 0.2777 0.2777
Echinococcus granulosus proteasome subunit beta t family 0.0111 0.2624 0.2624
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0034 0.0466 0.0824
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0027 0.026 0.026
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0117 0.2777 0.4911
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0136 0.3301 0.5839
Giardia lamblia 20S proteasome alpha subunit 4 0.016 0.3978 0.7035
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0106 0.2489 0.4402
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.016 0.3978 0.7035
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0014 0.0025
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0126 0.3046 0.3046
Trypanosoma cruzi 20S proteasome subunit 0.0111 0.2624 0.4641
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0044 0.0044
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0029 0.0328 0.058
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0111 0.2624 0.2624
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0116 0.2754 0.2754
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0088 0.1971 0.3486
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0111 0.2624 0.4641
Trypanosoma brucei proteasome beta 6 subunit 0.0136 0.3301 0.5839
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0481 0.0481
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0019 0.0042 0.0074
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.011 0.2583 0.4568
Loa Loa (eye worm) proteasome regulatory particle 0.0032 0.0413 0.0413
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0136 0.3301 0.5839
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.011 0.2583 0.2583
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0121 0.2889 0.2889
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0189 0.4798 0.4798
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0026 0.0239 0.0423
Echinococcus granulosus proteasome subunit alpha type 6 0.0127 0.307 0.307
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0029 0.0328 0.058
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0059 0.1152 0.2037
Toxoplasma gondii PCI domain-containing protein 0.0032 0.0413 0.0413
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0121 0.2889 0.5109
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0307 0.0307
Giardia lamblia 20S proteasome alpha subunit 5 0.0126 0.3046 0.5387
Leishmania major proteasome beta 5 subunit, putative 0.022 0.5654 1
Echinococcus granulosus adhesion regulating molecule 1 0.0376 1 1
Giardia lamblia 20S proteasome alpha subunit 3 0.0116 0.2766 0.4892
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0032 0.0413 0.0413
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0029 0.0331 0.0585
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0034 0.0481 0.085
Toxoplasma gondii proteasome subunit alpha type, putative 0.0072 0.1526 0.1526
Toxoplasma gondii proteasome subunit alpha type, putative 0.0116 0.2766 0.2766
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0264 0.0468
Entamoeba histolytica proteasome regulatory subunit, putative 0.0027 0.026 0.0461
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0116 0.2754 0.4871
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0116 0.2766 0.2766
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0032 0.0413 0.0413
Giardia lamblia Proteasome subunit beta type 1 0.0136 0.3301 0.5839
Leishmania major proteasome alpha 2 subunit, putative 0.0121 0.2889 0.5109
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0032 0.0413 0.0731
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0027 0.0264 0.0264
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0029 0.0328 0.058
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0307 0.0307
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0018 0.0014 0.0025
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0121 0.2889 0.2889
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0239 0.6173 1
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0019 0.0044 0.0044
Toxoplasma gondii hypothetical protein 0.0023 0.0172 0.0172
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0029 0.0328 0.058
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0018 0.0014 0.0014
Onchocerca volvulus 0.0018 0.0014 0.0023
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0106 0.2489 0.2489
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.011 0.2583 0.4568
Trichomonas vaginalis 26S proteasome subunit, putative 0.0027 0.026 0.0461
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0032 0.0413 0.0731
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0018 0.0028 0.005
Schistosoma mansoni proteasome regulatory subunit-related 0.0029 0.0331 0.0331
Giardia lamblia 26S protease regulatory subunit 6B 0.0018 0.0014 0.0025
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0088 0.1971 0.3486
Loa Loa (eye worm) proteasome subunit beta type 1 0.0136 0.3301 0.3301
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0034 0.0466 0.0824
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0018 0.0014 0.0025
Mycobacterium ulcerans proteasome PrcB 0.022 0.5654 1
Mycobacterium leprae proteasome (beta subunit) PrcB 0.022 0.5654 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0111 0.2624 0.2624
Plasmodium vivax proteasome subunit beta type-4, putative 0.011 0.2583 0.4568
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0088 0.1971 0.5
Schistosoma mansoni multiubiquitin binding protein S5a 0.0019 0.0042 0.0042
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0111 0.2624 0.2624
Onchocerca volvulus Notchless protein homolog 0.0118 0.2806 0.4546
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.011 0.2583 0.2583
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0106 0.2489 0.4402
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0034 0.0466 0.0824
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0059 0.1152 0.2037
Schistosoma mansoni 26S protease regulatory subunit 0.0018 0.0014 0.0014
Brugia malayi proteasome subunit beta type 2 0.0111 0.2624 0.2624
Giardia lamblia 20S proteasome alpha subunit 7 0.0118 0.2806 0.4963
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0034 0.0481 0.0481
Echinococcus multilocularis proteasome subunit alpha type 2 0.0121 0.2889 0.2889
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0227 0.0401
Brugia malayi Proteasome A-type and B-type family protein 0.022 0.5654 0.5654
Toxoplasma gondii SAC3/GANP family protein 0.0025 0.0227 0.0227
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0127 0.307 0.5429
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0034 0.0481 0.085
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0034 0.0481 0.085
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0018 0.0014 0.0025
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0116 0.2754 0.4871
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0014 0.0025
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0059 0.1152 0.2037
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0118 0.2806 0.4963
Echinococcus granulosus Proteasome subunit alpha beta 0.0118 0.2806 0.2806
Trypanosoma brucei proteasome subunit beta type-5, putative 0.022 0.5654 1
Brugia malayi Proteasome A-type and B-type family protein 0.0117 0.2777 0.2777
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0116 0.2766 0.2766
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0264 0.0264
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0044 0.0077
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0121 0.2889 0.2889
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0227 0.0401
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0042 0.0074
Echinococcus multilocularis proteasome subunit beta type 6 0.0117 0.2777 0.2777
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0117 0.2777 0.4911
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0117 0.2777 0.2777
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.022 0.5654 1
Toxoplasma gondii proteasome subunit 0.0117 0.2777 0.2777
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0136 0.3301 0.3301
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0111 0.2624 0.4641
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0111 0.2624 0.4641
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0117 0.2777 0.4911
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0111 0.2624 0.4641
Loa Loa (eye worm) hypothetical protein 0.0023 0.0172 0.0172
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0116 0.2766 0.2766
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0018 0.0014 0.0025
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0116 0.2766 0.4892
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0019 0.0044 0.0077
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0029 0.0331 0.0585
Entamoeba histolytica proteasome regulatory subunit, putative 0.0025 0.0227 0.0401
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0032 0.0413 0.0413
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0106 0.2489 0.4402
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.011 0.2583 0.4568
Leishmania major hypothetical protein, conserved 0.0196 0.4978 0.8804
Leishmania major proteasome beta 2 subunit, putative 0.0106 0.2489 0.4402
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0121 0.2889 0.5109
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0106 0.2489 0.4402
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.011 0.2583 0.4568
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0018 0.0028 0.005
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0018 0.0014 0.0014
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0088 0.1971 0.3486
Entamoeba histolytica proteasome regulatory subunit, putative 0.0019 0.0042 0.0074
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.011 0.2583 0.4568
Brugia malayi Proteasome A-type and B-type family protein 0.0315 0.8292 0.8292
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0028 0.0307 0.0543
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0088 0.1971 0.3486
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.011 0.2583 0.2583
Leishmania major proteasome beta 2 subunit, putative 0.0111 0.2624 0.4641
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0481 0.085
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0126 0.3046 0.5387
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0227 0.0401
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0029 0.0331 0.0585
Echinococcus multilocularis Proteasome subunit alpha type 7 0.016 0.3978 0.3978
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.022 0.5654 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0112 0.2646 0.2646
Echinococcus multilocularis Proteasome subunit alpha type 7 0.016 0.3978 0.3978
Plasmodium vivax proteasome subunit beta type-3, putative 0.0111 0.2624 0.4641
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.016 0.3978 0.7035
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0027 0.0264 0.0468
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0127 0.307 0.5429
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0019 0.0043 0.0076
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0118 0.2806 0.2806
Toxoplasma gondii proteasome 26S regulatory subunit 0.0018 0.0028 0.0028
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0227 0.0401
Toxoplasma gondii PCI domain-containing protein 0.0034 0.0481 0.0481
Loa Loa (eye worm) RPN-3 protein 0.0034 0.0481 0.0481
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0111 0.2624 0.4641
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0118 0.2806 0.4963
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0019 0.0044 0.0044
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0028 0.0307 0.0307
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0116 0.2754 0.2754
Trypanosoma brucei proteasome beta 7 subunit 0.011 0.2583 0.4568
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0019 0.0044 0.0077
Loa Loa (eye worm) proteasome Regulatory Particle 0.0029 0.0328 0.0328
Giardia lamblia 20S proteasome alpha subunit 6 0.0116 0.2754 0.4871
Echinococcus multilocularis proteasome subunit beta type 7 0.0315 0.8292 0.8292
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0038 0.0583 0.1031
Echinococcus granulosus Proteasome subunit alpha type 7 0.016 0.3978 0.3978
Leishmania major proteasome alpha 7 subunit, putative 0.016 0.3978 0.7035
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0025 0.0227 0.0401
Trypanosoma brucei proteasome alpha 7 subunit 0.0118 0.2806 0.4963
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0027 0.026 0.0461
Echinococcus granulosus proteasome subunit alpha type 2 0.0121 0.2889 0.2889
Loa Loa (eye worm) PCI domain-containing protein 0.0027 0.026 0.026
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0111 0.2624 0.2624
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0025 0.0227 0.0401
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0117 0.2777 0.4911
Toxoplasma gondii heat shock protein hslv, putative 0.0088 0.1971 0.1971
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0127 0.307 0.307
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0116 0.2766 0.4892
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0029 0.0331 0.0585
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0032 0.0413 0.0731
Onchocerca volvulus 0.0018 0.0014 0.0023
Plasmodium falciparum proteasome subunit beta type-4 0.011 0.2583 0.4568
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0116 0.2766 0.4892
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0025 0.0227 0.0401
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.016 0.3978 0.7035
Schistosoma mansoni hypothetical protein 0.0077 0.167 0.167
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0583 0.0583
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0034 0.0466 0.0466
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0116 0.2754 0.4871
Plasmodium vivax proteasome subunit beta type-7, putative 0.0106 0.2489 0.4402
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0029 0.0331 0.0585
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0018 0.0014 0.0014
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0126 0.3046 0.5387
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0126 0.3046 0.5387
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0059 0.1152 0.2037
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.016 0.3978 0.3978
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0038 0.0583 0.0583
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0126 0.3046 0.3046
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0027 0.026 0.0461
Echinococcus granulosus proteasome prosome macropain 0.022 0.5654 0.5654
Echinococcus granulosus subfamily T1A non peptidase ue 0.0126 0.3046 0.3046
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0127 0.307 0.5429
Brugia malayi Proteasome subunit alpha type 1 0.0102 0.2354 0.2354
Giardia lamblia Hypothetical protein 0.0032 0.0413 0.0731
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0264 0.0468
Loa Loa (eye worm) hypothetical protein 0.0025 0.0227 0.0227
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0117 0.2777 0.4911
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0118 0.2806 0.4963
Brugia malayi Proteasome subunit alpha type 7-1 0.016 0.3978 0.3978
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0014 0.0025
Giardia lamblia 26S protease regulatory subunit 6A 0.0019 0.0044 0.0077
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0034 0.0466 0.0466
Echinococcus multilocularis Proteasome subunit alpha type 7 0.016 0.3978 0.3978
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0018 0.0014 0.0014
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0111 0.2624 0.4641
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0019 0.0044 0.0044
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0032 0.0413 0.0731
Schistosoma mansoni hypothetical protein 0.0189 0.4798 0.4798
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.016 0.3978 0.7035
Echinococcus granulosus proteasome subunit beta type 6 0.0117 0.2777 0.2777
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0121 0.2889 0.5109
Giardia lamblia 20S proteasome alpha subunit 2 0.0121 0.2889 0.5109
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0088 0.1971 0.3486
Brugia malayi Proteasome A-type and B-type family protein 0.011 0.2583 0.2583
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0018 0.0014 0.0014
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0264 0.0468
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.016 0.3978 0.7035
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0127 0.307 0.5429
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0014 0.0025
Giardia lamblia Proteasome subunit beta type 2 0.0111 0.2624 0.4641
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0116 0.2754 0.4871
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0019 0.0044 0.0077

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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