TDR Targets

Basic information

Technical information

TDR Targets ID: 1377383
Name: [2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amin o]ethyl] 3-methoxybenzoate
MW: 353.329 | Formula: C18H15N3O5
H donors: 1 H acceptors: 4 LogP: 2.47 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C(=O)OCC(=O)Nc1nnc(o1)c1ccccc1
InChi: 1S/C18H15N3O5/c1-24-14-9-5-8-13(10-14)17(23)25-11-15(22)19-18-21-20-16(26-18)12-6-3-2-4-7-12/h2-10H,11H2,1H3,(H,19,21,22)
InChiKey: OAGWBJAXJJPFJC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-methoxybenzoic acid [2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl] ester
3-methoxybenzoic acid [2-keto-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl] ester
ZINC05470566

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references
Streptococcus pyogenes serotype M1	Streptokinase A	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Plasmodium berghei	transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Entamoeba histolytica	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium vivax	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Trypanosoma brucei gambiense	nascent polypeptide associated complex alpha subunit, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium knowlesi	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Cryptosporidium hominis	NAC domain protein	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium yoelii	basic transcription factor 3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Theileria parva	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania braziliensis	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma cruzi	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Babesia bovis	NAC domain containing protein	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania infantum	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Loa Loa (eye worm)	ICD-1 protein	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	ko:K01527 nascent polypeptide-associated complex subunit beta, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania mexicana	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Toxoplasma gondii	NAC domain-containing protein	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium falciparum	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Cryptosporidium parvum	BTF domain, basal transcription factor	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma brucei	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Brugia malayi	beta-NAC-like protein	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus multilocularis	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma cruzi	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0502	0.0887
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.1325	0.1302
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0019	0.0086	0.006
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0052	0.0725	0.0701
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.064	0.087
Brugia malayi	Pre-SET motif family protein	0.003	0.03	0.0309
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.1574	0.1552
Brugia malayi	conserved hypotetical protein	0.002	0.0093	0.0075
Brugia malayi	mbt repeat family protein	0.0048	0.0656	0.071
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0093	0.0075
Brugia malayi	Bromodomain containing protein	0.0039	0.0471	0.0501
Loa Loa (eye worm)	MH2 domain-containing protein	0.0239	0.4408	0.4946
Echinococcus granulosus	lysine specific demethylase 5A	0.0046	0.0608	0.0583
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0028	0.0093
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.064	0.087
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0165	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0537	0.0949
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0148	0.2615	0.492
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.1212	0.1338
Echinococcus granulosus	dna polymerase eta	0.0023	0.0165	0.0139
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.0329	0.0303
Schistosoma mansoni	hypothetical protein	0.0063	0.0939	0.0915
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0079	0.1263	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0303	0.5661	1
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0165	0.0007
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.064	0.0692
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0243	0.1737
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1263	0.2003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0165	0.2382
Echinococcus multilocularis	ecdysone induced protein 78C	0.0042	0.0526	0.0501
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0042	0.0526	0.0564
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0165	0.0139
Giardia lamblia	Fructose-bisphosphate aldolase	0.0303	0.5661	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.064	0.2365
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0664	0.064
Onchocerca volvulus		0.0042	0.0526	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0131	0.2288	0.2553
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0055	0.0787	0.0859
Echinococcus granulosus	nuclear receptor nhr 48	0.002	0.0093	0.0067
Schistosoma mansoni	zinc finger protein	0.0046	0.062	0.0595
Echinococcus multilocularis	lamin	0.0027	0.0231	0.0205
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1263	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0526	0.0564
Brugia malayi	nuclear receptor RXR	0.0022	0.0139	0.0127
Onchocerca volvulus		0.0082	0.1325	0.1402
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0052	0.0725	0.0701
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.064	0.0959
Echinococcus granulosus	expressed conserved protein	0.0094	0.1547	0.1525
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.0329	0.0303
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0042	0.0526	0.0501
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Echinococcus granulosus	FTZ F1 alpha	0.0042	0.0526	0.0501
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.1666	0.1644
Brugia malayi	Heterochromatin protein 1	0.0072	0.1126	0.1241
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0404	0.0426
Schistosoma mansoni	RAR-like nuclear receptor	0.0042	0.0526	0.0501
Schistosoma mansoni	transcription factor btf3	0.0042	0.0537	0.0512
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0231	0.0231
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0165	0.2382
Brugia malayi	hypothetical protein	0.0016	0.003	0.0004
Entamoeba histolytica	transcription factor BTF3, putative	0.0042	0.0537	0.0683
Schistosoma mansoni	zinc finger protein	0.002	0.0093	0.0067
Plasmodium vivax	basic transcription factor 3b, putative	0.0042	0.0537	0.4123
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0082	0.1319	0.1296
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0154	0.2735	0.3057
Plasmodium falciparum	phd finger protein, putative	0.0032	0.0329	0.2437
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.1666	0.1851
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0079	0.1263	0.124
Plasmodium falciparum	basic transcription factor 3b, putative	0.0042	0.0537	0.4123
Echinococcus granulosus	lamin dm0	0.0027	0.0231	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0231	0.0231
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0547	0.0522
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0526	0.0501
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1325	0.1466
Leishmania major	hypothetical protein, conserved	0.0046	0.062	0.9681
Onchocerca volvulus		0.003	0.0291	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0656	0.071
Onchocerca volvulus	Protein ultraspiracle homolog	0.0042	0.0526	0.0493
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1263	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0266	0.024
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0139	0.0127
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0042	0.0526	0.0501
Schistosoma mansoni	hypothetical protein	0.0523	1	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0664	0.064
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0162	0.1081
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0139	0.0127
Schistosoma mansoni	hypothetical protein	0.0049	0.0664	0.064
Trypanosoma brucei	ISWI complex protein	0.0046	0.062	1
Schistosoma mansoni	lamin	0.0027	0.0231	0.0205
Loa Loa (eye worm)	DR-78	0.002	0.0093	0.0075
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0042	0.0526	0.0564
Loa Loa (eye worm)	hypothetical protein	0.01	0.1666	0.1851
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0082	0.1319	0.1296
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.1325	0.1466
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.1126	0.1989
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1263	0.1396
Brugia malayi	hypothetical protein	0.0025	0.0208	0.0205
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0165	0.2382
Schistosoma mansoni	hypothetical protein	0.0049	0.0664	0.064
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0165	0.0139
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0052	0.0725	0.0701
Schistosoma mansoni	glutaminase	0.0276	0.5148	0.5136
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0022	0.0139	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0165	0.2382
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.5661	1
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0052	0.0725	0.0701
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.1574	0.1552
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0656	0.0631
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0303	0.5661	1
Brugia malayi	Bromodomain containing protein	0.0116	0.1995	0.2222
Loa Loa (eye worm)	hypothetical protein	0.0466	0.8886	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.1574	0.1552
Loa Loa (eye worm)	hypothetical protein	0.0047	0.064	0.0692
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0042	0.0526	0.0501
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0042	0.0526	0.0501
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0656	0.0631
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0042	0.0526	0.0564
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0042	0.0526	0.0564
Echinococcus multilocularis	zinc finger protein	0.0061	0.0909	0.0885
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0027	0.0243	0.033
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0526	0.0564
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0042	0.0526	0.0501
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Echinococcus multilocularis	geminin	0.0523	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.064	0.0959
Brugia malayi	TAR-binding protein	0.0076	0.1212	0.1338
Brugia malayi	steroid hormone receptor	0.0042	0.0526	0.0564
Entamoeba histolytica	hypothetical protein	0.0042	0.0537	0.0683
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0028	0.0002
Brugia malayi	Bromodomain containing protein	0.0229	0.4221	0.4735
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0165	0.0291
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0165	0.2382
Loa Loa (eye worm)	RNA binding protein	0.0076	0.1212	0.1338
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1212	0.1189
Brugia malayi	nuclear hormone receptor	0.0042	0.0526	0.0564
Brugia malayi	CHE-14 protein	0.0043	0.0547	0.0588
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0502	0.0887
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0015	0.001	0.0017
Echinococcus granulosus	tar DNA binding protein	0.0076	0.1212	0.1189
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0165	0.2382
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0065	0.0978	0.7689
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.03	0.0275
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.1574	0.1552
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0366	0.1305
Schistosoma mansoni	hypothetical protein	0.0046	0.062	0.0595
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0537	0.0949
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0162	0.1081
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0165	0.0156
Onchocerca volvulus		0.0032	0.033	0.027
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0526	0.0501
Loa Loa (eye worm)	transcription factor SMAD2	0.0239	0.4408	0.4946
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0656	0.064
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1212	0.1189
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.002	0.0093	0.0075
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0165	0.0156
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.3772	0.4228
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0664	0.072
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Loa Loa (eye worm)	glutaminase 2	0.0276	0.5148	0.5781
Schistosoma mansoni	chromobox protein	0.0072	0.1126	0.1102
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.064	0.0959
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.1574	0.1552
Echinococcus granulosus	lamin	0.0027	0.0231	0.0205
Loa Loa (eye worm)	ICD-1 protein	0.0042	0.0537	0.0577
Schistosoma mansoni	nuclear receptor	0.002	0.0093	0.0067
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0019	0.0086	0.006
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0291	0.0299
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0093	0.0067
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0422	0.0397
Brugia malayi	nuclear hormone receptor	0.002	0.0093	0.0075
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0243	0.0147
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0243	0.1737
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0547	0.0588
Onchocerca volvulus	Bile acid receptor homolog	0.0042	0.0526	0.0493
Echinococcus granulosus	Niemann Pick C1 protein	0.0142	0.2507	0.2487
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.1666	0.1644
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.0329	0.0303
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0028	0.0093
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0404	0.0486
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.5661	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0422	0.0397
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.1325	0.1302
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.027	0.0476
Schistosoma mansoni	nuclear receptor	0.002	0.0093	0.0067
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0165	0.231
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0404	0.0426
Brugia malayi	nuclear receptor NHR-67	0.002	0.0093	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0208	0.0205
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0208	0.1457
Schistosoma mansoni	hypothetical protein	0.0523	1	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.064	0.1949
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1263	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0165	0.0006
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.002	0.0093	0.0067
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0042	0.0526	0.0493
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0082	0.1319	0.1296
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0162	0.0516
Loa Loa (eye worm)	heterochromatin protein 1	0.0072	0.1126	0.1241
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0093	0.0067
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0664	0.072
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0109	0.1853	0.1832
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.064	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0071	0.0126
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0079	0.1263	1
Echinococcus multilocularis	chromobox protein 1	0.0072	0.1126	0.1102
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0046	0.0608	0.0583
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0028	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1212	0.1189
Schistosoma mansoni	jumonji domain containing protein	0.0082	0.1327	0.1304
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0208	0.3037
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0526	0.0501
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0165	0.0139
Onchocerca volvulus		0.0047	0.064	0.0622
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0042	0.0526	0.0564
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0165	0.2382
Mycobacterium ulcerans	hypothetical protein	0.0047	0.064	0.0959
Echinococcus multilocularis	FTZ F1 alpha	0.0042	0.0526	0.0501
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0095	0.1574	0.1747
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0404	0.3043
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0071	0.0126
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0329	0.2437
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0231	0.0205
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.5661	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0093	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0154	0.2735	0.3057
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0057	0.0035
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0231	0.0231
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.5661	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0664	0.072
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0079	0.1263	0.4489
Brugia malayi	F/Y-rich N-terminus family protein	0.0026	0.0224	0.0223
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0095	0.1574	0.1747
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0052	0.0727	0.27
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0526	0.0564
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.064	0.2365
Treponema pallidum	fructose-bisphosphate aldolase	0.0303	0.5661	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.5661	1
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0162	0.2182
Schistosoma mansoni	cpg binding protein	0.0037	0.0439	0.0413
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0055	0.0787	0.0763
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0165	0.2382
Brugia malayi	beta-NAC-like protein	0.0042	0.0537	0.0577
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0537	0.0949
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0019	0.0086	0.006
Brugia malayi	nuclear hormone receptor family member odr-7	0.002	0.0093	0.0075
Loa Loa (eye worm)	CHromoDomain protein family member	0.0019	0.0086	0.0067
Schistosoma mansoni	hypothetical protein	0.0036	0.0422	0.0397
Echinococcus multilocularis	protein patched	0.0043	0.0547	0.0522
Echinococcus granulosus	transcription factor btf3	0.0042	0.0537	0.0512
Trypanosoma cruzi	transcription factor btf3, putative	0.0042	0.0537	0.8597
Entamoeba histolytica	hypothetical protein	0.0036	0.0422	0.0474
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.1325	0.1302
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0042	0.0526	0.0564
Onchocerca volvulus		0.0027	0.0231	0.0157
Brugia malayi	RNA binding protein	0.0076	0.1212	0.1338
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0071	0.0126
Brugia malayi	PHD-finger family protein	0.0032	0.0329	0.0341
Schistosoma mansoni	hypothetical protein	0.0041	0.0517	0.0492
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0526	0.0501
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.019	0.3448	0.3431
Echinococcus multilocularis	cpg binding protein	0.0037	0.0439	0.0413
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0404	0.3043
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0022	0.0139	0.0113
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0183	0.3307	0.3289
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0656	0.0631
Echinococcus granulosus	jumonji domain containing protein	0.0044	0.0573	0.0548
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0028	0.0002
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.0526	0.0501
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0165	0.0139
Brugia malayi	hypothetical protein	0.0022	0.0139	0.0127
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.002	0.0093	0.0067
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1212	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0787	0.0859
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.064	0.0959
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0165	0.231
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0526	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0329	0.0341
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.002	0.0093	0.0067
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0101	0.1697	0.1674
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.064	0.0692
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0018	0.0055	0.0028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.1574	0.1552
Brugia malayi	tailless protein	0.002	0.0093	0.0075
Echinococcus granulosus	histone lysine methyltransferase setb	0.0082	0.1319	0.1296
Brugia malayi	chromobox protein homolog 3	0.004	0.0502	0.0537
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0165	0.2237
Entamoeba histolytica	hypothetical protein	0.0036	0.0422	0.0474
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0042	0.0526	0.0564
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0042	0.0526	0.0564
Brugia malayi	hypothetical protein	0.0022	0.0139	0.0127
Schistosoma mansoni	lamin	0.0027	0.0231	0.0205
Echinococcus granulosus	intermediate filament protein	0.0027	0.0231	0.0205
Brugia malayi	jmjC domain containing protein	0.0104	0.1746	0.1941
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.5661	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.002	0.0093	0.0075
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Schistosoma mansoni	hypothetical protein	0.0049	0.0664	0.064
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0526	0.0564
Brugia malayi	hypothetical protein	0.0036	0.0422	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0404	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1999	0.2227
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0028	0.0002
Echinococcus multilocularis	lysine specific demethylase 5A	0.0038	0.046	0.0435
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0042	0.0533	0.0507
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0329	0.2437
Loa Loa (eye worm)	MBCTL1	0.0055	0.0787	0.0859
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0656	0.071
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.03	0.2204
Echinococcus granulosus	GPCR family 2	0.0049	0.0664	0.064
Brugia malayi	PHD-finger family protein	0.0018	0.0057	0.0035
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0093	0.0067
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0022	0.0139	0.0113
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0071	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1776	0.1975
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0165	0.2382
Brugia malayi	hypothetical protein	0.002	0.0093	0.0075
Brugia malayi	ecdysone receptor	0.002	0.0093	0.0075
Plasmodium vivax	SET domain protein, putative	0.003	0.03	0.2204
Loa Loa (eye worm)	glutaminase	0.0276	0.5148	0.5781
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0156
Schistosoma mansoni	hypothetical protein	0.0041	0.0517	0.0492
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0366	0.1305
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0154	0.2735	0.3057
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0042	0.0526	0.0564
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0055	0.0787	0.0763
Schistosoma mansoni	bromodomain containing protein	0.0194	0.3521	0.3504
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0526	0.0501
Brugia malayi	orphan nuclear receptor NR2E1	0.002	0.0093	0.0075
Brugia malayi	Probable ClpP-like protease	0.0079	0.1263	0.1396
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0139	0.0127
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0208	0.1457
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0526	0.0564
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0664	0.072
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0139	0.0127
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0055	0.0787	0.0763
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0526	0.0564
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0664	0.064
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.0329	0.0341
Trypanosoma brucei	unspecified product	0.0023	0.0165	0.2382
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0165	0.231
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0165	0.0291
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0666	0.0641
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.03	0.0275
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.4332	0.7652
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0165	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0124	0.2141	0.2386
Trypanosoma brucei	transcription factor BTF3, putative	0.0042	0.0537	0.861
Echinococcus granulosus	thyroid hormone receptor alpha	0.002	0.0093	0.0067
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.002	0.0093	0.0067
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.002	0.0093	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0032	0.033	0.0343
Onchocerca volvulus		0.0466	0.8886	1
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0656	0.0631
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0656	0.0631
Schistosoma mansoni	hypothetical protein	0.0049	0.0664	0.064
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0165	0.2382
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0165	0.0139
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.007	0.1087	0.1063
Brugia malayi	mbt repeat family protein	0.0048	0.0656	0.071
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.1574	0.1552
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0366	0.1305
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.1212	0.1338
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0562	0.0993
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.019	0.3448	0.3431
Brugia malayi	Pre-SET motif family protein	0.0207	0.3772	0.4228
Echinococcus multilocularis	chromobox protein 1	0.0072	0.1126	0.1102
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0526	0.0501
Schistosoma mansoni	cpg binding protein	0.0037	0.0439	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1319	0.1459
Schistosoma mansoni	hypothetical protein	0.0041	0.0517	0.0492
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0042	0.0526	0.0501
Echinococcus granulosus	chromobox protein 1	0.0072	0.1126	0.1102
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.1126	0.1989
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0028	0.0002
Echinococcus granulosus	peregrin	0.0039	0.0471	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0526	0.0564
Onchocerca volvulus		0.0235	0.4332	0.4821
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0042	0.0526	0.0501
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1263	1
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.1212	0.1189
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0208	0.3102
Onchocerca volvulus		0.0042	0.0533	0.05
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0165	0.231
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0774	0.0844
Toxoplasma gondii	NAC domain-containing protein	0.0042	0.0537	0.4123
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.027	0.0476
Echinococcus multilocularis	jumonji domain containing protein	0.0044	0.0573	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0222	0.022
Brugia malayi	MH2 domain containing protein	0.0239	0.4408	0.4946
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.064	0.0959
Brugia malayi	CXXC zinc finger family protein	0.003	0.0291	0.0299
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0042	0.0526	0.0501
Schistosoma mansoni	coup transcription factor	0.0042	0.0526	0.0501
Loa Loa (eye worm)	hypothetical protein	0.0047	0.064	0.0692
Trypanosoma cruzi	ISWI complex protein	0.0046	0.062	1
Schistosoma mansoni	zinc finger protein	0.0061	0.0909	0.0885
Echinococcus granulosus	fetal alzheimer antigen falz	0.007	0.1087	0.1063
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.0165	0.231
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1212	0.1189
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0165	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0139	0.0127
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0366	0.1305
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0071	0.0126
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0042	0.0526	0.0564
Schistosoma mansoni	hypothetical protein	0.0293	0.5479	0.5467
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.007	0.1087	0.1063
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0071	0.0126
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0139	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0047	0.064	0.0692
Brugia malayi	glutaminase DH11.1	0.0276	0.5148	0.5781
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0165	0.0139
Echinococcus multilocularis	lamin dm0	0.0027	0.0231	0.0205
Schistosoma mansoni	cpg binding protein	0.003	0.0291	0.0266
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0165	0.0529
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.064	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0042	0.0526	0.0501
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0165	0.2382
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0526	0.0564
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0664	0.064
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0093	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0526	0.0564
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0162	0.2326
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0093	0.0067
Brugia malayi	nuclear hormone receptor family member nhr-6	0.002	0.0093	0.0075
Brugia malayi	nuclear receptor NHR-88	0.0042	0.0526	0.0564
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.1666	0.2736
Loa Loa (eye worm)	nuclear receptor NHR-67	0.002	0.0093	0.0075
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0042	0.0526	0.0501
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0656	0.0631
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0165	0.0139
Brugia malayi	PHD-finger family protein	0.0077	0.1228	0.1356
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0162	0.1081
Leishmania major	DNA polymerase eta, putative	0.0023	0.0165	0.2237
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0526	0.0564
Brugia malayi	CHD4 protein	0.0019	0.0086	0.0067
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.5661	1
Brugia malayi	intermediate filament protein	0.0027	0.0231	0.0231
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0969	0.0945
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0042	0.0526	0.0501
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0162	0.1081
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0183	0.3307	0.3289
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.001	0.0017
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0526	0.0564
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0502	0.0465
Onchocerca volvulus	Alhambra homolog	0.0032	0.0329	0.0269
Mycobacterium ulcerans	glutaminase	0.0276	0.5148	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0139	0.0127
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0562	0.0993
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0526	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0737	0.0801
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0042	0.0526	0.0564
Schistosoma mansoni	hypothetical protein	0.0041	0.0517	0.0492
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.064	0.087
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0656	0.0631
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0071	0.0126
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0139	0.0127
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.064	0.1949
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0055	0.0787	0.0763
Onchocerca volvulus		0.0027	0.0231	0.0157
Schistosoma mansoni	patched 1	0.0043	0.0547	0.0522
Brugia malayi	ecdysteroid receptor	0.0042	0.0526	0.0564
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0404	0.1452
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0165	0.2382
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0104	0.1746	0.1724
Brugia malayi	jmjC domain containing protein	0.0046	0.0608	0.0656
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0028	0.0002
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0208	0.1457
Brugia malayi	hypothetical protein	0.002	0.0093	0.0075
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0165	0.0156
Brugia malayi	nuclear receptor RXR	0.002	0.0093	0.0075
Schistosoma mansoni	hypothetical protein	0.0105	0.1776	0.1754
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0208	0.3037
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0071	0.0126
Schistosoma mansoni	hypothetical protein	0.0032	0.0329	0.0303
Schistosoma mansoni	retinoic acid receptor RXR	0.0042	0.0526	0.0501
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1263	1
Echinococcus granulosus	zinc finger protein	0.0061	0.0909	0.0885
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0526	0.0564
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0208	0.1457
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0404	0.22
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0052	0.0727	0.27
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0052	0.0727	0.2303
Echinococcus granulosus	ecdysone induced protein 78C	0.0042	0.0526	0.0501
Schistosoma mansoni	peptidase Clp (S14 family)	0.0079	0.1263	0.124
Echinococcus granulosus	cpg binding protein	0.0037	0.0439	0.0413
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0093	0.0075
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.5661	1
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0526	0.0501
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0165	0.2382
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0093	0.0067
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0042	0.0526	0.0501
Onchocerca volvulus		0.0048	0.0656	0.064
Toxoplasma gondii	hypothetical protein	0.0027	0.0243	0.1737
Echinococcus granulosus	histone acetyltransferase MYST2	0.0055	0.0787	0.0763
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0046	0.0608	0.0583
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0148	0.2615	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0404	0.0426
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0079	0.1263	0.124
Echinococcus multilocularis	expressed conserved protein	0.0094	0.1547	0.1525
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0547	0.0588
Loa Loa (eye worm)	steroid hormone receptor	0.0042	0.0526	0.0564
Echinococcus multilocularis	transcription factor btf3	0.0042	0.0537	0.0512
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0042	0.0526	0.0564
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0148	0.2615	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0018	0.0055	0.0028
Brugia malayi	nuclear receptor NHR-88	0.002	0.0093	0.0075
Leishmania major	basic transcription factor 3a, putative	0.0042	0.0537	0.8323
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0028	0.0002
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0042	0.0526	0.0501
Brugia malayi	latrophilin 2 splice variant baaae	0.0105	0.1776	0.1975
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0404	0.0426
Brugia malayi	photoreceptor-specific nuclear receptor	0.0042	0.0526	0.0564
Schistosoma mansoni	nuclear receptor nhr-48	0.002	0.0093	0.0067
Brugia malayi	hypothetical protein	0.0466	0.8886	1
Echinococcus granulosus	peptidase Clp S14 family	0.0052	0.0727	0.0702
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0154	0.2735	0.3057
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.064	0.0959
Giardia lamblia	PHD finger protein 15	0.0032	0.0329	0.0299
Loa Loa (eye worm)	jmjC domain-containing protein	0.0046	0.0608	0.0656
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0042	0.0526	0.0564
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0093	0.0067
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0104	0.1746	0.1724
Brugia malayi	Steroid receptor seven-up type 2	0.0042	0.0526	0.0564
Schistosoma mansoni	chromobox protein	0.0072	0.1126	0.1102
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.0139	0.0127
Echinococcus multilocularis	peregrin	0.0039	0.0471	0.0445
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0042	0.0526	0.0564
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0664	0.064
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0165	0.0139
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.064	0.0692
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.064	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3932	0.4409
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.064	1
Trichomonas vaginalis	glutaminase, putative	0.0276	0.5148	0.9094
Leishmania major	hypothetical protein, conserved	0.0025	0.0208	0.2941
Entamoeba histolytica	hypothetical protein	0.0036	0.0422	0.0474
Loa Loa (eye worm)	nuclear hormone receptor	0.002	0.0093	0.0075
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1263	0.2209
Loa Loa (eye worm)	bromodomain containing protein	0.0054	0.0762	0.083
Echinococcus multilocularis	nuclear receptor nhr 48	0.002	0.0093	0.0067
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0019	0.0077	0.005
Trypanosoma cruzi	ISWI complex protein	0.0046	0.062	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0109	0.1853	0.1832
Entamoeba histolytica	hypothetical protein	0.0036	0.0422	0.0474
Echinococcus multilocularis	Niemann Pick C1 protein	0.0142	0.2507	0.2487
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0547	0.0522
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.1212	0.1338
Echinococcus multilocularis	musashi	0.0027	0.0231	0.0205
Echinococcus granulosus	chromobox protein 1	0.0072	0.1126	0.1102
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0547	0.0522
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0052	0.0727	0.0702
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0042	0.0526	0.0501
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0028	0.0002
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0028	0.0002
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0526	0.0564
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0422	0.0397
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0329	0.2437
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0547	0.0967
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0028	0.0002
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0042	0.0526	0.0501
Loa Loa (eye worm)	PHD-finger family protein	0.0063	0.0939	0.103
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0165	0.2237
Loa Loa (eye worm)	jmjC domain-containing protein	0.0065	0.0992	0.109
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0042	0.0526	0.0501
Trypanosoma cruzi	transcription factor btf3, putative	0.0042	0.0537	0.8597
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0079	0.1263	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0562	0.0534
Loa Loa (eye worm)	hypothetical protein	0.004	0.0502	0.0537

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 8.675 um	PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)]	ChEMBL.	No reference
EC50 (functional)	> 150 um	PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)]	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1513829

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1377383