Detailed information for compound 1377611

Basic information

Technical information
  • TDR Targets ID: 1377611
  • Name: 3-[(1-tert-butyltetrazol-5-yl)-[4-(furan-2-ca rbonyl)piperazin-1-yl]methyl]-6,8-dimethyl-1H -quinolin-2-one
  • MW: 489.569 | Formula: C26H31N7O3
  • H donors: 1 H acceptors: 6 LogP: 3.33 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c2c(c1)cc(c(n2)O)C(c1nnnn1C(C)(C)C)N1CCN(CC1)C(=O)c1ccco1
  • InChi: 1S/C26H31N7O3/c1-16-13-17(2)21-18(14-16)15-19(24(34)27-21)22(23-28-29-30-33(23)26(3,4)5)31-8-10-32(11-9-31)25(35)20-7-6-12-36-20/h6-7,12-15,22H,8-11H2,1-5H3,(H,27,34)
  • InChiKey: QPFUYWBAIYEUIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(1-tert-butyl-5-tetrazolyl)-[4-(2-furyl-oxomethyl)-1-piperazinyl]methyl]-6,8-dimethyl-1H-quinolin-2-one
  • 3-[(1-tert-butyltetrazol-5-yl)-[4-(furan-2-carbonyl)piperazin-1-yl]methyl]-6,8-dimethyl-carbostyril
  • 3-[(1-tert-butyl-1,2,3,4-tetrazol-5-yl)-(4-furan-2-ylcarbonylpiperazin-1-yl)methyl]-6,8-dimethyl-1H-quinolin-2-one
  • Oprea1_212175
  • 3-{(1-tert-Butyl-1H-tetrazol-5-yl)-[4-(furan-2-carbonyl)-piperazin-1-yl]-methyl}-6,8-dimethyl-1H-quinolin-2-one
  • MLS000070671
  • SMR000003362
  • MLS000880198
  • ASN 04419962

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major carboxylase, putative 0.0143 0.2693 0.3226
Schistosoma mansoni opsin-like receptor 0.0032 0.0056 0.0068
Echinococcus granulosus pyruvate kinase 0.004 0.0253 0.0197
Loa Loa (eye worm) hypothetical protein 0.0163 0.3172 0.3971
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0056 0.0068
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0143 0.2693 0.9836
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.2389 0.8609
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0054 0.059 0.068
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0056 0.0068
Schistosoma mansoni amine GPCR 0.0032 0.0056 0.0068
Toxoplasma gondii thioredoxin reductase 0.0057 0.0652 0.0721
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0056 0.0005
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0056 0.0068
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0652 0.0599
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0056 0.0068
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0376 0.8215 0.8205
Brugia malayi MH2 domain containing protein 0.0144 0.272 0.3394
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0056 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0056 0.0068
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0054 0.059 0.0537
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0143 0.2693 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0056 0.0005
Mycobacterium ulcerans pyruvate kinase 0.004 0.0253 0.0718
Plasmodium vivax ubiquitin C-terminal hydrolase, family 1, putative 0.0037 0.0178 0.0201
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0056 0.0005
Brugia malayi glutathione reductase 0.0057 0.0652 0.0759
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0051 0.0505 0.1016
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.0037 0.0178 0.0123
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0652 0.1034
Loa Loa (eye worm) pyruvate kinase 0.004 0.0253 0.025
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0037 0.018 0.0218
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0037 0.018 0.0124
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.2389 0.8609
Schistosoma mansoni aspartate carbamoyltransferase 0.0032 0.0064 0.0078
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0056 0.0068
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0037 0.0178 0.0128
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0253 0.0397
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0051 0.0505 0.0614
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase isozyme L3, putative 0.0037 0.0178 0.0201
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.5264 0.6637
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0056 0.0005
Loa Loa (eye worm) pyruvate kinase 0.004 0.0253 0.025
Schistosoma mansoni voltage-gated potassium channel 0.0054 0.059 0.0718
Schistosoma mansoni amine GPCR 0.0032 0.0056 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0152 0.0185
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0037 0.018 0.0129
Echinococcus granulosus geminin 0.0205 0.4155 0.4122
Schistosoma mansoni acetyl-CoA carboxylase 0.0376 0.8215 1
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0143 0.2693 1
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0068
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0037 0.018 0.0129
Schistosoma mansoni biogenic amine receptor 0.0032 0.0056 0.0068
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0143 0.2693 0.9836
Echinococcus multilocularis hyperpolarization activated cyclic 0.0037 0.018 0.0129
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0122
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0037 0.018 0.0157
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0056 0.0005
Loa Loa (eye worm) glutathione reductase 0.0057 0.0652 0.0759
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0064 0.0817 1
Brugia malayi Carboxyl transferase domain containing protein 0.0362 0.7903 1
Schistosoma mansoni ubiquitinyl hydrolase-BAP1 (C12 family) 0.0037 0.0178 0.0217
Onchocerca volvulus 0.0036 0.0152 0.0159
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.2389 0.8609
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0188 0.3762 0.373
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0068
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0037 0.018 0.0129
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0152 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0056 0.0068
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0051 0.0505 0.1676
Schistosoma mansoni pyruvate carboxylase 0.0143 0.2693 0.3278
Toxoplasma gondii pyruvate carboxylase 0.0143 0.2693 0.3226
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0056 0.0068
Echinococcus granulosus hyperpolarization activated cyclic 0.0037 0.018 0.0124
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0056 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0056 0.0005
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0051 0.0505 0.1016
Trypanosoma brucei unspecified product 0.0094 0.1529 0.1798
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0056 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.2389 0.8609
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0253 0.0232
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.0037 0.0178 0.0217
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0188 0.3762 0.4722
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0056 0.0068
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0037 0.0178 0.0217
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0056 0.0005
Schistosoma mansoni neuropeptide receptor 0.0032 0.0056 0.0068
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0068
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.2734 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0037 0.018 0.0157
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0051 0.0505 0.0541
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0056 0.0005
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0056 0.0005
Leishmania major pyruvate kinase 0.004 0.0253 0.0232
Schistosoma mansoni neuropeptide receptor 0.0032 0.0056 0.0068
Echinococcus multilocularis pyruvate kinase 0.004 0.0253 0.0203
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0051 0.0505 0.1184
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0056 0.0068
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0037 0.018 0.0218
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0056 0.0005
Echinococcus multilocularis geminin 0.0205 0.4155 0.4125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0056 0.0005
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0056 0.0005
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0051 0.0505 0.1676
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0152 0.0108
Echinococcus multilocularis expressed protein 0.0451 1 1
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0037 0.0178 0.0217
Schistosoma mansoni voltage-gated potassium channel 0.0205 0.4172 0.5078
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0056 0.0005
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.2734 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0253 0.025
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0051 0.0505 0.0927
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0051 0.0505 0.0451
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0056 0.0068
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0056 0.0005
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.012 0.0065
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0068
Schistosoma mansoni voltage-gated potassium channel 0.0054 0.059 0.0718
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0054 0.059 0.0542
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0051 0.0505 0.1016
Echinococcus multilocularis hyperpolarization activated cyclic 0.0037 0.018 0.0129
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.0157
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0056 0.0068
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0176 0.3468 0.5566
Onchocerca volvulus 0.0286 0.6089 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.018 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0652 0.1237
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0178 0.014
Schistosoma mansoni voltage-gated potassium channel 0.0205 0.4172 0.5078
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase BAP1 0.0037 0.0178 0.0128
Schistosoma mansoni opsin-like receptor 0.0032 0.0056 0.0068
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0143 0.2693 0.3226
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.0037 0.0178 0.014
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0056 0.0005
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0064 0.0817 1
Leishmania major acetyl-CoA carboxylase, putative 0.0376 0.8215 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0253 0.0325
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0178 0.014
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0037 0.018 0.0218
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0056 0.0068
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0056 0.0068
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0272 0.5751 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.0037 0.0178 0.0156
Loa Loa (eye worm) ubiquitin C-terminal hydrolase UCH-L5 0.0037 0.0178 0.0156
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.0037 0.0178 0.014
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0056 0.0005
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0178 0.0241
Brugia malayi ubiquitin C-terminal hydrolase UCH-L5 0.0037 0.0178 0.0156
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0376 0.8215 1
Plasmodium vivax pyruvate kinase, putative 0.004 0.0253 0.0332
Schistosoma mansoni voltage-gated potassium channel 0.0037 0.018 0.0218
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.168 0.1633
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase BAP1 0.0037 0.0178 0.0123
Echinococcus multilocularis voltage gated potassium channel 0.0054 0.059 0.0542
Schistosoma mansoni opsin-like receptor 0.0032 0.0056 0.0068
Plasmodium vivax glutathione reductase, putative 0.0057 0.0652 0.1034
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0051 0.0505 0.1016
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0056 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0056 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.272 0.3394
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.2734 1
Echinococcus granulosus pyruvate kinase 0.004 0.0253 0.0197
Plasmodium falciparum pyruvate kinase 0.004 0.0253 0.0332
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0253 0.0126
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0056 0.0005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0176 0.3468 0.5566
Plasmodium falciparum glutathione reductase 0.0057 0.0652 0.1034
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.2389 0.8609
Schistosoma mansoni neuropeptide receptor 0.0032 0.0056 0.0068
Brugia malayi Thioredoxin reductase 0.0057 0.0652 0.0759
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0056 0.0068
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0253 0.0126
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0056 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0152 0.0185
Echinococcus granulosus hyperpolarization activated cyclic 0.0037 0.018 0.0124
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0037 0.018 0.0124
Echinococcus granulosus voltage gated potassium channel 0.0054 0.059 0.0537
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0376 0.8215 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0253 0.0325
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0037 0.018 0.0124
Schistosoma mansoni amine GPCR 0.0032 0.0056 0.0068
Echinococcus multilocularis serotonin receptor 0.0032 0.0056 0.0005
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.0037 0.0178 0.0217
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0056 0.0068
Schistosoma mansoni amine GPCR 0.0032 0.0056 0.0068
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0056 0.0005
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.168 0.2045
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0056 0.0005
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0143 0.2693 0.9836
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0051 0.0505 0.0927
Trypanosoma brucei trypanothione reductase 0.0057 0.0652 0.0721
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0362 0.7903 1
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0143 0.2693 0.2652
Schistosoma mansoni histamine h1 receptor 0.0032 0.0056 0.0068
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0056 0.0068
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0652 0.0604
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0056 0.0005
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0253 0.0232
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0143 0.2693 1
Plasmodium falciparum deubiquinating/deneddylating enzyme 0.0037 0.0178 0.0201
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0143 0.2693 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0056 0.0005
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0051 0.0505 0.1016
Leishmania major pyruvate kinase 0.004 0.0253 0.0232
Brugia malayi Pre-SET motif family protein 0.0036 0.0152 0.0122
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0051 0.0505 0.1676
Trypanosoma brucei pyruvate kinase 1 0.004 0.0253 0.0232
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0652 0.0759
Schistosoma mansoni adenoreceptor 0.0032 0.0056 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0056 0.0005
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0051 0.0505 0.1676
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0178 0.0241
Plasmodium vivax SET domain protein, putative 0.0036 0.0152 0.0155
Schistosoma mansoni pyruvate kinase 0.004 0.0253 0.0307
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0143 0.2693 0.3226
Loa Loa (eye worm) hypothetical protein 0.01 0.168 0.207
Leishmania major trypanothione reductase 0.0057 0.0652 0.0721
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0032 0.0064 0.0078
Trypanosoma cruzi acetyl-CoA carboxylase 0.0233 0.4818 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0056 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0152 0.0185
Loa Loa (eye worm) hypothetical protein 0.0054 0.059 0.068
Trypanosoma brucei acetyl-CoA carboxylase 0.0376 0.8215 1
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0056 0.0005
Chlamydia trachomatis biotin carboxylase 0.013 0.2381 1
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0272 0.5751 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0178 0.0241
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0253 0.025
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0051 0.0505 0.0541
Schistosoma mansoni hypothetical protein 0.0205 0.4155 0.5058
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0056 0.0068
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0051 0.0505 0.0456
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0056 0.0068
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0056 0.0005
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.168 0.207
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0143 0.2693 0.3278
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0188 0.3762 0.3726
Echinococcus multilocularis sex peptide receptor 0.0032 0.0056 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0056 0.0068
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0152 0.0101
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0056 0.0068
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0056 0.0068
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0037 0.018 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0056 0.0068
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0051 0.0505 0.1676
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0253 0.0325
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.0037 0.0178 0.014
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0056 0.0005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.2389 0.8609
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0152 0.0096
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0253 0.0397
Echinococcus multilocularis pyruvate kinase 0.004 0.0253 0.0203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0056 0.0005
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0056 0.0005
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0051 0.0505 0.0927
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0056 0.0005
Onchocerca volvulus 0.01 0.168 0.2692
Schistosoma mansoni amine GPCR 0.0032 0.0056 0.0068
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0652 0.1609
Echinococcus multilocularis somatostatin receptor 0.0032 0.0056 0.0005
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0051 0.0505 0.1676
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0051 0.0505 0.0541
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0143 0.2693 0.2656
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0056 0.0005
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.272 0.3394
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0056 0.0005
Schistosoma mansoni myosin xvIII 0.0032 0.0056 0.0068
Loa Loa (eye worm) hypothetical protein 0.004 0.0253 0.025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0156
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0037 0.018 0.0218
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0143 0.2693 0.5531
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0056 0.0005
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0032 0.0064 0.0078
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0056 0.0068
Schistosoma mansoni neuropeptide receptor 0.0032 0.0056 0.0068
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.0037 0.0178 0.0123
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0056 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.2734 1
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase UCHL3 0.0037 0.0178 0.014
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase isozyme L3 0.0037 0.0178 0.0201
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0056 0.0005
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0051 0.0505 0.0541
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0188 0.3762 0.4722
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.0037 0.0178 0.0217
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0056 0.0005
Mycobacterium ulcerans pyruvate carboxylase 0.0143 0.2693 1
Plasmodium falciparum thioredoxin reductase 0.0057 0.0652 0.1034
Echinococcus multilocularis serotonin receptor 0.0032 0.0056 0.0005
Schistosoma mansoni biogenic amine receptor 0.0032 0.0056 0.0068
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0037 0.018 0.0124
Brugia malayi Pre-SET motif family protein 0.0251 0.5264 0.6637
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0037 0.0178 0.0128
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0056 0.0068
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0056 0.0068
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0143 0.2693 0.3278
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.168 0.1638
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0037 0.0178 0.0128
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0056 0.0005
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0056 0.0005
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0051 0.0505 0.1676
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0143 0.2693 0.5531
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0056 0.0005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0056 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0152 0.0185
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0376 0.8215 0.8206
Schistosoma mansoni hypothetical protein 0.0205 0.4155 0.5058
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.018 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0286 0.6089 1
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0143 0.2693 0.3226
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0037 0.018 0.0218
Loa Loa (eye worm) pyruvate kinase 0.004 0.0253 0.025
Schistosoma mansoni pyruvate kinase 0.004 0.0253 0.0307
Schistosoma mansoni biogenic amine receptor 0.0032 0.0056 0.0068
Mycobacterium tuberculosis Probable reductase 0.013 0.2389 0.8609

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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