TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 401.335 | Formula: C13H16N5O6PS
H donors: 3 H acceptors: 6 LogP: -1.07 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: C=CCSc1nc2c(n1C1OC3C(C1O)OP(=O)(OC3)O)ncnc2N
InChi: 1S/C13H16N5O6PS/c1-2-3-26-13-17-7-10(14)15-5-16-11(7)18(13)12-8(19)9-6(23-12)4-22-25(20,21)24-9/h2,5-6,8-9,12,19H,1,3-4H2,(H,20,21)(H2,14,15,16)
InChiKey: BKFAEQHQUUBKMR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	aspartic protease BmAsp-2, identical	0.0066	0.0543	0.0819
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0016	0.0016
Brugia malayi	hypothetical protein	0.0083	0.0724	0.1093
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0106	0.1162
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0644	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0644	0.0972
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0214	0.1882
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0106	0.1162
Brugia malayi	MAP kinase sur-1	0.0052	0.0388	0.0586
Mycobacterium tuberculosis	Probable lipase LipD	0.0075	0.0644	0.1234
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0052	0.0388	0.5084
Schistosoma mansoni	alpha-glucosidase	0.0139	0.1331	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0106	0.016
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0034	0.0194	0.2235
Loa Loa (eye worm)	Smad1	0.0043	0.0289	0.0436
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0052	0.0388	0.5084
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0388	0.3789
Echinococcus multilocularis	geminin	0.0168	0.1644	0.1895
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0214	0.1733
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0317	0.0365
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0075	0.0644	0.0742
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0214	0.1733
Schistosoma mansoni	microtubule-associated protein tau	0.0815	0.8676	0.8676
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0214	0.2525
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0041	0.007
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0016	0.0016
Schistosoma mansoni	tar DNA-binding protein	0.0253	0.2569	0.2569
Brugia malayi	MH1 domain containing protein	0.0024	0.0082	0.0124
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0214	0.0246
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0388	0.3789
Onchocerca volvulus		0.0026	0.0106	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0644	0.0972
Echinococcus granulosus	intermediate filament protein	0.0028	0.0125	0.0144
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0066	0.0543	0.5472
Plasmodium falciparum	plasmepsin X	0.0066	0.0543	0.5504
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0214	0.2525
Loa Loa (eye worm)	hypothetical protein	0.0027	0.012	0.0181
Echinococcus multilocularis	smad	0.0043	0.0289	0.0333
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0214	0.1882
Loa Loa (eye worm)	hypothetical protein	0.002	0.0041	0.0063
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0125	0.0125
Brugia malayi	beta-lactamase family protein	0.0075	0.0644	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0613	0.0925
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0161	0.1574	0.2376
Loa Loa (eye worm)	aspartyl protease 6	0.0066	0.0543	0.0819
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0106	0.1162
Brugia malayi	RNA binding protein	0.0253	0.2569	0.3878
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0376	0.0568
Schistosoma mansoni	hypothetical protein	0.0035	0.0202	0.0202
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0477	0.0477
Plasmodium falciparum	plasmepsin III	0.0066	0.0543	0.5504
Onchocerca volvulus		0.0075	0.0644	0.7598
Leishmania major	hypothetical protein, conserved	0.0075	0.0644	0.8826
Mycobacterium ulcerans	hypothetical protein	0.0075	0.0644	1
Brugia malayi	MH1 domain containing protein	0.0024	0.0082	0.0124
Echinococcus multilocularis	lamin dm0	0.0028	0.0125	0.0144
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0106	0.0163
Loa Loa (eye worm)	TAR-binding protein	0.0253	0.2569	0.3878
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0106	0.0646
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0388	0.0388
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0376	0.0376
Brugia malayi	hypothetical protein	0.0066	0.0543	0.0819
Loa Loa (eye worm)	MH2 domain-containing protein	0.0626	0.6624	1
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0644	0.1234
Brugia malayi	Smad1	0.0043	0.0289	0.0436
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0317	0.0365
Plasmodium vivax	aspartyl proteinase, putative	0.0104	0.0957	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0043	0.0289	0.0333
Schistosoma mansoni	cathepsin D (A01 family)	0.0202	0.2016	0.2016
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0477	0.0903
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0376	0.0568
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0075	0.0644	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0477	0.055
Schistosoma mansoni	tar DNA-binding protein	0.0253	0.2569	0.2569
Schistosoma mansoni	hypothetical protein	0.0168	0.1644	0.1644
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0075	0.0644	0.1234
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0016	0.0016
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0052	0.0388	0.5084
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0052	0.0388	0.0448
Plasmodium falciparum	ataxin-2 like protein, putative	0.0083	0.0724	0.747
Toxoplasma gondii	aspartyl protease ASP3	0.0066	0.0543	0.5472
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0052	0.0388	0.5084
Echinococcus granulosus	microtubule associated protein 2	0.0815	0.8676	1
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0041	0.0048
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0388	0.3789
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0052	0.0388	0.5084
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0125	0.0189
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0477	0.7266
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0052	0.0388	0.3789
Schistosoma mansoni	lamin	0.0028	0.0125	0.0125
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0066	0.0543	0.0543
Trichomonas vaginalis	esterase, putative	0.0075	0.0644	0.6577
Mycobacterium leprae	conserved hypothetical protein	0.0075	0.0644	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0083	0.0724	0.747
Leishmania major	hypothetical protein, conserved	0.0034	0.0194	0.2235
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0106	0.1162
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0161	0.1574	0.2376
Loa Loa (eye worm)	RecQ helicase	0.002	0.0041	0.0063
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0066	0.0543	0.0543
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0066	0.0543	0.0543
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.1574	0.1814
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0066	0.0543	0.0543
Entamoeba histolytica	hypothetical protein	0.0112	0.1036	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0229	0.0229
Brugia malayi	MH1 domain containing protein	0.0043	0.0289	0.0436
Brugia malayi	beta-lactamase	0.0075	0.0644	0.0972
Mycobacterium leprae	Probable lipase LipE	0.0075	0.0644	1
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0041	0.0048
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0041	0.0063
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0034	0.0194	0.0224
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0214	0.1882
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0056	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0053
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.1574	0.1814
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0066	0.0543	0.0543
Onchocerca volvulus		0.0028	0.0125	0.1149
Plasmodium vivax	plasmepsin IV, putative	0.0104	0.0957	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0082	0.0124
Brugia malayi	MH2 domain containing protein	0.0626	0.6624	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0043	0.0289	0.0289
Mycobacterium ulcerans	lipase LipD	0.0075	0.0644	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0106	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0016	0.0024
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0226	0.026
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0075	0.0644	0.1234
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0214	0.0323
Loa Loa (eye worm)	hepatopoietin HPO2	0.0034	0.0194	0.0293
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0644	0.8826
Leishmania major	hypothetical protein, conserved	0.0083	0.0724	1
Schistosoma mansoni	transcription factor LCR-F1	0.0112	0.1036	0.1036
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0016	0.0018
Plasmodium falciparum	plasmepsin VIII, putative	0.0066	0.0543	0.5504
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0644	0.6577
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0644	0.6577
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.0041	0.007
Schistosoma mansoni	alpha glucosidase	0.0036	0.0214	0.0214
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0317	0.0365
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0214	0.2525
Plasmodium vivax	aspartyl proteinase, putative	0.0066	0.0543	0.5504
Schistosoma mansoni	hypothetical protein	0.0112	0.1036	0.1036
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0016	0.0018
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0106	0.0942
Toxoplasma gondii	ABC1 family protein	0.0075	0.0644	0.6577
Loa Loa (eye worm)	MH2 domain-containing protein	0.0043	0.0289	0.0436
Schistosoma mansoni	alpha-glucosidase	0.0139	0.1331	0.1331
Echinococcus multilocularis	lamin	0.0028	0.0125	0.0144
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0477	0.0477
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0214	0.1882
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0724	0.1093
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0077	0.0088
Trypanosoma brucei	protein kinase, putative	0.0052	0.0388	0.5084
Echinococcus granulosus	mitogen activated protein kinase 3	0.0052	0.0388	0.0448
Plasmodium vivax	plasmepsin V, putative	0.0066	0.0543	0.5504
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0644	0.1234
Echinococcus granulosus	mothers against decapentaplegic 5	0.0043	0.0289	0.0333
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0477	0.476
Brugia malayi	Augmenter of liver regeneration	0.0034	0.0194	0.0293
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0075	0.0644	0.0972
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0016	0.0018
Plasmodium vivax	aspartyl protease, putative	0.0066	0.0543	0.5504
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0016	0.0016
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0214	0.1882
Loa Loa (eye worm)	beta-lactamase	0.0075	0.0644	0.0972
Echinococcus multilocularis	mitogen activated protein kinase	0.0052	0.0388	0.0448
Echinococcus multilocularis	tar DNA binding protein	0.0253	0.2569	0.2961
Brugia malayi	Pepsin A precursor	0.0066	0.0543	0.0819
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0041	0.0048
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0317	0.0317
Plasmodium vivax	aspartyl protease, putative	0.0066	0.0543	0.5504
Plasmodium falciparum	plasmepsin VI	0.0104	0.0957	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0125	0.0189
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0477	0.7266
Toxoplasma gondii	Erv1 / Alr family protein	0.0034	0.0194	0.1665
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0104	0.0957	0.1104
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0482	0.5052	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0253	0.2569	0.3878
Toxoplasma gondii	LsmAD domain-containing protein	0.0083	0.0724	0.7452
Schistosoma mansoni	Smad4	0.0043	0.0289	0.0289
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0388	0.3789
Echinococcus multilocularis	tumor protein p63	0.0347	0.3587	0.4134
Mycobacterium ulcerans	beta-lactamase	0.0075	0.0644	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0644	0.6577
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0214	0.0246
Echinococcus granulosus	zinc finger protein	0.002	0.0044	0.005
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.049	0.0565
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0104	0.0957	1
Schistosoma mansoni	smad	0.0043	0.0289	0.0289
Loa Loa (eye worm)	MH1 domain-containing protein	0.0019	0.0033	0.005
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0957	0.1445
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0644	0.1234
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0041	0.0063
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0202	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0301	0.0454
Schistosoma mansoni	zinc finger protein	0.002	0.0044	0.0044
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0477	0.7266
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0033	0.005
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0034	0.0194	0.2235
Schistosoma mansoni	hypothetical protein	0.0168	0.1644	0.1644
Toxoplasma gondii	aspartyl protease	0.0066	0.0543	0.5472
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0214	0.1882
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0066	0.0543	0.0819
Schistosoma mansoni	smad1 5 8 and	0.0043	0.0289	0.0289
Trypanosoma cruzi	PAB1-binding protein , putative	0.0083	0.0724	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0106	0.016
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0253	0.0382
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0035	0.5
Onchocerca volvulus		0.0051	0.0376	0.4271
Plasmodium falciparum	plasmepsin V	0.0066	0.0543	0.5504
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0644	0.0644
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0106	0.1162
Schistosoma mansoni	Smad4	0.0019	0.0033	0.0033
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0041	0.0000000010718
Schistosoma mansoni	DNA helicase recq5	0.002	0.0041	0.0041
Plasmodium vivax	hypothetical protein, conserved	0.0075	0.0644	0.6601
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0644	0.6577
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0106	0.016
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0037	0.0229	0.0264
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0644	0.8826
Echinococcus granulosus	lamin	0.0028	0.0125	0.0144
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0066	0.0543	0.0819
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0106	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0053
Brugia malayi	MH2 domain containing protein	0.0019	0.0033	0.005
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0279	0.0422
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0112	0.1036	0.1194
Brugia malayi	MH2 domain containing protein	0.0043	0.0289	0.0436
Toxoplasma gondii	aspartyl protease ASP1	0.0104	0.0957	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0644	0.0972
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0041	0.0048
Mycobacterium tuberculosis	Probable hydrolase	0.0075	0.0644	0.1234
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0106	0.0942
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0034	0.0194	0.1724
Loa Loa (eye worm)	nuclear factor I	0.0024	0.0082	0.0124
Echinococcus granulosus	Smad4	0.0043	0.0289	0.0333
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0112	0.1036	0.1194
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0388	0.5084
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0477	0.055
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0376	0.0568
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0035	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0376	0.0568
Echinococcus granulosus	lysosomal alpha glucosidase	0.0161	0.1574	0.1814
Schistosoma mansoni	DNA helicase recq1	0.002	0.0041	0.0041
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0214	0.1882
Brugia malayi	hypothetical protein	0.0053	0.0406	0.0612
Toxoplasma gondii	Erv1 / Alr family protein	0.0034	0.0194	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0202	0.0305
Plasmodium falciparum	plasmepsin IX	0.0066	0.0543	0.5504
Loa Loa (eye worm)	MH2 domain-containing protein	0.0019	0.0033	0.005
Brugia malayi	PHD-finger family protein	0.0026	0.0103	0.0156
Mycobacterium ulcerans	esterase/lipase LipP	0.0075	0.0644	1
Trypanosoma brucei	glucosidase, putative	0.0036	0.0214	0.2525
Schistosoma mansoni	smad	0.0019	0.0033	0.0033
Plasmodium falciparum	plasmepsin I	0.0104	0.0957	1
Echinococcus multilocularis	Smad4	0.0043	0.0289	0.0333
Echinococcus granulosus	geminin	0.0168	0.1644	0.1895
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.0356	0.0538
Schistosoma mansoni	hypothetical protein	0.0021	0.0056	0.0056
Echinococcus granulosus	beta LACTamase domain containing family member	0.0075	0.0644	0.0742
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0037	0.0229	0.0264
Echinococcus granulosus	mothers against decapentaplegic 6	0.0019	0.0033	0.0038
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0019	0.0033	0.0038
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0104	0.0957	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0644	0.0972
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0106	0.1162
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0214	0.1882
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.049	0.0565
Trypanosoma brucei	PAB1-binding protein , putative	0.0083	0.0724	1
Entamoeba histolytica	hypothetical protein	0.0112	0.1036	1
Onchocerca volvulus		0.0028	0.0125	0.1149
Echinococcus multilocularis	musashi	0.0028	0.0125	0.0144
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0052	0.0388	0.0586
Schistosoma mansoni	tar DNA-binding protein	0.0253	0.2569	0.2569
Onchocerca volvulus		0.0093	0.0837	1
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0034	0.0194	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0543	0.0819
Plasmodium falciparum	plasmepsin VII	0.0066	0.0543	0.5504
Entamoeba histolytica	hypothetical protein	0.0112	0.1036	1
Brugia malayi	Cytochrome P450 family protein	0.0049	0.0356	0.0538
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0477	0.6388
Schistosoma mansoni	tar DNA-binding protein	0.0253	0.2569	0.2569
Echinococcus granulosus	tar DNA binding protein	0.0253	0.2569	0.2961
Loa Loa (eye worm)	transcription factor SMAD2	0.0626	0.6624	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0317	0.0478
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0041	0.0048
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0106	0.016
Brugia malayi	MH2 domain containing protein	0.0043	0.0289	0.0436
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0106	0.0942
Echinococcus granulosus	mitogen activated protein kinase	0.0052	0.0388	0.0448
Echinococcus granulosus	lamin dm0	0.0028	0.0125	0.0144
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0125	0.0189
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0376	0.0568
Plasmodium vivax	aspartyl protease, putative	0.0066	0.0543	0.5504
Echinococcus granulosus	tumor protein p63	0.0347	0.3587	0.4134
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0041	0.0063
Mycobacterium tuberculosis	Probable lipase LipE	0.0075	0.0644	0.1234
Echinococcus multilocularis	zinc finger protein	0.002	0.0044	0.005
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0543	0.0819
Schistosoma mansoni	bromodomain containing protein	0.0065	0.053	0.053
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0317	0.0478
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0106	0.0163
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0034	0.0194	0.2235
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0034	0.0194	0.2235
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0104	0.0957	0.1445
Brugia malayi	RNA recognition motif domain containing protein	0.0253	0.2569	0.3878
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0075	0.0644	0.1234
Brugia malayi	beta-lactamase family protein	0.0075	0.0644	0.0972
Echinococcus granulosus	mothers against decapentaplegic 2	0.0019	0.0033	0.0038
Brugia malayi	mothers against decapentaplegic homolog 3	0.0019	0.0033	0.005
Entamoeba histolytica	hypothetical protein	0.0112	0.1036	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0043	0.0289	0.0333
Trypanosoma cruzi	PAB1-binding protein , putative	0.0083	0.0724	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0214	0.0323
Loa Loa (eye worm)	MH1 domain-containing protein	0.0043	0.0289	0.0436
Plasmodium falciparum	plasmepsin IV	0.0104	0.0957	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0388	0.5084
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0104	0.0957	0.1104
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0066	0.0543	0.0543
Trypanosoma brucei	hypothetical protein, conserved	0.0075	0.0644	0.8826
Brugia malayi	intermediate filament protein	0.0028	0.0125	0.0189
Onchocerca volvulus		0.0075	0.0644	0.7598
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0214	0.1882
Schistosoma mansoni	lamin	0.0028	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0053
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0644	0.6577
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0066	0.0543	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0644	0.0972
Schistosoma mansoni	smad1 5 8 and	0.0043	0.0289	0.0289
Brugia malayi	hypothetical protein	0.0066	0.0543	0.0819
Schistosoma mansoni	smad1 5 8 and	0.0043	0.0289	0.0289
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0075	0.0644	0.0972
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0077	0.0088
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0226	0.026
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0053
Brugia malayi	TAR-binding protein	0.0253	0.2569	0.3878
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0106	0.016
Mycobacterium tuberculosis	Probable esterase LipL	0.0075	0.0644	0.1234
Schistosoma mansoni	Smad4	0.0019	0.0033	0.0033
Plasmodium falciparum	ataxin-2 like protein, putative	0.0083	0.0724	0.747
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0016	0.0018
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0104	0.0957	1
Onchocerca volvulus		0.0066	0.0543	0.6339
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0317	0.0317
Giardia lamblia	Kinase, CMGC MAPK	0.0052	0.0388	1
Echinococcus multilocularis	microtubule associated protein 2	0.0815	0.8676	1
Plasmodium falciparum	plasmepsin II	0.0104	0.0957	1
Brugia malayi	MH1 domain containing protein	0.0043	0.0289	0.0436
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0317	0.0365
Onchocerca volvulus		0.0075	0.0644	0.7598
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0053
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0022	0.0034
Brugia malayi	hypothetical protein	0.0112	0.1036	0.1564
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0077	0.0077
Brugia malayi	Bromodomain containing protein	0.0077	0.0661	0.0997
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0106	0.1162
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0106	0.0646
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0125	0.0189
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0066	0.0543	0.0543
Schistosoma mansoni	tar DNA-binding protein	0.0253	0.2569	0.2569
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0644	0.0972
Brugia malayi	aspartic protease BmAsp-1, identical	0.0066	0.0543	0.0819
Loa Loa (eye worm)	RNA binding protein	0.0253	0.2569	0.3878
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0317	0.0317
Echinococcus granulosus	bloom syndrome protein	0.002	0.0041	0.0048
Echinococcus granulosus	smad	0.0043	0.0289	0.0333
Onchocerca volvulus		0.0066	0.0543	0.6339
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0214	0.1882
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0034	0.0194	0.0224
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0043	0.0289	0.0333
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0106	0.016
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.0041	0.0063
Brugia malayi	Bromodomain containing protein	0.0039	0.0252	0.0381
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0019	0.0033	0.0038
Schistosoma mansoni	cathepsin D (A01 family)	0.0202	0.2016	0.2016

Activities

Activity type	Activity value	Assay description	Source	Reference
Hydrolysis (functional)	< 0.05	Susceptibility to be hydrolysed by a partially purified cAMP phosphodiesterase from rabbit kidney	ChEMBL.	6245211
I50 (binding)	= 29 uM	Inhibition of cAMP phosphodiesterase preparation from rabbit lung at a substrate concentration of 0.14 microM	ChEMBL.	6245211
I50 (binding)	= 33 uM	Inhibition of cAMP phosphodiesterase preparation from bovine heart at a substrate concentration of 0.14 microM	ChEMBL.	6245211
Ka' (binding)	= 1	Activate a partially purified type II cAMP-dependent protein kinase from bovine brain	ChEMBL.	6245211

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 234620

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 137768