Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4208 | 0.1775 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4208 | 0.1775 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4208 | 0.1775 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.2737 | 0.5 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.2485 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4208 | 0.1775 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4208 | 0.1775 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.2737 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4208 | 0.1775 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.2737 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.2485 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4208 | 0.1775 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4208 | 0.2109 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.2737 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2958 | 0.0317 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2958 | 0.0317 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.2737 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.2485 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4208 | 0.1775 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4208 | 0.1775 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4208 | 0.1775 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4208 | 0.1775 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.9711 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4208 | 0.1775 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 63.0957 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.