Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingomyelin phosphodiesterase 1, acid lysosomal | Starlite/ChEMBL | No references |
Schistosoma mansoni | Thioredoxin glutathione reductase | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.6774 | 0.8837 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.2288 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.7665 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.7665 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.6774 | 0.8837 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.465 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.2288 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.6774 | 0.8837 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.2288 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.7665 | 1 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 0.6431 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.0046 | 0.2288 | 0.492 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.2288 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.465 | 0.465 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 0.6431 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.465 | 0.5701 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.465 | 0.5701 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.465 | 0.465 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.7665 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.465 | 0.5701 |
Leishmania major | trypanothione reductase | 0.0046 | 0.2288 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0016 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.2288 | 0.492 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.2288 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.2335 | 0.5021 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.2335 | 0.5021 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.465 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.465 | 0.465 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.465 | 0.465 |
Treponema pallidum | NADH oxidase | 0.0016 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.465 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.465 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.465 | 0.465 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.2288 | 0.2985 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.2288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.6431 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.465 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.2288 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.