Detailed information for compound 1378026

Basic information

Technical information
  • TDR Targets ID: 1378026
  • Name: 2-[1-ethyl-3-(2-morpholin-4-ylethyl)-5-oxo-2- sulfanylideneimidazolidin-4-yl]-N-(4-methoxyp henyl)acetamide
  • MW: 420.526 | Formula: C20H28N4O4S
  • H donors: 1 H acceptors: 2 LogP: 0.76 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1C(=O)C(N(C1=S)CCN1CCOCC1)CC(=O)Nc1ccc(cc1)OC
  • InChi: 1S/C20H28N4O4S/c1-3-23-19(26)17(14-18(25)21-15-4-6-16(27-2)7-5-15)24(20(23)29)9-8-22-10-12-28-13-11-22/h4-7,17H,3,8-14H2,1-2H3,(H,21,25)
  • InChiKey: QUBNSKUGANKZBR-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[1-ethyl-3-(2-morpholinoethyl)-5-oxo-2-thioxo-imidazolidin-4-yl]-N-(4-methoxyphenyl)acetamide
  • 2-[1-ethyl-3-(2-morpholinoethyl)-5-oxo-2-thioxo-4-imidazolidinyl]-N-(4-methoxyphenyl)acetamide
  • 2-[1-ethyl-5-keto-3-(2-morpholinoethyl)-2-thioxo-imidazolidin-4-yl]-N-(4-methoxyphenyl)acetamide
  • 2-[1-ethyl-3-(2-morpholin-4-ylethyl)-5-oxo-2-sulfanylidene-imidazolidin-4-yl]-N-(4-methoxyphenyl)ethanamide
  • A3252/0138206
  • 2-[1-Ethyl-3-(2-morpholin-4-yl-ethyl)-5-oxo-2-thioxo-imidazolidin-4-yl]-N-(4-methoxy-phenyl)-acetamide
  • MLS000769587
  • SMR000434320

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni heat shock protein 0.0015 0.0037 0.0042
Brugia malayi Animal haem peroxidase family protein 0.0064 0.2383 0.3592
Echinococcus granulosus transcription factor btf3 0.0075 0.288 0.288
Trichomonas vaginalis heat shock protein, putative 0.003 0.0735 0.223
Loa Loa (eye worm) animal heme peroxidase 0.0064 0.2383 0.3628
Schistosoma mansoni chromobox protein 0.0081 0.3165 0.3636
Trypanosoma brucei transcription factor BTF3, putative 0.0075 0.288 1
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Echinococcus granulosus heat shock protein 0.0038 0.1102 0.1102
Echinococcus multilocularis peroxidasin 0.0064 0.2383 0.2383
Echinococcus granulosus heat shock protein 90 0.003 0.0735 0.0735
Echinococcus granulosus chromobox protein 1 0.0081 0.3165 0.3165
Mycobacterium ulcerans heat shock protein 90 0.003 0.0735 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0038 0.0038
Trichomonas vaginalis spcc417.12 protein, putative 0.0026 0.0526 0.1565
Treponema pallidum heat shock protein 90 0.003 0.0735 0.5
Schistosoma mansoni neuroligin 3 (S09 family) 0.0026 0.0526 0.0605
Schistosoma mansoni hypothetical protein 0.0196 0.8705 1
Schistosoma mansoni hypothetical protein 0.0196 0.8705 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1638 0.2451
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Echinococcus multilocularis heat shock protein 90 0.0038 0.1102 0.1102
Brugia malayi Animal haem peroxidase family protein 0.0064 0.2383 0.3592
Schistosoma mansoni transcription factor btf3 0.0075 0.288 0.3309
Loa Loa (eye worm) hypothetical protein 0.003 0.0756 0.1151
Loa Loa (eye worm) acetylcholinesterase 1 0.0152 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0526 0.0801
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0038 0.0002
Schistosoma mansoni acetylcholinesterase 0.0026 0.0526 0.0605
Brugia malayi Endoplasmin precursor 0.0038 0.1102 0.163
Echinococcus granulosus BC026374 protein S09 family 0.0026 0.0526 0.0526
Leishmania major hypothetical protein, conserved 0.003 0.0756 0.253
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Onchocerca volvulus 0.0026 0.0526 0.2086
Schistosoma mansoni hypothetical protein 0.0015 0.0038 0.0044
Echinococcus granulosus geminin 0.0196 0.8705 0.8705
Trypanosoma cruzi Heat shock protein 83, putative 0.0038 0.1102 0.3746
Brugia malayi hypothetical protein 0.002 0.0239 0.031
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0038 0.0002
Trypanosoma brucei Heat shock protein 83, putative 0.0038 0.1102 0.3746
Schistosoma mansoni hypothetical protein 0.0015 0.0038 0.0044
Loa Loa (eye worm) hypothetical protein 0.0152 0.657 1
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.1102 0.3746
Trichomonas vaginalis heat shock protein, putative 0.0023 0.0404 0.1175
Plasmodium vivax heat shock protein 86, putative 0.0038 0.1102 0.3746
Loa Loa (eye worm) hypothetical protein 0.0026 0.0526 0.0801
Onchocerca volvulus 0.0064 0.2383 1
Echinococcus granulosus acetylcholinesterase 0.0152 0.657 0.657
Trichomonas vaginalis heat shock protein, putative 0.0038 0.1102 0.3404
Plasmodium vivax basic transcription factor 3b, putative 0.0075 0.288 1
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0363 0.1145
Onchocerca volvulus Peroxidasin homolog 0.0064 0.2383 1
Trypanosoma brucei heat shock protein, putative 0.0038 0.1102 0.3746
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0038 0.0038
Brugia malayi chromobox protein homolog 3 0.0045 0.1466 0.2187
Brugia malayi Animal haem peroxidase family protein 0.0064 0.2383 0.3592
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0735 0.2453
Loa Loa (eye worm) hypothetical protein 0.0035 0.0997 0.1518
Loa Loa (eye worm) heat shock protein 90 0.0038 0.1102 0.1677
Schistosoma mansoni chromobox protein 0.0081 0.3165 0.3636
Onchocerca volvulus Peroxidase homolog 0.0064 0.2383 1
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.288 0.9088
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Entamoeba histolytica transcription factor BTF3, putative 0.0075 0.288 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.1466 0.2231
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.1102 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0756 0.253
Onchocerca volvulus 0.0064 0.2383 1
Brugia malayi hypothetical protein 0.0064 0.2383 0.3592
Brugia malayi hypothetical protein 0.003 0.0756 0.1101
Trypanosoma brucei heat shock protein, putative 0.0038 0.1102 0.3746
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Loa Loa (eye worm) hypothetical protein 0.0026 0.0526 0.0801
Schistosoma mansoni peroxidasin 0.0064 0.2383 0.2738
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.003 0.0735 1
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Echinococcus granulosus peroxidasin 0.0064 0.2383 0.2383
Echinococcus multilocularis heat shock protein 0.0038 0.1102 0.1102
Onchocerca volvulus 0.0026 0.0526 0.2086
Echinococcus granulosus chromobox protein 1 0.0081 0.3165 0.3165
Loa Loa (eye worm) hypothetical protein 0.0026 0.0526 0.0801
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0898 0.1317
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Onchocerca volvulus 0.0064 0.2383 1
Echinococcus multilocularis carboxylesterase 5A 0.0152 0.657 0.657
Onchocerca volvulus 0.0035 0.0997 0.4093
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.288 0.9088
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.1466 0.6089
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1638 0.2493
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.003 0.0735 0.0735
Brugia malayi Peroxidasin 0.0064 0.2383 0.3592
Schistosoma mansoni endoplasmin 0.0038 0.1102 0.1266
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0038 0.0038
Brugia malayi heat shock protein 90 0.0038 0.1102 0.163
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0756 0.253
Echinococcus granulosus endoplasmin 0.003 0.0735 0.0735
Trypanosoma brucei heat shock protein, putative 0.0038 0.1102 0.3746
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.1466 0.4567
Onchocerca volvulus Chorion peroxidase homolog 0.0064 0.2383 1
Echinococcus granulosus GPCR family 2 0.0015 0.0038 0.0038
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0058
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0756 0.253
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0038 0.0058
Brugia malayi Animal haem peroxidase family protein 0.0064 0.2383 0.3592
Entamoeba histolytica heat shock protein 90, putative 0.0038 0.1102 0.3746
Echinococcus multilocularis heat shock protein 90 0.003 0.0735 0.0735
Onchocerca volvulus Peroxidase homolog 0.0064 0.2383 1
Plasmodium vivax endoplasmin, putative 0.0038 0.1102 0.3746
Trypanosoma brucei heat shock protein, putative 0.0038 0.1102 0.3746
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Trichomonas vaginalis chromobox protein, putative 0.0049 0.163 0.5093
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Trichomonas vaginalis heat shock protein, putative 0.003 0.0735 0.223
Echinococcus granulosus para nitrobenzyl esterase 0.0026 0.0526 0.0526
Trichomonas vaginalis chromobox protein, putative 0.0081 0.3165 1
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.1102 0.3746
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Trypanosoma brucei heat shock protein, putative 0.0038 0.1102 0.3746
Brugia malayi Carboxylesterase family protein 0.0026 0.0526 0.0749
Loa Loa (eye worm) hypothetical protein 0.0152 0.657 1
Trypanosoma brucei heat shock protein, putative 0.0038 0.1102 0.3746
Brugia malayi Carboxylesterase family protein 0.0152 0.657 1
Echinococcus multilocularis transcription factor btf3 0.0075 0.288 0.288
Plasmodium falciparum heat shock protein 90 0.0038 0.1102 0.3746
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0735 0.2453
Brugia malayi Carboxylesterase family protein 0.0026 0.0526 0.0749
Schistosoma mansoni heat shock protein 0.0038 0.1102 0.1266
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Trichomonas vaginalis heat shock protein, putative 0.003 0.0735 0.223
Schistosoma mansoni endoplasmin 0.0038 0.1102 0.1266
Brugia malayi Heterochromatin protein 1 0.0081 0.3165 0.4788
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1638 0.2451
Brugia malayi Animal haem peroxidase family protein 0.0064 0.2383 0.3592
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0526 0.0605
Loa Loa (eye worm) animal heme peroxidase 0.0064 0.2383 0.3628
Echinococcus multilocularis para nitrobenzyl esterase 0.0026 0.0526 0.0526
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0026 0.0526 0.0526
Loa Loa (eye worm) carboxylesterase 0.0026 0.0526 0.0801
Schistosoma mansoni hypothetical protein 0.0015 0.0038 0.0044
Echinococcus multilocularis endoplasmin 0.003 0.0735 0.0735
Onchocerca volvulus 0.0026 0.0526 0.2086
Schistosoma mansoni gliotactin 0.0026 0.0526 0.0605
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0526 0.0605
Brugia malayi Carboxylesterase family protein 0.0152 0.657 1
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0526 0.0605
Loa Loa (eye worm) hypothetical protein 0.0026 0.0526 0.0801
Loa Loa (eye worm) carboxylesterase 0.0026 0.0526 0.0801
Echinococcus granulosus neuroligin 0.0026 0.0526 0.0526
Plasmodium falciparum basic transcription factor 3b, putative 0.0075 0.288 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0026 0.0526 0.1565
Onchocerca volvulus Peroxidasin homolog 0.0064 0.2383 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.003 0.0735 0.5
Schistosoma mansoni hypothetical protein 0.0033 0.0898 0.1031
Brugia malayi hypothetical protein 0.0026 0.0526 0.0749
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Trypanosoma cruzi transcription factor btf3, putative 0.0075 0.288 1
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Trichomonas vaginalis endoplasmin, putative 0.0023 0.0404 0.1175
Toxoplasma gondii heat shock protein HSP90 0.0038 0.1102 0.3746
Brugia malayi beta-NAC-like protein 0.0075 0.288 0.4352
Loa Loa (eye worm) hypothetical protein 0.0049 0.1638 0.2493
Toxoplasma gondii heat shock protein 90, putative 0.0038 0.1102 0.3746
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.003 0.0735 0.2453
Loa Loa (eye worm) heat shock protein 75 0.0015 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Echinococcus multilocularis neuroligin 0.0026 0.0526 0.0526
Brugia malayi Carboxylesterase family protein 0.0026 0.0526 0.0749
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0223 1 1
Brugia malayi Blistered cuticle protein 3 0.0064 0.2383 0.3592
Schistosoma mansoni heat shock protein 0.0038 0.1102 0.1266
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.003 0.0735 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0756 0.253
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.163 0.6791
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0015 0.0037 0.0037
Echinococcus multilocularis geminin 0.0196 0.8705 0.8705
Echinococcus multilocularis chromobox protein 1 0.0081 0.3165 0.3165
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Schistosoma mansoni BC026374 protein (S09 family) 0.0026 0.0526 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0833 0.2543
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.1102 0.3746
Leishmania major heat shock protein 83-1 0.0038 0.1102 0.3746
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0026 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1366
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0756 0.253
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0015 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Loa Loa (eye worm) hypothetical protein 0.0026 0.0526 0.0801
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.1102 0.3746
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Echinococcus granulosus acetylcholinesterase 0.0152 0.657 0.657
Onchocerca volvulus Dual oxidase homolog 0.0064 0.2383 1
Schistosoma mansoni peroxidasin 0.0064 0.2383 0.2738
Leishmania major basic transcription factor 3a, putative 0.0075 0.288 1
Onchocerca volvulus 0.0026 0.0526 0.2086
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.657 0.7548
Loa Loa (eye worm) animal heme peroxidase 0.0064 0.2383 0.3628
Loa Loa (eye worm) endoplasmin 0.0038 0.1102 0.1677
Brugia malayi Carboxylesterase family protein 0.0026 0.0526 0.0749
Echinococcus multilocularis acetylcholinesterase 0.0152 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0026 0.0526 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0833 0.2543
Loa Loa (eye worm) hypothetical protein 0.0064 0.2383 0.3628
Toxoplasma gondii NAC domain-containing protein 0.0075 0.288 1
Schistosoma mansoni hypothetical protein 0.0015 0.0038 0.0044
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.3165 0.4818
Trichomonas vaginalis chromobox protein, putative 0.0049 0.163 0.5093
Onchocerca volvulus 0.0026 0.0526 0.2086
Trypanosoma brucei heat shock protein 90, putative 0.0038 0.1102 0.3746
Loa Loa (eye worm) animal heme peroxidase 0.0064 0.2383 0.3628
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0756 0.253
Loa Loa (eye worm) carboxylesterase 0.0152 0.657 1
Echinococcus multilocularis acetylcholinesterase 0.0152 0.657 0.657
Plasmodium falciparum endoplasmin, putative 0.0023 0.0404 0.1292
Trypanosoma brucei heat shock protein 90, putative 0.0038 0.1102 0.3746
Echinococcus multilocularis chromobox protein 1 0.0081 0.3165 0.3165
Trypanosoma brucei heat shock protein, putative 0.0038 0.1102 0.3746
Entamoeba histolytica heat shock protein 90, putative 0.0038 0.1102 0.3746
Echinococcus granulosus carboxylesterase 5A 0.0152 0.657 0.657
Echinococcus granulosus heat shock protein 90 0.0038 0.1102 0.1102
Trypanosoma cruzi transcription factor btf3, putative 0.0075 0.288 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0026 0.0526 0.0526
Entamoeba histolytica hypothetical protein 0.0075 0.288 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0064 0.2383 0.3628
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0756 0.253
Loa Loa (eye worm) ICD-1 protein 0.0075 0.288 0.4384
Trypanosoma brucei heat shock protein, putative 0.0038 0.1102 0.3746
Trichomonas vaginalis chromobox protein, putative 0.0081 0.3165 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.1466 0.4567
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.288 0.9088

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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