Detailed information for compound 1378048

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 294.305 | Formula: C17H14N2O3
  • H donors: 1 H acceptors: 3 LogP: 3.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(c1ccccc1)C)c1noc(c1)c1ccccc1O
  • InChi: 1S/C17H14N2O3/c1-19(12-7-3-2-4-8-12)17(21)14-11-16(22-18-14)13-9-5-6-10-15(13)20/h2-11,20H,1H3
  • InChiKey: XQNINTDADPZVOR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei beta lactamase 0.0072 0.0627 0.9446
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0147 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0089 0.0234
Mycobacterium leprae POSSIBLE HYDROLASE 0.0033 0.0147 0.1078
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0677 0.178
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0089 0.0205
Plasmodium falciparum eukaryotic initiation factor 4A 0.0075 0.0655 1
Brugia malayi RNA recognition motif domain containing protein 0.0272 0.3085 0.8108
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0147 0.0101
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0075 0.0655 0.2736
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0147 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0147 0.0924
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0147 0.0101
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0041 0.004
Loa Loa (eye worm) TAR-binding protein 0.0272 0.3085 0.8114
Mycobacterium ulcerans hydrolase 0.0033 0.0147 0.0387
Schistosoma mansoni chromobox protein 0.0076 0.0677 0.0676
Plasmodium vivax RNA helicase-1, putative 0.0075 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0655 0.1723
Brugia malayi MH2 domain containing protein 0.0262 0.2968 0.78
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0089 0.0234
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0033 0.0147 0.0146
Echinococcus granulosus ETHE1 protein 0.0033 0.0147 0.0146
Onchocerca volvulus 0.0034 0.015 0.0293
Echinococcus granulosus chromobox protein 1 0.0076 0.0677 0.0676
Entamoeba histolytica metallo-beta-lactamase family protein 0.0033 0.0147 0.053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.1572 0.1571
Brugia malayi PHD-finger family protein 0.0027 0.0073 0.0162
Loa Loa (eye worm) hypothetical protein 0.0118 0.1184 0.3114
Echinococcus granulosus eukaryotic initiation factor 4A 0.0075 0.0655 0.0655
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0139 0.0138
Mycobacterium leprae Beta-lactamase-like protein 0.0033 0.0147 0.1078
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0033 0.0147 0.0146
Loa Loa (eye worm) RNA binding protein 0.0272 0.3085 0.8114
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0138
Plasmodium falciparum cytosolic glyoxalase II 0.0033 0.0147 0.2246
Mycobacterium ulcerans hydrolase 0.0033 0.0147 0.0387
Brugia malayi follicle stimulating hormone receptor 0.0237 0.2651 0.6964
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0075 0.0655 0.1477
Mycobacterium ulcerans hypothetical protein 0.0029 0.0089 0.0234
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0264 0.0843
Brugia malayi metallo-beta-lactamase superfamily protein 0.0033 0.0147 0.0358
Mycobacterium ulcerans beta lactamase-like protein 0.0033 0.0147 0.0387
Loa Loa (eye worm) hypothetical protein 0.0033 0.0139 0.0365
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0221 0.0221
Brugia malayi hypothetical protein 0.0148 0.1558 0.4079
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0033 0.0147 0.0387
Trichomonas vaginalis glutaminase, putative 0.033 0.3802 1
Mycobacterium ulcerans hydrolase 0.0033 0.0147 0.0387
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0075 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0108 0.1071 0.2817
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0118 0.1184 0.291
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0033 0.0147 0.0387
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.2651 0.6973
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0075 0.0655 1
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.2288 0.59
Trichomonas vaginalis apoptosis inducing factor, putative 0.0033 0.0147 0.0101
Leishmania major hypothetical protein, conserved 0.0033 0.0147 0.1025
Brugia malayi Heterochromatin protein 1 0.0076 0.0677 0.1756
Echinococcus multilocularis tar DNA binding protein 0.0272 0.3085 0.3085
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0075 0.0655 0.517
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0075 0.0655 0.0655
Schistosoma mansoni zinc phosphodiesterase 0.0033 0.0147 0.0146
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0075 0.0655 1
Entamoeba histolytica rodhanase-like domain containing protein 0.0118 0.1184 1
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0118 0.1184 0.291
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.1572 0.1571
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0089 0.0234
Onchocerca volvulus 0.0118 0.1184 0.5293
Schistosoma mansoni chromobox protein 0.0076 0.0677 0.0676
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1007 0.265
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0033 0.0147 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0264 0.0417
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.047 0.0469
Echinococcus multilocularis zinc phosphodiesterase 0.0033 0.0147 0.0146
Entamoeba histolytica rodhanase-like domain containing protein 0.0118 0.1184 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0286 0.0753
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.03 0.3427 0.9013
Schistosoma mansoni tar DNA-binding protein 0.0272 0.3085 0.3085
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0304 0.0525
Schistosoma mansoni tar DNA-binding protein 0.0272 0.3085 0.3085
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0033 0.0147 0.053
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0072 0.0627 1
Mycobacterium ulcerans hypothetical protein 0.0033 0.0147 0.0387
Trichomonas vaginalis A-type flavoprotein 0.0033 0.0147 0.0101
Loa Loa (eye worm) glutaminase 2 0.033 0.3802 1
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0118 0.1184 0.1183
Mycobacterium tuberculosis Conserved protein 0.0033 0.0147 0.0924
Loa Loa (eye worm) hypothetical protein 0.0155 0.1646 0.433
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.3427 0.8983
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0147 0.1078
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0108 0.1071 0.2817
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0033 0.0147 0.1025
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.2288 0.59
Loa Loa (eye worm) hypothetical protein 0.0071 0.0605 0.1592
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2158 0.5547
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0147 0.0101
Entamoeba histolytica type A flavoprotein, putative 0.0033 0.0147 0.053
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0147 0.0924
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.047 0.1236
Loa Loa (eye worm) hypothetical protein 0.0077 0.0691 0.1817
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0118 0.1184 0.1183
Schistosoma mansoni bromodomain containing protein 0.0069 0.0591 0.059
Trichomonas vaginalis cdc25b, putative 0.0118 0.1184 0.291
Mycobacterium ulcerans hypothetical protein 0.0033 0.0147 0.0387
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.1572 0.1571
Loa Loa (eye worm) hypothetical protein 0.0034 0.015 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0264 0.0417
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0234
Entamoeba histolytica metallo-beta-lactamase family protein 0.0033 0.0147 0.053
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0089 0.0234
Echinococcus granulosus muscleblind protein 0.0155 0.1646 0.1646
Loa Loa (eye worm) transcription factor SMAD2 0.0262 0.2968 0.7806
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0075 0.0655 0.1477
Loa Loa (eye worm) hypothetical protein 0.0033 0.0147 0.0387
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0139 0.0365
Loa Loa (eye worm) hypothetical protein 0.0103 0.1007 0.265
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0149 0.1572 0.4117
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2158 0.5547
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0118 0.1184 0.291
Plasmodium vivax unspecified product 0.0033 0.0147 0.2246
Loa Loa (eye worm) glutaminase 0.033 0.3802 1
Echinococcus multilocularis GPCR, family 2 0.0033 0.0139 0.0138
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0118 0.1184 0.1183
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0139 0.0138
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0421 0.1106
Trichomonas vaginalis cdc25c, putative 0.0118 0.1184 0.291
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0147 0.0101
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0033 0.0147 0.2246
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.3427 0.8983
Trichomonas vaginalis cdc25b, putative 0.0118 0.1184 0.291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1572 0.1571
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0033 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0033 0.0147 0.0387
Schistosoma mansoni tar DNA-binding protein 0.0272 0.3085 0.3085
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0693
Echinococcus granulosus geminin 0.0165 0.177 0.177
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0075 0.0655 1
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.0146
Onchocerca volvulus 0.0033 0.0147 0.028
Leishmania major metallo-beta-lactamase family protein-like protein 0.0033 0.0147 0.1025
Brugia malayi Muscleblind-like protein 0.0155 0.1646 0.4313
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0033 0.0147 0.0358
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1007 0.2628
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.3427 0.8983
Mycobacterium ulcerans lipoprotein LpqF 0.0072 0.0627 0.1649
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0542 0.0542
Entamoeba histolytica alkyl sulfatase, putative 0.0033 0.0147 0.053
Schistosoma mansoni zinc phosphodiesterase 0.0033 0.0147 0.0146
Onchocerca volvulus 0.0118 0.1184 0.5293
Echinococcus multilocularis ETHE1 protein 0.0033 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0042 0.0254 0.0669
Schistosoma mansoni glutaminase 0.033 0.3802 0.3802
Brugia malayi RNA binding protein 0.0272 0.3085 0.8108
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0138
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0151 0.1592 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.047 0.2952
Loa Loa (eye worm) hypothetical protein 0.0155 0.1646 0.433
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0089 0.0205
Brugia malayi chromobox protein homolog 3 0.0043 0.0264 0.0666
Onchocerca volvulus Putative hydrolase PNKD 0.0033 0.0147 0.028
Echinococcus multilocularis chromobox protein 1 0.0076 0.0677 0.0676
Entamoeba histolytica alkyl sulfatase, putative 0.0033 0.0147 0.053
Schistosoma mansoni hypothetical protein 0.0165 0.177 0.177
Leishmania major eukaryotic initiation factor 4a, putative 0.0075 0.0655 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0033 0.0147 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2158 0.5547
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0075 0.0655 0.0655
Entamoeba histolytica type A flavoprotein, putative 0.0033 0.0147 0.053
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2158 0.5547
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0139 0.0138
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0304 0.0525
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0033 0.0147 0.0387
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0139 0.0336
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.047 0.0469
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0075 0.0655 0.4116
Echinococcus granulosus GPCR family 2 0.0033 0.0139 0.0138
Mycobacterium tuberculosis Conserved protein 0.0033 0.0147 0.0924
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.1572 0.1571
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0075 0.0655 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0147 0.0101
Brugia malayi eukaryotic initiation factor 4A 0.0075 0.0655 0.1699
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0033 0.0147 0.0146
Schistosoma mansoni lipoxygenase 0.0087 0.081 0.0809
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0089 0.0234
Brugia malayi Rhodanese-like domain containing protein 0.0118 0.1184 0.3094
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.1271 0.1271
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0015 0.0039
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0089 0.056
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0234
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0221 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.3427 0.8983
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2158 0.5547
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0147 0.0101
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0312 0.0821
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.1271 0.1271
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0151 0.1592 0.4187
Echinococcus granulosus chromobox protein 1 0.0076 0.0677 0.0676
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0033 0.0147 0.5
Onchocerca volvulus Glucosylceramidase homolog 0.0197 0.2158 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0147 0.0924
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.3427 0.8983
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0304 0.1037
Brugia malayi glutaminase DH11.1 0.033 0.3802 1
Brugia malayi TAR-binding protein 0.0272 0.3085 0.8108
Onchocerca volvulus 0.0033 0.0147 0.028
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0542 0.0542
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0075 0.0655 0.0655
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0138
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0149 0.1572 0.4134
Brugia malayi Bromodomain containing protein 0.0042 0.0253 0.0639
Loa Loa (eye worm) hypothetical protein 0.0033 0.0147 0.0387
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.0146
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0147 0.053
Loa Loa (eye worm) MH2 domain-containing protein 0.0262 0.2968 0.7806
Mycobacterium ulcerans hypothetical protein 0.0033 0.0147 0.0387
Mycobacterium ulcerans hypothetical protein 0.0033 0.0147 0.0387
Echinococcus granulosus zinc phosphodiesterase 0.0033 0.0147 0.0146
Echinococcus multilocularis chromobox protein 1 0.0076 0.0677 0.0676
Mycobacterium tuberculosis Possible hydrolase 0.0033 0.0147 0.0924
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0272 0.3085 0.8114
Loa Loa (eye worm) hypothetical protein 0.0118 0.1184 0.3114
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0147 0.0101
Echinococcus multilocularis muscleblind protein 1 0.0155 0.1646 0.1646
Brugia malayi ethe1-prov protein 0.0033 0.0147 0.0358
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.047 0.1236
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0075 0.0655 0.0655
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0089 0.0234
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0118 0.1184 0.291
Echinococcus multilocularis muscleblind protein 0.0155 0.1646 0.1646
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0139 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1572 0.1571
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0072 0.0627 0.3939
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0033 0.0147 0.1025
Brugia malayi Bromodomain containing protein 0.0082 0.0749 0.1945
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0075 0.0655 0.1477
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0677 0.1536
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0033 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0234
Brugia malayi Rhodanese-like domain containing protein 0.0118 0.1184 0.3094
Leishmania major eukaryotic initiation factor 4a, putative 0.0075 0.0655 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0147 0.0101
Mycobacterium tuberculosis Conserved protein 0.0033 0.0147 0.0924
Mycobacterium ulcerans glutaminase 0.033 0.3802 1
Onchocerca volvulus 0.0118 0.1184 0.5293
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.047 0.6728
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.047 0.121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0089 0.056
Mycobacterium ulcerans glyoxalase II, GloB 0.0033 0.0147 0.0387
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0605 0.1567
Brugia malayi hypothetical protein 0.0033 0.0147 0.0358
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0089 0.0205
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0147 0.0101
Entamoeba histolytica metallo-beta-lactamase family protein 0.0033 0.0147 0.053
Entamoeba histolytica rodhanase-like domain containing protein 0.0118 0.1184 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1007 0.2628
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0033 0.0147 0.053
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2158 0.5547
Loa Loa (eye worm) hypothetical protein 0.0148 0.1558 0.4097
Echinococcus multilocularis geminin 0.0165 0.177 0.177
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.3427 0.8983
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0033 0.0147 0.0387
Treponema pallidum ATP-dependent RNA helicase 0.0075 0.0655 1
Mycobacterium tuberculosis Possible hydrolase 0.0033 0.0147 0.0924
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.03 0.3427 0.901
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0075 0.0655 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0089 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0272 0.3085 0.3085
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0677 0.1536
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0014
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0011 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2158 0.5547
Schistosoma mansoni lipoxygenase 0.0125 0.1271 0.1271
Chlamydia trachomatis ribonuclease Z 0.0033 0.0147 1
Schistosoma mansoni tar DNA-binding protein 0.0272 0.3085 0.3085
Brugia malayi metallo-beta-lactamase superfamily protein 0.0033 0.0147 0.0358
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0147 0.0101
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0033 0.0147 0.0146
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0147 0.0101
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.047 0.0469
Onchocerca volvulus 0.0148 0.1558 0.7099
Schistosoma mansoni hypothetical protein 0.0165 0.177 0.177
Schistosoma mansoni hypothetical protein 0.0071 0.0605 0.0605
Mycobacterium tuberculosis Beta lactamase like protein 0.0033 0.0147 0.0924
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0147 0.1078
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0118 0.1184 0.291
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0139 0.0138
Echinococcus granulosus tar DNA binding protein 0.0272 0.3085 0.3085
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0033 0.0147 0.028
Onchocerca volvulus 0.0118 0.1184 0.5293
Leishmania major metallo-beta-lactamase family-like protein 0.0033 0.0147 0.1025
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1572 0.1571

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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