TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 397.534 | Formula: C22H27N3O2S
H donors: 2 H acceptors: 2 LogP: 5.05 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cc(OCCCNc2nc3c(s2)cccc3)cc(c1)CN1CCCCC1
InChi: 1S/C22H27N3O2S/c26-18-13-17(16-25-10-4-1-5-11-25)14-19(15-18)27-12-6-9-23-22-24-20-7-2-3-8-21(20)28-22/h2-3,7-8,13-15,26H,1,4-6,9-12,16H2,(H,23,24)
InChiKey: JEFCUUBCWLGGCU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	transporter, major facilitator family protein	0.0033	0.0625	0.6641
Brugia malayi	hypothetical protein	0.0033	0.0625	0.1334
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0022	0.0234	0.2451
Echinococcus granulosus	ecdysone induced protein 78C	0.0057	0.154	0.2771
Brugia malayi	nuclear receptor NHR-67	0.0027	0.0405	0.0861
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0027	0.0405	0.0861
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0027	0.0405	0.0655
Loa Loa (eye worm)	hypothetical protein	0.003	0.0526	0.1131
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0179	0.6109	1
Echinococcus granulosus	FTZ F1 alpha	0.0057	0.154	0.2771
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	1	1
Schistosoma mansoni	hypothetical protein	0.0164	0.5542	0.9071
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0057	0.154	0.2514
Onchocerca volvulus		0.0024	0.0289	0.1502
Trypanosoma brucei	p-glycoprotein	0.0016	0.0005	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.003	0.0526	0.0854
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0057	0.154	0.2514
Brugia malayi	Steroid receptor seven-up type 2	0.0057	0.154	0.3302
Brugia malayi	nuclear receptor NHR-88	0.0027	0.0405	0.0861
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0025	0.0053
Echinococcus granulosus	geminin	0.0164	0.5542	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0025	0.0053
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0061	0.1692	0.2764
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0057	0.154	0.2514
Brugia malayi	orphan nuclear receptor NR2E1	0.0027	0.0405	0.0861
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0234	0.0503
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0057	0.154	0.3309
Brugia malayi	prostaglandin transporter	0.0033	0.0625	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0353	0.0758
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0057	0.154	0.3302
Brugia malayi	nuclear hormone receptor family member odr-7	0.0027	0.0405	0.0861
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0138	0.4574	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0081	0.244	0.3989
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0405	0.0655
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0027	0.0405	0.087
Echinococcus granulosus	agrin	0.0022	0.0234	0.0413
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0022	0.0234	0.2451
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.003	0.0526	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0234	0.0503
Brugia malayi	SPARC precursor	0.0022	0.0234	0.0492
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0027	0.0405	0.0655
Onchocerca volvulus		0.0064	0.1785	1
Brugia malayi	nuclear receptor RXR	0.003	0.0526	0.1122
Echinococcus multilocularis	lamin	0.0026	0.0371	0.0599
Schistosoma mansoni	jun-related protein	0.0066	0.1869	0.3053
Schistosoma mansoni	lamin	0.0026	0.0371	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0625	0.1344
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0939	0.5
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.081	0.0805
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0371	0.0599
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0057	0.154	0.2771
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0016	0.0005	0.5
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0016	0.0005	0.5
Echinococcus granulosus	lamin dm0	0.0026	0.0371	0.066
Brugia malayi	photoreceptor-specific nuclear receptor	0.0057	0.154	0.3302
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0057	0.154	0.3309
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0057	0.154	0.2514
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0057	0.154	0.3309
Brugia malayi	nuclear hormone receptor	0.0027	0.0405	0.0861
Trypanosoma cruzi	MFS transporter, putative	0.0033	0.0625	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0289	0.0465
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0033	0.0625	0.1344
Onchocerca volvulus		0.0033	0.0625	0.3411
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0939	0.1686
Loa Loa (eye worm)	DR-78	0.0027	0.0405	0.087
Schistosoma mansoni	lamin	0.0026	0.0371	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0371	0.0787
Loa Loa (eye worm)	hypothetical protein	0.003	0.0526	0.1131
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0021	0.0162	0.0339
Toxoplasma gondii	protease inhibitor PI2	0.0022	0.0234	0.2451
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0138	0.4574	1
Brugia malayi	intermediate filament protein	0.0026	0.0371	0.0787
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0016	0.0005	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0057	0.154	0.2514
Brugia malayi	hypothetical protein	0.0064	0.1785	0.3831
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0625	0.1344
Echinococcus multilocularis	nuclear receptor nhr 48	0.0027	0.0405	0.0655
Schistosoma mansoni	thyroid hormone receptor	0.0179	0.6109	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0057	0.154	0.3302
Leishmania major	pentamidine resistance protein 1	0.0016	0.0005	0.5
Onchocerca volvulus	Matrilysin homolog	0.0037	0.0795	0.4377
Loa Loa (eye worm)	acetyltransferase	0.014	0.4652	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0057	0.154	0.3302
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0405	0.0722
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0057	0.154	0.2514
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.154	0.3309
Echinococcus multilocularis	geminin	0.0164	0.5542	0.9071
Onchocerca volvulus		0.0026	0.0371	0.1965
Brugia malayi	sodium-independent organic anion transporter family protein	0.0033	0.0625	0.1334
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0027	0.0405	0.0861
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0027	0.0405	0.216
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0057	0.154	0.2514
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0057	0.154	0.2514
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0057	0.154	0.3309
Brugia malayi	Matrixin family protein	0.0017	0.0025	0.0042
Loa Loa (eye worm)	agrin synaptic family protein	0.0022	0.0234	0.0503
Brugia malayi	Matrixin family protein	0.0041	0.0922	0.1973
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0057	0.154	0.3302
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0625	0.1344
Brugia malayi	steroid hormone receptor	0.0057	0.154	0.3302
Brugia malayi	ecdysone receptor	0.0027	0.0405	0.0861
Loa Loa (eye worm)	matrixin family protein	0.0037	0.0795	0.1709
Loa Loa (eye worm)	nuclear hormone receptor	0.0027	0.0405	0.087
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0057	0.154	0.2514
Schistosoma mansoni	retinoic acid receptor RXR	0.0057	0.154	0.2514
Trypanosoma brucei	multidrug resistance protein E	0.0016	0.0005	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0057	0.154	0.2771
Onchocerca volvulus		0.0033	0.0625	0.3411
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0057	0.154	0.2771
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0025	0.0053
Schistosoma mansoni	agrin	0.0022	0.0234	0.0375
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0371	0.0796
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0022	0.0234	0.2451
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0057	0.154	0.2514
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0371	0.0796
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0057	0.154	0.2771
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0057	0.154	0.2771
Brugia malayi	nuclear receptor NHR-88	0.0057	0.154	0.3302
Giardia lamblia	Multidrug resistance-associated protein 1	0.0016	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor E75	0.0027	0.0405	0.0861
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0033	0.0625	0.1016
Leishmania major	p-glycoprotein e	0.0016	0.0005	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0027	0.0405	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Schistosoma mansoni	organic anion transporter	0.0033	0.0625	0.1016
Loa Loa (eye worm)	hypothetical protein	0.003	0.0526	0.1131
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0057	0.154	0.3302
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0037	0.0795	0.4377
Onchocerca volvulus		0.0033	0.0625	0.3411
Schistosoma mansoni	hypothetical protein	0.0122	0.3961	0.6481
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0057	0.154	0.3309
Loa Loa (eye worm)	hypothetical protein	0.0057	0.154	0.3309
Loa Loa (eye worm)	hypothetical protein	0.0057	0.154	0.3309
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0162	0.0349
Onchocerca volvulus	Putative organic anion transporter	0.0033	0.0625	0.3411
Brugia malayi	Matrixin family protein	0.0017	0.0025	0.0042
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0017	0.0025	0.0032
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0057	0.154	0.3309
Onchocerca volvulus		0.0026	0.0371	0.1965
Echinococcus granulosus	nuclear receptor nhr 48	0.0027	0.0405	0.0722
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0057	0.154	0.3302
Echinococcus multilocularis	jun protein	0.0081	0.244	0.3989
Onchocerca volvulus	Putative organic anion transporter	0.0033	0.0625	0.3411
Schistosoma mansoni	hypothetical protein	0.0066	0.1869	0.3053
Brugia malayi	sodium-independent organic anion transporter family protein	0.0033	0.0625	0.1334
Schistosoma mansoni	zinc finger protein	0.0027	0.0405	0.0655
Giardia lamblia	Fructose-bisphosphate aldolase	0.0282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0057	0.154	0.2514
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0057	0.154	0.3302
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0027	0.0405	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Brugia malayi	hypothetical protein	0.003	0.0526	0.1122
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0027	0.0405	0.216
Onchocerca volvulus		0.0027	0.0405	0.216
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0057	0.154	0.2514
Schistosoma mansoni	nuclear receptor nhr-48	0.0027	0.0405	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0625	0.1344
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0057	0.154	0.8605
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	1	1
Brugia malayi	hypothetical protein	0.0027	0.0405	0.0861
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0405	0.0655
Schistosoma mansoni	thyroid hormone receptor	0.0179	0.6109	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	1	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.3961	0.6481
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0057	0.154	0.3309
Loa Loa (eye worm)	hypothetical protein	0.003	0.0526	0.1131
Brugia malayi	hypothetical protein	0.003	0.0526	0.1122
Echinococcus granulosus	lamin	0.0026	0.0371	0.066
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0138	0.4574	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0234	0.0503
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0033	0.0625	0.112
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.003	0.0526	0.0942
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0016	0.0005	0.5
Loa Loa (eye worm)	matrixin family protein	0.0041	0.0922	0.1981
Brugia malayi	ecdysteroid receptor	0.0057	0.154	0.3302
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0057	0.154	0.3302
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0016	0.0005	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0027	0.0405	0.0722
Echinococcus multilocularis	lamin dm0	0.0026	0.0371	0.0599
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.4652	0.7614
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0405	0.0655
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0016	0.0005	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0625	0.1344
Echinococcus granulosus	jun protein	0.0081	0.244	0.4397
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0057	0.154	0.3302
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.081	0.5
Brugia malayi	Hemopexin family protein	0.0024	0.0289	0.0611
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.4652	0.7614
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.004	0.0895	0.1457
Brugia malayi	conserved hypotetical protein	0.0027	0.0405	0.0861
Treponema pallidum	fructose-bisphosphate aldolase	0.0282	1	0.5
Brugia malayi	secreted modular calcium-binding protein 1	0.0022	0.0234	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0371	0.0796
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0022	0.0234	0.0503
Giardia lamblia	ABC transporter, putative	0.0016	0.0005	0.0005
Brugia malayi	sodium-independent organic anion transporter family protein	0.0033	0.0625	0.1334
Leishmania major	ABC-thiol transporter	0.0016	0.0005	0.5
Onchocerca volvulus		0.0033	0.0625	0.3411
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0027	0.0405	0.0655
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0057	0.154	0.3302
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0081	0.244	0.4397
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0939	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0027	0.0405	0.0655
Echinococcus granulosus	follistatin	0.0022	0.0234	0.0413
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.3961	0.7145
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Echinococcus multilocularis	follistatin	0.0022	0.0234	0.0375
Brugia malayi	tailless protein	0.0027	0.0405	0.0861
Onchocerca volvulus		0.0057	0.154	0.8605
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0057	0.154	0.2514
Giardia lamblia	MRP-like ABC transporter	0.0016	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0625	0.1344
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0234	0.0503
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0939	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0027	0.0405	0.0722
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.081	0.081
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0057	0.154	0.2514
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0022	0.0234	0.0492
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0057	0.154	0.2771
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0027	0.0405	0.0722
Loa Loa (eye worm)	matrix metalloproteinase	0.0017	0.0025	0.0053
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.4505	0.8127
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0526	0.1122
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.154	0.3309
Schistosoma mansoni	nuclear receptor	0.0027	0.0405	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0057	0.154	0.2771
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.003	0.0526	0.1131
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0022	0.0234	0.2451
Loa Loa (eye worm)	hypothetical protein	0.0057	0.154	0.3309
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0011
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0526	0.0854
Schistosoma mansoni	organic anion transporter	0.0033	0.0625	0.1016
Schistosoma mansoni	RAR-like nuclear receptor	0.0057	0.154	0.2514
Brugia malayi	Nuclear hormone receptor E75	0.0027	0.0405	0.0861
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	1	1
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.4652	1
Onchocerca volvulus	Bile acid receptor homolog	0.0057	0.154	0.8605
Echinococcus multilocularis	expressed protein	0.0022	0.0234	0.0375
Brugia malayi	Matrixin family protein	0.0017	0.0025	0.0042
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0057	0.154	0.3302
Brugia malayi	nuclear receptor RXR	0.0027	0.0405	0.0861
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0526	0.1122
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0625	0.1344
Onchocerca volvulus		0.0027	0.0405	0.216
Brugia malayi	nuclear hormone receptor	0.0057	0.154	0.3302
Schistosoma mansoni	hypothetical protein	0.0164	0.5542	0.9071
Echinococcus granulosus	intermediate filament protein	0.0026	0.0371	0.066
Brugia malayi	hypothetical protein	0.0033	0.0625	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.087
Loa Loa (eye worm)	hypothetical protein	0.0057	0.154	0.3309
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0022	0.0234	0.0492
Loa Loa (eye worm)	hypothetical protein	0.003	0.0526	0.1131
Brugia malayi	Matrixin family protein	0.0017	0.0025	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0057	0.154	0.3309
Onchocerca volvulus		0.0033	0.0625	0.3411
Brugia malayi	hypothetical protein	0.0027	0.0405	0.0861
Echinococcus multilocularis	agrin	0.0022	0.0234	0.0375
Schistosoma mansoni	nuclear receptor	0.0027	0.0405	0.0655
Brugia malayi	Nuclear hormone receptor-like 1	0.0057	0.154	0.3302
Loa Loa (eye worm)	steroid hormone receptor	0.0057	0.154	0.3309
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0033	0.0625	0.112
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0027	0.0405	0.087
Loa Loa (eye worm)	hypothetical protein	0.0079	0.2356	0.5064
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0057	0.154	0.3302
Giardia lamblia	Multidrug resistance-associated protein 1	0.0016	0.0005	0.0005
Onchocerca volvulus		0.0022	0.0234	0.1189
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0061	0.1692	0.3047
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0033	0.0625	0.1016
Onchocerca volvulus	Protein ultraspiracle homolog	0.0057	0.154	0.8605
Echinococcus multilocularis	musashi	0.0026	0.0371	0.0599
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0282	1	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0027	0.0405	0.0722
Echinococcus multilocularis	ecdysone induced protein 78C	0.0057	0.154	0.2514
Schistosoma mansoni	nuclear hormone receptor	0.0057	0.154	0.2514
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0022	0.0234	0.0492
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0057	0.154	0.3302
Loa Loa (eye worm)	hypothetical protein	0.0057	0.154	0.3309
Schistosoma mansoni	follistatin	0.0022	0.0234	0.0375
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0022	0.0234	0.0492
Schistosoma mansoni	coup transcription factor	0.0057	0.154	0.2514
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0016	0.0005	0.0011
Brugia malayi	bZIP transcription factor family protein	0.0081	0.244	0.5239
Onchocerca volvulus	Putative organic anion transporter	0.0033	0.0625	0.3411

Activities

Activity type	Activity value	Assay description	Source	Reference
Log BB (ADMET)	= -0.28	Predicted blood-brain distribution of compound determined	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 137871