Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 0.0195 | 0.2291 |
Trichomonas vaginalis | cyclins, putative | 0.009 | 0.0693 | 1 |
Echinococcus granulosus | cyclin B | 0.009 | 0.0693 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.4039 | 0.4039 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0261 | 0.6936 | 0.907 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0188 | 0.4271 | 0.5557 |
Trypanosoma cruzi | cyclin, putative | 0.009 | 0.0693 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.009 | 0.0693 | 1 |
Onchocerca volvulus | 0.0189 | 0.4312 | 0.5883 | |
Brugia malayi | Protein kinase c protein 2 | 0.0191 | 0.4373 | 0.5692 |
Echinococcus granulosus | cyclin b3 | 0.009 | 0.0693 | 0.0906 |
Schistosoma mansoni | cyclins | 0.009 | 0.0693 | 0.0906 |
Echinococcus multilocularis | cyclins | 0.009 | 0.0693 | 0.0906 |
Entamoeba histolytica | cyclin family protein | 0.009 | 0.0693 | 0.2522 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.028 | 0.7647 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0261 | 0.6936 | 0.907 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0261 | 0.6936 | 0.907 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1766 | 0.1766 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0073 | 0.0047 | 0.0062 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.028 | 0.7647 | 0.7647 |
Echinococcus multilocularis | cyclins | 0.009 | 0.0693 | 0.0906 |
Echinococcus multilocularis | cyclin B | 0.009 | 0.0693 | 0.0906 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.009 | 0.0693 | 0.0693 |
Trichomonas vaginalis | conserved hypothetical protein | 0.009 | 0.0693 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.009 | 0.0693 | 1 |
Schistosoma mansoni | cyclin B | 0.009 | 0.0693 | 0.0906 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 0.0195 | 0.2291 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0261 | 0.6939 | 0.6939 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0155 | 0.3072 | 0.3072 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0073 | 0.0047 | 0.0062 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0116 | 0.1642 | 0.2147 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0139 | 0.246 | 0.3217 |
Echinococcus multilocularis | protein kinase c iota type | 0.0219 | 0.5417 | 0.7084 |
Brugia malayi | protein kinase C II. | 0.028 | 0.7647 | 1 |
Echinococcus granulosus | NDR protein kinase | 0.0073 | 0.0047 | 0.0062 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0073 | 0.0047 | 0.0062 |
Toxoplasma gondii | AGC kinase | 0.0073 | 0.0047 | 0.5 |
Brugia malayi | C1-like domain containing protein | 0.0188 | 0.4271 | 0.5557 |
Trichomonas vaginalis | cyclins, putative | 0.009 | 0.0693 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.009 | 0.0693 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.009 | 0.0693 | 0.085 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0073 | 0.0047 | 0.0062 |
Entamoeba histolytica | cyclin, putative | 0.009 | 0.0693 | 0.2522 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 0.0195 | 0.2291 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 0.0195 | 0.2291 |
Echinococcus multilocularis | cyclins | 0.009 | 0.0693 | 0.0906 |
Trichomonas vaginalis | cyclin B, putative | 0.009 | 0.0693 | 1 |
Echinococcus multilocularis | cyclin b3 | 0.009 | 0.0693 | 0.0906 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0073 | 0.0047 | 0.0062 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0073 | 0.0047 | 0.0047 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0073 | 0.0047 | 0.0062 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0188 | 0.4271 | 0.4271 |
Trichomonas vaginalis | cyclin D, putative | 0.009 | 0.0693 | 1 |
Giardia lamblia | Cyclin A | 0.009 | 0.0693 | 0.5 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.009 | 0.0693 | 0.0906 |
Brugia malayi | protein kinase C3,putative | 0.0149 | 0.2854 | 0.3693 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 0.0195 | 0.2291 |
Brugia malayi | Protein kinase domain containing protein | 0.0077 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0073 | 0.0047 | 0.0047 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0073 | 0.0047 | 0.0062 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0073 | 0.0047 | 0.0047 |
Echinococcus multilocularis | cyclins | 0.009 | 0.0693 | 0.0906 |
Entamoeba histolytica | protein kinase, putative | 0.0077 | 0.0195 | 0.0578 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0125 | 0.1975 | 0.1975 |
Echinococcus granulosus | protein kinase c iota type | 0.0219 | 0.5417 | 0.7084 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0073 | 0.0047 | 0.0062 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0077 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.9726 | 0.9726 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0209 | 0.5024 | 0.6569 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1766 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.4164 | 0.4164 |
Schistosoma mansoni | serine/threonine kinase | 0.0073 | 0.0047 | 0.0062 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 0.0195 | 0.2291 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0073 | 0.0047 | 0.0047 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0073 | 0.0047 | 0.0062 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0261 | 0.6939 | 0.9068 |
Trichomonas vaginalis | cyclin B, putative | 0.009 | 0.0693 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.009 | 0.0693 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.009 | 0.0693 | 0.085 |
Trypanosoma cruzi | cyclin 6, putative | 0.009 | 0.0693 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.009 | 0.0693 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0225 | 0.5636 | 0.7369 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.7329 | 0.7329 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0195 | 0.4539 | 0.5935 |
Echinococcus granulosus | cyclins | 0.009 | 0.0693 | 0.0906 |
Echinococcus multilocularis | cyclins | 0.009 | 0.0693 | 0.0906 |
Trichomonas vaginalis | cyclin B3, putative | 0.009 | 0.0693 | 1 |
Echinococcus granulosus | cyclins | 0.009 | 0.0693 | 0.0906 |
Schistosoma mansoni | serine/threonine protein kinase | 0.028 | 0.7647 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0073 | 0.0047 | 0.0062 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0261 | 0.6936 | 0.907 |
Entamoeba histolytica | protein kinase, putative | 0.0077 | 0.0195 | 0.0578 |
Echinococcus granulosus | cyclin B3 1 | 0.009 | 0.0693 | 0.0906 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0073 | 0.0047 | 0.0047 |
Echinococcus granulosus | protein kinase C gamma type | 0.0195 | 0.4539 | 0.5935 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.7329 | 0.7329 |
Echinococcus multilocularis | cyclins | 0.009 | 0.0693 | 0.0906 |
Trypanosoma cruzi | cyclin, putative | 0.009 | 0.0693 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0693 | 0.0693 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0123 | 0.1874 | 0.1874 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.4312 | 0.4312 |
Schistosoma mansoni | protein kinase C mu | 0.0188 | 0.4271 | 0.5585 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 0.0195 | 0.2291 |
Trypanosoma brucei | mitotic cyclin 6 | 0.009 | 0.0693 | 1 |
Schistosoma mansoni | cyclin B3 | 0.009 | 0.0693 | 0.0906 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.009 | 0.0693 | 0.085 |
Onchocerca volvulus | 0.0185 | 0.4164 | 0.5681 | |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0073 | 0.0047 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.7329 | 0.7329 |
Echinococcus granulosus | cyclins | 0.009 | 0.0693 | 0.0906 |
Onchocerca volvulus | 0.009 | 0.0693 | 0.0946 | |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0116 | 0.1642 | 0.2147 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.009 | 0.0693 | 0.0906 |
Leishmania major | cyclin | 0.009 | 0.0693 | 0.5 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0116 | 0.1642 | 0.2147 |
Trichomonas vaginalis | cyclin B, putative | 0.009 | 0.0693 | 1 |
Entamoeba histolytica | cyclin family protein | 0.009 | 0.0693 | 0.2522 |
Trichomonas vaginalis | cyclin B, putative | 0.009 | 0.0693 | 1 |
Giardia lamblia | Hypothetical protein | 0.009 | 0.0693 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1642 | 0.1642 |
Echinococcus granulosus | protein kinase c epsilon type | 0.028 | 0.7647 | 1 |
Onchocerca volvulus | 0.0271 | 0.7329 | 1 | |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0143 | 0.2608 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.009 | 0.0693 | 1 |
Echinococcus multilocularis | cyclin B3 1 | 0.009 | 0.0693 | 0.0906 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0073 | 0.0047 | 0.0062 |
Onchocerca volvulus | 0.012 | 0.1766 | 0.241 | |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0693 | 0.0693 |
Plasmodium falciparum | cyclin | 0.009 | 0.0693 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.009 | 0.0693 | 0.2522 |
Echinococcus granulosus | cyclins | 0.009 | 0.0693 | 0.0906 |
Echinococcus granulosus | cyclins | 0.009 | 0.0693 | 0.0906 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.009 | 0.0693 | 0.5 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0073 | 0.0047 | 0.0047 |
Trichomonas vaginalis | cyclins, putative | 0.009 | 0.0693 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0073 | 0.0047 | 0.0062 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.009 | 0.0693 | 0.5 |
Echinococcus multilocularis | cyclins | 0.009 | 0.0693 | 0.0906 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 0.0195 | 0.2291 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.