Detailed information for compound 1379220

Basic information

Technical information
  • TDR Targets ID: 1379220
  • Name: [2-[[4-chloro-2-(trifluoromethyl)phenyl]amino ]-2-oxo-1-phenylethyl] 5,6-dihydro-1,4-dioxin e-2-carboxylate
  • MW: 441.785 | Formula: C20H15ClF3NO5
  • H donors: 1 H acceptors: 2 LogP: 4.39 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(c1ccccc1)OC(=O)C1=COCCO1)Nc1ccc(cc1C(F)(F)F)Cl
  • InChi: 1S/C20H15ClF3NO5/c21-13-6-7-15(14(10-13)20(22,23)24)25-18(26)17(12-4-2-1-3-5-12)30-19(27)16-11-28-8-9-29-16/h1-7,10-11,17H,8-9H2,(H,25,26)
  • InChiKey: NKJZDWWHWWBAIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[[4-chloro-2-(trifluoromethyl)phenyl]amino]-2-oxo-1-phenyl-ethyl] 5,6-dihydro-1,4-dioxine-2-carboxylate
  • 5,6-dihydro-1,4-dioxine-2-carboxylic acid [2-[[4-chloro-2-(trifluoromethyl)phenyl]amino]-2-oxo-1-phenylethyl] ester
  • 5,6-dihydro-1,4-dioxine-2-carboxylic acid [2-[[4-chloro-2-(trifluoromethyl)phenyl]amino]-2-keto-1-phenyl-ethyl] ester
  • T5251384
  • MLS000335876
  • SMR000253630

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0014 0.0014
Onchocerca volvulus 0.0037 0.0227 0.0412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Schistosoma mansoni cpg binding protein 0.0063 0.0526 0.0526
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.0025 0.0025
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0076 0.0674 0.1291
Onchocerca volvulus 0.0234 0.2453 0.4717
Schistosoma mansoni carbonic anhydrase-related 0.0091 0.0841 0.0841
Echinococcus granulosus organic anion transporting polypeptide 30B 0.006 0.0493 0.0493
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0456 0.3952
Leishmania major cathepsin L-like protease 0.0037 0.0227 0.0707
Brugia malayi MH2 domain containing protein 0.0263 0.2784 0.5366
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.006 0.0493 0.094
Loa Loa (eye worm) agrin synaptic family protein 0.0041 0.0276 0.0522
Brugia malayi Cathepsin L-like cysteine proteinase 0.0025 0.0089 0.0162
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0162 0.1641 0.1641
Schistosoma mansoni cpg binding protein 0.0067 0.0566 0.0566
Loa Loa (eye worm) fibroinase 0.0037 0.0227 0.0428
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0014 0.0017
Schistosoma mansoni survival motor neuron protein 0.0058 0.0468 0.0468
Echinococcus granulosus cathepsin L cysteine proteinase 0.0037 0.0227 0.0227
Echinococcus granulosus Solute carrier organic anion transporter family 0.006 0.0493 0.0493
Schistosoma mansoni nuclear hormone receptor 0.0162 0.1641 0.1641
Brugia malayi photoreceptor-specific nuclear receptor 0.0162 0.1641 0.3158
Plasmodium vivax SET domain protein, putative 0.0031 0.0157 0.5252
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0082 0.0731 0.0731
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0019 0.0025 0.0062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0162 0.1641 0.1641
Echinococcus multilocularis musashi 0.0026 0.0107 0.0107
Echinococcus granulosus thyroid hormone receptor alpha 0.0076 0.0674 0.0674
Schistosoma mansoni single-minded 0.0055 0.0427 0.0427
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.1491
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0128 0.1261 0.4002
Echinococcus multilocularis FTZ F1 alpha 0.0162 0.1641 0.1641
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0014 0.0014
Brugia malayi hypothetical protein 0.006 0.0493 0.094
Brugia malayi Cathepsin L-like precursor 0.0037 0.0227 0.0428
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.041 0.4442 0.4442
Echinococcus granulosus tumor protein p63 0.0363 0.391 0.391
Echinococcus granulosus intermediate filament protein 0.0026 0.0107 0.0107
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.0731 0.2313
Brugia malayi nuclear hormone receptor family member odr-7 0.0076 0.0674 0.1291
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0014 0.0014
Echinococcus granulosus tar DNA binding protein 0.0125 0.1228 0.1228
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0162 0.1641 0.1641
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0227 0.0833
Schistosoma mansoni ap endonuclease 0.0041 0.0276 0.0276
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0014 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0162 0.1641 0.3158
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0014 0.0017
Echinococcus granulosus carbonic anhydrase 0.0091 0.0841 0.0841
Echinococcus granulosus geminin 0.0365 0.394 0.394
Brugia malayi hypothetical protein 0.002 0.0032 0.0052
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.022 0.2294 0.4419
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0162 0.1641 0.3158
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0076 0.0674 0.0674
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0276 0.0862
Schistosoma mansoni smad 0.0018 0.0013 0.0013
Schistosoma mansoni organic anion transporter 0.006 0.0493 0.0493
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0547 1
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.006 0.0493 0.0493
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0076 0.0674 0.0674
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0014 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0456 0.1775
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0089 0.0089
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0154 0.1583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0089 0.0265
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0014 0.0017
Mycobacterium ulcerans putative regulatory protein 0.004 0.0266 0.4821
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0014 0.0017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0162 0.1641 0.3158
Echinococcus multilocularis ecdysone induced protein 78C 0.0162 0.1641 0.1641
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0014 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0025 0.0038
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0082 0.0731 0.0731
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0014 0.0014
Brugia malayi Nuclear hormone receptor-like 1 0.0162 0.1641 0.3158
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0044 0.0074
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0162 0.1641 0.1641
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0082 0.0731 0.0731
Echinococcus granulosus muscleblind protein 0.018 0.1849 0.1849
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0013 0.0014
Echinococcus multilocularis carbonic anhydrase 0.0091 0.0841 0.0841
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0157 0.0157
Brugia malayi latrophilin 2 splice variant baaae 0.015 0.1508 0.2901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0162 0.1641 0.3158
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0596 0.0596
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0462 0.5035 0.5035
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0107 0.0196
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0276 0.1191
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0276 0.1191
Loa Loa (eye worm) hypothetical protein 0.0025 0.0089 0.0162
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0456 0.1775
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0162 0.1641 0.1641
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0661 0.0661
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0086 0.0777 0.0777
Plasmodium vivax vivapain-2 0.0037 0.0227 0.8058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0596 0.114
Loa Loa (eye worm) hypothetical protein 0.0082 0.0731 0.1402
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0227 0.0227
Brugia malayi Cation transporter family protein 0.0018 0.0014 0.0017
Echinococcus multilocularis nAChR subunit 0.0018 0.0014 0.0014
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0547 0.3836
Schistosoma mansoni nuclear receptor 0.0076 0.0674 0.0674
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0276 0.0522
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0014 0.0014
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0276 0.0862
Brugia malayi hypothetical protein 0.003 0.0154 0.0287
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0468 0.0894
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0157 0.0026
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0089 0.0911
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0276 0.4997
Schistosoma mansoni intermediate filament proteins 0.0026 0.0107 0.0107
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0276 0.0522
Schistosoma mansoni hypothetical protein 0.007 0.0596 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0162 0.1641 0.3158
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.1491
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0014 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0162 0.1641 0.3158
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0295 0.3144 1
Echinococcus multilocularis smad 0.0018 0.0013 0.0013
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0154 0.5147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0227 0.0833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0162 0.1641 0.3158
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.0731 0.2313
Schistosoma mansoni hypothetical protein 0.0901 1 1
Echinococcus granulosus single minded 2 0.004 0.0266 0.0266
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0276 0.1034
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0154 0.1583
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0456 0.1435
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0227 0.2863
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0013 0.0013
Brugia malayi Cytochrome P450 family protein 0.0029 0.014 0.026
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0276 0.5
Loa Loa (eye worm) hypothetical protein 0.0162 0.1641 0.3158
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0014 0.0017
Schistosoma mansoni lozenge 0.006 0.0484 0.0484
Schistosoma mansoni hypothetical protein 0.0365 0.394 0.394
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0162 0.1641 0.3158
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0183 0.1879 0.3617
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0493 0.094
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0014 0.0017
Brugia malayi nuclear receptor NHR-67 0.0076 0.0674 0.1291
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0596 0.114
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0014 0.0014
Brugia malayi MH2 domain containing protein 0.0018 0.0013 0.0014
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0162 0.1641 0.1641
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0162 0.1641 0.3158
Onchocerca volvulus 0.0037 0.0227 0.0412
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0037 0.0227 0.2478
Trypanosoma brucei carbonic anhydrase-like protein 0.0295 0.3144 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0025 0.0025
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0076 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.006 0.0493 0.094
Echinococcus multilocularis dnaJ subfamily B 0.0901 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0162 0.1641 0.1641
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0082 0.0731 0.2313
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0107 0.0196
Loa Loa (eye worm) hypothetical protein 0.006 0.0493 0.094
Loa Loa (eye worm) DR-78 0.0076 0.0674 0.1291
Onchocerca volvulus 0.0041 0.0276 0.0506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Brugia malayi ecdysone receptor 0.0076 0.0674 0.1291
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0596 0.0596
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0086 0.0777 0.0777
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0547 0.0547
Echinococcus multilocularis GPCR, family 2 0.007 0.0596 0.0596
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0091 0.0841 0.1614
Brugia malayi hypothetical protein 0.0286 0.3038 0.5855
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0227 0.0227
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0162 0.1641 0.3147
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0014 0.0014
Echinococcus granulosus lamin dm0 0.0026 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0091 0.0841 0.0841
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0295 0.3144 0.3144
Loa Loa (eye worm) nuclear hormone receptor 0.0076 0.0674 0.1291
Schistosoma mansoni follistatin 0.0041 0.0276 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.0227 0.0833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Brugia malayi tailless protein 0.0076 0.0674 0.1291
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0456 0.1435
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0162 0.1641 0.1641
Loa Loa (eye worm) hypothetical protein 0.0041 0.0276 0.0522
Leishmania major cathepsin L-like protease 0.0141 0.1399 0.4442
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0014 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0227 0.0833
Brugia malayi ecdysteroid receptor 0.0162 0.1641 0.3158
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0014 0.0014
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.015 0.1508 0.2901
Schistosoma mansoni RAR-like nuclear receptor 0.0162 0.1641 0.1641
Loa Loa (eye worm) hypothetical protein 0.0162 0.1641 0.3158
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0162 0.1641 0.1641
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0014 0.0014
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0107 0.0196
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0276 0.0522
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.0674 0.0674
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.0227 0.0833
Echinococcus granulosus carbonic anhydrase 0.0091 0.0841 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Echinococcus multilocularis thyroid hormone receptor alpha 0.0572 0.6273 0.6273
Loa Loa (eye worm) hypothetical protein 0.0091 0.0841 0.1614
Loa Loa (eye worm) runx1 0.006 0.0484 0.0924
Onchocerca volvulus Cathepsin F homolog 0.0037 0.0227 0.0412
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0276 0.0862
Echinococcus granulosus Smad4 0.0018 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0162 0.1641 0.3158
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0154 0.0474
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0091 0.0841 0.1614
Schistosoma mansoni hypothetical protein 0.007 0.0596 0.0596
Echinococcus multilocularis agrin 0.0041 0.0276 0.0276
Brugia malayi hypothetical protein 0.0086 0.0777 0.1491
Onchocerca volvulus 0.0475 0.5184 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0162 0.1641 0.1641
Loa Loa (eye worm) hypothetical protein 0.018 0.1849 0.356
Echinococcus multilocularis geminin 0.0365 0.394 0.394
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.1491
Brugia malayi nuclear hormone receptor 0.0162 0.1641 0.3158
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1228 0.1228
Echinococcus granulosus cathepsin l cysteine peptidase 0.0037 0.0227 0.0227
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.041 0.4442 0.4442
Onchocerca volvulus 0.0037 0.0227 0.0412
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.1228 0.2361
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0295 0.3144 0.3144
Plasmodium falciparum cysteine proteinase falcipain 3 0.0037 0.0227 0.2478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.1178 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Onchocerca volvulus 0.004 0.0266 0.0488
Echinococcus granulosus ecdysone induced protein 78C 0.0162 0.1641 0.1641
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0162 0.1641 0.1641
Onchocerca volvulus 0.006 0.0493 0.0925
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0227 0.0412
Schistosoma mansoni hypothetical protein 0.0075 0.0661 0.0661
Brugia malayi Smad1 0.0018 0.0013 0.0014
Echinococcus multilocularis lamin 0.0026 0.0107 0.0107
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.041 0.041
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0162 0.1641 0.3158
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.0777 0.1491
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1228 0.1228
Brugia malayi Steroid receptor seven-up type 2 0.0162 0.1641 0.3158
Schistosoma mansoni hypothetical protein 0.007 0.0596 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0162 0.1641 0.3158
Leishmania major cathepsin L-like protease 0.0037 0.0227 0.0707
Brugia malayi nuclear hormone receptor family member nhr-6 0.0076 0.0674 0.1291
Loa Loa (eye worm) hypothetical protein 0.0041 0.0276 0.0522
Leishmania major cathepsin L-like protease 0.0037 0.0227 0.0707
Schistosoma mansoni Smad4 0.0018 0.0013 0.0013
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0082 0.0731 0.1402
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0547 1
Loa Loa (eye worm) steroid hormone receptor 0.0162 0.1641 0.3158
Onchocerca volvulus 0.0076 0.0674 0.1276
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0014 0.0014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0276 0.0276
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0276 0.0522
Brugia malayi orphan nuclear receptor NR2E1 0.0076 0.0674 0.1291
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0162 0.1641 0.3158
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0162 0.1641 0.1641
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0456 0.1435
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.022 0.2294 0.4419
Schistosoma mansoni steroid hormone receptor ad4bp 0.0162 0.1641 0.1641
Loa Loa (eye worm) nuclear receptor NHR-67 0.0076 0.0674 0.1291
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0157 0.0292
Echinococcus granulosus cysteine protease 0.0019 0.0025 0.0025
Brugia malayi conserved hypotetical protein 0.0076 0.0674 0.1291
Brugia malayi Cathepsin L-like precursor 0.0037 0.0227 0.0428
Brugia malayi SPARC precursor 0.0041 0.0276 0.0522
Echinococcus multilocularis Protein lozenge 0.006 0.0484 0.0484
Onchocerca volvulus Putative organic anion transporter 0.006 0.0493 0.0925
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0456 0.1435
Onchocerca volvulus Bile acid receptor homolog 0.0162 0.1641 0.3147
Schistosoma mansoni nAChR subunit 0.0018 0.0014 0.0014
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0014 0.0014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0162 0.1641 0.1641
Brugia malayi Pre-SET motif family protein 0.0206 0.2134 0.411
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0227 0.0227
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.0731 0.291
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0082 0.0731 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0025 0.0025
Leishmania major carbonic anhydrase-like protein 0.0295 0.3144 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0493 0.094
Brugia malayi Cation transporter family protein 0.0018 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0091 0.0841 0.1614
Onchocerca volvulus 0.0026 0.0107 0.0179
Echinococcus granulosus FTZ F1 alpha 0.0162 0.1641 0.1641
Leishmania major hypothetical protein, conserved 0.003 0.0154 0.0474
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0276 1
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0731 0.291
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1228 0.1228
Brugia malayi Cathepsin L-like precursor 0.0025 0.0089 0.0162
Loa Loa (eye worm) hypothetical protein 0.0162 0.1641 0.3158
Brugia malayi MH1 domain containing protein 0.0018 0.0013 0.0014
Onchocerca volvulus 0.006 0.0493 0.0925
Brugia malayi TAR-binding protein 0.0125 0.1228 0.2361
Echinococcus multilocularis muscleblind protein 1 0.018 0.1849 0.1849
Echinococcus granulosus GPCR family 2 0.007 0.0596 0.0596
Trypanosoma cruzi major cysteine proteinase, putative 0.0111 0.1059 0.3358
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0082 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0475 0.5184 1
Brugia malayi Cathepsin L-like precursor 0.0037 0.0227 0.0428
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0014 0.0014
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0014 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0227 0.0833
Brugia malayi hypothetical protein 0.0076 0.0674 0.1291
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0276 0.1191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0162 0.1641 0.3158
Echinococcus multilocularis ubiquitin specific protease 41 0.0082 0.0731 0.0731
Echinococcus multilocularis cysteine protease 0.0037 0.0227 0.0227
Brugia malayi steroid hormone receptor 0.0162 0.1641 0.3158
Schistosoma mansoni hypothetical protein 0.0365 0.394 0.394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Schistosoma mansoni nAChR subunit 0.0018 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0456 0.1435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Echinococcus granulosus lamin 0.0026 0.0107 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0025 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0025 0.0062
Onchocerca volvulus Putative organic anion transporter 0.006 0.0493 0.0925
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0014 0.0017
Brugia malayi RNA binding protein 0.0125 0.1228 0.2361
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Schistosoma mansoni nuclear receptor 0.0076 0.0674 0.0674
Onchocerca volvulus 0.0162 0.1641 0.3147
Loa Loa (eye worm) hypothetical protein 0.0041 0.0276 0.0522
Onchocerca volvulus Protein ultraspiracle homolog 0.0162 0.1641 0.3147
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0076 0.0674 0.1276
Brugia malayi hypothetical protein 0.0183 0.1879 0.3617
Schistosoma mansoni nAChR subunit 0.0018 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.006 0.0493 0.094
Brugia malayi nuclear receptor NHR-88 0.0076 0.0674 0.1291
Loa Loa (eye worm) hypothetical protein 0.0162 0.1641 0.3158
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0014 0.0017
Brugia malayi Latrophilin receptor protein 2 0.007 0.0596 0.114
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0547 0.0547
Plasmodium vivax vivapain-2 0.0037 0.0227 0.8058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Trypanosoma cruzi cruzipain precursor, putative 0.0141 0.1399 0.4442
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0014 0.0017
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0025 0.0062
Onchocerca volvulus 0.006 0.0493 0.0925
Onchocerca volvulus 0.0076 0.0674 0.1276
Loa Loa (eye worm) hypothetical protein 0.0053 0.041 0.0781
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0456 0.1775
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0014 0.0014
Onchocerca volvulus 0.0037 0.0227 0.0412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0162 0.1641 0.3158
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0076 0.0674 0.1291
Onchocerca volvulus 0.0025 0.0089 0.0145
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0547 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.0731 0.2313
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0276 0.1191
Brugia malayi Calcitonin receptor-like protein seb-1 0.022 0.2294 0.4419
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1228 0.1228
Echinococcus granulosus nAChR subunit 0.0018 0.0014 0.0014
Brugia malayi nuclear receptor RXR 0.0086 0.0777 0.1491
Schistosoma mansoni thyroid hormone receptor 0.0572 0.6273 0.6273
Echinococcus granulosus cathepsin l1 0.0037 0.0227 0.0227
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0596 0.0596
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0014 0.0017
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0014 0.0014
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0456 0.0456
Brugia malayi hypoxia-induced factor 1 0.0169 0.1718 0.3308
Entamoeba histolytica hypothetical protein 0.0075 0.0661 0.9002
Schistosoma mansoni lamin 0.0026 0.0107 0.0107
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0025 0.0038
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0075 0.0661 0.9002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0089 0.0162
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0041 0.0068
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0014 0.0014
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0456 0.087
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.018 0.1849 0.356
Loa Loa (eye worm) hypothetical protein 0.0026 0.0102 0.0185
Echinococcus granulosus ubiquitin specific protease 41 0.0082 0.0731 0.0731
Echinococcus granulosus cathepsin l1 0.0025 0.0089 0.0089
Echinococcus multilocularis tar DNA binding protein 0.0125 0.1228 0.1228
Loa Loa (eye worm) Smad1 0.0018 0.0013 0.0014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0162 0.1641 0.1641
Schistosoma mansoni lamin 0.0026 0.0107 0.0107
Onchocerca volvulus 0.0058 0.0468 0.0878
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0266 0.0266
Echinococcus multilocularis carbonic anhydrase II 0.0295 0.3144 0.3144
Brugia malayi hypothetical protein 0.0086 0.0777 0.1491
Schistosoma mansoni smad1 5 8 and 0.0018 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0286 0.3038 0.5855
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.0777 0.1491
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.1491
Echinococcus granulosus carbonic anhydrase 0.0091 0.0841 0.0841
Loa Loa (eye worm) cysteine protease 0.0037 0.0227 0.0428
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Schistosoma mansoni organic anion transporter 0.006 0.0493 0.0493
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0014 0.0014
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0456 0.2948
Echinococcus granulosus follistatin 0.0041 0.0276 0.0276
Echinococcus granulosus Nuclear hormone receptor HR96 0.0076 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Loa Loa (eye worm) hypothetical protein 0.0162 0.1641 0.3158
Onchocerca volvulus Putative organic anion transporter 0.006 0.0493 0.0925
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0427 0.0427
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0044 0.0044
Echinococcus multilocularis expressed protein 0.0041 0.0276 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0162 0.1641 0.3158
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0129 0.0129
Onchocerca volvulus 0.0031 0.0157 0.0276
Onchocerca volvulus 0.0037 0.0227 0.0412
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0014 0.0014
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0276 0.3553
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2134 0.411
Brugia malayi MH2 domain containing protein 0.0018 0.0013 0.0014
Brugia malayi hypothetical protein 0.0076 0.0674 0.1291
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0076 0.0674 0.0674
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0076 0.0674 0.0674
Brugia malayi Nuclear hormone receptor E75 0.0076 0.0674 0.1291
Brugia malayi nuclear receptor NHR-88 0.0162 0.1641 0.3158
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0162 0.1641 0.3158
Brugia malayi MAP kinase sur-1 0.0057 0.0456 0.087
Brugia malayi nuclear receptor RXR 0.0076 0.0674 0.1291
Loa Loa (eye worm) pigment dispersing factor receptor c 0.022 0.2294 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0276 0.5
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0091 0.0841 0.1614
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0547 0.0547
Brugia malayi Pre-SET motif family protein 0.0031 0.0157 0.0292
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0227 0.0833
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0526 0.1004
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0493 0.094
Onchocerca volvulus 0.0026 0.0107 0.0179
Brugia malayi hypothetical protein 0.0475 0.5184 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0162 0.1641 0.3158
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.006 0.0493 0.094
Loa Loa (eye worm) RNA binding protein 0.0125 0.1228 0.2361
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1228 0.1228
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0082 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.006 0.0493 0.094
Loa Loa (eye worm) TAR-binding protein 0.0125 0.1228 0.2361
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0674 0.0674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0295 0.3144 1
Onchocerca volvulus 0.0053 0.041 0.0766
Toxoplasma gondii transporter, major facilitator family protein 0.006 0.0493 0.3306
Echinococcus multilocularis cpg binding protein 0.0067 0.0566 0.0566
Echinococcus granulosus cathepsin L 0.0019 0.0025 0.0025
Loa Loa (eye worm) ctsf protein 0.0037 0.0227 0.0428
Brugia malayi Cation transporter family protein 0.0018 0.0014 0.0017
Loa Loa (eye worm) transcription factor SMAD2 0.0263 0.2784 0.5366
Echinococcus multilocularis Solute carrier organic anion transporter family 0.006 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0276 0.3075
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.1399 0.4442
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.041 0.4442 0.4442
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0014 0.0014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0596 0.0596
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Entamoeba histolytica cysteine protease, putative 0.0037 0.0227 0.2863
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0162 0.1641 0.3158
Trypanosoma cruzi cysteine protease, putative 0.0019 0.0025 0.0062
Echinococcus multilocularis nuclear receptor nhr 48 0.0076 0.0674 0.0674
Schistosoma mansoni coup transcription factor 0.0162 0.1641 0.1641
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0037 0.0227 0.0428
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0456 0.1435
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0547 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.0674 0.0674
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0276 0.0522
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.1399 0.4442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0082 0.0731 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0089 0.0265
Echinococcus multilocularis Smad4 0.0018 0.0013 0.0013
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0086 0.0777 0.0777
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0661 0.0661
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0082 0.0731 0.0731
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0014 0.0014
Brugia malayi Cathepsin L-like precursor 0.0037 0.0227 0.0428
Loa Loa (eye worm) hypothetical protein 0.0041 0.0276 0.0522
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0227 0.0833
Toxoplasma gondii exonuclease III APE 0.0041 0.0276 0.119
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0086 0.0777 0.0777
Echinococcus granulosus carbonic anhydrase II 0.0295 0.3144 0.3144
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0014 0.0017
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0014 0.0014
Leishmania major cathepsin L-like protease 0.0037 0.0227 0.0707
Echinococcus multilocularis lamin dm0 0.0026 0.0107 0.0107
Leishmania major cathepsin L-like protease 0.0141 0.1399 0.4442
Brugia malayi Cathepsin L-like precursor 0.0025 0.0089 0.0162
Brugia malayi MH1 domain containing protein 0.0018 0.0013 0.0014
Echinococcus multilocularis tumor protein p63 0.0363 0.391 0.391
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0014 0.0017
Brugia malayi Nuclear hormone receptor E75 0.0076 0.0674 0.1291
Brugia malayi cathepsin L-like precursor 0.0025 0.0089 0.0162
Trypanosoma brucei protein kinase, putative 0.0057 0.0456 0.1435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0227 0.0833
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0037 0.0227 0.2478
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0162 0.1641 0.3158
Brugia malayi Cathepsin L-like precursor 0.0037 0.0227 0.0428
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.1399 0.4442
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0227 0.2863
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0091 0.0841 0.1614
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0547 0.1725
Onchocerca volvulus 0.0037 0.0227 0.0412
Schistosoma mansoni retinoic acid receptor RXR 0.0162 0.1641 0.1641
Schistosoma mansoni hypothetical protein 0.007 0.0596 0.0596
Schistosoma mansoni smad1 5 8 and 0.0018 0.0013 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.014 0.026
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0014 0.0017
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0227 0.0412
Toxoplasma gondii cathepsin CPL 0.0037 0.0227 0.0714
Echinococcus granulosus cpg binding protein 0.0067 0.0566 0.0566
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0157 0.0157
Echinococcus multilocularis carbonic anhydrase 0.0091 0.0841 0.0841
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0227 0.0707
Schistosoma mansoni nuclear receptor nhr-48 0.0076 0.0674 0.0674
Schistosoma mansoni cpg binding protein 0.0067 0.0566 0.0566
Loa Loa (eye worm) carbonic anhydrase 3 0.0295 0.3144 0.606
Trypanosoma cruzi MFS transporter, putative 0.006 0.0493 0.1552
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0162 0.1641 0.1641
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0025 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Brugia malayi hypothetical protein 0.0075 0.0661 0.1265
Onchocerca volvulus 0.006 0.0493 0.0925
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0162 0.1641 0.3158
Brugia malayi prostaglandin transporter 0.006 0.0493 0.094
Entamoeba histolytica hypothetical protein 0.0075 0.0661 0.9002
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3038 0.3038
Schistosoma mansoni hypothetical protein 0.015 0.1508 0.1508
Loa Loa (eye worm) MH2 domain-containing protein 0.0263 0.2784 0.5366
Echinococcus granulosus nuclear receptor nhr 48 0.0076 0.0674 0.0674
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0162 0.1641 0.1641
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0456 0.1435
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0162 0.1641 0.1641
Loa Loa (eye worm) hypothetical protein 0.0091 0.0841 0.1614
Leishmania major cathepsin L-like protease 0.0141 0.1399 0.4442
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0227 0.0428
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0014 0.0017
Echinococcus multilocularis cysteine protease 0.0037 0.0227 0.0227
Schistosoma mansoni carbonic anhydrase-related 0.0091 0.0841 0.0841
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0091 0.0841 0.1614
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0086 0.0777 0.1491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0076 0.0674 0.1276
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.0731 0.291
Brugia malayi CXXC zinc finger family protein 0.0063 0.0526 0.1004
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0014 0.0014
Toxoplasma gondii protease inhibitor PI2 0.0041 0.0276 0.1191
Onchocerca volvulus 0.0063 0.0526 0.0989
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.1491
Schistosoma mansoni nAChR subunit 0.0018 0.0014 0.0014
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0013 0.0014
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0295 0.3144 0.606
Echinococcus granulosus agrin 0.0041 0.0276 0.0276
Brugia malayi nuclear hormone receptor 0.0076 0.0674 0.1291
Echinococcus multilocularis follistatin 0.0041 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.1228 0.2361
Brugia malayi Cathepsin L-like precursor 0.0037 0.0227 0.0428
Schistosoma mansoni nAChR subunit 0.0018 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.007 0.0596 0.114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0162 0.1641 0.3158
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0162 0.1641 0.1641
Onchocerca volvulus 0.006 0.0493 0.0925
Plasmodium falciparum carbonic anhydrase 0.0091 0.0841 1
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0227 0.0428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0227 0.0833
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0276 0.0522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0014 0.0014
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0014 0.0017
Echinococcus multilocularis carbonic anhydrase 0.0091 0.0841 0.0841
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0076 0.0674 0.0674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0014 0.0017
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0227 0.0227
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0091 0.0841 0.1614
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Brugia malayi bHLH-PAS transcription factor 0.004 0.0266 0.0504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0227 0.0833
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0276 0.0522
Leishmania major cathepsin L-like protease 0.0037 0.0227 0.0707
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0162 0.1641 0.3158
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0013 0.0013
Loa Loa (eye worm) sodium-independent organic anion transporter 0.006 0.0493 0.094
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3038 0.3038
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2453 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.1291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.1399 0.4442
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0456 0.0456
Schistosoma mansoni thyroid hormone receptor 0.0572 0.6273 0.6273
Brugia malayi PAS domain containing protein 0.0055 0.0427 0.0813
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0154 0.0474
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0157 0.0157
Echinococcus granulosus smad 0.0018 0.0013 0.0013
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0154 0.0474
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0014 0.0017
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0075 0.0661 0.9002
Echinococcus multilocularis muscleblind protein 0.018 0.1849 0.1849
Schistosoma mansoni nAChR subunit 0.0018 0.0014 0.0014
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0227 0.0227
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0295 0.3144 0.606
Schistosoma mansoni ap endonuclease 0.0041 0.0276 0.0276
Echinococcus multilocularis cathepsin L 0.0019 0.0025 0.0025
Brugia malayi hypothetical protein 0.006 0.0493 0.094
Brugia malayi Muscleblind-like protein 0.018 0.1849 0.356
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0456 0.1775
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0058 0.0468 0.0468
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0017
Schistosoma mansoni carbonic anhydrase 0.0091 0.0841 0.0841
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.003 0.0154 0.0287
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0475 0.5184 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0162 0.1641 0.1641
Brugia malayi secreted modular calcium-binding protein 1 0.0041 0.0276 0.0522
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0276 0.0862
Leishmania major cysteine peptidase A (CPA) 0.0037 0.0227 0.0707
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0014 0.0017
Echinococcus granulosus Nuclear hormone receptor HR96 0.0076 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.006 0.0493 0.094
Loa Loa (eye worm) hypothetical protein 0.0037 0.0227 0.0428
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0295 0.3144 0.606
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0276 0.1034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0196
Onchocerca volvulus 0.0037 0.0227 0.0412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0227 0.0833
Loa Loa (eye worm) hypothetical protein 0.0025 0.0089 0.0162
Loa Loa (eye worm) hypoxia-induced factor 1 0.0169 0.1718 0.3308
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0157 0.0157
Brugia malayi intermediate filament protein 0.0026 0.0107 0.0196
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0025 0.0062
Toxoplasma gondii hypothetical protein 0.0091 0.0841 0.6713
Schistosoma mansoni agrin 0.0041 0.0276 0.0276
Schistosoma mansoni carbonic anhydrase-related 0.0091 0.0841 0.0841
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0014 0.0014
Schistosoma mansoni smad1 5 8 and 0.0018 0.0013 0.0013
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0014 0.0014
Schistosoma mansoni nAChR subunit 0.0018 0.0014 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.134 0.134
Schistosoma mansoni zinc finger protein 0.0076 0.0674 0.0674
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0456 0.0456

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 0.1 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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