Detailed information for compound 1379321

Basic information

Technical information
  • TDR Targets ID: 1379321
  • Name: [4-(2,5-dioxopyrrolidin-1-yl)phenyl] 2-phenyl acetate
  • MW: 309.316 | Formula: C18H15NO4
  • H donors: 0 H acceptors: 3 LogP: 2.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccccc1)Oc1ccc(cc1)N1C(=O)CCC1=O
  • InChi: 1S/C18H15NO4/c20-16-10-11-17(21)19(16)14-6-8-15(9-7-14)23-18(22)12-13-4-2-1-3-5-13/h1-9H,10-12H2
  • InChiKey: BIPLWCAKTLFCMB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-phenylacetic acid [4-(2,5-dioxo-1-pyrrolidinyl)phenyl] ester
  • 2-phenylacetic acid (4-succinimidophenyl) ester
  • [4-(2,5-dioxopyrrolidin-1-yl)phenyl] 2-phenylethanoate
  • ZINC00313126
  • Oprea1_714738
  • STK268829
  • 4-(2,5-dioxo-1-pyrrolidinyl)phenyl phenylacetate
  • MLS000534736
  • SMR000142193

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major short chain dehydrogenase/reductase, putative 0.0005 0.0082 0.5
Mycobacterium ulcerans oxidoreductase 0.0005 0.0082 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.0082 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0005 0.0082 0.5
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0005 0.0082 0.1229
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0936 0.1172
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0005 0.0082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Brugia malayi CXXC zinc finger family protein 0.0035 0.4403 0.5935
Trypanosoma brucei short-chain dehydrogenase, putative 0.0005 0.0082 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 1
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0005 0.0082 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0005 0.0082 1
Mycobacterium ulcerans ketoacyl reductase 0.0005 0.0082 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.7362 0.7362
Mycobacterium ulcerans dehydrogenase/reductase 0.0005 0.0082 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 1
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Plasmodium vivax hypothetical protein, conserved 0.0005 0.0082 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0651 0.0781
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Mycobacterium ulcerans short-chain type oxidoreductase 0.0005 0.0082 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0005 0.0082 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Giardia lamblia Reductase, putative 0.0005 0.0082 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0651 0.0651
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0082 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0005 0.0082 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.7362 1
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0005 0.0082 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0005 0.0082 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0005 0.0082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Leishmania major hypothetical protein, conserved 0.0005 0.0082 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.0082 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 1
Mycobacterium ulcerans dehydrogenase 0.0005 0.0082 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0005 0.0082 0.0082
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0005 0.0082 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0127 0.0127
Schistosoma mansoni carbonyl reductase 0.0005 0.0082 0.0082
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.0082 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0542 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0542 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium leprae Probable oxidoreductase 0.0005 0.0082 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0005 0.0082 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.0082 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0005 0.0082 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.0082 0.1229
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0005 0.0082 0.5
Mycobacterium ulcerans oxidoreductase 0.0005 0.0082 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0005 0.0082 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 1
Leishmania major short chain dehydrogenase-like protein 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.0082 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.0082 0.1229
Giardia lamblia Hypothetical protein 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0651 0.0781
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.0082 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.0082 0.0082
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Leishmania major hypothetical protein, conserved 0.0005 0.0082 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0005 0.0082 0.5
Echinococcus granulosus cpg binding protein 0.0037 0.4688 0.6326
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0005 0.0082 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.7362 1
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0005 0.0082 0.5
Leishmania major hypothetical protein, conserved 0.0005 0.0082 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0005 0.0082 0.5
Leishmania major hypothetical protein, conserved 0.0005 0.0082 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.7362 0.7362
Leishmania major hypothetical protein, conserved 0.0005 0.0082 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0005 0.0082 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0005 0.0082 1
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0651 0.0781
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0005 0.0082 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0005 0.0082 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0005 0.0082 0.5
Entamoeba histolytica hypothetical protein 0.0005 0.0082 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0005 0.0082 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.0082 0.1229
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.0082 0.1229
Schistosoma mansoni cpg binding protein 0.0037 0.4688 0.4688
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.0082 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.0082 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 1
Trichomonas vaginalis steroid dehydrogenase, putative 0.0005 0.0082 0.1229
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0005 0.0082 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0005 0.0082 0.0082
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.0082 0.1229
Schistosoma mansoni steroid dehydrogenase 0.0005 0.0082 0.0082
Schistosoma mansoni steroid dehydrogenase 0.0005 0.0082 0.0082
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0005 0.0082 0.0082
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0005 0.0082 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0005 0.0082 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0005 0.0082 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0082 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0651 0.0781
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 1
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Echinococcus multilocularis cpg binding protein 0.0037 0.4688 0.6326
Schistosoma mansoni carbonyl reductase 0.0005 0.0082 0.0082
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0005 0.0082 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 1
Leishmania major oxidoreductase-like protein 0.0005 0.0082 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0005 0.0082 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0956 0.1199
Mycobacterium ulcerans ketoacyl reductase 0.0005 0.0082 0.5
Trypanosoma brucei oxidoreductase-like protein 0.0005 0.0082 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0005 0.0082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.0082 0.0082
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.0082 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.7362 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0005 0.0082 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0005 0.0082 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0005 0.0082 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0005 0.0082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Schistosoma mansoni carbonyl reductase 0.0005 0.0082 0.0082
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0005 0.0082 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0005 0.0082 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0956 0.1199
Leishmania major short chain dehydrogenase, putative 0.0005 0.0082 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0005 0.0082 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.8869 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0005 0.0082 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.0082 0.0082
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.0082 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0005 0.0082 1
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.7362 0.7362
Leishmania major pteridine reductase 1 0.0005 0.0082 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0005 0.0082 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0005 0.0082 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0005 0.0082 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.7362 1
Onchocerca volvulus 0.0035 0.4403 1
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0956 0.1199
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0005 0.0082 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0005 0.0082 1
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Schistosoma mansoni steroid dehydrogenase 0.0005 0.0082 0.0082
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0005 0.0082 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0005 0.0082 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0005 0.0082 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.7362 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0082 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.0082 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0082 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0005 0.0082 0.1229
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0005 0.0082 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0005 0.0082 0.5
Schistosoma mansoni cpg binding protein 0.0037 0.4688 0.4688
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0005 0.0082 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.0082 0.1229
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0005 0.0082 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0005 0.0082 0.5
Leishmania major dehydrogenase-like protein 0.0005 0.0082 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0005 0.0082 0.5
Schistosoma mansoni retinal dehydrogenase 0.0005 0.0082 0.0082
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0005 0.0082 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0005 0.0082 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.0082 0.5
Trichomonas vaginalis helicase, putative 0.0008 0.0542 1
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0005 0.0082 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0005 0.0082 0.5
Schistosoma mansoni cpg binding protein 0.0035 0.4403 0.4403
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.0082 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0005 0.0082 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0005 0.0082 1
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.0082 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0005 0.0082 0.5
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0005 0.0082 0.1229
Mycobacterium ulcerans short-chain dehydrogenase 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0005 0.0082 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.0082 0.0082
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0005 0.0082 1
Leishmania major short chain dehydrogenase, putative 0.0005 0.0082 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0005 0.0082 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.0082 0.1229
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.0082 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0005 0.0082 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.0082 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.0082 0.0082
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.0082 0.1229
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.4403 0.5935
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.7362 1
Schistosoma mansoni steroid dehydrogenase 0.0005 0.0082 0.0082
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0005 0.0082 0.0082
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0005 0.0082 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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