Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0026 | 0.0274 | 0.0278 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0026 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | nuclear factor I | 0.0014 | 0.0002 | 0.0002 |
Brugia malayi | MH2 domain containing protein | 0.0026 | 0.0274 | 0.0319 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.011 | 0.2219 | 0.2581 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0181 | 0.3879 | 0.4512 |
Brugia malayi | Isocitrate dehydrogenase | 0.0035 | 0.0468 | 0.0545 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0037 | 0.0522 | 0.0522 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0082 | 0.1575 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.425 | 0.4314 |
Brugia malayi | hypothetical protein | 0.0082 | 0.1575 | 0.1832 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0274 | 0.0278 |
Brugia malayi | MH2 domain containing protein | 0.0026 | 0.0274 | 0.0319 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0445 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0035 | 0.0468 | 0.0545 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.425 | 0.4314 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0474 | 0.0481 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0474 | 0.0551 |
Loa Loa (eye worm) | RNA binding protein | 0.0197 | 0.425 | 0.425 |
Brugia malayi | RNA binding protein | 0.0197 | 0.425 | 0.4944 |
Echinococcus granulosus | tar DNA binding protein | 0.0197 | 0.425 | 0.425 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0037 | 0.0522 | 0.0522 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0474 | 0.0481 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.0474 | 0.0474 |
Schistosoma mansoni | Smad4 | 0.0026 | 0.0274 | 0.0278 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0474 | 0.0474 |
Brugia malayi | MH1 domain containing protein | 0.0014 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | Smad1 | 0.0026 | 0.0274 | 0.0274 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0026 | 0.0274 | 0.0274 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0026 | 0.0274 | 0.0274 |
Echinococcus granulosus | Smad4 | 0.0026 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0035 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0242 | 0.5293 | 0.5293 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.027 | 0.5932 | 0.69 |
Brugia malayi | MH2 domain containing protein | 0.0384 | 0.8596 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0384 | 0.8596 | 0.8596 |
Onchocerca volvulus | 0.0242 | 0.5293 | 0.5 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0197 | 0.425 | 0.425 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0082 | 0.1575 | 1 |
Schistosoma mansoni | smad | 0.0026 | 0.0274 | 0.0278 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0274 | 0.0278 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0474 | 0.0474 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0197 | 0.425 | 0.4944 |
Leishmania major | hypothetical protein, conserved | 0.0082 | 0.1575 | 1 |
Brugia malayi | TAR-binding protein | 0.0197 | 0.425 | 0.4944 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0082 | 0.1575 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0026 | 0.0274 | 0.0319 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0026 | 0.0274 | 0.0274 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0035 | 0.0468 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.1411 | 0.1642 |
Echinococcus multilocularis | smad | 0.0026 | 0.0274 | 0.0274 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0468 | 0.0468 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0082 | 0.1575 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.011 | 0.2219 | 0.2219 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.425 | 0.4314 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0035 | 0.0468 | 0.0475 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0468 | 0.0468 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0002 | 0.0002 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0474 | 0.0551 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0181 | 0.3879 | 0.3879 |
Brugia malayi | Smad1 | 0.0026 | 0.0274 | 0.0319 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.011 | 0.2219 | 0.2581 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0474 | 0.0474 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0197 | 0.425 | 0.425 |
Brugia malayi | MH1 domain containing protein | 0.0026 | 0.0274 | 0.0319 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0082 | 0.1575 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0035 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0026 | 0.0274 | 0.0274 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.1411 | 0.1433 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0899 | 0.1045 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0474 | 0.0474 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0082 | 0.1575 | 1 |
Brugia malayi | Pax transcription factor protein 2 | 0.0242 | 0.5293 | 0.6157 |
Echinococcus granulosus | smad | 0.0026 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2219 | 0.2219 |
Schistosoma mansoni | tyrosine kinase | 0.0438 | 0.9852 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0197 | 0.425 | 0.425 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0026 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.3586 | 0.3586 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.425 | 0.4314 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0474 | 0.0481 |
Echinococcus multilocularis | Smad4 | 0.0026 | 0.0274 | 0.0274 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.425 | 0.4314 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0445 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0014 | 0.0002 | 0.0003 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0474 | 0.0474 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.0474 | 0.0474 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0522 | 0.053 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0082 | 0.1575 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0474 | 0.0481 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0035 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1411 | 0.1411 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0384 | 0.8596 | 0.8596 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0274 | 0.0278 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0474 | 0.0474 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.