Detailed information for compound 1379864

Basic information

Technical information
  • TDR Targets ID: 1379864
  • Name: N-(furan-2-ylmethyl)-5-[(4-methylphenyl)methy l]-6-oxobenzo[b][1,4]benzothiazepine-3-carbox amide
  • MW: 454.54 | Formula: C27H22N2O3S
  • H donors: 1 H acceptors: 2 LogP: 4.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CN1c2cc(ccc2Sc2c(C1=O)cccc2)C(=O)NCc1ccco1
  • InChi: 1S/C27H22N2O3S/c1-18-8-10-19(11-9-18)17-29-23-15-20(26(30)28-16-21-5-4-14-32-21)12-13-25(23)33-24-7-3-2-6-22(24)27(29)31/h2-15H,16-17H2,1H3,(H,28,30)
  • InChiKey: XSKPKKJCQHMHPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-furylmethyl)-5-[(4-methylphenyl)methyl]-6-oxo-benzo[b][1,4]benzothiazepine-3-carboxamide
  • N-(2-furylmethyl)-5-[(4-methylphenyl)methyl]-6-oxo-3-benzo[b][1,4]benzothiazepinecarboxamide
  • N-(2-furylmethyl)-6-keto-5-(4-methylbenzyl)benzo[b][1,4]benzothiazepine-3-carboxamide
  • N-(furan-2-ylmethyl)-5-[(4-methylphenyl)methyl]-6-oxo-benzo[b][1,4]benzothiazepine-3-carboxamide
  • K784-7392
  • NCGC00139720-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0313 0.1478
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0028 0.0041
Loa Loa (eye worm) hypothetical protein 0.0182 0.5707 1
Onchocerca volvulus 0.0018 0.016 0.028
Loa Loa (eye worm) hypothetical protein 0.0033 0.066 0.1157
Brugia malayi PAN domain containing protein 0.0033 0.066 0.1157
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0182 0.5707 1
Toxoplasma gondii microneme protein MIC17C 0.0033 0.066 0.0634
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0117 0.0132
Plasmodium falciparum enoyl-acyl carrier reductase 0.0214 0.6799 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.1275 0.2233
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0072 0.1962 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0015 0.0028 0.0048
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.1275 0.1842
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0015 0.0028 0.0141
Onchocerca volvulus 0.0182 0.5707 1
Loa Loa (eye worm) tyrosinase 1 0.0182 0.5707 1
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0018 0.016 0.0814
Toxoplasma gondii PAN domain-containing protein 0.0033 0.066 0.0634
Echinococcus granulosus casein kinase ii subunit beta 0.0072 0.1962 1
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0015 0.0028 0.0048
Loa Loa (eye worm) oxidoreductase 0.0015 0.0028 0.0048
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Loa Loa (eye worm) casein kinase II 0.0021 0.0245 0.0428
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0182 0.5707 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.066 0.1157
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0017 0.0124 0.0143
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0549
Onchocerca volvulus 0.0051 0.1275 0.2233
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0313 0.0422
Plasmodium vivax casein kinase II beta chain, putative 0.0072 0.1962 0.2857
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0028 0.0041
Mycobacterium ulcerans hypothetical protein 0.0023 0.0313 0.0461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0085 0.0085
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.066 0.1157
Onchocerca volvulus 0.0033 0.066 0.1157
Loa Loa (eye worm) retinol dehydrogenase 12 0.0015 0.0028 0.0048
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0018 0.016 0.028
Loa Loa (eye worm) ShTK domain-containing protein 0.0182 0.5707 1
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0214 0.6799 1
Schistosoma mansoni tyrosinase precursor 0.0182 0.5707 1
Echinococcus multilocularis casein kinase ii subunit beta 0.0072 0.1962 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0313 0.0422
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0015 0.0028 0.0041
Loa Loa (eye worm) hypothetical protein 0.0033 0.066 0.1157
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Loa Loa (eye worm) hypothetical protein 0.0018 0.016 0.028
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0072 0.1962 1
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0214 0.6799 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0028 0.0041
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0028 0.0048
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.066 0.1157
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0028 0.0041
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0313 0.1478
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0313 0.0549
Toxoplasma gondii kringle domain-containing protein 0.0051 0.1275 0.125
Loa Loa (eye worm) Csnk2b protein 0.0072 0.1962 0.3437
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0015 0.0028 0.0041
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0017 0.0124 0.0218
Brugia malayi Csnk2b protein 0.0072 0.1962 0.3437
Brugia malayi casein kinase II, putaitve 0.0021 0.0245 0.0428
Onchocerca volvulus 0.0033 0.066 0.1157
Onchocerca volvulus 0.0033 0.066 0.1157
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0313 0.0461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0313 0.0422
Onchocerca volvulus 0.0033 0.066 0.1157
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Brugia malayi Kringle domain containing protein 0.0051 0.1275 0.2233
Brugia malayi PAN domain containing protein 0.0033 0.066 0.1157
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0117 0.0132
Toxoplasma gondii hypothetical protein 0.0033 0.066 0.0634
Schistosoma mansoni dihydropteridine reductase 0.0015 0.0028 0.0048
Plasmodium falciparum casein kinase II beta chain 0.0072 0.1962 0.2857
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0205
Loa Loa (eye worm) hypothetical protein 0.0033 0.066 0.1157
Toxoplasma gondii PAN/Apple domain-containing protein 0.0033 0.066 0.0634
Loa Loa (eye worm) hypothetical protein 0.0018 0.016 0.028
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0028 0.0041
Toxoplasma gondii ck2 beta subunit 0.0072 0.1962 0.194
Trichomonas vaginalis hypothetical protein 0.0214 0.6799 1
Onchocerca volvulus 0.0033 0.066 0.1157
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0072 0.1962 1
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0245 0.1121
Brugia malayi PAN domain containing protein 0.0033 0.066 0.1157
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0245 0.1121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0085 0.0085
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0313 0.0461
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0017 0.0124 0.0499
Loa Loa (eye worm) hypothetical protein 0.0033 0.066 0.1157
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0072 0.1962 0.3437
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0028 0.0041
Loa Loa (eye worm) hypothetical protein 0.0051 0.1275 0.2233
Onchocerca volvulus 0.0033 0.066 0.1157
Onchocerca volvulus 0.0033 0.066 0.1157
Plasmodium vivax casein kinase II beta chain, putative 0.0072 0.1962 0.2857
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.1275 0.6446
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0214 0.6799 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0028 0.0041
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0214 0.6799 0.679
Brugia malayi PAN domain containing protein 0.0033 0.066 0.1157
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0017 0.0124 0.0499
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0018 0.016 0.0682
Plasmodium vivax phospholipase C-like, putative 0.0017 0.0124 0.0143
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0205
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0182 0.5707 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0085 0.0085
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0205
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0205
Leishmania major hypothetical protein, conserved 0.0051 0.1275 0.6446
Onchocerca volvulus 0.0018 0.016 0.028
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0117 0.0132
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0313 0.1478
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0214 0.6799 1
Brugia malayi Protein kinase domain containing protein 0.0051 0.1275 0.2233
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0072 0.1962 0.3437
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.066 0.1157
Toxoplasma gondii microneme protein MIC17B 0.0033 0.066 0.0634
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.066 0.1157
Mycobacterium ulcerans oxidoreductase 0.0015 0.0028 0.0041
Giardia lamblia Casein kinase II beta chain 0.0072 0.1962 1
Leishmania major phospholipase c-like protein 0.0018 0.016 0.0682
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0028 0.0041
Toxoplasma gondii microneme protein MIC17A 0.0033 0.066 0.0634
Schistosoma mansoni tyrosinase precursor 0.0182 0.5707 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0214 0.6799 1
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0072 0.1962 0.194
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0182 0.5707 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0028 0.0041
Toxoplasma gondii PAN domain-containing protein 0.0033 0.066 0.0634
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0127 0.3837 0.6722
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0313 0.1478
Toxoplasma gondii hypothetical protein 0.0033 0.066 0.0634
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0549
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0313 0.0422
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0549
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0072 0.1962 1
Onchocerca volvulus 0.0033 0.066 0.1157
Loa Loa (eye worm) hypothetical protein 0.0033 0.066 0.1157
Plasmodium falciparum casein kinase II beta chain 0.0072 0.1962 0.2857
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0205
Toxoplasma gondii PAN domain-containing protein 0.0033 0.066 0.0634
Onchocerca volvulus 0.0033 0.066 0.1157
Onchocerca volvulus 0.0033 0.066 0.1157
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0072 0.1962 1
Onchocerca volvulus 0.0015 0.0028 0.0048
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0313 0.0461
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0018 0.016 0.0132
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0015 0.0028 0.0141
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.1275 0.6497
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.016 0.028
Toxoplasma gondii microneme protein MIC4 0.0033 0.066 0.0634
Loa Loa (eye worm) ShTK domain-containing protein 0.0182 0.5707 1
Brugia malayi Variant SH3 domain containing protein 0.0127 0.3837 0.6722
Onchocerca volvulus 0.0182 0.5707 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0028 0.0041
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0018 0.016 0.0814
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Onchocerca volvulus 0.0182 0.5707 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0028 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0313 0.1478
Onchocerca volvulus 0.0033 0.066 0.1157
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0214 0.6799 1
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.1275 0.6497
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0015 0.0028 0.0041
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0028 0.0041
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0028 0.0041
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0313 0.0461
Brugia malayi ShTK domain containing protein 0.0182 0.5707 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0085 0.0085
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0313 0.0461
Toxoplasma gondii microneme protein, putative 0.0033 0.066 0.0634
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0117 0.0132
Toxoplasma gondii PAN domain-containing protein 0.0033 0.066 0.0634
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0313 0.0549
Brugia malayi PAN domain containing protein 0.0033 0.066 0.1157
Brugia malayi Common central domain of tyrosinase family protein 0.0182 0.5707 1
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0072 0.1962 1
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Brugia malayi PAN domain containing protein 0.0033 0.066 0.1157
Brugia malayi PAN domain containing protein 0.0033 0.066 0.1157
Toxoplasma gondii PAN domain-containing protein 0.0309 1 1
Onchocerca volvulus 0.0015 0.0028 0.0048
Loa Loa (eye worm) hypothetical protein 0.0182 0.5707 1
Toxoplasma gondii subtilisin SUB12 0.0033 0.066 0.0634
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0033 0.066 0.0634
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Loa Loa (eye worm) Plcb4 protein 0.0017 0.0124 0.0218
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0018 0.016 0.0682
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0313 0.0549
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0028 0.0041
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0028 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0313 0.0461
Brugia malayi PAN domain containing protein 0.0033 0.066 0.1157
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0117 0.0172
Brugia malayi PAN domain containing protein 0.0033 0.066 0.1157
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0072 0.1962 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0048
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.1275 0.1842
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.1962 0.262
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0313 0.0461
Onchocerca volvulus 0.0023 0.0313 0.0549
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0313 0.1478
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0218
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.066 0.1157
Onchocerca volvulus 0.0182 0.5707 1
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0017 0.0124 0.0218
Loa Loa (eye worm) hypothetical protein 0.0033 0.066 0.1157
Schistosoma mansoni hypothetical protein 0.0051 0.1275 0.2233
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0015 0.0028 0.0041
Schistosoma mansoni phospholipase C beta 0.0017 0.0124 0.0218
Schistosoma mansoni casein kinase II beta subunit 0.0072 0.1962 0.3437
Brugia malayi PAN domain containing protein 0.0033 0.066 0.1157

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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