TDR Targets

Basic information

Technical information

TDR Targets ID: 1379920
Name: 8-[(4-fluorophenyl)methyl]-6-phenylpteridin-7 -one
MW: 332.331 | Formula: C19H13FN4O
H donors: 0 H acceptors: 3 LogP: 2.74 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)Cn1c2ncncc2nc(c1=O)c1ccccc1
InChi: 1S/C19H13FN4O/c20-15-8-6-13(7-9-15)11-24-18-16(10-21-12-22-18)23-17(19(24)25)14-4-2-1-3-5-14/h1-10,12H,11H2
InChiKey: CUQQCHJRTDOXFH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

8-[(4-fluorophenyl)methyl]-6-phenyl-pteridin-7-one
8-[(4-fluorophenyl)methyl]-6-phenyl-7-pteridinone
8-(4-fluorobenzyl)-6-phenyl-pteridin-7-one
PCOP-159303
NCGC00010492

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 3, subfamily A, polypeptide 4	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 2, subfamily C, polypeptide 9	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 1, subfamily A, polypeptide 2	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 2, subfamily C, polypeptide 19	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	cytochrome P450 556	Get druggable targets OG5_126554	All targets in OG5_126554
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Leishmania major	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126554	All targets in OG5_126554
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma congolense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania donovani	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Candida albicans	cytochrome P450 56	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania braziliensis	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	CYP4Cod1	Get druggable targets OG5_126554	All targets in OG5_126554

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	cytochrome P450	cytochrome P450, family 3, subfamily A, polypeptide 4	502 aa	492 aa	24.2 %
Brugia malayi	Cytochrome P450 family protein	cytochrome P450, family 1, subfamily A, polypeptide 2	516 aa	470 aa	26.2 %
Leishmania major	cytochrome p450-like protein	cytochrome P450, family 2, subfamily C, polypeptide 19	490 aa	411 aa	23.1 %
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	cytochrome P450, family 2, subfamily C, polypeptide 9	490 aa	441 aa	21.8 %
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0265	0.033
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0286	0.6357	0.7938
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.0265	0.033
Trichomonas vaginalis	rotamase, putative	0.0334	0.7511	1
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.0265	0.0265
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0069	0.1222	0.0937
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0265	0.033
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0265	0.0265
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0041	0.0572	0.0625
Onchocerca volvulus		0.0028	0.0265	0.0608
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0495	0.0618
Loa Loa (eye worm)	cytochrome P450 family protein	0.0063	0.1091	0.1363
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Brugia malayi	Cation transporter family protein	0.0121	0.2458	0.3069
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.0495	0.0495
Schistosoma mansoni	amine GPCR	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0041	0.0572	0.0572
Onchocerca volvulus		0.0028	0.0265	0.0608
Onchocerca volvulus		0.0028	0.0265	0.0608
Echinococcus multilocularis	serotonin receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0038	0.0495	0.0618
Brugia malayi	Cation transporter family protein	0.0038	0.0495	0.0618
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0038	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0653	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0017	0	0.5
Loa Loa (eye worm)	AUR protein kinase	0.0041	0.0572	0.0715
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0251	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0653	0.0815
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.0265	0.0265
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0265	0.0265
Brugia malayi	endoprotease bli-4 precursor	0.0355	0.8008	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0022	0.0123	0.0153
Onchocerca volvulus		0.0028	0.0265	0.0608
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.0265	0.033
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.0265	0.0265
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0153
Trichomonas vaginalis	conserved hypothetical protein	0.0334	0.7511	1
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0038	0.0495	0.0618
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0017	0	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0084	0.1582	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.0102	0.2002	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.0265	0.0265
Brugia malayi	Cation transporter family protein	0.0038	0.0495	0.0618
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0017	0	0.5
Brugia malayi	AKH receptor	0.0028	0.0265	0.033
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0265	0.033
Brugia malayi	hypothetical protein	0.0028	0.0265	0.033
Echinococcus granulosus	nAChR subunit	0.0022	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0017	0	0.5
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.0495	0.0495
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0022	0.0123	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus granulosus	furin	0.0355	0.8008	0.8008
Schistosoma mansoni	nAChR subunit	0.0038	0.0495	0.0618
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0355	0.8008	1
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0041	0.0572	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0265	0.0265
Entamoeba histolytica	protein kinase domain containing protein	0.0041	0.0572	0.0625
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.0265	0.0265
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.0265	0.033
Echinococcus granulosus	Furin 1	0.0084	0.1582	0.1582
Brugia malayi	hypothetical protein	0.0028	0.0265	0.033
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0025	0.0195	0.0195
Echinococcus granulosus	orexin receptor type 2	0.0028	0.0265	0.0265
Echinococcus granulosus	neuropeptide receptor	0.0221	0.4816	0.4816
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0038	0.0495	0.0495
Brugia malayi	hypothetical protein	0.0286	0.6357	0.7938
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.0653	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	celfurPC protein	0.0287	0.638	0.7968
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.0265	0.0265
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.0265	0.0265
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0653	0.0815
Schistosoma mansoni	opsin-like receptor	0.0028	0.0265	0.033
Echinococcus multilocularis	potassium voltage gated channel protein	0.0025	0.0195	0.0195
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0084	0.1582	0.1976
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0265	0.033
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0265	0.0265
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0017	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.0265	0.033
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0265	0.033
Trichomonas vaginalis	rotamase, putative	0.0326	0.7325	0.9731
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0017	0	0.5
Echinococcus granulosus	potassium voltage gated channel protein	0.0025	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0153
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.0495	0.0618
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0153
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0495	0.0618
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0017	0	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.0265	0.033
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0265	0.0265
Brugia malayi	neuroendocrine convertase 1 precursor	0.0223	0.4882	0.6096
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0069	0.1222	0.0937
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0265	0.0265
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.0265	0.033
Schistosoma mansoni	opsin-like receptor	0.0028	0.0265	0.033
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.2002	0.2733
Brugia malayi	proprotein convertase 2	0.0223	0.4882	0.6096
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0495	0.0618
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.0495	0.0495
Schistosoma mansoni	hypothetical protein	0.0028	0.0265	0.033
Schistosoma mansoni	hypothetical protein	0.0058	0.0974	0.1217
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.0265	0.033
Schistosoma mansoni	amine GPCR	0.0028	0.0265	0.033
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0495	0.0618
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0038	0.0495	0.0618
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0038	0.0495	0.0495
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	Dopamine receptor protein 2	0.0028	0.0265	0.033
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Schistosoma mansoni	hypothetical protein	0.0069	0.1222	0.1527
Loa Loa (eye worm)	endoprotease bli-4	0.0355	0.8008	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.2085	0.2604
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0265	0.033
Onchocerca volvulus		0.0028	0.0265	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0265	0.0265
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0017	0	0.5
Brugia malayi	larval opioid receptor	0.0028	0.0265	0.033
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0326	0.7325	1
Onchocerca volvulus		0.0028	0.0265	0.0608
Schistosoma mansoni	amine GPCR	0.0028	0.0265	0.033
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0038	0.0495	0.0618
Onchocerca volvulus		0.0038	0.0495	0.1594
Brugia malayi	sulfakinin receptor protein	0.0028	0.0265	0.033
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0153
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0326	0.7325	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0121	0.2458	0.3069
Onchocerca volvulus		0.0028	0.0265	0.0608
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0653	0.0653
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0326	0.7325	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0028	0.0265	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.0265	0.0265
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0265	0.033
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0265	0.033
Entamoeba histolytica	protein kinase , putative	0.0041	0.0572	0.0625
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0653	0.0653
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0038	0.0495	0.0495
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.0265	0.0265
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0017	0	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0022	0.0123	0.0153
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0017	0	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.0265	0.033
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0265	0.033
Schistosoma mansoni	amine GPCR	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.0265	0.0265
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0265	0.033
Brugia malayi	neuropeptide F receptor	0.0028	0.0265	0.033
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Echinococcus granulosus	sex peptide receptor	0.0028	0.0265	0.0265
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.0265	0.0265
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0121	0.2458	0.3069
Schistosoma mansoni	neuropeptide receptor	0.0221	0.4816	0.6015
Brugia malayi	neuropeptide F receptor	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0844	0.1055
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.0653	0.0891
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0974	0.1217
Echinococcus granulosus	aurora kinase A	0.0041	0.0572	0.0572
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0017	0	0.5
Trypanosoma brucei	cytochrome P450, putative	0.0028	0.0251	0.0342
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0084	0.1582	0.1455
Brugia malayi	hypothetical protein	0.0028	0.0265	0.033
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.0265	0.033
Onchocerca volvulus		0.0121	0.2458	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0265	0.033
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0038	0.0495	0.0618
Brugia malayi	Melatonin receptor type 1A	0.0028	0.0265	0.033
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0265	0.0265
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0069	0.1222	0.0937
Echinococcus multilocularis	neuropeptides capa receptor	0.0439	1	1
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.0251	0.0342
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0265	0.033
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.0265	0.033
Schistosoma mansoni	hypothetical protein	0.0031	0.0322	0.0402
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0265	0.033
Onchocerca volvulus		0.0038	0.0495	0.1594
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.6357	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0653	0.0891
Onchocerca volvulus		0.0028	0.0265	0.0608
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0231	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Brugia malayi	serine/threonine kinase 12	0.0041	0.0572	0.0715
Echinococcus granulosus	somatostatin receptor	0.0028	0.0265	0.0265
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0022	0.0123	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus granulosus	neuroendocrine convertase 2	0.0223	0.4882	0.4882
Onchocerca volvulus		0.0028	0.0265	0.0608
Onchocerca volvulus		0.0038	0.0495	0.1594
Schistosoma mansoni	rotamase	0.0334	0.7511	0.938
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0017	0	0.5
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0038	0.0495	0.0618
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0653	0.0891
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0265	0.033
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Onchocerca volvulus		0.0028	0.0265	0.0608
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0495	0.0495
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0084	0.1582	0.1455
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.0265	0.0265
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0495	0.0495
Trichomonas vaginalis	hypothetical protein	0.0069	0.1222	0.0937
Giardia lamblia	High cysteine membrane protein Group 2	0.0132	0.2721	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Giardia lamblia	Furin precursor putative serine protease	0.0069	0.1222	0.3025
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0326	0.7325	1
Echinococcus multilocularis	expressed protein	0.0334	0.7511	0.7511
Brugia malayi	Cytochrome P450 family protein	0.0063	0.1091	0.1363
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0053	0.0858	0.0858
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.0265	0.033
Echinococcus multilocularis	aurora kinase A	0.0041	0.0572	0.0572
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0265	0.033
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.0653	0.0373
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0216	0.4708	0.4708
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0495	0.0618
Brugia malayi	ephrin receptor 1 precursor	0.0025	0.0198	0.0247
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0139	0.2895	0.3615
Schistosoma mansoni	nAChR subunit	0.0038	0.0495	0.0618
Onchocerca volvulus		0.0028	0.0265	0.0608
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0265	0.0265
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0041	0.0572	0.5
Schistosoma mansoni	nAChR subunit	0.0038	0.0495	0.0618
Entamoeba histolytica	protein kinase, putative	0.0041	0.0572	0.0625
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0216	0.4708	0.596
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0653	0.0891
Loa Loa (eye worm)	AUR protein kinase	0.0041	0.0572	0.0715
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0216	0.4708	0.596
Toxoplasma gondii	PPIC-type PPIASE domain-containing protein	0.0102	0.2002	0.2733
Entamoeba histolytica	protein kinase, putative	0.0041	0.0572	0.0625
Brugia malayi	hypothetical protein	0.0028	0.0265	0.033
Schistosoma mansoni	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.0265	0.0265
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.2002	0.2733
Schistosoma mansoni	opsin-like receptor	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0265	0.0265
Echinococcus multilocularis	somatostatin receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Loa Loa (eye worm)	TK/EPH protein kinase	0.0068	0.1201	0.1499
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.0265	0.033
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0265	0.0265
Schistosoma mansoni	hypothetical protein	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0153
Schistosoma mansoni	histamine h1 receptor	0.0028	0.0265	0.033
Brugia malayi	ORL1-like opioid receptor	0.0028	0.0265	0.033
Onchocerca volvulus		0.0028	0.0265	0.0608
Schistosoma mansoni	hypothetical protein	0.0028	0.0265	0.033
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0495	0.0618
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0251	0.0313
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.0265	0.033
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0495	0.0618
Loa Loa (eye worm)	LGC-31 protein	0.0038	0.0495	0.0618
Brugia malayi	hypothetical protein	0.0028	0.0265	0.033
Onchocerca volvulus		0.0028	0.0265	0.0608
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0041	0.0572	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	Dopamine receptor	0.0028	0.0265	0.033
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0038	0.0495	0.0495
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.0495	0.0495
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0495	0.0495
Echinococcus multilocularis	nAChR subunit	0.0038	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	G protein coupled receptor 139	0.0221	0.4816	0.4816
Brugia malayi	hypothetical protein	0.0028	0.0265	0.033
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0028	0.0265	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0495	0.0618
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0251	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0653	0.0653
Schistosoma mansoni	amine GPCR	0.0028	0.0265	0.033
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0265	0.033
Brugia malayi	RE15519p	0.0028	0.0265	0.033
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	G-protein coupled receptor	0.0028	0.0265	0.033
Echinococcus multilocularis	neuroendocrine convertase 2	0.0223	0.4882	0.4882
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0265	0.0265
Onchocerca volvulus	Putative nachr subunit	0.0038	0.0495	0.1594
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0038	0.0495	0.0618
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.0572	0.0715
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0251	0.0313
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0653	0.0653
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0153
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Brugia malayi	Serotonin receptor	0.0028	0.0265	0.033
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.0265	0.0265
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0334	0.7511	0.938
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0265	0.033
Trypanosoma brucei	aurora B kinase	0.0041	0.0572	0.0781
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0265	0.0265
Mycobacterium leprae	putative cytochrome p450	0.0017	0	0.5
Brugia malayi	GnHR receptor homolog	0.0028	0.0265	0.033
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.0265	0.033
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0495	0.0618
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.0265	0.033
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0038	0.0495	0.0495
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0653	0.0653
Schistosoma mansoni	nAChR subunit	0.0038	0.0495	0.0618
Loa Loa (eye worm)	GABA receptor subunit	0.0022	0.0123	0.0153
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0326	0.7325	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0265	0.0265
Schistosoma mansoni	furin-1 (S08 family)	0.0155	0.3254	0.4064
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.0265	0.0265
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.0265	0.033
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0495	0.0618
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0495	0.0495
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0495	0.0618
Schistosoma mansoni	voltage-gated potassium channel	0.0025	0.0195	0.0243
Onchocerca volvulus		0.0028	0.0265	0.0608
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Trypanosoma cruzi	aurora B kinase, putative	0.0041	0.0572	0.0781
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.0265	0.0265
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0084	0.1582	0.1455
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.6357	0.6357
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0265	0.033
Onchocerca volvulus		0.0028	0.0265	0.0608
Brugia malayi	G-protein coupled receptor	0.0028	0.0265	0.033
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0102	0.2002	0.2733
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0038	0.0495	0.0618
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.0265	0.0265
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0017	0	0.5
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0495	0.0618
Onchocerca volvulus		0.0121	0.2458	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.0265	0.0265
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.0495	0.0495
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.0265	0.0265
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0028	0.0251	1
Schistosoma mansoni	nAChR subunit	0.0038	0.0495	0.0618
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0265	0.033
Schistosoma mansoni	nAChR subunit	0.0038	0.0495	0.0618
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0495	0.0495
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0265	0.0265
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0025	0.0195	0.0243
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0017	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Echinococcus multilocularis	serotonin receptor	0.0028	0.0265	0.0265
Schistosoma mansoni	myosin xvIII	0.0028	0.0265	0.033
Echinococcus granulosus	expressed protein	0.0334	0.7511	0.7511
Brugia malayi	hypothetical protein	0.0028	0.0265	0.033
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0017	0	0.5
Trypanosoma brucei	RNA helicase, putative	0.0031	0.0322	0.0439
Echinococcus granulosus	ephrin type A receptor 4 A	0.0053	0.0858	0.0858
Schistosoma mansoni	protein kinase	0.0041	0.0572	0.0715
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0653	0.0116
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0041	0.0572	0.0625
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0038	0.0495	0.0495
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0102	0.2002	0.2733
Loa Loa (eye worm)	proprotein convertase 2	0.0084	0.1582	0.1976
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0265	0.033
Echinococcus multilocularis	Furin 1	0.0084	0.1582	0.1582
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	serine/threonine protein kinase 6	0.0041	0.0572	0.0715
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0017	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0265	0.033
Brugia malayi	Serotonin receptor	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0974	0.1217
Brugia malayi	Dopamine receptor protein 1	0.0028	0.0265	0.033
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0017	0	0.5
Schistosoma mansoni	ephrin receptor	0.0053	0.0858	0.1072
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Schistosoma mansoni	neurotransmitter gated ion channel	0.0022	0.0123	0.0153
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0265	0.033
Echinococcus multilocularis	neuropeptide receptor	0.0221	0.4816	0.4816
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0355	0.8008	1
Schistosoma mansoni	nAChR subunit	0.0038	0.0495	0.0618
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0265	0.0265
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0084	0.1582	0.1455
Onchocerca volvulus		0.0121	0.2458	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0216	0.4708	0.4708
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	excitatory GABA receptor EXP-1A	0.0038	0.0495	0.0618
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0084	0.1582	0.1455
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.0265	0.0265
Loa Loa (eye worm)	CYP4Cod1	0.0028	0.0251	0.0313
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0334	0.7511	0.938
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0195	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	G protein-coupled receptor	0.0028	0.0265	0.033
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.0265	0.033
Schistosoma mansoni	adenoreceptor	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0653	0.0815
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0038	0.0495	0.0618
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.0265	0.033
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.0251	0.0342
Loa Loa (eye worm)	AUR protein kinase	0.0041	0.0572	0.0715
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0038	0.0495	0.0618
Mycobacterium leprae	Conserved hypothetical protein	0.0017	0	0.5
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0041	0.0572	0.0572
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0495	0.0618
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0038	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0121	0.2458	0.3069
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0495	0.0495
Toxoplasma gondii	aurora kinase	0.0041	0.0572	0.0781
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.0265	0.0265
Onchocerca volvulus		0.0028	0.0265	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0153
Brugia malayi	serine/threonine-protein kinase 6	0.0041	0.0572	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0653	0.0653
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0653	0.0116
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0038	0.0495	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0265	0.0265
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.0265	0.033
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0022	0.0123	0.0153
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0024	0.0169	0.0169
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0265	0.0265
Leishmania major	protein kinase, putative	0.0041	0.0572	0.0781
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0265	0.0265
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0265	0.0265
Echinococcus multilocularis	sex peptide receptor	0.0028	0.0265	0.0265
Onchocerca volvulus		0.0058	0.0974	0.3648
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0121	0.2458	0.3069
Echinococcus granulosus	fmrfamide receptor	0.0028	0.0265	0.0265
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.0265	0.0265
Onchocerca volvulus		0.0028	0.0265	0.0608
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0265	0.033
Brugia malayi	hypothetical protein	0.0028	0.0265	0.033
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.0495	0.0618
Echinococcus multilocularis	nAChR subunit	0.0022	0.0123	0.0123
Echinococcus granulosus	serotonin receptor	0.0028	0.0265	0.0265
Echinococcus granulosus	nAChR subunit	0.0038	0.0495	0.0495
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.0265	0.033
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0038	0.0495	0.0618
Echinococcus multilocularis		0.0287	0.638	0.638
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0265	0.033
Onchocerca volvulus		0.0053	0.0844	0.3091
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.0495	0.0495
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0038	0.0495	0.0618
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1222	0.0937
Leishmania major	cytochrome p450-like protein	0.0028	0.0251	0.0342
Brugia malayi	putative neuropeptide receptor	0.0028	0.0265	0.033
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0017	0	0.5
Echinococcus granulosus	hypothetical protein	0.0028	0.0265	0.0265
Schistosoma mansoni	voltage-gated potassium channel	0.0025	0.0195	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0653	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0495	0.0618
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.0265	0.033
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0265	0.033
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0265	0.033
Toxoplasma gondii	peptidylprolyl isomerase	0.0326	0.7325	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0022	0.0123	0.0153
Echinococcus granulosus	allatostatin A receptor	0.0028	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.033
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.0495	0.0495
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0038	0.0495	0.0495

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 0.794328235 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 6.309573445 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 12.58925412 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 12.58925412 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
Potency (ADMET)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (ADMET)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (ADMET)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (ADMET)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1513347

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1379920