TDR Targets

Basic information

Technical information

TDR Targets ID: 1380460
Name: 2-phenyl-N-[2-(4-phenylpiperazin-1-yl)sulfony lethyl]acetamide
MW: 387.496 | Formula: C20H25N3O3S
H donors: 1 H acceptors: 3 LogP: 2.01 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1ccccc1)NCCS(=O)(=O)N1CCN(CC1)c1ccccc1
InChi: 1S/C20H25N3O3S/c24-20(17-18-7-3-1-4-8-18)21-11-16-27(25,26)23-14-12-22(13-15-23)19-9-5-2-6-10-19/h1-10H,11-17H2,(H,21,24)
InChiKey: UUQZXKIMYLRBNW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-phenyl-N-[2-[(4-phenyl-1-piperazinyl)sulfonyl]ethyl]acetamide
2-phenyl-N-[2-(4-phenylpiperazin-1-yl)sulfonylethyl]ethanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine protease, putative	0.0536	0.7361	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0536	0.7361	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0298	0.3713	0.0507
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0285	0.3518	0.3518
Brugia malayi	Cathepsin L-like precursor	0.0536	0.7361	0.7361
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0536	0.7361	0.7361
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0365	0.4741	0.4741
Giardia lamblia	Cathepsin B precursor	0.0298	0.3713	1
Leishmania major	cathepsin L-like protease	0.0536	0.7361	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0536	0.7361	0.7361
Schistosoma mansoni	cathepsin C	0.0114	0.0898	0.0898
Plasmodium vivax	vivapain-2	0.0536	0.7361	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0536	0.7361	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1774	0.1774
Trypanosoma cruzi	cysteine peptidase, putative	0.0536	0.7361	0.7101
Leishmania major	cathepsin L-like protease	0.0536	0.7361	1
Brugia malayi	Cathepsin L-like precursor	0.0365	0.4741	0.4741
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Plasmodium vivax	vivapain-1	0.0285	0.3518	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0114	0.0898	0.0898
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0536	0.7361	0.7361
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0708	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Echinococcus granulosus	cathepsin L	0.0285	0.3518	0.3518
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0114	0.0898	0.0898
Brugia malayi	cathepsin F-like cysteine proteinase	0.0114	0.0898	0.0898
Echinococcus granulosus	cathepsin b	0.0708	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0285	0.3518	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Echinococcus granulosus	cathepsin L	0.0114	0.0898	0.0898
Entamoeba histolytica	cysteine proteinase, putative	0.0536	0.7361	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0536	0.7361	1
Brugia malayi	fibroinase precursor	0.0114	0.0898	0.0898
Onchocerca volvulus	Cathepsin F homolog	0.0536	0.7361	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1774	0.1774
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0536	0.7361	1
Toxoplasma gondii	cathepsin CPL	0.0536	0.7361	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0298	0.3713	0.3093
Trypanosoma cruzi	cysteine peptidase, putative	0.0536	0.7361	0.7101
Trypanosoma cruzi	cysteine proteinase, putative	0.0285	0.3518	0.2879
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0536	0.7361	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0285	0.3518	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0114	0.0898	0.0898
Brugia malayi	Cathepsin L-like precursor	0.0536	0.7361	0.7361
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0536	0.7361	1
Leishmania major	cathepsin L-like protease	0.0536	0.7361	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0536	0.7361	0.7361
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0114	0.0898	0.0898
Onchocerca volvulus	Cathepsin L homolog	0.0536	0.7361	1
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0536	0.7361	0.7361
Trypanosoma cruzi	cruzipain precursor, putative	0.0536	0.7361	0.7101
Onchocerca volvulus		0.0536	0.7361	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0171	0.1774	0.1774
Plasmodium vivax	vivapain-3	0.0285	0.3518	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Schistosoma mansoni	cathepsin s	0.0171	0.1774	0.1774
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0114	0.0898	0.0898
Echinococcus granulosus	cathepsin l1	0.0365	0.4741	0.4741
Loa Loa (eye worm)	fibroinase	0.0536	0.7361	0.7361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0285	0.3518	0.3518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0171	0.1774	0.1774
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Echinococcus multilocularis	cathepsin L	0.0114	0.0898	0.0898
Toxoplasma gondii	cathepsin B	0.0298	0.3713	0.4356
Brugia malayi	Papain family cysteine protease containing protein	0.0536	0.7361	0.7361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0536	0.7361	0.7361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Plasmodium vivax	unspecified product	0.0285	0.3518	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0708	1	1
Plasmodium vivax	vivapain-2	0.0536	0.7361	1
Leishmania major	cathepsin L-like protease	0.0536	0.7361	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.4741	0.4741
Echinococcus granulosus	cathepsin b	0.0708	1	1
Echinococcus multilocularis	cathepsin L	0.0285	0.3518	0.3518
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0114	0.0898	0.0898
Entamoeba histolytica	cysteine proteinase, putative	0.0285	0.3518	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0536	0.7361	0.7361
Brugia malayi	Papain family cysteine protease containing protein	0.0285	0.3518	0.3518
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0536	0.7361	0.7361
Onchocerca volvulus		0.0365	0.4741	0.5946
Echinococcus granulosus	cathepsin l1	0.0536	0.7361	0.7361
Trypanosoma cruzi	cysteine proteinase, putative	0.0285	0.3518	0.2879
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0365	0.4741	0.5946
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0114	0.0898	0.0898
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.3407	0.5
Giardia lamblia	Cathepsin B precursor	0.0298	0.3713	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0898	0.0898
Echinococcus multilocularis	cysteine protease	0.0536	0.7361	0.7361
Echinococcus multilocularis	cathepsin b	0.0708	1	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1774	0.1774
Loa Loa (eye worm)	hypothetical protein	0.0365	0.4741	0.4741
Brugia malayi	Cathepsin L-like precursor	0.0171	0.1774	0.1774
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0898	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0536	0.7361	0.7361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0536	0.7361	1
Onchocerca volvulus	Cathepsin L homolog	0.0536	0.7361	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0536	0.7361	1
Giardia lamblia	Cathepsin B precursor	0.0298	0.3713	1
Brugia malayi	Cathepsin L-like precursor	0.0365	0.4741	0.4741
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Schistosoma mansoni	cathepsin S (C01 family)	0.0114	0.0898	0.0898
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0536	0.7361	0.7361
Leishmania major	cathepsin L-like protease	0.0536	0.7361	1
Trypanosoma cruzi	cysteine protease, putative	0.0285	0.3518	0.2879
Trypanosoma cruzi	cruzipain precursor, putative	0.0171	0.1774	0.0962
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0536	0.7361	0.7101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0536	0.7361	1
Entamoeba histolytica	cysteine proteinase, putative	0.0285	0.3518	0.4054
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1361	0.1361
Brugia malayi	Papain family cysteine protease containing protein	0.0114	0.0898	0.0898
Leishmania major	cathepsin L-like protease	0.0536	0.7361	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Entamoeba histolytica	cysteine proteinase, putative	0.0285	0.3518	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0536	0.7361	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1361	0.1361
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0285	0.3518	0.2879
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0114	0.0898	0.0898
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0365	0.4741	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0536	0.7361	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0365	0.4741	0.4222
Entamoeba histolytica	cysteine proteinase, putative	0.0536	0.7361	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0536	0.7361	0.7101
Onchocerca volvulus		0.0536	0.7361	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0365	0.4741	0.4741
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0536	0.7361	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0114	0.0898	0.0898
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0298	0.3713	0.3713
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Echinococcus multilocularis	cathepsin b	0.0708	1	1
Onchocerca volvulus		0.0536	0.7361	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0114	0.0898	0.0898
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0114	0.0898	0.0898
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0536	0.7361	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0171	0.1774	0.0962
Loa Loa (eye worm)	ctsf protein	0.0536	0.7361	0.7361
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0114	0.0898	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0898	0.0898
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0114	0.0898	0.0898
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0114	0.0898	0.0898
Brugia malayi	cathepsin L precursor	0.0114	0.0898	0.0898
Entamoeba histolytica	cysteine proteinase, putative	0.0365	0.4741	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0114	0.0898	0.0898
Loa Loa (eye worm)	cysteine protease	0.0536	0.7361	0.7361
Brugia malayi	Cathepsin L-like precursor	0.0536	0.7361	0.7361
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0708	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0536	0.7361	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.4741	0.4741
Echinococcus multilocularis	cysteine protease	0.0536	0.7361	0.7361
Schistosoma mansoni	cathepsin B (C01 family)	0.0114	0.0898	0.0898
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0536	0.7361	0.7361
Plasmodium vivax	unspecified product	0.0171	0.1774	0.1355
Echinococcus multilocularis	cathepsin L cysteine protease	0.0536	0.7361	0.7361
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0285	0.3518	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0285	0.3518	0.3518
Brugia malayi	Cathepsin L-like precursor	0.0536	0.7361	0.7361
Brugia malayi	Papain family cysteine protease containing protein	0.0114	0.0898	0.0898
Trypanosoma cruzi	cysteine peptidase, putative	0.0285	0.3518	0.2879
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0898	0.0898
Entamoeba histolytica	cysteine proteinase 2	0.0285	0.3518	0.4054
Onchocerca volvulus		0.0536	0.7361	1
Brugia malayi	MH2 domain containing protein	0.0144	0.1361	0.1361
Loa Loa (eye worm)	cathepsin B	0.0298	0.3713	0.3713
Onchocerca volvulus		0.0536	0.7361	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0171	0.1774	0.1774
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0708	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0285	0.3518	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0285	0.3518	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0898	0.0898
Onchocerca volvulus		0.0536	0.7361	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0298	0.3713	0.4356
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0708	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0536	0.7361	1
Loa Loa (eye worm)	hypothetical protein	0.0708	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0536	0.7361	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0536	0.7361	0.7361
Leishmania major	cathepsin L-like protease	0.0536	0.7361	1
Entamoeba histolytica	cysteine protease, putative	0.0285	0.3518	0.4054
Onchocerca volvulus		0.0536	0.7361	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0114	0.0898	0.0898
Echinococcus granulosus	cysteine protease	0.0285	0.3518	0.3518
Leishmania major	cathepsin L-like protease	0.0536	0.7361	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0285	0.3518	0.3518
Brugia malayi	Papain family cysteine protease containing protein	0.0285	0.3518	0.3518
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0114	0.0898	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0898	0.0898
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0536	0.7361	1
Brugia malayi	cathepsin L-like precursor	0.0365	0.4741	0.4741

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 22.091 um	PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)]	ChEMBL.	No reference
EC50 (functional)	> 150 um	PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)]	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1513192

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1380460